How old is your brain?

University of Delaware researchers find brain stiffness measurements are reliable predictors

Mar 31, 2025

2 min


University of Delaware researchers have found that measuring brain stiffness is a reliable way to predict brain age. This information could be used to identify structural differences that indicate departure from the normal aging process, potentially identifying and addressing disorders such as Alzheimer’s disease and Parkinson’s disease.


In recent findings, Curtis Johnson, associate professor of biomedical engineering, and Austin Brockmeier, assistant professor of electrical and computer engineering, show that measuring both brain stiffness and brain volume produces the most accurate predictions of chronological age. Their findings were published in a recent edition of the journal Biology Methods and Protocols. The pair worked with three current and former UD students to reach their conclusions.


“Brain volume is a common measure that we use to study the brain,” Johnson said. “But something has to be happening to cause a brain to shrink. Something is happening at the microscale that causes it to shrink — changes in the tissue that also cause stiffness to change. And that precedes whatever happens when the volume changes.”


“The stiffness maps all seem kind of random — until we see a large number of images and the randomness fades away and we start to see common patterns in stiffness,” Johnson said. “We sort of knew there was more [information] in there than what we were extracting."


A cutting-edge magnetic resonance imaging (MRI) scanner at UD’s Center for Biomedical and Brain Imaging handled the brain scanning. On the artificial intelligence side, the brain maps were analyzed by three-dimensional “convolutional neural networks,” which — as the name suggests — are convoluted and complicated, incorporating many layers and dimensions.


To arrange and interview with Johnson or Brockmeier, send an email to mediarelations@udel.edu



Powered by

You might also like...

Check out some other posts from University of Delaware

From Baseball to Business: The Science of Team Success featured image

2 min

From Baseball to Business: The Science of Team Success

The ingredients that create a World Series team often mirrors how units achieve success in business. How did they get there? The University of Delaware's Kyle Emich says the answer goes beyond assembling a roster of star players. Emich, a professor of management, says that how players combine their strengths, respond to opponents and create opportunities together can be just as important as individual talent. The same is true in business, where a collection of talented employees doesn’t automatically translate into a high-performing team, he said. One example is the approach that the 2026 Milwaukee Brewers’ took during their postseason run. Rather than relying exclusively on home runs and individual star power, the team created opportunities through a combination of speed, patience at the plate, timely hitting and pressure on opposing defenses. A stolen base, a walk or a defensive mistake might seem like a small event on its own, but the effects can build as players’ actions interact. These interactions matter, he says, because teams are not simply collections of individuals; their performance emerges from how people and their activities affect one another within a larger environment. The same is true in business as well as baseball. Businesses may recruit exceptional employees or invest in promising technologies such as artificial intelligence, yet fail to realize their potential if their processes, team structures and working practices don’t support those strengths. Emich can discuss: • Beyond Moneyball: What baseball’s emphasis on statistics and individual talent reveals about the limits of evaluating people in isolation. • Building better teams: How coordination, complementary strengths and the interaction among team members contribute to performance. • Strategy and competition: What baseball teams’ adjustments to opponents can teach business leaders about responding to competitors and changing conditions. • Technology and the future of work: Why adopting artificial intelligence or other new technologies is not enough without considering how people, processes and technology work together. To reach Emich directly and arrange an interview, visit his profile page and click on the "contact" button. Interested reporters can also send an email to MediaRelations@udel.edu.

NBA stars and Achilles injuries: The road back to peak performance featured image

2 min

NBA stars and Achilles injuries: The road back to peak performance

A new NBA season brings plenty of storylines, from star players in new uniforms to the debut of promising rookies. But for players recovering from Achilles tendon injuries, returning to the court is just the beginning, says the University of Delaware's Karin Grävare Silbernagel. Regaining strength, explosiveness and consistent performance can take longer to achieve, said Silbernagel, a professor of physical therapy who studies tendon injuries and rehabilitation, with a focus on Achilles tendon ruptures, ankle function and long-term physical performance. Her research explores why recovery involves more than healing tissue or returning to competition. Strength, movement, tendon function and the ability to perform under the demands of sport all matter, she said. In a recent study, Silbernagel and colleagues examined single-leg jumping in people about two years after an Achilles tendon rupture. They found that fatigue affected ankle power differently on the injured and uninjured sides, highlighting how an injury can influence movement and the way the body distributes physical demands even well into recovery. Silbernagel can discuss: • Why returning to the court does not necessarily mean an NBA player has regained full strength, explosiveness or durability. • How clinicians assess recovery and readiness to return to sport after an Achilles tendon rupture. • How rehabilitation, progressive loading and return-to-sport testing can help guide recovery. • What research reveals about lingering changes in movement and function after tendon injuries. • What Achilles injuries can mean for athletic performance over time. Silbernagel leads the Delaware Tendon Research Group and consults with professional sports teams. Her research has helped inform clinical guidelines for treating tendon injuries. To reach Silbernagel directly and arrange and interview, visit her profile and click on the "contact" button. Interested reporters can also send an email to MediaRelations@udel.edu.

Experts on Hurricane Preparedness, Public Health and Community Recovery featured image

2 min

Experts on Hurricane Preparedness, Public Health and Community Recovery

When hurricanes threaten communities already facing social and economic challenges, the need for effective disaster preparedness and response becomes even more critical. University of Delaware disaster research experts can discuss the challenges communities face before, during and after hurricanes, including Hurricane Isaias and its potential impacts across Alabama, Mississippi, the Florida Panhandle and other parts of the northern Gulf Coast. The following experts from UD's Disaster Research Center are available to discuss the public health consequences of hurricanes, disaster preparedness and community recovery. Sarah DeYoung, associate professor of sociology and criminal justice, can discuss the needs of refugee and immigrant communities before, during and after disasters, including challenges accessing information, assistance and essential resources. She worked for several years with refugee and immigrant communities in southern Alabama through a grant-funded project. Jennifer Horney, professor of epidemiology, can discuss the public health consequences of hurricanes and other disasters, including evacuation decisions, the risks posed by inland flooding and the challenges communities face during recovery. She was part of the public health response to Hurricane Harvey and can discuss how communities still recovering from major storms may face additional challenges when another hurricane threatens the region. Jennifer Trivedi, associate professor of anthropology, studies how disasters affect marginalized communities. She can discuss how disasters compound existing challenges for people struggling to meet basic needs, particularly when flooding disrupts housing, transportation, food access and other essential services. Tricia Wachtendorf, co-director of the Disaster Research Center, can discuss the social impacts of hurricanes and inland flooding, including evacuation, preparedness, community response and recovery. She can also discuss how storms that are not the most powerful can nonetheless cause significant damage and disruption. To reach these experts directly, visit their ExpertFile profile and click on the "contact" button. Interested journalists can also contact MediaRelations@udel.edu.

View all posts