Thomas Schwaab, M.D., PH.D.

Researchers at ChristianaCare and Delaware-based Lisen Imprinting Diagnostics (LisenID) are launching a study to validate a technology designed to detect one of the earliest molecular markers linked to lung cancer development, potentially helping physicians find answers when biopsy results are unclear. The collaboration, led by ChristianaCare’s Cawley Center for Translational Cancer Research, will evaluate LisenID’s QCIGISH (Quantitative Chromogenic Imprinted Gene In-Situ Hybridization) diagnostic platform in patients enrolled in ChristianaCare’s lung cancer screening and diagnostics program. Researchers will validate whether the technology can identify early molecular changes linked to cancer in tissue samples before those changes are visible on pathology under a microscope, potentially adding useful information when biopsy results are inconclusive. Lung cancer remains the leading cause of cancer death in Delaware and across the United States. Survival is much higher when the disease is found early, which has increased interest in tools that may help improve the speed and accuracy of diagnosis. Addressing a common challenge in cancer diagnosis As cancer screening technology evolves, earlier and smaller lesions are found that clinicians must confidently and accurately diagnose. In about 20% of cases, a lung biopsy does not provide enough information to confirm or rule out cancer. Other times, the tissue sample is limited or the results are unclear, leading to repeat testing, months of delay to diagnosis and worse patient outcomes. Traditional pathology relies on examining cells under a microscope. LisenID’s technology is designed to detect early molecular changes in biopsy samples linked to cancer that may not yet be visible through standard methods. Researchers will evaluate whether this technology can help in difficult diagnostic cases. “Advances in cancer care depend on evaluating new approaches that may improve diagnosis,” said Thomas Schwaab, M.D., Ph.D., Bank of America Endowed Medical Director of ChristianaCare’s Helen F. Graham Cancer Center & Research Institute. “This collaboration brings together clinicians and researchers to study a technology that could help reduce uncertainty for patients and support better decisions in challenging cases.” Bringing research to patient care The project brings together specialists from ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, including thoracic surgeons, interventional pulmonologists and cancer researchers. The clinical effort is being led by Brian Nam, M.D., chief of Thoracic Surgery and Interventional Pulmonary. “One of the most difficult situations for patients is when a biopsy does not give a clear answer,” Nam said. “We may not have enough tissue or the results may be unclear. We are evaluating whether this technology can provide additional information that helps guide next steps and reduce uncertainty.” Jennifer Sims-Mourtada, Ph.D., associate director of the Cawley Center for Translational Cancer Research, said the study reflects the center’s focus on moving promising discoveries into clinical testing. “Our role is to rigorously evaluate new approaches in a clinical setting,” Sims-Mourtada said. “This technology has shown promise in published research and through collaborations with leading institutions. We are now working to determine whether it can provide meaningful information that supports better clinical decisions.” Building on prior research The collaboration builds on prior research involving the technology. LisenID reports its platform has been built on research on more than 10,000 clinical cases through collaborations with hospitals and medical centers in the United States and Internationally. Research published in peer-reviewed journals, including the Journal of Clinical Oncology and Clinical Epigenetics, has suggested that early molecular changes in gene activity may help identify early lung cancer and evaluate small pulmonary nodules. Last year, LisenID also announced a research collaboration with Mayo Clinic focused on advancing applications of its technology in cancer diagnosis. The company was recognized as one of the top graduates of the 2026 Creative Destruction Lab Cancer Stream, a highly selective international accelerator for science-based startups. Tina Cheng, M.D., co-founder of LisenID, said the collaboration will help evaluate the technology in real-world clinical settings. “Some of the earliest changes in cancer occur at a molecular level before they can be seen under a microscope,” Cheng said. “Our goal is to validate the applicability of our test in clinical cases to see how the test can help physicians when standard testing does not provide clear answers.” The collaboration highlights growing ties between Delaware’s health care and biotechnology communities. By combining ChristianaCare’s cancer expertise with LisenID’s diagnostic technology, the organizations aim to improve tools that may help physicians diagnose lung cancer more accurately and earlier.

ChristianaCare’s Helen F. Graham Cancer Center & Research Institute is the first in Delaware to offer a powerful new tool in the fight against multiple myeloma—a type of blood cancer that affects plasma cells in the bone marrow. That tool is a new chimeric antigen receptor (CAR) T-cell therapy, called CARVYKTI, which can improve treatment for adults with multiple myeloma that has returned or stopped responding to other treatments. “CAR-T cell therapy represents a paradigm shift in the treatment of multiple myeloma,” said Thomas Schwaab, M.D., Ph.D., Bank of America Endowed Medical Director of the Helen F. Graham Cancer Center & Research Institute." We are expanding access to this life-extending therapy right here in Delaware — close to home, close to hope. This is part of our ongoing commitment at the Graham Cancer Center to ensure our community has access to the most advanced cancer therapies.” Multiple myeloma is a relatively rare cancer, but it still affects a significant number of people each year. In the United States, it is estimated that around 36,110 new cases will be diagnosed in 2025, according to the American Cancer Society What is CAR-T Therapy? CAR-T cell therapy uses a patient’s own immune cells to fight cancer. Doctors first collect the patient’s T cells, which are a type of white blood cell that helps the body fight infections. In the lab, these T cells are reprogrammed by adding a special receptor called a chimeric antigen receptor (CAR). This receptor allows the T cells to recognize specific proteins on cancer cells, acting like a navigation system to help the T cells find and attack the cancer. After this genetic modification, the reprogrammed T cells are expanded in the lab to create a larger army of cancer-fighting cells. Then, they are infused back into the patient’s body, where they go on to find and destroy the cancer cells. This therapy is approved for adults who have already tried several standard treatments, like proteasome inhibitors, immunomodulators and anti-CD38 antibodies, without success. When those treatments stop working, CARVYKTI can offer a powerful new option. CAR T-cell therapy has given new hope to patients with multiple myeloma whose cancer has returned or stopped responding to other treatments. Many people see their cancer shrink or even disappear for a period of time, which can help them live longer and feel better. While the treatment can have short-term side effects, many patients report feeling stronger and having fewer symptoms once they recover. It’s not a cure, but for some, it can mean more time with loved ones and a better quality of life. “This therapy gives our patients a chance when other treatments have failed,” said Zhifu Xiang, M.D., medical oncologist at ChristianaCare Oncology Hematology. “It’s a deeply personalized approach that uses the patient’s own immune system to fight the cancer in a powerful new way. Being able to offer this locally means our patients don’t have to travel far for world-class care.” A Leader in Cell Therapy The Graham Cancer Center’s dedicated team of specialists have been offering CAR-T cell therapy for other cancer types, such as lymphoma and leukemia, since 2018. The center is also recognized by the Foundation for the Accreditation of Cellular Therapy (FACT) for meeting the highest standards in safety, quality and patient care. To learn more about CAR-T cell therapy or other cancer treatments at ChristianaCare, visit christianacare.org/cancer or call the Helen F. Graham Cancer Center & Research Institute at 302-733-HOPE (4673).