Featured Post from University of Delaware

Researchers race to detect Alzheimer's sooner using $3.9M grant

Nov 15, 2024

3 min

Too often, people learn they have Alzheimer’s disease when it’s too late. The changes in the brain that lead to the disease manifesting with symptoms have already been occurring for decades.

Researchers at the University of Delaware will attempt to detect the disease sooner through a new study that examines changes in the arteries and brain tissue in midlife adults in their 50s and 60s. The findings of this work, funded by a nearly $4 million grant from the National Institute on Aging (NIA), could identify the earliest mechanisms linking vascular aging to the loss of brain tissue integrity, leading to new targets for interventions aimed at preventing age-related cognitive impairment.

“People who develop high blood pressure or stiffening of the aorta and carotid arteries in midlife are at a much higher risk for developing cognitive impairment or dementia in late life,” said Christopher Martens, the principal investigator of the study.

Martens, an associate professor of kinesiology and applied physiology in UD's College of Health Sciences and director of the Delaware Center for Cognitive Aging (DECCAR), is working closely with Curtis Johnson, an associate professor of biomedical engineering in the College of Engineering and leader of the neuroimaging biomarker core within DECCAR, on research funded by a nearly $4 million grant from the National Institute on Aging (NIA), a division of the National Institutes of Health (NIH).

“A lot happens as we age, so we’re aiming to pinpoint the timing and exact mechanisms that cause these changes in midlife adults,” Martens said.

This latest grant extends DECCAR’s ongoing Delaware Longitudinal Study for Alzheimer’s Prevention (DeLSAP), which seeks to study how risk and protective factors for dementia are related and change over time. Those eligible for DeLSAP could also meet the criteria for participating in the new study.

In his Neurovascular Aging Laboratory, Martens studies mechanisms leading to the stiffening of arteries, while Johnson is specifically interested in measuring the stiffness of the brain.

“As a person ages, the brain gets softer and breaks down, and we’re looking to see whether changes in arterial stiffness and patterns of blood flow in the brain cause this decline,” Johnson said.

Changes in blood flow to the brain come from controllable factors. Smoking, cardiovascular health, diet and exercise all impact blood flow positively and negatively.

“A lot of aging research is done at the end of life,” Johnson said. “We want to look at midlife and try to predict what happens later in life so we can prevent it.”

While the brain gets softer with age, arteries get stiffer.

“We hypothesize that midlife increases in stiffness in blood vessels cause damaging pulsatile pressure to enter the brain,” Martens said. “We believe this is one of the reasons we start to develop cognitive issues at an older age because the brain is exposed to increased pressure; that pressure is likely inflicting damage on surrounding brain tissue.”

In Johnson’s Mechanical Neuroimaging Lab, researchers will use high-resolution magnetic resonance elastography (MRE) to determine where brain damage occurs and what specific brain structures may be affected.

“From an MRI perspective, most researchers look at AD and other neurodegenerative diseases like multiple sclerosis with an emphasis on detection in a hospital setting,” Johnson said. “Using highly specialized techniques we’ve developed, we focus on the earlier side and how these changes progress into disease from the neuroscience side, emphasizing prevention.”

Together, they’ll seek to learn whether arterial stiffness causes the kind of cognitive impairment seen in AD or whether the decline is associated with a loss in the integrity of brain tissue.

“If we can prove arterial stiffness is playing a causal role in cognitive aging, that would provide further support for focusing on blood vessel health as an intervention for delaying AD or other forms of dementia versus solely focusing on the brain,” Martens said.

Connect with:

Chris Martens

Associate Professor, Kinesiology & Applied Physiology

Prof. Martens's laboratory is interested in understanding mechanisms by which impaired vascular function contributes to cognitive declines.

Alzheimer's DiseaseAgingClinical TrialsCerebral Blood FlowVascular Aging

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May 14, 2026

4 min

New clues about how earthquakes work

University of Delaware researcher Jessica Warren helped uncover evidence that sections of fast-moving underwater faults may act like “brakes,” controlling the occurrence of big earthquake events on transform faults. Warren can discuss what the findings, released today in the journal Science, mean for earthquake science and future modeling. Situated along a stretch of the equator in the Pacific Ocean, between Indonesia and Central America, the Gofar transform fault is one of the fastest moving faults on Earth — cruising along the seafloor at about 140 millimeters per year. This is over four times faster than the San Andreas fault is moving in California. “Geologically speaking, it's like looking at a moving Acela train next to a SEPTA train on the tracks,” said Warren, a professor of earth sciences at UD. Researchers know that the Gofar transform fault line has experienced a magnitude 6 earthquake about every five to six years over the last three decades. It’s been studied extensively, as these earthquakes occur at the same places along the fault and at the same intensity, time after time. What’s been unknown, until now, is why parts of this fault experience many small microshocks leading up to a main earthquake rupture, then shut down, while other parts of the fault are quiet before the big event and then experience many aftershocks. Now, a multi-institutional team of researchers, including UD’s Warren, reports that sections of the fault without large magnitude earthquakes actually act like brakes in a fast-moving car, controlling the occurrence of big earthquake events on transform faults. This finding is in contrast with currently accepted models of earthquake behavior. The team includes researchers from UD, Indiana University, Woods Hole Oceanographic Institution, Scripps Institution of Oceanography at UC San Diego, the U.S. Geological Survey, Boston College, Western Washington University, the University of New Hampshire and McGill University. In the study, the researchers analyzed two zones along the Gofar transform fault they say have stopped about 15 magnitude 6 earthquakes over the past 30 years. The study findings will inform globally what’s known about how faults and earthquakes behave, at sea and on land. Warren's contributions include leading the initial field research at sea in 2019 on the R/V Atlantis and interpreting results throughout the project, with a focus on connecting the earthquake observations to how rocks in the fault fracture and distort during an earthquake. Why were you studying the Gofar transform fault, in particular? Warren: Geoscientists want to understand faults and earthquakes because they are obviously a big hazard on land. The rocks that make up the seafloor are simpler than those found on land, providing a more controlled space to study earthquakes, despite the challenges of doing research underwater. If you want to understand how faults build up stress and then release it (and where), the Gofar transform fault is amazing, because it experiences earthquakes at reliable intervals of five to six years. This is a lot more regular than any other fault. In 2019, I led a research cruise on the R/V Atlantis that deployed 51 seismometers two miles down on the seafloor to detect these small events. We were able to compare the results of our measurements from 2019 to 2020 to an experiment conducted by my colleague Jeff McGuire on the same fault in 2008. The similarities in the two datasets brought us to the realization that fault sections without large magnitude earthquakes control the overall occurrence of big events on transform faults. When we had that observation in 2008, that might have been a one-off, but getting back this new data and seeing such similar behavior was a new insight into what's happening in the fault. How does that tell you about how earthquakes occur on land? Warren: On land, people spend a lot of time looking at how rainwater and groundwater move in a fault system, and how that influences the behavior of the fault. In the oceans, we have an unlimited amount of water. Once the rock cracks, the water is going to get in there. Being able to look at how a fault changes through the earthquake cycle — which we've now measured most of on this one fault — can help us understand what is universal about how faults work, and how rock friction works. And one of the big players is water. That's why the rock samples that my lab works on matter. Fault structure is another thing that we've been trying to understand. We know from on land that some parts of a fault are linear, while other parts have lots of strands and maybe contain more fractures and that, if you start putting water in the picture, this can limit or change how water moves into the system. Now, we have these very high-resolution maps of the seafloor, where we can see, for the first time, where the fault itself is. One of the next things we want to understand is how fluid gets into the fault, and then how friction in a fault changes when water is there. Why is this important? Warren: The next step is to translate the understanding that we've gained from this specific fault to understanding how faults behave in general. This is the longer path to really understanding earthquake hazards. It's not going to change our hazard models tomorrow, but hopefully it will in the decades to come. To reach Warren directly and arrange an interview, visit her profile and click on the "contact" button. Interested reporters can also email MediaRelations@udel.edu.

May 8, 2026

4 min

Survey says: Senior leaders are using AI, but they could use more direction

Over the years, study upon study has shown that senior leaders are slower to adapt to new technology – email, the Internet and social media – than younger employees. That’s not necessarily so with AI, according to the University of Delaware’s Saleem Mistry. Mistry, associate professor of management at UD's Alfred Lerner College of Business & Economics, recently conducted a survey of more than 200 university alumni, 75% of which had more than 16 years of professional experience. He found that senior leaders are actively adopting AI to solve their biggest challenges. However, they are doing so largely without structured support or guidance. Here are four findings from Mistry's survey that shows how AI is actually being used at the top. Senior Leaders Are Overwhelmingly Self-Taught Mistry said his most glaring finding is the gap between high AI adoption among senior leaders and the near-total absence of formal corporate support. Although a majority use these tools, they are almost entirely self-taught, which highlights visible opportunity that organizations aren’t really steering the AI conversation for leaders: • High usage. 62% of all senior leaders surveyed use AI tools "regularly" or "occasionally" in their work. • Training gap. Of those users, an overwhelming 80% report their organization provides "Never" or only "Sometimes" (mostly never) adequate training. Mistry said this shows that leaders from VP level down are using tools like ChatGPT and Copilot informally to keep up with heavy workloads, without any real organizational guidance. The stakes are high. In the survey, a vice president of legal was using AI for compliance tasks and a manager of three was using it for performance reviews, both with no formal training. “These are senior leaders handling sensitive work while essentially figuring it out on their own,” Mistry said. There is a clear ladder of AI use Leaders are not using AI randomly. There is a clear progression in how they use it, moving through three levels. • Tier 1 (The Drafters) This is the most common starting point. Leaders use AI to improve writing and communication. They draft emails, shape documents, and refine tone. As one Director of Product put it, it helps him "polish phrasing" and adjust tone and voice. • Tier 2 (The Synthesizers) At this stage, leaders use AI to manage information overload. They summarize meetings, condense documents, and pull together research so they can keep up with large volumes of input. As one leader managing a team of 200 said, "Being a leader requires attention in a variety of areas. AI helps me manage the vast amounts of information I need to consume." • Tier 3 (The Architects) Here, leaders move beyond writing and summarizing. They use AI to automate parts of their work. This includes building agents, creating custom GPTs, or designing tools that track work and performance. One leader managing 300 people said, "It will eliminate half or more of my overhead." Managers and individual contributors use AI for different reasons People managers and individual contributors (IC) are using AI for very different reasons based on their roles. • For people managers, their main challenge is scale. They are overloaded with communication and administration, so they use AI to reduce noise and keep up. They lean heavily on summarization and tone adjustment tools. • For project leads and ICs, their focus is output. They use AI to produce work faster, including drafting content, building decks, writing code, or generating ideas. This difference reflects their jobs. One group is trying to keep up, the other is trying to produce more. It also shows that AI is not a single-use tool. Its value depends on the problem it is being used to solve. This difference reflects their jobs. One group is trying to keep up, the other is trying to produce more. It also shows that AI is not a single-use tool. Its value depends on the problem it is being used to solve. Resistance to AI is mostly intentional Among the 38 percent of leaders who do not use AI, resistance is usually not based on lack of awareness. It falls into three groups: • The Ethical Objectors. Some avoid AI due to concerns about its broader impact. • The Quality Skeptics. Some do not trust the output and feel it is not reliable enough for important work. • The Blocked. Some are not allowed to use AI due to company policy. Mistry concludes that there is a clear overall pattern: Leaders are using AI in practical ways, but mostly without structured support or guidance. “If it feels like you are figuring this out as you go without much help from your organization, that is consistent with what most leaders are experiencing,” Mistry said. To connect directly with Mistry and arrange an interview, visit his profile page and click on the "connect" button. Interested reporters can also email MediaRelations@udel.edu.

May 13, 2026

2 min

UD experts break down the 2026 World Cup

As the world gears up for the 2026 FIFA World Cup, experts from the University of Delaware are available to provide timely insight on the science, business, and human impact behind the global tournament. Player Safety, Concussions and the Future of the Game Tom Kaminski, professor of kinesiology and applied physiology, is a leading authority on player safety and head injuries. As the sole U.S. representative on FIFA’s Heading Expert Group, Kaminski is helping shape international guidelines around heading in soccer—particularly for youth athletes. He can speak to concussion risks, prevention strategies, and how evolving safety standards are influencing the modern game. Joining him is Tom Buckley, who also specializes in concussion research and athlete health, offering additional perspective on injury trends and recovery in elite competition. The Business of the World Cup: Tourism and Global Impact Matt Robinson from UD’s Lerner College of Business and Economics explores how mega-events like the World Cup drive tourism, economic growth, and global connection. Robinson can discuss how host cities benefit, the long-term economic ripple effects, and how sports act as a powerful unifier across cultures. Youth, Development and the Next Generation of Fans Sara Goldstein brings expertise in adolescent development, offering insight into how traditions with family shape youth identity, social development, and engagement with physical activity. Her perspective is especially relevant for younger audiences experiencing the World Cup through schools and community programs, including UD’s Lab School initiatives. Inside the Game: Sports Analytics in Action With the rise of data-driven performance, UD’s new Sports Performance Analytics major is preparing students to analyze gameplay at the highest level. Martin Heintzelman, department chair, can connect media with program leaders and practitioners including Jack Davis and Christina Rasnake, who are helping students apply real-time analytics to global competitions like the World Cup. The Science Beneath the Game: Playing Surfaces World Cup matches are required to be played on natural grass—a costly and complex requirement, especially for indoor stadiums. Erik Ervin can discuss how turfgrass systems have evolved, the science behind maintaining elite playing surfaces, and the massive investment required to meet international standards. Why Watching Together Matters Amit Kumar studies the psychology of happiness and shared experiences. He can speak to why gathering to watch World Cup matches—whether in stadiums, bars, or living rooms—boosts well-being and strengthens social bonds, making the tournament as meaningful off the field as it is on it. Connect with UD experts to explore every angle of the 2026 World Cup – from the pitch to the people. Email mediarelations@udel.edu to connect with these experts.