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Researchers laying the groundwork to eventually detect cerebral palsy via blood test

University of Delaware professor hopes this work leads to cerebral palsy being detected at birth.

Apr 18, 2025

2 min

At the University of Delaware, molecular biologist Mona Batish in collaboration with Dr. Robert Akins at Nemours Children Hospital, is studying tiny loops in our cells called circular RNAs — once thought to be useless leftovers, but now believed to play an important role in diseases like cancer and cerebral palsy (CP). This is detailed in a new article in the Journal of Biological Chemistry. 


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What are circular RNAs?


They’re a special type of RNA that doesn’t make proteins but instead helps control how genes are turned on and off. Because they’re stable and can be found in blood, they may help doctors detect diseases more easily.


So what’s the connection to cerebral palsy?


CP is the most common physical disability in children, but right now it’s diagnosed only after symptoms appear — there’s no clear-cut test for it. Batish and her team are trying to change that.


Working with researchers at Nemours Children’s Health, Batish discovered that in children with CP, a certain circular RNA — circNFIX — is found at much lower levels in muscle cells. This RNA normally helps the body make an important muscle-building protein called MEF2C. When circNFIX is missing or low, MEF2C isn’t made properly, which may lead to the weakened, shorter muscles seen in CP.

This is the first time researchers have shown a link between circular RNAs and human muscle development in cerebral palsy.


Why does this matter? 


If scientists can confirm this link, it could lead to:


  • Earlier and more accurate diagnosis of CP using a simple blood test
  • New treatments that help improve muscle development in affected children


Batish’s ultimate goal? To create a test that can spot CP at birth — or even before — giving kids a better shot at early treatment and a higher quality of life.


To speak to Batish, contact mediarelations@udel.edu. 



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