Featured Post from University of Delaware

Researchers race to detect Alzheimer's sooner using $3.9M grant

Nov 15, 2024

3 min

Too often, people learn they have Alzheimer’s disease when it’s too late. The changes in the brain that lead to the disease manifesting with symptoms have already been occurring for decades.

Researchers at the University of Delaware will attempt to detect the disease sooner through a new study that examines changes in the arteries and brain tissue in midlife adults in their 50s and 60s. The findings of this work, funded by a nearly $4 million grant from the National Institute on Aging (NIA), could identify the earliest mechanisms linking vascular aging to the loss of brain tissue integrity, leading to new targets for interventions aimed at preventing age-related cognitive impairment.

“People who develop high blood pressure or stiffening of the aorta and carotid arteries in midlife are at a much higher risk for developing cognitive impairment or dementia in late life,” said Christopher Martens, the principal investigator of the study.

Martens, an associate professor of kinesiology and applied physiology in UD's College of Health Sciences and director of the Delaware Center for Cognitive Aging (DECCAR), is working closely with Curtis Johnson, an associate professor of biomedical engineering in the College of Engineering and leader of the neuroimaging biomarker core within DECCAR, on research funded by a nearly $4 million grant from the National Institute on Aging (NIA), a division of the National Institutes of Health (NIH).

“A lot happens as we age, so we’re aiming to pinpoint the timing and exact mechanisms that cause these changes in midlife adults,” Martens said.

This latest grant extends DECCAR’s ongoing Delaware Longitudinal Study for Alzheimer’s Prevention (DeLSAP), which seeks to study how risk and protective factors for dementia are related and change over time. Those eligible for DeLSAP could also meet the criteria for participating in the new study.

In his Neurovascular Aging Laboratory, Martens studies mechanisms leading to the stiffening of arteries, while Johnson is specifically interested in measuring the stiffness of the brain.

“As a person ages, the brain gets softer and breaks down, and we’re looking to see whether changes in arterial stiffness and patterns of blood flow in the brain cause this decline,” Johnson said.

Changes in blood flow to the brain come from controllable factors. Smoking, cardiovascular health, diet and exercise all impact blood flow positively and negatively.

“A lot of aging research is done at the end of life,” Johnson said. “We want to look at midlife and try to predict what happens later in life so we can prevent it.”

While the brain gets softer with age, arteries get stiffer.

“We hypothesize that midlife increases in stiffness in blood vessels cause damaging pulsatile pressure to enter the brain,” Martens said. “We believe this is one of the reasons we start to develop cognitive issues at an older age because the brain is exposed to increased pressure; that pressure is likely inflicting damage on surrounding brain tissue.”

In Johnson’s Mechanical Neuroimaging Lab, researchers will use high-resolution magnetic resonance elastography (MRE) to determine where brain damage occurs and what specific brain structures may be affected.

“From an MRI perspective, most researchers look at AD and other neurodegenerative diseases like multiple sclerosis with an emphasis on detection in a hospital setting,” Johnson said. “Using highly specialized techniques we’ve developed, we focus on the earlier side and how these changes progress into disease from the neuroscience side, emphasizing prevention.”

Together, they’ll seek to learn whether arterial stiffness causes the kind of cognitive impairment seen in AD or whether the decline is associated with a loss in the integrity of brain tissue.

“If we can prove arterial stiffness is playing a causal role in cognitive aging, that would provide further support for focusing on blood vessel health as an intervention for delaying AD or other forms of dementia versus solely focusing on the brain,” Martens said.

Connect with:

Chris Martens

Associate Professor, Kinesiology & Applied Physiology

Prof. Martens's laboratory is interested in understanding mechanisms by which impaired vascular function contributes to cognitive declines.

Alzheimer's DiseaseAgingClinical TrialsCerebral Blood FlowVascular Aging

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Jun 2, 2026

2 min

Nurse-midwife master’s program addresses maternal healthcare shortages

Counties across the U.S. are seeing an increase in “maternity care deserts” – areas that completely lack OB/GYNs, midwives or birthing facilities. The University of Delaware's School of Nursing will join the effort to address this shortage by launching the state's first nurse-midwife master’s program and post-graduate certificate this fall. Amanda Watson, director of the nurse-midwife program and assistant professor of nursing at UD's College of Health Sciences, can talk about the issue both on a national scale and at the hyper-local level. In Delaware, for example, 67 percent of pregnant women in Kent County and nearly half of pregnant women in Sussex County who experienced a stillbirth or infant death have late or no access to prenatal care, according to the Maternal and Child Death Review Commission (MCDRC). “The program is in direct response to workforce needs and healthcare shortages in the state and aligns with our mission in the School of Nursing to promote nurses at the earliest levels to the advanced practice level,” said Elizabeth Speakman, chief nurse administrator and senior associate dean of SON. She added that current nursing students wanted to see a program like this. “We’ve had undergraduate students tell us they want to continue their experience as a Blue Hen through a nurse-midwife program, so we expect this program to be quite popular, especially with our direct admission pathway,” Speakman said. The full-time, two-year program is being supported by a $1 million investment from the state of Delaware. It will be led by Watson and launch this fall with an eight-student cohort that will complete clinical rotations at Christiana, Bayhealth and Beebe hospitals, as well as The Birth Center in Newark. “We will prioritize students living and working in Delaware to make a quicker impact on the workforce shortage,” Watson said. The pipeline strategy is central to the program, said Dr. Meena Ramakrishnan, a consultant and epidemiologist with the MCDRC. “More nurse-midwives who train here, know Delaware and its resources, make connections and stay here to practice, is an important step toward improving outcomes,” Ramakrishnan said. Watson said the program reflects what makes change possible in Delaware’s healthcare system. “I saw a flawed healthcare system in this state, and I’m blessed to be in a state small enough that people who want to fix the problem are given opportunities to affect change,” she said. To connect with Watson directly and arrange an interview, visit her profile page and click the "contact" button. Interested reporters can also send an email to mediarelations@udel.edu.

Jun 1, 2026

7 min

UD English professors reveal 2026 beach reads, tying summer picks to big themes in today’s culture

When summer rolls around, the best beach reads do more than just pass the time—they somehow capture what everyone’s talking about right now. That’s the vibe behind University of Delaware’s professor-picked list: books that are fun to sink into, but also surprisingly sharp about the world we’re living in. Think big feelings, messy relationships, culture shifts, and the kind of stories that make you look up from the page and go, “Yep, that tracks.” "There Is No Antimemetics Division" By qntm A Reddit novel turned print bestseller, "There Is No Antimemetics Division" is a surreal horror story that follows an X-Fileish government division fighting aliens whose battlefield is the human mind. How do you fight an enemy whose existence you cannot remember? – Siobhan Carroll, Associate Professor "The Briar Club" By Kate Quinn I'm a big fan of Kate Quinn. Her books never disappoint. Her writing is wonderful and captivating, and the voices and characters are authentic. This book, set in the 50s, is a post-war reflection on a group of tenants in a boarding house who, over food (recipes included!), become friends and navigate McCarthyism, conspiracies and fear. It is historical fiction written to remind us that history repeats itself. – Christine Cucciarre, Professor "Guido Brunetti mysteries" By Donna Leon I've gotten completely hooked on these mysteries set in Venice. Fans will tell you the best is the fifth book in the series, "Acqua Alta," but be sure you read the first book to meet the characters! – Emily S. Davis, Director of Graduate Studies "When We Cease to Understand the World" By Benjamin Labatut An English professor recommending a book detailing the lives of physicists, scientists and mathematicians? Yes! History, heady concepts, madness, melancholy and beautiful prose come together in a haunting way. – Viet Dinh, Associate Professor "Dungeon Crawler Carl series" By Matt Dinniman What if you smushed role-playing video games/tabletop games with The Running Man? Plus, there's a sassy cat who talks! – Lowell Duckert, Associate Professor "Just Kids" By Patti Smith I've recently read "M Train" by Patti Smith, and now I'm looking forward to reading the book for which she won the National Book Award. Smith's memoirs can be impressionistic, but they often come down to some unexpected detail or some ongoing longing. If you know her music, you can sometimes hear it in the background, or you can spot those moments in her life when music would almost necessarily emerge as a great force gathered by her authentic approach to life. She's one of those writers who can change how you look for and find what most matters to you, how you look for and embrace your own soul. – John Ernest, Chair in English "Prairie Fires: The American Dreams of Laura Ingalls Wilder" By Caroline Fraser I loved reading the "Little House" books as a child. It seemed like a life full of adventure and love, even through "The Long Winter." But this biography of author Laura Ingalls Wilder reveals a life full of struggle and loss behind the calico dresses and the fiddle lullabies. Caroline Fraser won the 2018 Pulitzer Prize for "Prairie Fires," using unpublished manuscripts, letters, diaries, and land and financial records to pull back the pioneer spirit curtain and show readers the reality of life on the prairie. – Dawn Fallik, Associate Professor "The School for Good Mothers" By Jessamine Chan Warning: Do not bring this book to the beach without plenty of sun screen, because you will not put it down and that might make YOU a candidate for enrollment in The School. Second Warning: The book is compelling precisely because it will make you mad and freak you out. My wife gave it to friends as a Mother's Day present, and every mother who read it could relate. – Peter X Feng, Associate Professor "Audition" By Katie Kitamura This book has been on my bedside table for months now, just waiting for the semester to end. I am a sucker for books that shift perspective in the middle (see also: Susan Choi's "Trust Exercise"). – Peter X Feng, Associate Professor "The Road to Tender Hearts" By Annie Hartnett You might not expect a book that features domestic violence, children being orphaned and a 63-year-old man still pathetically dependent on his ex-wife to be funny. But I laughed out loud multiple times—and had some tears as well—as I read this novel! Follow the adventures of PJ, two children from his town, and a death-predicting cat as they road trip across the country. "The Road to Tender Hearts" was the best book I read all year! – Jill Flynn, Professor "The Stories of John Cheever" By John Cheever One of the finest collections of short fiction ever published. Witty, magical, often devastating portraits of people navigating mid-century New York. – McKay Jenkins, Cornelius Tilghman Professor of English "Vacationland: True Stories from Painful Beaches" By John Hodgman This book is a collection of nonfiction essays by John Hodgman (Daily Show writer and "Judge John Hodgman" podcast and The NY Times Magazine column). It is laugh-out-loud funny in a very self-deprecating, Gen X way. – Matthew Kinservik, Professor "Cloud Cuckoo Land" By Anthony Doerr This is one of the best novels I've ever read. Ever. It follows three stories set in very different times and places (15th-century Constantinople, 21st-century Idaho, and the not-too-distant future on a spacecraft headed to a new planet that will support human habitation). It's a book about the value of books and human storytelling. The stories eventually get braided together in moving and surprising ways. Amazing. – Matthew Kinservik, Professor "The Wilderness" By Angela Flournoy Have you wondered how your friendships in your early 20s might follow you into middle age? "The Wilderness" focuses on the friendships between four women: Desiree, Monique, Nakia and January from 2008 until 2027, when they are in their early 40s. They support one another through marriage, divorce, career anxiety, loss and a persistent set of questions about who they each want to be in the world and the lives they want to live. "The Wilderness" is told from many perspectives and details how culture, place, habits, friendships and childhood experiences combine to make and remake our adult lives. – Davy Knittle, Assistant Professor "Kin" By Tayari Jones "Kin" is about two motherless girls from Louisiana who find themselves as grown women on two very different paths, looking to other mother figures along the way. The writing is beautiful and engaging! I could not put this book down. I truly fell in love with all of the characters, and even the locations come alive. – Meg McGuire, Associate Director of First-Year Writing "How to Solve Your Own Murder" By Kristen Perrin This truly is a cozy mystery about a woman called Frances Adams—a resident of the moody Castle Knoll. When Frances is a teenager, she encounters a fortune teller who portends Frances's murder. Frances then spends most of her life sort of obsessively surveilling everyone around her, trying to figure out who will kill her. When she does die, her great niece Annie is surprised to learn that the late Frances has left Annie her entire estate, even though they have never actually met. When Annie arrives in Castle Knoll and at the estate, she follows in her great aunt's footsteps by holding all of the town's quirky characters at arm's length while she tries to discover who killed her late great aunt. This is an easy-breezy read, even if it does include a murder mystery at the center. Perfect for a day at the beach. Best of all, if you fall in love with the characters and the place, it's part of a series of three books, so you can keep going! – Cathryn Molloy, Professor "The Order of Time" By Carlo Rovelli You could read any Rovelli book, really—I am reading the one on the birth of science at the moment— but this is the one that drew me in. He merges a physics/science‒centered approach to time with a human/experienced‒centered view of it, which I just cannot get enough of. It is beautifully written, at times verging on poetic, while also bringing in a lot of the information and knowledge I seem to have skipped over as a terrible science student. It's joyful and intense and meditative. And yes, this is what I read for fun! – Amish Trivedi, Assistant Professor "The Season of Styx Malone" By Kekla Magoon Two young Black boys in small-town Indiana fall under the spell of Styx Malone, a mysterious new kid who arrives for the summer and stirs things up by persuading them to pursue their biggest dreams and breaking a few rules along the way. I collect multicultural kids books and stumbled across this one six years ago. It captured me because it celebrates family and friendship, depicts young people with rich interior lives, and mixes in a little mystery and humor. There's something sweet and down-home about it. It's a refreshing little respite from, well, everything ... – Délice Williams, Associate Professor To speak to the professors more about what makes these books the perfect summer reads, email mediarelations@udel.edu.

May 14, 2026

4 min

New clues about how earthquakes work

University of Delaware researcher Jessica Warren helped uncover evidence that sections of fast-moving underwater faults may act like “brakes,” controlling the occurrence of big earthquake events on transform faults. Warren can discuss what the findings, released today in the journal Science, mean for earthquake science and future modeling. Situated along a stretch of the equator in the Pacific Ocean, between Indonesia and Central America, the Gofar transform fault is one of the fastest moving faults on Earth — cruising along the seafloor at about 140 millimeters per year. This is over four times faster than the San Andreas fault is moving in California. “Geologically speaking, it's like looking at a moving Acela train next to a SEPTA train on the tracks,” said Warren, a professor of earth sciences at UD. Researchers know that the Gofar transform fault line has experienced a magnitude 6 earthquake about every five to six years over the last three decades. It’s been studied extensively, as these earthquakes occur at the same places along the fault and at the same intensity, time after time. What’s been unknown, until now, is why parts of this fault experience many small microshocks leading up to a main earthquake rupture, then shut down, while other parts of the fault are quiet before the big event and then experience many aftershocks. Now, a multi-institutional team of researchers, including UD’s Warren, reports that sections of the fault without large magnitude earthquakes actually act like brakes in a fast-moving car, controlling the occurrence of big earthquake events on transform faults. This finding is in contrast with currently accepted models of earthquake behavior. The team includes researchers from UD, Indiana University, Woods Hole Oceanographic Institution, Scripps Institution of Oceanography at UC San Diego, the U.S. Geological Survey, Boston College, Western Washington University, the University of New Hampshire and McGill University. In the study, the researchers analyzed two zones along the Gofar transform fault they say have stopped about 15 magnitude 6 earthquakes over the past 30 years. The study findings will inform globally what’s known about how faults and earthquakes behave, at sea and on land. Warren's contributions include leading the initial field research at sea in 2019 on the R/V Atlantis and interpreting results throughout the project, with a focus on connecting the earthquake observations to how rocks in the fault fracture and distort during an earthquake. Why were you studying the Gofar transform fault, in particular? Warren: Geoscientists want to understand faults and earthquakes because they are obviously a big hazard on land. The rocks that make up the seafloor are simpler than those found on land, providing a more controlled space to study earthquakes, despite the challenges of doing research underwater. If you want to understand how faults build up stress and then release it (and where), the Gofar transform fault is amazing, because it experiences earthquakes at reliable intervals of five to six years. This is a lot more regular than any other fault. In 2019, I led a research cruise on the R/V Atlantis that deployed 51 seismometers two miles down on the seafloor to detect these small events. We were able to compare the results of our measurements from 2019 to 2020 to an experiment conducted by my colleague Jeff McGuire on the same fault in 2008. The similarities in the two datasets brought us to the realization that fault sections without large magnitude earthquakes control the overall occurrence of big events on transform faults. When we had that observation in 2008, that might have been a one-off, but getting back this new data and seeing such similar behavior was a new insight into what's happening in the fault. How does that tell you about how earthquakes occur on land? Warren: On land, people spend a lot of time looking at how rainwater and groundwater move in a fault system, and how that influences the behavior of the fault. In the oceans, we have an unlimited amount of water. Once the rock cracks, the water is going to get in there. Being able to look at how a fault changes through the earthquake cycle — which we've now measured most of on this one fault — can help us understand what is universal about how faults work, and how rock friction works. And one of the big players is water. That's why the rock samples that my lab works on matter. Fault structure is another thing that we've been trying to understand. We know from on land that some parts of a fault are linear, while other parts have lots of strands and maybe contain more fractures and that, if you start putting water in the picture, this can limit or change how water moves into the system. Now, we have these very high-resolution maps of the seafloor, where we can see, for the first time, where the fault itself is. One of the next things we want to understand is how fluid gets into the fault, and then how friction in a fault changes when water is there. Why is this important? Warren: The next step is to translate the understanding that we've gained from this specific fault to understanding how faults behave in general. This is the longer path to really understanding earthquake hazards. It's not going to change our hazard models tomorrow, but hopefully it will in the decades to come. To reach Warren directly and arrange an interview, visit her profile and click on the "contact" button. Interested reporters can also email MediaRelations@udel.edu.