Areas of Expertise (7)
Society for Endocrinology Clinical Prize Lecture
‘Society for Endocrinology Clinical Prize Lecture’ delivered at the British Endocrine Societies Annual Conference in 2009.
University of Oxford Medical Sciences Divisional Research Prize
Winner of the University of Oxford Medical Sciences Divisional Research Prize in 2009.
Selected Media Appearances (5)
Feel the burn: the science of boosting your metabolism
The Times Online online
Have you ever watched a svelte friend inhale a plate of carbonara and thought: “I wish that I had their metabolism”? If you found yourself beginning the month with yet another failed diet under your belt (and a belt still on the same notch) it’s easy to feel that your metabolism is to blame.
Want to lose weight? It is all in the MIND: Study reveals overweight people who attend ‘mindfulness’ classes lose 6.2lbs more than those who don’t
Mail Online online
Dr Thomas Barber, of the University Hospitals Coventry and Warwickshire NHS Trust, another researcher on the paper, said: ‘Mindfulness has huge potential as a strategy for achieving and maintaining good health and wellbeing.
How to lose weight: Mindfulness linked to shedding pounds
Dr. Thomas M. Barber, the study's senior author at the Warwickshire Institute for the Study of Diabetes Endocrinology and Metabolism at University Hospitals Coventry and Warwickshire NHS Trust, told Newsweek it was surprising how "easily mindfulness techniques could be taught in a group setting, and how compliant most of the participants in our study were."
Can you ‘speed up’ your metabolism?
Live Science online
"People do differ in their metabolic rate, but if you look at people's metabolism per unit or per kilogram of lean mass, then actually, metabolic rate in those terms is remarkably constant across the population," said Dr. Thomas Barber, an associate professor and honorary consultant endocrinologist at the University of Warwick and University Hospitals Coventry and Warwickshire in England.
What is obesity?
The Guardian online
From a medical perspective, obesity is defined simply by body mass index (BMI). BMI is the ratio between body mass (measured in kilograms) to height (in metres) squared, and expressed as kg/m2. The threshold differs for different groups.
Selected Articles (7)
Glycaemic benefit of iGlarLixi in insulin-naive type 2 diabetes patients with high HbA1c or those with inadequate glycaemic control on two oral antihyperglycaemic drugsDiabetes, Obesity, Metabolism
2019 In this post hoc analysis of the randomized controlled LixiLan-O trial in insulin-naive patients with type 2 diabetes mellitus (T2DM) not controlled with metformin, with or without a second oral antihyperglycaemic drug (OAD), the efficacy and safety of the fixed-ratio combination, iGlarLixi (insulin glargine 100 U [iGlar] and lixisenatide [Lixi]), compared to its individual components was assessed in two patient subgroups: group 1) baseline HbA1c ≥9% (n = 134); group 2) inadequate control (HbA1c ≥7.0% and ≤9.0%) despite administration of two OADs at screening (n = 725).
Application of Mindfulness in a Tier 3 Obesity Service Improves Eating Behavior and Facilitates Successful Weight LossJournal of Clinical Endocrinology & Metabolism
2018 Recruitment of participants (n = 53, including n = 33 completers) from patients attending a tier 3-based obesity service at University Hospitals Coventry and Warwickshire. Each participant attended four group sessions, at which mindfulness-based eating behavior strategies were taught.
Genome-wide Association of Polycystic Ovary Syndrome implicates alterations in gonadotropin secretion in European ancestry populationsNature Communications
2015 Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and developmental exposure to androgens are hypothesized to play a causal role in PCOS. Here we map common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels. Three loci reach genome-wide significance in the case-control meta-analysis, two novel loci mapping to chr 8p23.1 [Corrected] and chr 11p14.1, and a chr 9q22.32 locus previously found in Chinese PCOS. The same chr 11p14.1 SNP, rs11031006, in the region of the follicle-stimulating hormone B polypeptide (FSHB) gene strongly associates with PCOS diagnosis and luteinizing hormone levels. These findings implicate neuroendocrine changes in disease pathogenesis.
Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowlyClincal Endocrinology
2015 Meal duration may influence cardiometabolic health. The aim of this study was to explore postprandial effects of meal duration on human metabolism and appetite.
Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmationJournal of Clinical Endocrinology and Metabolism
2014 Manipulation of human brown adipose tissue (BAT) represents a novel therapeutic option for diabesity. The aim of our study was to develop and test a novel magnetic resonance (MR) imaging-based method to identify human BAT, delineate it from white adipose tissue, and validate it through immunohistochemistry.
PTEN mutations predisposing to monogenic cancer syndrome cause constitutive insulin sensitivity and obesity in humansNew England Journal of Medicine
2012 Epidemiologic and genetic evidence links type 2 diabetes, obesity, and cancer. The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growth and metabolic signaling. Germline PTEN mutations cause a cancer-predisposition syndrome, providing an opportunity to study the effect of PTEN haploinsufficiency in humans.
Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndromeJournal of Clinical Endocrinology and Metabolism
2009 Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, and susceptibility to the metabolic syndrome. Altered peripheral cortisol metabolism has been reported in PCOS, but also in simple obesity.