
Zahra Keshavarz Motamed
Assistant Professor McMaster University, Department of Mechanical Engineering
Social
Biography
Dr. Motamed’s research interests are in the areas of translational and basic cardiovascular mechanics. In her multidisciplinary research, she uses and advances knowledge in biomechanics, fluid mechanics, solid mechanics, medical imaging and mathematical modelling.
Cardiovascular disease is the leading cause of death globally, taking more lives than all forms of cancer combined. Despite advancement in surgical/interventional techniques, many cardiovascular patients do not respond favorably to treatments and, consequently, life expectancy for them remains reduced. Sources of morbidity can be explained on the basis of abnormal hemodynamics that lead to initiation and progression of cardiovascular diseases.
A major part of Dr. Motamed's work is dedicated to the development of advanced numerical algorithms for simulation of cardiovascular mechanics and patient-specific modelling using medical imaging and clinical measurements with the following objectives:
- To develop most needed quantitative non-invasive diagnostic methods for cardiovascular disease
- To design, develop, evaluate and optimize cardiovascular devices such as transcatheter heart valves and vascular stents
- To lead multidisciplinary collaborative efforts to translate engineering-based findings and developments into clinical practice
Due to the interdisciplinary nature of her research, Dr. Motamed established a very strong collaborative network with other researchers such as clinical scientists, surgeons, cardiologists, engineers and applied mathematicians in Canada, USA and Europe as well as with medical-device companies.
Industry Expertise
Areas of Expertise
Education
Massachusetts Institute of Technology (MIT) (Cambridge, USA)
Biomedical Engineering
2016
Concordia University (Montreal, Canada)
PhD
Mechanical Engineering
2012
Sharif University of Technology (Tehran, Iran)
B.Sc., M.Sc.
Mechanical Engineering
2001
Links
Articles
Keshavarz-Motamed Z, Rikhtegar Nezami F, Partida RA, Nakamura K, Staziaki PV, Ben-Assa E, Ghoshhajra B, Bhatt AB, Edelman ER
JACC: Cardiovascular Interventions. 2016, 9(18): 1953-1965Elimination of trans-coarctation pressure gradients has no impact on left ventricular function or aortic shear stress post intervention in patients with mild coarctation
Keshavarz-Motamed Z, Edelman ER, Motamed PK, Garcia J, Dahdah N, Kadem L
J Biomech. 2015, 48(16): 4229-4237The role of aortic compliance in determination of coarctation severity: lumped parameter modeling, in vitro study and clinical evaluation. Journal of Biomechanics
Keshavarz-Motamed Z, Motamed PK, Maftoon N
Medical Engineering & Physics. 2015, 37(3): 321-327Non-invasive determination of aortic valve trans-catheter pressure gradient: an analytical model
Benevento E, Dejebbari A, Keshavarz-Motamed Z, Cecere R, Kadem L
LoS One. 2015, 10(4): e0123000Flow distribution in aortic valve bypass: a mathematical modeling approach
Keshavarz-Motamed Z, Garcia J, Gaillard E, Capoulade R, LeVen FL, Cloutier G, Kadem L, Pibarot P
PLoS One. 2014, 9(1): e86793Non-invasive determination of left ventricular workload in patients with aortic stenosis using magnetic resonance imaging and Doppler echocardiography
Keshavarz-Motamed Z, Saijo Y, Majdouline Y, Ohayon J, Cloutier G
Atherosclerosis. 2014, 235(1): 140-149Coronary artery atherectomy stabilizes plaque shear strains: an endovascular elastography imaging study
Keshavarz-Motamed Z, Garcia J, Gaillard E, Maftoon N, Di Labbio G, Cloutier G, Kadem L
Experiments in Fluids. 2014, 55: 1696Effect of coarctation of the aorta and bicuspid aortic valve on flow dynamics and turbulence in the aorta using particle image velocimetry
Majdouline Y, Ohayon J, Keshavarz-Motamed Z, Roy Cardinal MH, Garcia D, Allard L, Lerouge S, Arsenault F, Soulez G, Cloutier G
Ultrasound in Medicine & Biology. 2014, 40(5): 890-903Endovascular shear strain elastography for detection and characterization the severity of atherosclerotic plaques: in vitro validation and in vivo evaluation
Keshavarz-Motamed Z, Garcia J, Kadem L
PLoS One. 2013, 8(8): e72394Fluid dynamics of coarctation of the aorta and effect of bicuspid aortic valve
Keshavarz-Motamed Z, Garcia J, Maftoon N, Bedard E, Chetaille P, Kadem L
Journal of Biomechanics. 2012, 45(7): 1239-1245A new approach for the evaluation of the severity of coarctation of the aorta using Doppler velocity index and effective orifice area: in vitro study and clinical implications
Keshavarz-Motamed Z, Garcia J, Pibarot P, Kadem L
Journal of Biomechanics. 2011, 44(16): 2817-2825Modeling the impact of concomitant aortic stenosis and coarctation of the aorta on left ventricular workload
Keshavarz-Motamed Z, Kadem L
Medical Engineering and Physics. 2010, 33(3): 315-324Pulsatile flow in a curved tube with coexisting model of aortic stenosis and coarctationof the aorta
Keshavarz-Motamed Z, Kadem L, Dolatabadi A
Journal of Microfluidics and Nanofluidics. 2010, 8(1): 47-56Effects of dynamic contact angle on numerical modeling of electrowetting in parallel plate microchannels