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For years, Florida Tech’s Catherine Talbot, assistant professor of psychology, has worked to understand the sociality of male rhesus monkeys and how low-social monkeys can serve as a model for humans with autism. Her most recent findings show that replenishing a deficient hormone, vasopressin, helped the monkeys become more social without increasing their aggression – a discovery that could change autism treatment.
Currently, the Centers for Disease Control and Prevention report that one in 36 children in the United States is affected by autism spectrum disorder (ASD). That’s an increase from one in 44 children reported in 2018. Two FDA-approved treatments currently exist, Talbot said, but they only address associated symptoms, not the root of ASD. The boost in both prevalence and awareness of the disorder prompts the following question: What is the cause?
Some rhesus monkeys are naturally low-social, meaning they demonstrate poor social cognitive skills, while others are highly social. Their individual variation in sociality is comparable to how human sociality varies, ranging from people we consider social butterflies to those who are not interested in social interactions, similar to some people diagnosed with ASD, Talbot said. Her goal has been to understand how variations in biology and behavior influence social cognition.
In the recent research paper published in the journal PNAS, “Nebulized vasopressin penetrates CSF [cerebral spinal fluid] and improves social cognition without inducing aggression in a rhesus monkey model of autism,” Talbot and researchers with Stanford, the University of California, Davis and the California National Primate Research Center explored vasopressin, a hormone that is known to contribute to mammalian social behavior, as a potential therapeutic treatment that may ultimately help people with autism better function in society. Previous work from this research group found that vasopressin levels are lower in their low-social rhesus monkey model, as well as in a select group of people with ASD.
Previous studies testing vasopressin in rodents found that increased hormone levels caused more aggression. As a result, researchers warned against administering vasopressin as treatment, Talbot said. However, she argued that in those studies, vasopressin induced aggression in contexts where aggression is the socially appropriate response, such as guarding mates in their home territory, so the hormone may promote species-typical behavior.
She also noted that the previous studies tested vasopressin in “neurotypical” rodents, as opposed to animals with low-social tendencies.
“It may be that individuals with the lowest levels of vasopressin may benefit the most from it – that is the step forward toward precision medicine that we now need to study,” Talbot said. In her latest paper, Talbot and her co-authors tested how low-social monkeys, with low vasopressin levels and high autistic-like trait burden, responded to vasopressin supplementation to make up for their natural deficiency. They administered the hormone through a nebulizer, which the monkeys could opt into. For a few minutes each week, the monkeys voluntarily held their face up to a nebulizer to receive their dose while sipping white grape juice – a favorite among the monkeys, Talbot said.
After administering the hormone and verifying that it increased vasopressin levels in the central nervous system, the researchers wanted to see how the monkeys responded to both affiliative and aggressive stimuli by showing them videos depicting these behaviors. They also compared their ability to recognize and remember new objects and faces, which is another important social skill.
They found that normally low-social monkeys do not respond to social communication and were better at recognizing and remembering objects compared to faces, similar to some humans diagnosed with ASD. When the monkeys were given vasopressin, they began reciprocating affiliative, pro-social behaviors, but not aggression. It also improved their facial recognition memory, making it equivalent to their recognition memory of objects.
In other words, vasopressin “rescued” low-social monkeys’ ability to respond prosocially to others and to remember new faces. The treatment was successful – vasopressin selectively improved the social cognition of these low-social monkeys.
“It was really exciting to see this come to fruition after pouring so much work into this project and overcoming so many challenges,” Talbot said of her findings. One of Talbot’s co-authors has already begun translating this work to cohorts of autism patients. She expects more clinical trials to follow.
In the immediate future, Talbot is examining how other, more complex social cognitive abilities like theory of mind – the ability to take the perspective of another – may differ in low-social monkeys compared to more social monkeys and how this relates to their underlying biology. Beyond that, Talbot hopes that they can target young monkeys who are “at-risk” of developing social deficits related to autism for vasopressin treatment to see if early intervention might help change their developmental trajectory and eventually translate this therapy to targeted human trials.
Catherine F. Talbot is an Assistant Professor in the School of Psychology at Florida Tech and co-director of the Animal Cognitive Research Center at Brevard Zoo.
Dr. Talbot joined Florida Tech from the Neuroscience and Behavior Unit at the California National Primate Research Center at the University of California, Davis, where she worked as a postdoc on a collaborative bio-behavioral project examining naturally occurring low-sociability in rhesus monkeys as a model for the core social deficits seen in people with autism spectrum disorder, specifically targeting the underlying mechanisms of social functioning.
If you're interested in connecting with Catherine Talbot - simply contact Adam Lowenstein, Director of Media Communications at Florida Institute of Technology at adam@fit.edu to arrange an interview today.
The roots of scuba diving lie in exploration. But in an age when advanced instruments can drive research, too, why not stay dry on land?
Researchers have used scuba diving as a tool for decades, but as technology evolves, remotely operated vehicles (ROVs) can aid, and sometimes replace, divers in the research process. Still, argues Stephen Wood, no existing tools have the full capability of a human.
The professor of ocean engineering says the ability to grab items or quickly turn one’s head is difficult to replicate in an ROV. He also argues that although robots can collect and send data, the ability to assess and interpret an environment through a human lens is essential.
“The human cannot leave” the research, Wood says. The American Academy of Underwater Sciences (AAUS) defines scientific diving as “diving performed solely as a necessary part of a scientific, research, or educational activity by employees whose sole purpose for diving is to perform scientific research tasks.” With more than 140 organizational members, AAUS supports diving as a research tool and protects scientific divers’ health and safety.
Researchers and students must obtain an AAUS certification, which Florida Tech offers, before undertaking a scientific dive. At Florida Tech, any diver who plans to use compressed air or air blends for activity involving teaching or research must comply with AAUS.
Robert van Woesik, professor of marine sciences, studies the dynamics of coral reefs worldwide. He and his students scuba dive to examine and photograph coral assemblages, then return with information they can use to predict the impact of local and global disturbances, recovery from disturbances and future growth.
The ability to personally identify different species underwater is crucial to understanding coral reef dynamics. He says that without scuba, the necessary training to develop that skill falls away.
“I think it’s still worthwhile knowing the species composition of a reef underwater instead of just saying, ‘Okay, we don’t need scuba divers anymore. We just need photographs and ROVs,’” van Woesik says. He learns the most when he can descend to a reef and see the seascape himself.
“I think there’s something to be said to just go in the water and ask some questions,” van Woesik says. “That’s the valuable part of being able to scuba dive, getting amongst it to experience the reef, in tandem with analyzing photographs from around the world on the computer.” Assistant professor of marine sciences Austin Fox says in his research in the Indian River Lagoon, diving is essential for operating—and sometimes finding—instruments.
“We spend a lot of time trying to figure out ways to do this stuff without diving…but there’s just no replacement for it.” Austin fox, Assistant professor of marine sciences Scientific diving has taken Florida Tech researchers across the globe, from the murky floor of the Indian River Lagoon to the depths of Antarctica’s McMurdo Sound.
Rich Aronson, department head and professor of ocean engineering and marine sciences, studies coral reefs in the tropics and subtidal communities in Antarctica. In 1997, he had the opportunity to visit the McMurdo Station to study invertebrate ecology—specifically, who eats what and whether they leave traces of their predatory activity on the shells of their prey.
There, he completed 27 dives of up to 130 feet deep. Some were done through ice-cracks in remote areas, he recalls, whereas others were from holes drilled through 10 feet of sea-ice. He noted that the time to prepare for these dives was extensive—two 30-minute dives took eight hours—and they weren’t without risk.
“That was the first and only time I’ve dived under the ice. It’s dangerous because there’s a ceiling above you,” Aronson says. “You jump in the hole and try not to screw it up because if you screw it up, you’re dead.” Though risky, Aronson says scuba diving was crucial to the research. He argues that neither ROVs nor oceanographic sensors could have collected or sampled organisms at fine scales, run transects and made behavioral observations like a human could.
Additionally, he says his observations at depth, such as the “sting of subzero water” on his face and “the slowness of reaction of the animals living down there,” are what later inspired a project of his combining deep-sea oceanography and paleontology to project the future of Antarctic seafloor communities in a rapidly warming world.
“Science is a lot more subjective than you might think, and feeling the environment helps you understand it.” Richard Aronson, department head and professor of marine sciences The risky nature of scuba diving is why programs like AAUS exist: to standardize safe and responsible diving practices for conducting scientific research.
Divers are at risk for a number of pressure-related injuries, such as decompression sickness: a condition in which residual nitrogen can create bubbles in the blood and body tissue upon ascent if the diver rises to the surface too fast. To reduce their risk, divers must plan and track how deep they are going, the time at which they are that depth (and subsequent depths) and how long they need to wait before changing depth.
Technology has also evolved since the beginning of scuba to support divers’ safety further.
Digital dive computers, developed in the 1980s, help divers estimate how long they can stay at their current depth while underwater (among other things). Additionally, Enriched Air Nitrox (Nitrox) is a gas mixture that contains a higher percentage of oxygen than standard air. Divers who use Nitrox can extend their time at depth and reduce their risk of decompression sickness because of its reduced nitrogen pressure.
Van Woesik predicts that dive technology will keep evolving. He imagines there could soon be a system that allows divers to upload data at depth, and a system that aids in species identification without having to decipher an image at the surface.
He also believes that innovators will keep working to reduce hazards and prioritize safety, because despite the risks, divers will always get in the water.
“Hopefully that technology will get better so we can go deeper, safer, and so we can stay down a bit longer to explore and further understand the natural wonders of the oceans,” van Woesik says. If you're interested in connecting with Stephen Wood, Austin Fox, Richard Aronson or Robert van Woesik - simply contact Adam Lowenstein, Director of Media Communications at Florida Institute of Technology at adam@fit.edu to arrange an interview today.
Name: Adrian Peter
Title: Associate professor of mathematics and systems engineering and electrical engineering and computer science (joint appointment); director, Center for Advanced Data Analytics and Systems (CADAS)
Department/College: Department of Mathematics and Systems Engineering and Department of Electrical Engineering and Computer Science/College of Engineering and Science
Current research funding: $2.19 million
General research focus: Our Multi-domain, Multi-sensor, Cyber-physical Tactical Exploitation (M2CTE) project addresses a critical need for a robust analytic processing framework capable of supporting autonomous sensing and analytics on the edge – where devices and sensors collect data – with the ability to reach back to the cloud for more improvement.
Adrian Peter's research interests are in applying advanced analytics (e.g. machine learning, statistical modeling, optimization and visualization) to solve large-scale computing problems across a variety of domain areas (signal processing, geospatial, environmental, sensor fusion and enterprise intelligence). Q: What has you excited about your current research? We have built our entire infrastructure with the immensely talented graduate and undergraduate students at Florida Tech. Their tireless efforts have led to us delivering practical and operational real-world, machine-learning solutions that make us among the global leaders in machine learning at the edge. Q: Why is it important to conduct research? The objective of all research is to advance the frontiers of knowledge in a specific discipline. In my research, we are continually pushing state-of-the-art distributed sensing and edge analytics. Our results have helped transition conceptual ideas and customer requirements into operational solutions that improve situational awareness at tactical edge. Adrian Peter is available to speak with media. Contact Adam Lowenstein, Director of Media Communications at Florida Institute of Technology, at adam@fit.edu to arrange an interview today.
