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Zahra Keshavarz Motamed - McMaster University, Department of Mechanical Engineering. Hamilton, ON, CA

Zahra Keshavarz Motamed

Assistant Professor | McMaster University, Department of Mechanical Engineering

Hamilton, ON, Canada

Assistant Professor, Department of Mechanical Engineering, McMaster University

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Biography

Dr. Motamed is an assistant professor at the Department of Mechanical Engineering at McMaster University. She was a postdoctoral fellow in the Institute for Medical Engineering & Science at MIT (Cambridge, USA) and Harvard-MIT Biomedical Engineering Center (2014-2016). She received her PhD in mechanical engineering from Concordia University (Montreal, Canada) in 2012 where she was a part-time/adjunct faculty member from 2013 to 2014. Furthermore, she was a postdoctoral fellow in University of Montreal/Laval University. She is a scientific consultant to medical device companies. She also has 8 years of industrial experience in the design sector with a proven record of leadership and project and team management.

Dr. Motamed’s research interests are in the areas of translational and basic cardiovascular mechanics. In her multidisciplinary research, she uses and advances knowledge in biomechanics, fluid mechanics, solid mechanics, medical imaging and mathematical modelling.

Cardiovascular disease is the leading cause of death globally, taking more lives than all forms of cancer combined. Despite advancement in surgical/interventional techniques, many cardiovascular patients do not respond favorably to treatments and, consequently, life expectancy for them remains reduced. Sources of morbidity can be explained on the basis of abnormal hemodynamics that lead to initiation and progression of cardiovascular diseases.

A major part of Dr. Motamed's work is dedicated to the development of advanced numerical algorithms for simulation of cardiovascular mechanics and patient-specific modelling using medical imaging and clinical measurements with the following objectives:

- To develop most needed quantitative non-invasive diagnostic methods for cardiovascular disease
- To design, develop, evaluate and optimize cardiovascular devices such as transcatheter heart valves and vascular stents
- To lead multidisciplinary collaborative efforts to translate engineering-based findings and developments into clinical practice

Due to the interdisciplinary nature of her research, Dr. Motamed established a very strong collaborative network with other researchers such as clinical scientists, surgeons, cardiologists, engineers and applied mathematicians in Canada, USA and Europe as well as with medical-device companies.

Industry Expertise (2)

Medical Devices Automotive

Areas of Expertise (9)

Translational & basic cardiovascular mechanics Biomechanics Fluid Mechanics Solid Mechanics Medical Imaging Mathematical Modelling Medical Device Development of advanced numerical algorithms Patient-specific modelling

Education (3)

Massachusetts Institute of Technology (MIT) (Cambridge, USA): PDF, Biomedical Engineering 2016

Concordia University (Montreal, Canada): PhD, Mechanical Engineering 2012

Sharif University of Technology (Tehran, Iran): B.Sc., M.Sc., Mechanical Engineering 2001

Articles (13)

Keshavarz-Motamed Z, Rikhtegar Nezami F, Partida RA, Nakamura K, Staziaki PV, Ben-Assa E, Ghoshhajra B, Bhatt AB, Edelman ER JACC: Cardiovascular Interventions. 2016, 9(18): 1953-1965

Elimination of trans-coarctation pressure gradients has no impact on left ventricular function or aortic shear stress post intervention in patients with mild coarctation

Keshavarz-Motamed Z, Edelman ER, Motamed PK, Garcia J, Dahdah N, Kadem L J Biomech. 2015, 48(16): 4229-4237

The role of aortic compliance in determination of coarctation severity: lumped parameter modeling, in vitro study and clinical evaluation. Journal of Biomechanics

Keshavarz-Motamed Z, Motamed PK, Maftoon N Medical Engineering & Physics. 2015, 37(3): 321-327

Non-invasive determination of aortic valve trans-catheter pressure gradient: an analytical model

Benevento E, Dejebbari A, Keshavarz-Motamed Z, Cecere R, Kadem L LoS One. 2015, 10(4): e0123000

Flow distribution in aortic valve bypass: a mathematical modeling approach

Keshavarz-Motamed Z, Garcia J, Gaillard E, Capoulade R, LeVen FL, Cloutier G, Kadem L, Pibarot P PLoS One. 2014, 9(1): e86793

Non-invasive determination of left ventricular workload in patients with aortic stenosis using magnetic resonance imaging and Doppler echocardiography

Keshavarz-Motamed Z, Saijo Y, Majdouline Y, Ohayon J, Cloutier G Atherosclerosis. 2014, 235(1): 140-149

Coronary artery atherectomy stabilizes plaque shear strains: an endovascular elastography imaging study

Keshavarz-Motamed Z, Garcia J, Gaillard E, Maftoon N, Di Labbio G, Cloutier G, Kadem L Experiments in Fluids. 2014, 55: 1696

Effect of coarctation of the aorta and bicuspid aortic valve on flow dynamics and turbulence in the aorta using particle image velocimetry

Majdouline Y, Ohayon J, Keshavarz-Motamed Z, Roy Cardinal MH, Garcia D, Allard L, Lerouge S, Arsenault F, Soulez G, Cloutier G Ultrasound in Medicine & Biology. 2014, 40(5): 890-903

Endovascular shear strain elastography for detection and characterization the severity of atherosclerotic plaques: in vitro validation and in vivo evaluation

Keshavarz-Motamed Z, Garcia J, Kadem L PLoS One. 2013, 8(8): e72394

Fluid dynamics of coarctation of the aorta and effect of bicuspid aortic valve

Keshavarz-Motamed Z, Garcia J, Maftoon N, Bedard E, Chetaille P, Kadem L Journal of Biomechanics. 2012, 45(7): 1239-1245

A new approach for the evaluation of the severity of coarctation of the aorta using Doppler velocity index and effective orifice area: in vitro study and clinical implications

Keshavarz-Motamed Z, Garcia J, Pibarot P, Kadem L Journal of Biomechanics. 2011, 44(16): 2817-2825

Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload

Keshavarz-Motamed Z, Kadem L Medical Engineering and Physics. 2010, 33(3): 315-324

Pulsatile flow in a curved tube with coexisting model of aortic stenosis and coarctationof the aorta

Keshavarz-Motamed Z, Kadem L, Dolatabadi A Journal of Microfluidics and Nanofluidics. 2010, 8(1): 47-56

Effects of dynamic contact angle on numerical modeling of electrowetting in parallel plate microchannels

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