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Yue Zhang, Ph.D. - VCU College of Engineering. Richmond , VA, US

Yue Zhang, Ph.D. Yue Zhang, Ph.D.

Associate Professor, Department of Biomedical Engineering | VCU College of Engineering

Richmond , VA, UNITED STATES

Dr. Zhang's research topics include bone biology, regeneration and animal models of musculoskeletal conditions.

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Biography

Dr. Zhang's research topics include bone biology and regeneration, cartilage biology and nimal models of musculoskeletal conditions.

Industry Expertise (2)

Research

Education/Learning

Areas of Expertise (3)

Bone biology and regeneration

Cartilage biology

Animal Models of Musculoskeletal Conditions

Education (3)

Pennsylvania State University, College of Medicine: Postdoctoral, Bone and Cartilage Biology

University of Pavia, Italy: Ph.D., Genetics

Beijing Agriculture University, China: B.S., Biochemistry

Selected Articles (3)

Effect of tamoxifen on fatty degeneration and atrophy of rotator cuff muscles in chronic rotator cuff tear: An animal model study

Journal of Orthopaedic Research

2015 Fatty degeneration of the rotator cuff muscles is an irreversible change resulting from chronic rotator cuff tear and is associated with poor clinical outcomes following rotator cuff repair. We evaluated the effect of Tamoxifen, a competitive estrogen receptor inhibitor, on fatty degeneration using a mouse model for chronic rotator cuff tear.

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Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways

Journal of Biomechanics

2014 Osteocytes, positioned within bone׳s porous structure, are subject to interstitial fluid flow upon whole bone loading. Such fluid flow is widely theorized to be a mechanical signal transduced by osteocytes, initiating a poorly understood cascade of signaling events mediating bone adaptation to mechanical load. The objective of this study was to examine the time course of flow-induced changes in osteocyte gene transcript and protein levels using high-throughput approaches.

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Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis

BMC Musculoskeletal Disorders

2014 Connexin 43 (Cx43) is the predominant gap junction protein in bone. Mice with a bone-specific deletion of Cx43 (cKO) have an osteopenic cortical phenotype. In a recent study, we demonstrated that cKO mice are resistant to bone loss induced by hindlimb suspension (HLS), an animal model of skeletal unloading. This protective effect occurred primarily as a result of lower osteoclast-mediated bone resorption.

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