Rensselaer is America’s oldest technological research university, offering bachelor’s, master’s, and doctoral degrees in engineering, the sciences, information technology and web science, architecture, management, and the humanities, arts, and social sciences.

The university offers degrees from five schools: Engineering; Science; Architecture; Humanities, Arts, and Social Sciences; and the Lally School of Management; as well as an interdisciplinary degree in Information Technology and Web Science.

Rensselaer offers more than 145 programs at the bachelor’s, master’s, and doctoral levels. Students are encouraged to work in interdisciplinary programs that allow them to combine scholarly work from several departments or schools. The university provides rigorous, engaging, interactive learning environments and campus-wide opportunities for leadership, collaboration, and creativity.

Driven by talented, dedicated, and forward-thinking faculty, Rensselaer has dramatically expanded the research enterprise by leveraging our existing strengths and focusing on five signature research areas: biotechnology and the life sciences; energy and the environment; computational science and engineering; nanotechnology and advanced materials; and media, arts, science, and technology.

The Institute is especially well-known for its success in the transfer of technology from the laboratory to the marketplace so that new discoveries and inventions benefit human life, protect the environment, and strengthen economic development.

Rensselaer Polytechnic Institute

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Substrate interaction inhibits intramembrane proteolysis and amyloid production

Rare 3‐O‐sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake.

Chunyu Wang, professor of Biological Sciences, and Chemistry and Chemical Biology at Rensselaer, is an expert in nuclear magnetic resonance (NMR) structural biology and in structural mechanisms of Alzheimer’s disease and cancer. In the field of Alzheimer’s research, his lab is studying the structural mechanisms of the generation of amyloid-β peptide (Aβ), as well as the interaction between glycan and tau, which facilitates the spread of tau pathology, neurofibrillary tangle (NFT, the other pathological hallmark of AD). In cancer, his lab is studying the structural mechanism of Hedgehog signaling and p53 interactions.

After establishing his own research group at Rensselaer in 2005, he developed a strong research program in structural mechanisms in protein autoprocessing and Alzheimer’s disease. Recently, his group is venturing into new and exciting areas such as drug discovery and biological sulfation. He has been awarded multiple grants from NIH and several grants for Alzheimer’s research, from Alzheimer’s Association, Warren Alpert Foundation, New York State and American Health Assistance Foundation (Now BrightFocus foundation).

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