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Gates Foundation to Fund RPI Research to Develop Low-Cost Monoclonal Antibody Treatments
Professor Todd Przybycien, Ph.D., head of RPI’s Department of Chemical and Biological Engineering, has been awarded a $3.1 million share of a Gates Foundation Global Grand Challenge grant to advance exceptionally low-cost monoclonal antibody (mAb) manufacturing. Monoclonal antibodies have proven effective at treating a wide range of conditions, including infectious diseases like COVID-19, autoimmune disorders, and certain types of cancer. But they are expensive to produce, and current market prices of $50 to $100 per gram put them effectively out-of-reach for millions of people around the world. The goal of the Gates Grand Challenge is to reduce the price of mAbs to just $10 per gram. Last month, the Gates Foundation announced $10.5 million in funding to a team led by the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) in order to achieve that goal. Professor Przybycien’s group is part of that team and will focus on improving the process of purifying monoclonal antibodies after they have been produced by engineered cells. “Optimization and intensification of the downstream purification process offer the exciting possibility of breaking through to the $10/g overall target,” Przybycien said. “We are excited to advance the precipitation-based process we have developed with our collaborator at Penn State as part of the manufacturing solution to sustainably meet the global need for monoclonal antibodies.” Przybycien is an internationally recognized researcher in biomanufacturing and applied biophysics, focusing on developing processes to manufacture recombinant proteins, mRNA, and viral vectors. He has won numerous awards including the NSF CAREER Award and the Camille Dreyfus Teacher-Scholar Award. He is also a fellow of the American Chemical Society, AIChE, and AIMBE. “This grant is a testament to the years of work Todd Przybycien and his team have done to optimize and improve biopharmaceutical manufacturing processes,” said Shekhar Garde, Ph.D., the Thomas R. Farino, Jr. ’67 and Patricia E. Farino Dean of the School of Engineering. “It will pave the way for affordable access to lifesaving medications for millions of people who desperately need them.” “We are excited by the opportunity to demonstrate that there are existing solutions developed by industry and academic partners that can significantly reduce cost of goods and accelerate timelines,” said Kelvin Lee, NIIMBL Institute Director. “We are honored to receive this grant from the Gates Foundation, which will enable this exceptional team to deliver meaningful advances to antibody production efficiency.” This Gates Grand Challenge was established in honor of Dr. Steve Hadley, who championed the reduction of mAbs costs to make them affordable in low- and middle-income countries. The team’s first target will be a monoclonal antibody to treat malaria, an infectious disease which kills more than half a million people each year, primarily in Africa.
Navigating Grief During the Holiday Season
The holiday season is a time of joy, togetherness and celebration, but for many – especially those who are grieving the death of a loved one or a deep loss – it can bring a complex mix of emotions, ranging from sadness and sorrow to gratitude and joy. Baylor University professors Candi Cann, Ph.D., a death scholar and associate professor of religion in the Honors College, and Jo-Ann Tsang, Ph.D., a leading gratitude researcher and associate professor of psychology, offer four strategies for people experiencing difficult emotions and grief during the holidays. Embrace the spectrum of emotions Both Tsang and Cann say the key to maintaining balance and authenticity – even while deep in grief – is understanding and accepting where you are emotionally. “It’s possible and normal to feel different emotions at one time,” Tsang said. “You can feel happiness during the holidays, but also sad that you miss someone who you wish were present. Being grateful does not rule out feeling other emotions; we can cultivate gratitude, but that does not necessitate running away from other emotions.” Cann pointed out that grief can be complicated if the death or loss is from a difficult relationship. “It is okay to feel relief in addition to grief and it is important to validate all of your feelings – it’s a complicated grief because it was a complicated relationship,” Cann said. The importance of self-care Self-care is vital during this time, Cann said. She encourages grieving people to stay active, eat healthy, go outside to be in nature and get enough sleep. “It’s totally normal to need more sleep when you're depressed and grieving. You just have to be gracious with yourself about that,” Cann said. Allowing ourselves to feel emotions like stress, sadness or grief gives us insight into what we value and “can motivate us to take some time for self-care,” Tsang said. Acknowledging that we are stressed might lead us to reach out to others for help with tasks that overwhelm us or to let go of things to reduce stress. In addition to taking care of your physical health, staying engaged in your community or church and being in community with others is beneficial for mental health, Cann said. But at the same time, be honest with yourself about what you want to do and only accept invitations or participate in activities that you feel you can handle, she added. The place of gratitude Tsang suggests approaching challenging emotions with gratitude as it “might also provide context and perspective for our loss and potentially transform our negative emotions.” “As an example, I might feel frustrated that I am sad but then feel grateful that I have good family and neighbors to check on me and coworkers to help me finish the tasks that I can’t do while I’m down,” Tsang said. “This gratitude might help reduce my frustration by helping me see the support that is present in my life, on which I had not previously reflected.” At the same time, she reiterated that, in addition to cultivating gratitude, it’s important for people to permit themselves to experience negative emotions such as grief and sadness in response to life circumstances. “It’s okay if it’s hard to experience gratitude. God meets us where we are,” Tsang said. Evaluate traditions and embrace memories Cann suggests evaluating family traditions, choosing those that are most important to continue and starting new traditions that include their loved one. “A lot of people feel like when that person is gone, the love is gone too, but the love is still there,” Cann said. “You wouldn't feel the grief or the big hole that you now have if you didn't have all of this love in the first place.” She suggests embracing their loved one’s presence by including a place at the table for Christmas dinner, making their favorite recipe or finding other ways to continue the bonds. By doing these things, “you're including them in your conversation, and you're making space for that person, both literally and symbolically,” Cann said. Supporting someone who is grieving Being supportive of someone grieving requires patience and vulnerability. “Engage with the person and ask how you can best support them, and let them know that you are thinking about them during this time,” Cann said. Sometimes, friends or family members don’t want to bring up death during the holidays because they don't want to make people sad at a joyful time. “But the point is, they already are sad, so bringing it up allows them to express it” and feel accepted in their pain, Cann said. It also is important to remember that not all grief is related to death. There are many types of loss that people experience such as divorce or disease. The Baylor researchers note that we can’t decide or predict what defines another person's grief, but we can offer love and support. Approaching the holidays when experiencing grief over a death or a deep loss may be painful at first, but using these strategies can help us face the future by celebrating with gratitude what we had in the past. Ultimately, the holidays are a time for reflection, connection and self-compassion. Allow yourself to feel your emotions fully – whether joyful, challenging or a mix of both – and use them as guides for meaningful action. Looking to know more or arrange an interview? Simply click on the expert's icon below or contact: Shelby Cefaratti-Bertin today.
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The National Cancer Institute (NCI) has renewed the Cancer Center Support Grant (CCSG) for The Wistar Institute and ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, awarding $16.3 million over the next five years. The renewal received an “exceptional” rating — the highest possible — recognizing the strength and impact of a partnership that combines world-class basic science with leading community-based cancer care. A One-of-a-Kind National Model This collaboration is the only one of its kind in the nation, joining Wistar, an NCI-Designated Basic Cancer Center, with ChristianaCare, one of the country’s premier academic community cancer centers and a National Cancer Institute Community Oncology Research Program. Together, they focus on driving advances against some of the most challenging cancers, including pancreatic, melanoma, breast, lung and ovarian cancers. The grant supports shared infrastructure, scientific resources and programs that enable researchers and clinicians to work seamlessly across both institutions. By connecting laboratory breakthroughs at Wistar with ChristianaCare’s ability to rapidly apply new approaches in a diverse patient population, the partnership accelerates the path from discovery to care. NCI highlighted the collaboration’s effectiveness, noting that “the ongoing alliance with the Helen F. Graham Cancer Center & Research Institute is where most clinical translation into active oncology trials is occurring, supported by productive collaboration between Wistar investigators and Graham Cancer Center oncologists.” Impact on Patients and Community “At ChristianaCare, we are committed to bringing innovation directly to the people we serve. Our collaboration with Wistar connects the best of basic science with the realities of patient care,” said Thomas Schwaab, M.D., Ph.D., Bank of America Endowed Medical Director of the Helen F. Graham Cancer Center & Research Institute. “The NCI’s exceptional score recognizes the promise of this work and the progress we are making together. It is a powerful affirmation that our patients are benefiting from research at the highest level.” “This renewal from the NCI is proof that we are building a model for how cancer research and community care can come together,” said Nicholas J. Petrelli, M.D., director of the Cawley Center for Translational Cancer Research at the Helen F. Graham Cancer Center & Research Institute and associate director of Translational Research at The Wistar Institute Cancer Center. “Through our partnership with Wistar, patients in Delaware and beyond are gaining access to cutting-edge research and therapies for some of the toughest cancers we face.” Dario Altieri, M.D., president and CEO of The Wistar Institute and director of its Ellen and Ronald Caplan Cancer Center, added: “An exceptional rating from the NCI is a reflection of the scientific excellence and real-world impact of this partnership. What makes this collaboration unique is its ability to take discoveries in areas such as melanoma and ovarian cancer and bring them rapidly into clinical practice through ChristianaCare.” NCI underscored the alliance’s reach, noting that “the partnership with the Graham Cancer Center brought cutting-edge cancer research to the community and advanced groundbreaking discoveries to first-in-human oncology clinical trials.” A Pipeline of Research Advancing Faster Than Ever Research achievements supported by the Wistar—ChristianaCare partnership include: Advancing multiple Wistar discoveries into investigator-initiated, first-in-human oncology clinical trials, including studies in pancreatic, melanoma, lung, breast and ovarian cancers. Launching joint research programs across several cancer types, with expanding efforts in cancer risk and population health. Increasing access to high-quality biospecimens — including tumor tissue, biopsies and blood samples — that fuel translational research. Strengthening shared scientific infrastructure supporting immunotherapy research, organoid development, xenograft models and molecular profiling. The Wistar—ChristianaCare partnership, established in 2011, has grown into a nationally recognized alliance that bridges science and medicine. With this CCSG renewal, the collaboration will expand research in pancreatic, melanoma, breast, lung and ovarian cancers and continue advancing prevention, early detection and training programs for the next generation of physician—scientists. The Helen F. Graham Cancer Center & Research Institute depends on grants and community support to keep this work moving forward. To learn more or make a gift, visit Support the Helen F. Graham Cancer Center & Research Institute.
Violence alters human genomes for generations, researchers discover
In February of 1982, the Syrian government besieged the city of Hama, killing tens of thousands of its own citizens in sectarian violence. Four decades later, rebels used the memory of the massacre to help inspire the toppling of the Assad family that had overseen the operation. But there is another lasting effect of the attack, hidden deep in the genes of Syrian families. The grandchildren of women who were pregnant during the siege — grandchildren who never experienced such violence themselves — nonetheless bear marks of it in their genomes. Passed down through their mothers, this genetic imprint offers the first human evidence of a phenomenon previously documented only in animal models. The genetic transmission of stress across multiple generations. “The idea that trauma and violence can have repercussions into future generations should help people be more empathetic, help policymakers pay more attention to the problem of violence,” said Connie Mulligan, Ph.D., a professor of Anthropology and the Genetics Institute at the University of Florida and co-senior author of the new study. “It could even help explain some of the seemingly unbreakable intergenerational cycles of abuse and poverty and trauma that we see around the world, including in the U.S.” While our genes are not changed by life experiences, they can be tuned through a system known as epigenetics. In response to stress or other events, our cells can add small chemical flags to genes that may quiet them down or alter their behavior. These changes may help us adapt to stressful environments, although the effects aren’t well understood. It is these tell-tale chemical flags that Mulligan and her team were looking for in the genes of Syrian families. While lab experiments have shown that animals can pass along epigenetic signatures of stress to future generations, proving the same in people has been nearly impossible. “Resilience and perseverance is quite possibly a uniquely human trait.” —Connie Mulligan Mulligan worked with Rana Dajani, Ph.D., a molecular biologist at Hashemite University in Jordan and co-senior author, as well as anthropologist Catherine Panter-Brick, Ph.D., of Yale University, to conduct the unique study. Dajani envisioned the research project; because of her intimate knowledge of the Syrian population and its tragic history, she designed the study to cover three generations of Syrian refugees to Jordan. Some families had lived through the Hama attack before fleeing to Jordan. Other families avoided Hama, but lived through the recent civil war against the Assad regime. The team collected samples from grandmothers and mothers who were pregnant during the two conflicts, as well as from their children. This study design meant there were grandmothers, mothers and children who had each experienced violence at different stages of development. A third group of families had immigrated to Jordan before 1980, avoiding the decades of violence in Syria. These early immigrants served as a crucial control to compare to the families who had experienced the stress of civil war. Study coauthor Dima Hamadmad, a Syrian researcher and the daughter of refugees, led the search for families that met the study criteria and collected cheek swabs from 138 people across 48 families. "The participants took part in the research out of love for their children and concern for future generations,” she said. “But more than that, they wanted their stories of trauma to be heard and acknowledged.” Back in Florida, Mulligan’s lab scanned the DNA for epigenetic modifications and looked for any relationship with the families’ experience of violence. In the grandchildren of Hama survivors, the researchers discovered 14 areas in the genome that had been modified in response to the violence their grandmothers experienced. These 14 modifications demonstrate that stress-induced epigenetic changes may indeed appear in future generations in humans, just as they can in animals. The study also uncovered 21 epigenetic sites in the genomes of people who had directly experienced violence in Syria. In a third finding, the researchers reported that people exposed to violence while in their mothers’ wombs showed evidence of accelerated epigenetic aging, a type of biological aging that may be associated with susceptibility to age-related diseases. Most of these epigenetic changes showed the same pattern after exposure to violence, suggesting a kind of common epigenetic response to stress – one that can not only affect people directly exposed to stress, but also future generations. “We think our work is relevant to many forms of violence, not just refugees. Domestic violence, sexual violence, gun violence: all the different kinds of violence we have in the U.S,” said Mulligan. “We should study the effects of violence. We should take it more seriously.” It’s not clear what, if any, effect these epigenetic changes have in the lives of people carrying them inside their genomes. But some studies have found a link between stress-induced epigenetic changes and diseases like diabetes. One famous study of Dutch survivors of famine during World War II suggested that their offspring carried epigenetic changes that increased their odds of being overweight later in life. While many of these modifications likely have no effect, It’s possible that some have functional effects that can affect our health, Mulligan said. The researchers published their findings, which were supported by the National Science Foundation, Feb. 27 in the journal Scientific Reports. While carefully searching for evidence of the lasting effects of war and trauma stamped into our genomes, Mulligan and her collaborators were also struck by the perseverance of the families they worked with. Their story was much bigger than merely surviving war, Mulligan said. “In the midst of all this violence we can still celebrate their extraordinary resilience. They have persevered,” Mulligan said. “That resilience and perseverance is quite possibly a uniquely human trait.”
The School of Science at Rensselaer Polytechnic Institute (RPI) has launched a new minor in quantum computing, positioning students at the forefront of one of the most rapidly developing fields in technology. The minor leverages RPI's unique status as the first university in the world to house an IBM Quantum System One on campus, providing students with unprecedented access to utility-scale quantum computing technology. The minor, which is now available to all currently enrolled students, requires four courses drawn from physics, computer science, mathematics, and engineering. The curriculum provides both theoretical foundations and practical exposure to quantum hardware and software, and gives students a leg up in a field rapidly approaching quantum advantage — the point at which quantum systems outperform classical computing approaches on meaningful tasks. "The quantum computing minor will augment the training of RPI students with insight into an emerging technology that will reshape industries from pharmaceuticals to artificial intelligence," said Steven Tait, Ph.D., Dean of the School of Science. "With direct access to the IBM Quantum System One, our students will gain hands-on experience with cutting-edge tools that are not yet widely available. This minor equips them with the interdisciplinary foundation needed to understand and contribute to quantum-enabled innovation." The minor arrives at a pivotal moment in quantum computing's evolution. IBM's demonstration of quantum utility in 2023 marked the beginning of an era in which quantum systems serve as scientific tools to explore complex problems in chemistry, physics, and materials science — areas where quantum advantage offers transformative potential. Hannah Xiuying Fried, graduating this December, is one of the first students to declare the minor. “I'm not a physics or computer science major, so it allows me an accredited way to prove a relevant background to future employers,” she said. “It prepares me for graduate school where I plan to continue pursuing quantum hardware research.” Currently enrolled students may declare the minor now and pursue it alongside their established degree programs. Interested students should contact Chad Christensen at sciencehub@rpi.edu.
Trim the Clutter, Keep the Cheer
The holiday season brings warmth, joy and a touch of magic into our homes, but it also can bring excess clutter, waste and energy consumption, making it hard to feel festive. However, there are simple and creative ways to decorate sustainably without sacrificing the festive spirit. Baylor University human sciences and design professor Elise King, M.I.D., M.A., an expert in interior design and built environments, says embracing sustainable decorations, changing to energy-efficient lights, eliminating clutter and reducing waste can help maintain a tidy, eco-friendly home – and create a holiday atmosphere that resonates with joy and meaning. “The holidays can often feel busy and stressful, so it’s helpful to focus on traditions and decorations that bring joy and add meaning to the season,” King said. By taking simple steps to reuse materials, reduce energy consumption and focus on what matters most, families can celebrate the season with both heart and mindfulness, King said. Decorating sustainably One of the easiest ways to approach sustainable decorating is by reusing or repurposing materials you already have or finding decorations at resale shops. "Upcycling items from thrift stores or turning last year’s Christmas cards into garlands are simple and creative ideas," King said. “Beyond thriftiness, these practices add a personal and nostalgic touch to decorations.” King also said that it is important to consider the lifecycle of a product, beyond just being recyclable. "Also consider elements such as durability/longevity, manufacturing processes, transportation, energy consumption and disposal,” she said. “I recommend people make the best-informed decisions they can, while also remembering not to let it become overwhelming. Switch to LED Christmas lights Changing from incandescent to LED Christmas lights is good for both style and sustainability. LED lights reduce energy usage, are more durable and typically last longer than incandescent. Plus, they have come a long way over the past few years. “The criticism used to be that LEDs had a blue hue and were ‘cold’ compared to incandescent,” King said. “That isn’t really the case anymore. You have to be particular about what you purchase, but several companies offer lights that are virtually indistinguishable from vintage lights.” A clutter-free peaceful mindset While holiday decorations create a festive touch around the house, they can add to the clutter and busyness, which ultimately takes away the joy, King said. Decluttering and organization can help create a peaceful environment. “Most people enjoy Christmas decorations, but over the years we tend to accumulate a lot of them,” King said. “Sadly, for many, the thought of decorating for Christmas no longer brings feelings of excitement and joy. Instead, we dread going into the attic, dragging out the tree and boxes of ornaments, checking strands of lights, fixing broken bulbs, etc., only to know that we’ll have to put it all back in about a month. "Keep decorations that bring joy and let go of what no longer feels fulfilling can make a big difference in decreasing the excess while emphasizing what is important to you and your family," she said. By clearing both physical and mental space, families can better prioritize the activities and moments that truly matter. Reducing paper use It can be difficult to go fully paperless because of gift wrapping, but there are ways to reduce paper in the holidays from reusing materials or gifting experiences. “You can reuse paper shopping bags or even cut up the bags or other paper you have around the house and wrap gifts,” King said. Gifting experiences rather than physical items is another growing trend. “I find that many people are interested in receiving or gifting experiences, which can also reduce wrapping needs,” King said. “Not only does this minimize waste, but it also emphasizes shared moments over material possessions.” King noted that since COVID, there has been a trend to go paperless and people tend to be more comfortable with virtual communication and remote collaboration in general, which can also eliminate the need for Christmas cards and other paper products.
Confused About the Economy? We can Help!
In a recent piece on CNN ... eyebrows were raised about the state of America's economy. The article describes a growing disconnect in the U.S. economy: strong growth and rising corporate productivity driven by artificial intelligence, but weak job creation. Companies are investing heavily in AI and automation, which allows them to increase output without hiring more workers — especially in roles involving routine or administrative tasks. This dynamic has produced what economists call a “jobless boom”: profits and productivity rise, while new jobs lag behind. The Federal Reserve is increasingly concerned because this trend creates risks for both workers and the broader economy. Lower-skilled and entry-level workers face displacement, wage inequality may widen, and traditional unemployment metrics may understate how difficult it has become for people to re-enter the job market. Policymakers now face a harder balancing act as AI reshapes labor demand, raising questions about retraining, social supports, and how to manage an economy where growth no longer guarantees broad-based job creation. If you're confused - don't feel bad. In fact, if you're a journalist covering this topic - let us help. Dr. Jared Pincin is a nationally respected expert on economic issues facing the United States of America. He's available to speak with media - simply click on his icon now to arrange an interview today.
Ape Ancestors and Neanderthals Likely Kissed, New Analysis Finds
Kissing occurs in a variety of animals but presents an evolutionary puzzle: it appears to carry high risks, such as disease transmission, while offering no obvious reproductive or survival advantage. Despite kissing carrying cultural and emotional significance in many human societies, up to now researchers have paid little attention to its evolutionary history. In the new study, “A comparative approach to the evolution of kissing,” published this week in the journal Evolution and Human Behavior, the researchers carried out the first attempt to reconstruct the evolutionary history of kissing using a cross-species approach based on the primate family tree. The results indicate that kissing is an ancient trait in the large apes, evolving in the ancestor to that group 21.5 – 16.9 million years ago. Kissing was retained over the course of evolution and is still present in most of the large apes. The team also found that our extinct human relatives, Neanderthals, were likely to have engaged in kissing too. This finding, together with previous studies showing that humans and Neanderthals shared oral microbes (via saliva transfer) and genetic material (via interbreeding), strongly suggests that humans and Neanderthals kissed one another. “While kissing may seem like an ordinary or universal behavior, it is only documented in 46% of human cultures,” said Catherine Talbot, co-author and assistant professor in the College of Psychology at Florida Tech. “The social norms and context vary widely across societies, raising the question of whether kissing is an evolved behavior or cultural invention. This is the first step in addressing that question.” Matilda Brindle, lead author and evolutionary biologist at Oxford’s Department of Biology, said: “This is the first time anyone has taken a broad evolutionary lens to examine kissing. Our findings add to a growing body of work highlighting the remarkable diversity of sexual behaviors exhibited by our primate cousins.” To run the analyses, the team first defined what constitutes a kiss. This was challenging because many mouth-to-mouth behaviours look like kissing. Since the researchers were exploring kissing across different species, the definition also needed to be applicable to a wide range of animals. They therefore defined kissing as non-aggressive, mouth-to-mouth contact that did not involve food transfer. Having established this definition, the researchers collected data from the literature on which modern primate species have been observed kissing, focusing on the group of monkeys and apes that evolved in Africa, Europe and Asia. This included chimpanzees, bonobos, and orangutans, all of which have been observed kissing. They then ran a phylogenetic analysis, treating kissing as a ‘trait’ and mapping this to the family tree of primates. They used a statistical approach (called Bayesian modelling) to simulate different evolution scenarios along the branches of the tree, to estimate the probability that different ancestors also engaged in kissing. The model was run 10 million times to give robust statistical estimates. Stuart West, co-author and professor of evolutionary biology at Oxford, said, “By integrating evolutionary biology with behavioral data, we’re able to make informed inferences about traits that don’t fossilise – like kissing. This lets us study social behaviour in both modern and extinct species.” While the researchers caution that existing data are limited – particularly outside the large apes – the study offers a framework for future work and provides a way for primatologists to record kissing behaviors in nonhuman animals using a consistent definition.
RPI to Host Holiday Concert and Troy Victorian Stroll Kickoff December 6
RPI President Martin A. Schmidt ’81, and his wife, Lyn, invite the Capital Region to join them for the RPI Holiday Concert and Troy Victorian Stroll Kickoff, which will take place on Saturday, December 6, at 7 p.m. in the Concert Hall of the Curtis R. Priem Experimental Media and Performing Arts Center (EMPAC) on RPI’s campus. This event is free and open to the public, and a reception with refreshments will follow. The concert, titled “Light in Winter,” will include performances from the RPI Wind Symphony, Concert Choir, and Orchestra, all under the direction of Robert Whalen, RPI lecturer in music and conducting. For the second year in a row, the concert will also serve as the kickoff for the 43rd annual Troy Victorian Stroll, made possible through RPI’s partnership with the Rensselaer County Regional Chamber of Commerce. “This concert is a wonderful opportunity for our students, who work so hard all year, to share their passion for music and create something meaningful for the entire community,” said Whalen. The program, following a “Light in Winter” theme, celebrates the various ways we bring light and joy to the darker winter season. “There is a common connection across cultures of lighting up the darkness in the late fall and winter, said Whalen. “Consider Diwali, Hannukah, Christmas, Alban Arthan, and others. Music and the arts, as well as education, each represent a way of sharing our inner creative light to illuminate the darkness.” During the concert, students will perform music by Smetana, Tchaikovsky, Gershwin, Lauridsen, and Saint-Saens, all following the “Light in Winter” theme. The program will feature two winners of the 2025 RPI Concerto Competition, Reese Bush '27 in Saint-Saens' "Introduction and Rondo capriccioso" for Violin and Orchestra, and Avery Roach '25 singing Gershwin's gorgeous and evocative "Summertime". Performers across the three groups represent 160 students from 34 different majors and all 5 schools, a reminder of just how curious and well-rounded RPI students are, and that art and science don’t just coexist, they actually enhance each other. The opportunity to continue growing as a musician while pursuing an engineering degree is something that connects many of us and inspires the music we create,” said Bush. “We’re excited to share our hard work and passion with the community.” The Holiday Concert is an annual tradition that celebrates peace and unity, the creativity and hard work of RPI students, and the confluence of science, engineering, and art. Combining the concert with the Troy Victorian Stroll has been a great opportunity for RPI to partner with its home city and further engage with the community. RSVP here: Media are welcome to attend.