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Thomas D. Roper, Ph.D. - VCU College of Engineering. Biotech Eight, 4th floor, Room 420, Richmond, VA, US

Thomas D. Roper, Ph.D. Thomas D. Roper, Ph.D.

Director, Pharmaceutical Engineering and Professor, Department of Chemical and Life Science Engineering | VCU College of Engineering

Biotech Eight, 4th floor, Room 420, Richmond, VA, UNITED STATES

Dr. Roper specializes in efforts to bring engineering and science closer to patients who utilize medicines via novel technologies.

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Biography

Dr. Thomas Roper is a professor of Chemical Engineering and Director of the Pharmaceutical Engineering program for the School of Engineering. He is the principal investigator for the Pharmaceuticals on Demand project at VCU, and collaborator on the Medicines for All initiative. His research interests are in the miniaturization of manufacturing footprints, including continuous chemistry and formulation technologies. Bringing science, technology, medicine and education close to the point of use is a major theme for his research efforts. Roper was previously with GSK Pharmaceuticals for 22 years where his past positions included “Head of API Chemistry and Analysis US” and “Global Head of Exploratory Development Sciences”.

Industry Expertise (6)

Education/Learning Writing and Editing Health and Wellness Pharmaceuticals Biotechnology Chemicals

Areas of Expertise (9)

Metabolic Engineering and Biocatalysis 3D Printing of Dose Forms Long Acting Therapy Development Nanomaterials and Particle Sciences Continuous Chemical Reaction Engineering Cost Effective Therapeutic Treatments for the Developing World Drug Development Drug Discovery Pharmaceutical Innovation

Accomplishments (1)

NIH Postdoctoral Fellow (professional)

2013

Harvard University

Education (3)

Harvard University: Postdoctoral Associate, Organic Chemistry 1993

Postdoctoral Associate in the laboratories of Professor E.J. Corey

University of Virignia: Ph.D., Organic Chemistry 1992

Virginia Commonwealth University: B.Sc., Chemistry 1986

Selected Articles (2)

Synthesis of 4-Fluoro-β-(4-fluorophenyl)-l-phenylalanine by an Asymmetric Phase-Transfer Catalyzed Alkylation: Synthesis on Scale and Catalyst Stability Organic Process Research and Development

2007

4-Fluoro-β-(4-fluorophenyl)-l-phenylalanine was synthesized by the asymmetric phase-transfer catalyzed alkylation of tert-butyl glycinate-benzophenone Schiff base using the cinchona alkaloid derived catalyst. Upon scaling, it was observed that to achieve high levels of enantioselectivity, it was necessary to add the catalyst or base last. From these studies, insight into the stability of the catalyst under the reaction conditions was gained.

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Convergent Synthesis of Adenosine A2a Agonist GW328267C: New Approaches to 2-Alkylaminoadenosines Journal of Organic Chemistry

2004

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