Zbigniew Darzynkiewicz, M.D., Ph.D.
Professor of Pathology, Medicine and Microbiology/Immunology | New York Medical College
Valhalla, NY, UNITED STATES
Dr. Darzynkiewicz has published over 720 articles in peer-reviewed journals, and has edited, co-authored 15 books and holds 8 US patents
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Biography
Zbigniew Darzynkiewicz, M.D., Ph.D. is the Director of Brander Cancer Research Institute at the New York Medical College and the Professor of Pathology, Medicine and Microbiology/Immunology at the same College. Formerly (1980-90) Dr. Darzynkiewicz was the Member of the Sloan-Kettering Institute for Cancer Research, New York, N.Y. and the Professor of Cell Biology and Genetics at Cornell University Medical School. Dr. Darzynkiewicz received his M.D. (with the highest honors) and his Ph.D. degrees from the Medical University of Warsaw, Warsaw, Poland and completed his post-graduate studies at the State University of New York at Buffalo and at the Medical Nobel Institute of Karolinska Institute, Stockholm, Sweden.
Dr. Darzynkiewicz's research concentrates on cell biology with a focus on molecular mechanisms associated with cell proliferation, apoptosis, and sensitivity to anti-cancer drugs. He developed several analytical methodologies to analyze cell cycle kinetics, tumor progression, apoptosis and cell senescence that have world-wide application. He is the past President of the Cell Kinetics Society (1986-87) and also President of the International Society for Analytical Cytology (ISAC; 1993-1994). Since 1972 his research has been continuously supported, by the grants from National Institute of Health, including a prestigious MERIT award. He was also a recipient of a grant from NASA to develop technologies for cell analysis applicable to the micro-gravity conditions of the International Space Station. Dr. Darzynkiewicz is the Editor or/Co-editor of 5 scientific journals and a Member of the Editorial Board of 11 other scientific journals. He is the Foreign Member of the Polish Academy of Sciences (PAN; Warsaw), Polish Academy of Learning (PAU, Krakow) and the Fellow of American Institute for Medical and Biological Engineering (AIMBE). In 2014 Dr. Darzynkiewicz received a degree of Doctor Honoris Causa from his alma mater, the Warsaw Medical University, and the prestigious Casimir Funk Natural Sciences Award from the Polish Institute of Arts and Sciences in America (PIASA).
Google Scholar citation website is: http://scholar.google.com/citations?user=olM19WIAAAAJ&hl=en
Industry Expertise (4)
Health Care - Services
Education/Learning
Biotechnology
Research
Areas of Expertise (5)
Apoptosis
Anti Cancer Research
Pathology
Cell Biology
Cell Proliferation
Accomplishments (5)
Honoris Causa degree (professional)
2014-01-01
Received from Warsaw Medical University, Poland.
Distinguished Fellow (professional)
2014-01-01
Conferred by The Kosciuszko Foundation Collegium of Eminent Scientists.
The Casimir Funk Natural Sciences Award (professional)
2014-01-01
Awarded by the Polish Institute of Arts and Sciences (PIASA) in New York.
Distinguished Scientist Award (professional)
2012-01-01
Awarded by the American Chemical Society.
Leon L. Wheeless Innovation in Cytometry Award (professional)
2012-01-01
Awarded by Western New York Cytometry Users Group, University of Rochester Medical Center.
Education (2)
Medical University of Warsaw, Poland: Doctor of Medical Sciences (Equivalent to Ph.D.), Medicine
Medical University of Warsaw, Poland: M.D., Medicine
Affiliations (2)
- Polish Academy of Sciences : Foreign Member
- Polish Academy of Learning : Foreign Member
Languages (2)
- Polish
- Russian (passive)
Media Appearances (1)
Tobacco-and Nicotine-free Cigarettes More Dangerous Than Regular Cigarettes
Med India online
2010-05-14
The research team was led by Zbigniew Darzynkiewicz, M.D., Ph.D., professor of pathology. Their study, "DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes," will appear in the June 1 issue of Cell Cycle.sing laser scanning cytometry (LSC) technology to measure DNA damage response to the smoke from commercially available tobacco- and nicotine-free cigarettes, the research team expected to find the alternative products were less hazardous than regular tobacco cigarettes...
Sample Talks (1)
Overall speaking activity
Since 1980 he presented by invitation over 360 lectures and seminars on national and international congresses, symposia, and in various research institutions.
Articles (selected) (5)
Cell Cycle Analysis by Flow Cytometry
eLS
2001-01-01
Flow cytometry, the methodology that provides a way to measure physical and chemical attributes of individual cells rapidly and with high accuracy, is widely used in cell cycle analysis. The most common assays are: univariate analysis of cellular deoxyribonucleic acid (DNA) content discloses frequencies of cells in G0/1, S and G2/M phases; bivariate analysis of DNA versus ribonucleic acid (RNA) content reveals frequencies of G0, G1, S and G2M cells, of DNA content versus histone H3 phosphorylated on Ser10 defines frequencies of G0/1, S, G2 and M cells...
Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis)
Cytometry
1997-01-01
The term cell necrobiology is introduced to comprise the life processes associated with morphological, biochemical, and molecular changes which predispose, precede, and accompany cell death, as well as the consequences and tissue response to cell death. Two alternative modes of cell death can be distinguished, apoptosis and accidental cell death, generally defined as necrosis...
A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry
Analytical Biochemistry
1994-01-01
In cells undergoing apoptosis (programmed cell death), a fraction of nuclear DNA is fragmented to the size equivalent of DNA in mono-or oligonucleosomes. When such DNA is analyzed by agarose gel electrophoresis it generates the characteristic" ladder" pattern of discontinuous DNA fragments...
Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays
Cancer Research
1993-01-01
DNA strand breaks which occur in HL-60 cells as a result of activation of endonuclease during apoptosis induced by cell treatment with the DNA topoisomerase I inhibitor camptothecin and topoisomerase II inhibitors teniposide, 4′-(9-acridinylamino)-3-methanesulfon-m-anisidide, and fostriecin were labeled in situ, in individual fixed and permeabilized cells...
Relation of mammalian sperm chromatin heterogeneity to fertility
American Association for the Advancement of Science
1980-01-01
Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility...
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