Dr. Thomas Roper is a professor of Chemical Engineering and Director of the Pharmaceutical Engineering program for the School of Engineering. He is the principal investigator for the Pharmaceuticals on Demand project at VCU, and collaborator on the Medicines for All initiative. His research interests are in the miniaturization of manufacturing footprints, including continuous chemistry and formulation technologies. Bringing science, technology, medicine and education close to the point of use is a major theme for his research efforts. Roper was previously with GSK Pharmaceuticals for 22 years where his past positions included “Head of API Chemistry and Analysis US” and “Global Head of Exploratory Development Sciences”.
Industry Expertise (6)
Areas of Expertise (9)
NIH Postdoctoral Fellow (professional)
Harvard University: Postdoctoral Associate, Organic Chemistry 1993
Postdoctoral Associate in the laboratories of Professor E.J. Corey
University of Virignia: Ph.D., Organic Chemistry 1992
Virginia Commonwealth University: B.Sc., Chemistry 1986
Selected Articles (2)
4-Fluoro-β-(4-fluorophenyl)-l-phenylalanine was synthesized by the asymmetric phase-transfer catalyzed alkylation of tert-butyl glycinate-benzophenone Schiff base using the cinchona alkaloid derived catalyst. Upon scaling, it was observed that to achieve high levels of enantioselectivity, it was necessary to add the catalyst or base last. From these studies, insight into the stability of the catalyst under the reaction conditions was gained.