Zubair Karim, PhD

Assistant Professor, Department of Interdisciplinary Health Sciences Augusta University

  • Augusta GA

Karim researches signaling and the SNARE secretory machinery in platelets to understand their contribution to health and disease.

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4 min

Up in smoke? With vaping on the edge of banishment, let our experts help with your coverage

The U.S. Food and Drug Administration (FDA) has paused a ban on the sale of Juul Labs' e-cigarettes, saying an additional review of the company's marketing application is required. The once thriving company won a temporary reprieve a couple of weeks ago after a federal appeals court stayed the FDA's ban, following an appeal from Juul for an emergency review of the regulator's order. Juul has always been in the spotlight, in part because of its prominent placement atop the e-cigarette chain, but with the company facing a potential demise, it could be the first casualty, with the rest of the vaping industry in the government's sights. Dr. Zubair Karim, assistant professor in the Department of Interdisciplinary Health Sciences at Augusta University, fields a few questions and lends his expert perspective on this topic. With the ban on Juul products, could this result in a ban on other companies’ e-cigarette products as well, or was there something specifically about Juul that caused their ban? This is the first steps toward the banning of the e-cigarette, i.e., Juul, where the FDA took a significant and bold step. Gradually, this will open the path for banning of the other e-cigarette products. There are no differences in the Juul and other products but Juul became more popular in our young generation. Many local and state jurisdictions have recently begun enacting laws that prohibit e-cigarette usage that smoking is banned, although some state laws with comprehensive smoke-free laws will still allow for vaping to be permitted in bars and restaurants while prohibiting e-cigarettes in other indoor places. On a more basic level, what are platelets (where are they, and what do they do) and do we know what has caused them to react more negatively compared to traditional smoking? Platelets are small and colorless stem cell fragments present in our blood. They are disk-shaped and don’t have a nucleus. It plays an important role in maintaining vascular integrity based on their ability to respond to lesions in a vessel wall. Hyperactivity of platelets is known to cause spurious clot formation and occlusive loss of blood flow, leading to strokes and heart attacks, whereas hypoactivity causes bleeding diathesis with life-threatening consequences. Several studies have been reported that smoking induces oxidative stress, leading to increased platelet activation, whereas nicotine causes the damage of endothelial lining of the arterial and venous system and ultimately leads to the severe life-threatening consequences. What are thrombotic events and why should someone be worried about them? Thrombosis is the formation of a blood clot (partial or complete blockage) within blood vessels, whether venous or arterial, limiting the natural flow of blood. There are several complications depending on where the thrombosis is located. The most serious problems include stroke, heart attack and serious breathing problems, which is called pulmonary embolism. If the patients are not treated in a timely manner, it will lead to life-threatening conditions. However, progression of the disease can be prevented by following changes in our lifestyle such as increasing physical activity, quitting smoking, losing weight, eating a balanced diet, quitting junk food and managing other health conditions. How do nicotine and other harmful chemical levels compare in vaping vs. traditional cigarettes? Both smoking and vaping have similar side effects and cause serious health risks in the long run. Scientists do not fully understand the long-term health effects of electronic cigarettes (e-cigarettes), yet science indicates that they are not a safe alternative to smoking. In the last several years it has been observed that vaping is growing in popularity among teenagers. Moreover, e-cigarettes contain a large dose of nicotine, a substance known to slow the development of brains in fetuses, children and teens. Furthermore, vaping involves breathing in aerosol that contains several chemicals, including nicotine and flavoring through an e-cigarette or other devices. Also, the liquid present in the e-cigarettes which creates the vapor is dangerous to adults and children if they swallow, inhale, or get it on the skin. Nonetheless, vaping also delivers dangerous chemicals, including diacetyl, cancer-causing chemicals, heavy metals, volatile organic compounds (VOCs), and such toxic chemicals that are not generated in traditional cigarettes. In summary, long-term vaping causes similar toxic impact to overall health compared to traditional cigarettes. This court case will be getting a lot of attention and could determine the future of the e-cigarette industry. If you're a journalist looking to know then let Augusta University's expert help. Karim is available to speak with reporters about vaping and e-cigarettes. Simply click on his icon now to arrange an interview today.

Zubair Karim, PhD

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Biography

Karim is an assistant professor in the Department of Interdisciplinary Health Sciences at Augusta University, where he has served since 2021.

His research is based around understanding signaling and the SNARE secretory machinery in platelets as well as to understand their contribution to health and disease. His research also includes drug discovery in the thrombosis and haemostasis, pre-clinical trials and basic mechanisms of the drug in cell system especially in platelets.

He received an M.S. from the Hamadard University, New Delhi, India. He received his Ph.D. in Biochemistry from the Institute of Medical Sciences, Banaras Hindu University, Varanasi, India in 2004. In 2004, he joined Dr. Sidney Whiteheart (University of Kentucky, Lexington, KY) as a post-doctoral fellow.

Areas of Expertise

Smoking and Cardiovascular Disease
Thrombosis
Hemostasis
Platelet Exocytosis and Signaling
E-cigarettes

Accomplishments

U.S. Patent

Co-Inventor of Thromboxane Receptor-Based Vaccine for Managing Thrombogenesis (Publication Number: US-2019-0358308-A1; Publication Date: 11/28/2019)

Scientist Development Grant

American Heart Association (2013)

Tom Vanaman Award

University of Kentucky (2008)

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Education

Institute of Medical Sciences, Banaras Hindu University

Ph.D.

Biochemistry

Hamdard University

Master's of Science

Biochemistry

S. K. University

Bachelor of Science

Biochemistry

Affiliations

  • American Heart Association
  • American Society of Cell Biology
  • Biotechnology Society of India
  • Indian Society of Cell Biology
  • Society of Biological Chemistry, India
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Media Appearances

Augusta University Professor warns about long-lasting e-cigarette effects

WRDW  tv

2022-07-23

The FDA is looking to pull Juul E-Cigarettes off the shelves. They were originally created as a way to wean smokers off tobacco products. Researchers at Augusta University have been looking into the lasting effects vapes can have.

Dr. Zubair Karim, an assistant professor of interdisciplinary health sciences at A-U says, “There is no such remedy that we can take the alternative to the smocking pattern.”

According to the CDC in 2021, 2.06 million U.S. middle and high school students used e-cigs in the past 30 days.

A.U. experts began testing back in 2020 by exposing mice to the nicotine found in Juul’s and collecting blood samples.

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Answers

How do nicotine and other harmful chemical levels compare in vaping vs. traditional cigarettes?
Zubair Karim, PhD

Both smoking and vaping have similar side effects and cause serious health risks in the long run. Scientists do not fully understand the long-term health effects of electronic cigarettes (e-cigarettes), yet science indicates that they are not a safe alternative to smoking. In the last several years it has been observed that vaping is growing in popularity among teenagers. Moreover, e-cigarettes contain a large dose of nicotine, a substance known to slow the development of brains in fetuses, children and teens.

With the ban on Juul products, could this result in a ban on other companies’ e-cigarette products as well, or was there something specifically about Juul that caused their ban?
Zubair Karim, PhD

This is the first steps toward the banning of the e-cigarette, i.e., Juul, where the FDA took a significant and bold step. Gradually, this will open the path for banning of the other e-cigarette products. There are no differences in the Juul and other products but Juul became more popular in our young generation.

Articles

In utero thirdhand smoke exposure modulates platelet function in a sex-dependent manner

Haematologica

1. Ali, H.E.A., Alarabi, A.B., Karim, Z.A., Rodriguez, V., Hernandez, K.R., Lozano, P.A., El- Halawany, M.S., Alshbool, F.Z., Khasawneh, F.T.

2021-09-16

Thirdhand smoke (THS), the persistent residue of tobacco smoke that remains after a cigarette is extinguished, materialized as a threat for human health over the last decade. These toxic residues end up depositing on surfaces and objects where tobacco has been used (e.g., homes) and persist for weeks/months after the last smoking.1 THS toxicants undergo chemical reactions and changes over time potentially making them more toxic.2 Given that the routes of exposure to THS involve skin absorption, inhalation and ingestion,3 it is thought to be more toxic by producing more toxicants in the blood of the exposed person.4 Indeed, there is a growing body of evidence documenting THS-induced health risks,5 including cardiovascular disease (CVD). For example, we previously showed that THS exposure modulates platelet function and enhances thrombogenesis in adult exposed mice.6 However, it has not yet been established whether prenatal/in utero THS exposure impacts platelet function and related disorders, which is paramount since the developing embryo is especially sensitive to environmental toxicants, including cigarette smoke.7 Therefore, this study was designed to address this issue, utilizing the offspring of exposed females. In addition, we also examined whether sex differences exist in THS-induced effects.

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The G-protein βγ subunits regulate platelet function

Life Sciences

2. Alarabi, A.A., Karim, Z.A., Hinojos, V., Lozano, P.A., Hernandez, K.R., Montes, R.J.E., Ali, H.A., Khasawneh, F.T., Alshbool, F.Z.

2020-09-21

G-protein coupled receptors (GPCRs) tightly regulate platelet function by interacting with various physiological agonists. An essential mediator of GPCR signaling is the G protein αβγ heterotrimers, in which the βγ subunits are central players in downstream signaling. Herein, we investigated the role of Gβγ subunits in platelet function, hemostasis and thrombogenesis.

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The JUUL E-Cigarette Elevates the Risk of Thrombosis and Potentiates Platelet Activation

Pharmacology & Therapeutics

3. Ramirez, J.E.M., Karim, Z.A., Alarabi, A.B., Hernandez, K.R., Taleb, Z.B., Rivera, J.O., Khasawneh, F.T., Alshbool, F.Z.

2020-07-21

Smoking is the main preventable cause of death in the United States and worldwide and is associated with serious cardiovascular health consequences, including thrombotic diseases. Recently, electronic cigarettes (e-cigarettes) and, in particular JUUL, have attained wide popularity among smokers, nonsmokers, pregnant females, and even the youth, which is alarming. Interestingly, there is/are no information/studies regarding the effect of JUUL on cardiovascular diseases, specifically in the context of modulation of platelet activation. Thus, it is important to discern the cardiovascular disease health risks associated with JUUL.

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