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Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues

A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunity

Bacterial elicitation and evasion of plant innate immunity

A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase

Pseudomonas type III effector AvrPtoB induces plant disease susceptibility by inhibition of host programmed cell death

Mycobacterium tuberculosis causes tuberculosis in humans and is one of the leading causes of death by an infectious disease.  A signature feature of M. tuberculosis pathogenesis is that the bacterium survives inside macrophages, a host immune cell that kills many other bacteria.  The goals of my research program are to: 1) characterize how M. tuberculosis adapts to life inside a macrophage, and 2) apply these discoveries towards the development of new drugs. To achieve these goals we are utilizing genetic, genomic, and biochemical approaches to characterize new genes and proteins that enable M. tuberculosis to succeed as an intracellular pathogen.  These findings are then translated into high throughput screening (HTS) platforms to identify small molecule compounds that interfere with M. tuberculosis adaptation physiology.  In summary, the mission of my lab is to make basic research discoveries that jump-start the development of new drugs to treat tuberculosis.

Drug Discovery

Plant Pathology

Microbiology

Research

Tuberculosis

Antibiotic Resistance

College of Veterinary Medicine

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MSU nominates undergrad researchers for national Goldwater scholarship

Ancient Chinese malaria remedy fights TB

Simple food additive slows E. coli poisoning

MSU scientists set sights on glaucoma medication to treat TB

Professor

Every day, researcher Robert Abramovitch enters his lab in the Physical Sciences building motivated and ready to find new solutions for treating tuberculosis (TB). Read more: go.msu.edu/abramovitch #EmpowerMSU

Illuminating Solutions - Robert Abramovitch

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