Featured Post from University of Delaware

Discovery pinpoints potential Achilles’ Heel in HIV, opening new frontier in drug development

Feb 19, 2026

2 min

Scientists have long known that detecting HIV early is crucial in slowing and treating the virus. During the acute stage of infection, a single human cell can produce as many as 10,000 new HIV particles. A discovery led by the University of Delaware's Juan Perilla offers hope: A new drug target early in the virus's life cycle that could save millions of lives.

In the surprising discovery, published Feb. 18 in Nature, Perilla and collaborators in the U.S. and the United Kingdom, have revealed a previously unknown role for the viral protein integrase. Scientists already knew that integrase helps HIV insert itself into human DNA. But this new study provides the first direct evidence that integrase plays a critical structural role earlier on in HIV’s life cycle — when the virus matures into an infectious force.

Using high-resolution cryo-electron microscopy (cryo-EM), the research team – which also included UD doctoral student Juan S. Rey – found that integrase proteins form gluey filaments that line the inside of the capsid. Each segment of the filament slots neatly into the capsid’s hexagon-shaped tiles, while gripping tightly to HIV’s RNA genome. This zipper-like arrangement organizes and packs the virus, preparing it to hijack a cell and start making copies of itself.

“Integrase plays a structural role inside the HIV capsid — nobody expected that,” Perilla said. “This protein forms filaments that anchor the RNA to the capsid. Without these filaments, the virus is non-infective.”

Seeing inside HIV is no small feat. The capsid is only about 120 nanometers wide —roughly 1/800th the thickness of a human hair. It is incredibly small, fragile, densely packed and constantly changing, Perilla said.

To reveal its hidden architecture, the researchers relied on deep collaboration and a combination of sophisticated microscopy, molecular modeling and experimentation. Read more about the science behind the study here.

“The thing with HIV is that people are chronically living with it,” Perilla said. “Treatments are effective, but patients always need new therapeutics. We want to help develop the next generation of inhibitors and hope to have a significant contribution.”

To reach Perilla directly and arrange an interview, visit his profile page. Interested reporters can also email MediaRelations@udel.edu.

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Juan Perilla

Assistant Professor

Juan Perilla develops physical and chemical based methodologies for the understanding of biological process related to life and disease

Computational PhysicsComputational ChemistryData ScienceMachine LearningMolecular Virology

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Aug 10, 2026

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Experts on earthquake response, community recovery and building safety

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Aug 5, 2026

1 min

Mapping the ancient world with underwater robotics

As audiences flock to theaters for Christopher Nolan's The Odyssey, University of Delaware professor Art Trembanis is leading a real-life expedition to uncover one of ancient Greece's most important maritime landscapes. Trembanis, a professor in UD's School of Marine Science and Policy and an expert in seafloor mapping, marine robotics and underwater sensing technologies, recently led a team of students and researchers to the ancient harbor of Kenchreai, where they deployed autonomous underwater vehicles, advanced sonar systems and other cutting-edge mapping technologies to document a harbor that has remained hidden beneath the Mediterranean Sea for centuries. The expedition collected geospatial data that will allow researchers to reconstruct the ancient port in remarkable detail and ultimately create a "digital twin" of the site. The virtual model will enable archaeologists, engineers, students and the public to explore the harbor as if the water had been removed, preserving an invaluable piece of cultural heritage while advancing the use of marine technology in archaeology. Trembanis can discuss: Marine robotics and autonomous underwater vehicles Seafloor mapping and underwater imaging technologies The use of digital twins and 3D modeling to study underwater environments Advances in marine geospatial technology and ocean exploration Underwater archaeology and documenting submerged cultural heritage How engineering and marine science are transforming the study of oceans and ancient landscapes The role of emerging technologies in scientific discovery and education To arrange an interview with Trembanis, click on his profile or email mediarelations@udel.edu.

Jul 28, 2026

1 min

How Wildfires Impact Vulnerable Communities, Pets and Public Health Systems

Wildfires burning across the world, now in parts of France and Spain, are forcing hundreds of thousands of people to evacuate. University of Delaware experts are available to discuss wildfire evacuations, vulnerable communities, animal rescue and the health effects of wildfire smoke exposure. Those experts, from UD’s Disaster Research Center, include: Sarah DeYoung Professor of sociology and criminal justice: • How people are forced to make split-second decisions involving horses, livestock and companion animals during fast-moving wildfires. • Why some owners must turn animals loose when evacuation time is limited. • Lessons from past disasters and animal rescue research. Jennifer Trivedi Assistant professor of anthropology: • The unique challenges faced by vulnerable populations during wildfires. • Complications surrounding evacuation decision-making and evacuation needs. • Long-term recovery following catastrophic disasters. Jennifer Horney Chair of UD’s Department of Epidemiology: • Health risks associated with wildfire smoke exposure, including respiratory infections. • How wildfire smoke and airborne pollutants affect population health. • The strain major wildfires can place on public health and health care systems. To arrange an interview with these experts, visit their profile page and click on the "contact" button. Interested journalists can also send an email to MediaRelations@udel.edu.