Featured Post from University of Delaware

Researchers race to detect Alzheimer's sooner using $3.9M grant

Nov 15, 2024

3 min

Too often, people learn they have Alzheimer’s disease when it’s too late. The changes in the brain that lead to the disease manifesting with symptoms have already been occurring for decades.

Researchers at the University of Delaware will attempt to detect the disease sooner through a new study that examines changes in the arteries and brain tissue in midlife adults in their 50s and 60s. The findings of this work, funded by a nearly $4 million grant from the National Institute on Aging (NIA), could identify the earliest mechanisms linking vascular aging to the loss of brain tissue integrity, leading to new targets for interventions aimed at preventing age-related cognitive impairment.

“People who develop high blood pressure or stiffening of the aorta and carotid arteries in midlife are at a much higher risk for developing cognitive impairment or dementia in late life,” said Christopher Martens, the principal investigator of the study.

Martens, an associate professor of kinesiology and applied physiology in UD's College of Health Sciences and director of the Delaware Center for Cognitive Aging (DECCAR), is working closely with Curtis Johnson, an associate professor of biomedical engineering in the College of Engineering and leader of the neuroimaging biomarker core within DECCAR, on research funded by a nearly $4 million grant from the National Institute on Aging (NIA), a division of the National Institutes of Health (NIH).

“A lot happens as we age, so we’re aiming to pinpoint the timing and exact mechanisms that cause these changes in midlife adults,” Martens said.

This latest grant extends DECCAR’s ongoing Delaware Longitudinal Study for Alzheimer’s Prevention (DeLSAP), which seeks to study how risk and protective factors for dementia are related and change over time. Those eligible for DeLSAP could also meet the criteria for participating in the new study.

In his Neurovascular Aging Laboratory, Martens studies mechanisms leading to the stiffening of arteries, while Johnson is specifically interested in measuring the stiffness of the brain.

“As a person ages, the brain gets softer and breaks down, and we’re looking to see whether changes in arterial stiffness and patterns of blood flow in the brain cause this decline,” Johnson said.

Changes in blood flow to the brain come from controllable factors. Smoking, cardiovascular health, diet and exercise all impact blood flow positively and negatively.

“A lot of aging research is done at the end of life,” Johnson said. “We want to look at midlife and try to predict what happens later in life so we can prevent it.”

While the brain gets softer with age, arteries get stiffer.

“We hypothesize that midlife increases in stiffness in blood vessels cause damaging pulsatile pressure to enter the brain,” Martens said. “We believe this is one of the reasons we start to develop cognitive issues at an older age because the brain is exposed to increased pressure; that pressure is likely inflicting damage on surrounding brain tissue.”

In Johnson’s Mechanical Neuroimaging Lab, researchers will use high-resolution magnetic resonance elastography (MRE) to determine where brain damage occurs and what specific brain structures may be affected.

“From an MRI perspective, most researchers look at AD and other neurodegenerative diseases like multiple sclerosis with an emphasis on detection in a hospital setting,” Johnson said. “Using highly specialized techniques we’ve developed, we focus on the earlier side and how these changes progress into disease from the neuroscience side, emphasizing prevention.”

Together, they’ll seek to learn whether arterial stiffness causes the kind of cognitive impairment seen in AD or whether the decline is associated with a loss in the integrity of brain tissue.

“If we can prove arterial stiffness is playing a causal role in cognitive aging, that would provide further support for focusing on blood vessel health as an intervention for delaying AD or other forms of dementia versus solely focusing on the brain,” Martens said.

Connect with:

Chris Martens

Associate Professor, Kinesiology & Applied Physiology

Prof. Martens's laboratory is interested in understanding mechanisms by which impaired vascular function contributes to cognitive declines.

Alzheimer's DiseaseAgingClinical TrialsCerebral Blood FlowVascular Aging

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Oct 19, 2026

2 min

NBA stars and Achilles injuries: The road back to peak performance

A new NBA season brings plenty of storylines, from star players in new uniforms to the debut of promising rookies. But for players recovering from Achilles tendon injuries, returning to the court is just the beginning, says the University of Delaware's Karin Grävare Silbernagel. Regaining strength, explosiveness and consistent performance can take longer to achieve, said Silbernagel, a professor of physical therapy who studies tendon injuries and rehabilitation, with a focus on Achilles tendon ruptures, ankle function and long-term physical performance. Her research explores why recovery involves more than healing tissue or returning to competition. Strength, movement, tendon function and the ability to perform under the demands of sport all matter, she said. In a recent study, Silbernagel and colleagues examined single-leg jumping in people about two years after an Achilles tendon rupture. They found that fatigue affected ankle power differently on the injured and uninjured sides, highlighting how an injury can influence movement and the way the body distributes physical demands even well into recovery. Silbernagel can discuss: • Why returning to the court does not necessarily mean an NBA player has regained full strength, explosiveness or durability. • How clinicians assess recovery and readiness to return to sport after an Achilles tendon rupture. • How rehabilitation, progressive loading and return-to-sport testing can help guide recovery. • What research reveals about lingering changes in movement and function after tendon injuries. • What Achilles injuries can mean for athletic performance over time. Silbernagel leads the Delaware Tendon Research Group and consults with professional sports teams. Her research has helped inform clinical guidelines for treating tendon injuries. To reach Silbernagel directly and arrange and interview, visit her profile and click on the "contact" button. Interested reporters can also send an email to MediaRelations@udel.edu.

Oct 9, 2026

2 min

Experts on Hurricane Preparedness, Public Health and Community Recovery

When hurricanes threaten communities already facing social and economic challenges, the need for effective disaster preparedness and response becomes even more critical. University of Delaware disaster research experts can discuss the challenges communities face before, during and after hurricanes, including Hurricane Isaias and its potential impacts across Alabama, Mississippi, the Florida Panhandle and other parts of the northern Gulf Coast. The following experts from UD's Disaster Research Center are available to discuss the public health consequences of hurricanes, disaster preparedness and community recovery. Sarah DeYoung, associate professor of sociology and criminal justice, can discuss the needs of refugee and immigrant communities before, during and after disasters, including challenges accessing information, assistance and essential resources. She worked for several years with refugee and immigrant communities in southern Alabama through a grant-funded project. Jennifer Horney, professor of epidemiology, can discuss the public health consequences of hurricanes and other disasters, including evacuation decisions, the risks posed by inland flooding and the challenges communities face during recovery. She was part of the public health response to Hurricane Harvey and can discuss how communities still recovering from major storms may face additional challenges when another hurricane threatens the region. Jennifer Trivedi, associate professor of anthropology, studies how disasters affect marginalized communities. She can discuss how disasters compound existing challenges for people struggling to meet basic needs, particularly when flooding disrupts housing, transportation, food access and other essential services. Tricia Wachtendorf, co-director of the Disaster Research Center, can discuss the social impacts of hurricanes and inland flooding, including evacuation, preparedness, community response and recovery. She can also discuss how storms that are not the most powerful can nonetheless cause significant damage and disruption. To reach these experts directly, visit their ExpertFile profile and click on the "contact" button. Interested journalists can also contact MediaRelations@udel.edu.

Sep 25, 2026

1 min

How should journalists cover politics when democracy is at stake

Political coverage often centers on the president, but according to the University of Delaware’s Dannagal Young, journalists can sometimes provide more meaningful coverage by focusing more on democracy and less on the commander in chief’s every movement. Young calls this approach “democracy-centered reporting.” Instead of treating every presidential announcement or provocative statement as the central event, democracy-centered reporting asks how political actions affect democratic institutions, constitutional principles and Americans’ ability to exercise their rights as citizens, Young says. Young, professor of communication and director of UD’s Center for Political Communication, says “access journalism” has an important role, but an overreliance on access can also make political leaders the organizing principle of coverage. In moments when executive power is expanding, she argues, journalists should consider whether their coverage is inadvertently amplifying the power they are trying to scrutinize. Young can discuss: • How journalists can cover presidents without making the president the center of every story • The benefits and risks of access journalism • How coverage of political conflict affects public understanding of democracy To arrange an interview with Young, visit her profile and click on the "contact" button. Interested reporters can also send an email to MediaRelations@udel.edu.