Dr. Motamed is an assistant professor at the Department of Mechanical Engineering at McMaster University. She was a postdoctoral fellow in the Institute for Medical Engineering & Science at MIT (Cambridge, USA) and Harvard-MIT Biomedical Engineering Center (2014-2016). She received her PhD in mechanical engineering from Concordia University (Montreal, Canada) in 2012 where she was a part-time/adjunct faculty member from 2013 to 2014. Furthermore, she was a postdoctoral fellow in University of Montreal/Laval University. She is a scientific consultant to medical device companies. She also has 8 years of industrial experience in the design sector with a proven record of leadership and project and team management.
Dr. Motamed’s research interests are in the areas of translational and basic cardiovascular mechanics. In her multidisciplinary research, she uses and advances knowledge in biomechanics, fluid mechanics, solid mechanics, medical imaging and mathematical modelling.
Cardiovascular disease is the leading cause of death globally, taking more lives than all forms of cancer combined. Despite advancement in surgical/interventional techniques, many cardiovascular patients do not respond favorably to treatments and, consequently, life expectancy for them remains reduced. Sources of morbidity can be explained on the basis of abnormal hemodynamics that lead to initiation and progression of cardiovascular diseases.
A major part of Dr. Motamed's work is dedicated to the development of advanced numerical algorithms for simulation of cardiovascular mechanics and patient-specific modelling using medical imaging and clinical measurements with the following objectives:
- To develop most needed quantitative non-invasive diagnostic methods for cardiovascular disease
- To design, develop, evaluate and optimize cardiovascular devices such as transcatheter heart valves and vascular stents
- To lead multidisciplinary collaborative efforts to translate engineering-based findings and developments into clinical practice
Due to the interdisciplinary nature of her research, Dr. Motamed established a very strong collaborative network with other researchers such as clinical scientists, surgeons, cardiologists, engineers and applied mathematicians in Canada, USA and Europe as well as with medical-device companies.
Industry Expertise (2)
Areas of Expertise (9)
Translational & basic cardiovascular mechanics
Development of advanced numerical algorithms
Massachusetts Institute of Technology (MIT) (Cambridge, USA): PDF, Biomedical Engineering 2016
Concordia University (Montreal, Canada): PhD, Mechanical Engineering 2012
Sharif University of Technology (Tehran, Iran): B.Sc., M.Sc., Mechanical Engineering 2001
Elimination of trans-coarctation pressure gradients has no impact on left ventricular function or aortic shear stress post intervention in patients with mild coarctation
The role of aortic compliance in determination of coarctation severity: lumped parameter modeling, in vitro study and clinical evaluation. Journal of Biomechanics
Non-invasive determination of aortic valve trans-catheter pressure gradient: an analytical model
Flow distribution in aortic valve bypass: a mathematical modeling approach
Non-invasive determination of left ventricular workload in patients with aortic stenosis using magnetic resonance imaging and Doppler echocardiography
Coronary artery atherectomy stabilizes plaque shear strains: an endovascular elastography imaging study
Effect of coarctation of the aorta and bicuspid aortic valve on flow dynamics and turbulence in the aorta using particle image velocimetry
Endovascular shear strain elastography for detection and characterization the severity of atherosclerotic plaques: in vitro validation and in vivo evaluation
Fluid dynamics of coarctation of the aorta and effect of bicuspid aortic valve
A new approach for the evaluation of the severity of coarctation of the aorta using Doppler velocity index and effective orifice area: in vitro study and clinical implications
Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload
Pulsatile flow in a curved tube with coexisting model of aortic stenosis and coarctationof the aorta
Effects of dynamic contact angle on numerical modeling of electrowetting in parallel plate microchannels