Featured Post from University of Delaware

Discovery pinpoints potential Achilles’ Heel in HIV, opening new frontier in drug development

Feb 19, 2026

2 min

Scientists have long known that detecting HIV early is crucial in slowing and treating the virus. During the acute stage of infection, a single human cell can produce as many as 10,000 new HIV particles. A discovery led by the University of Delaware's Juan Perilla offers hope: A new drug target early in the virus's life cycle that could save millions of lives.

In the surprising discovery, published Feb. 18 in Nature, Perilla and collaborators in the U.S. and the United Kingdom, have revealed a previously unknown role for the viral protein integrase. Scientists already knew that integrase helps HIV insert itself into human DNA. But this new study provides the first direct evidence that integrase plays a critical structural role earlier on in HIV’s life cycle — when the virus matures into an infectious force.

Using high-resolution cryo-electron microscopy (cryo-EM), the research team – which also included UD doctoral student Juan S. Rey – found that integrase proteins form gluey filaments that line the inside of the capsid. Each segment of the filament slots neatly into the capsid’s hexagon-shaped tiles, while gripping tightly to HIV’s RNA genome. This zipper-like arrangement organizes and packs the virus, preparing it to hijack a cell and start making copies of itself.

“Integrase plays a structural role inside the HIV capsid — nobody expected that,” Perilla said. “This protein forms filaments that anchor the RNA to the capsid. Without these filaments, the virus is non-infective.”

Seeing inside HIV is no small feat. The capsid is only about 120 nanometers wide —roughly 1/800th the thickness of a human hair. It is incredibly small, fragile, densely packed and constantly changing, Perilla said.

To reveal its hidden architecture, the researchers relied on deep collaboration and a combination of sophisticated microscopy, molecular modeling and experimentation. Read more about the science behind the study here.

“The thing with HIV is that people are chronically living with it,” Perilla said. “Treatments are effective, but patients always need new therapeutics. We want to help develop the next generation of inhibitors and hope to have a significant contribution.”

To reach Perilla directly and arrange an interview, visit his profile page. Interested reporters can also email MediaRelations@udel.edu.

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Juan Perilla

Assistant Professor

Juan Perilla develops physical and chemical based methodologies for the understanding of biological process related to life and disease

Computational PhysicsComputational ChemistryData ScienceMachine LearningMolecular Virology

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Jul 28, 2026

1 min

How Wildfires Impact Vulnerable Communities, Pets and Public Health Systems

Wildfires burning across the world, now in parts of France and Spain, are forcing hundreds of thousands of people to evacuate. University of Delaware experts are available to discuss wildfire evacuations, vulnerable communities, animal rescue and the health effects of wildfire smoke exposure. Those experts, from UD’s Disaster Research Center, include: Sarah DeYoung Professor of sociology and criminal justice: • How people are forced to make split-second decisions involving horses, livestock and companion animals during fast-moving wildfires. • Why some owners must turn animals loose when evacuation time is limited. • Lessons from past disasters and animal rescue research. Jennifer Trivedi Assistant professor of anthropology: • The unique challenges faced by vulnerable populations during wildfires. • Complications surrounding evacuation decision-making and evacuation needs. • Long-term recovery following catastrophic disasters. Jennifer Horney Chair of UD’s Department of Epidemiology: • Health risks associated with wildfire smoke exposure, including respiratory infections. • How wildfire smoke and airborne pollutants affect population health. • The strain major wildfires can place on public health and health care systems. To arrange an interview with these experts, visit their profile page and click on the "contact" button. Interested journalists can also send an email to MediaRelations@udel.edu.

Jul 22, 2026

2 min

Summer slide isn't just about academics

As summer reaches its midpoint, many parents are wondering how to keep their children engaged without turning the rest of the break into summer school. University of Delaware professors from the College of Education and Human Development say "summer slide" is real. However, preventing summer learning loss doesn't require expensive camps, tutors or educational apps. Instead, simple everyday activities can help children build academic skills, executive functioning and social-emotional development before they head back to school. Roberta Michnick Golinkoff, internationally recognized expert in child development and early learning can comment on: Why children lose academic skills over the summer – and why the effects are greatest for under-resourced families Why parents shouldn't rely on "educational" apps Free, research-backed ways to keep preschoolers and elementary-age children learning through play, reading and everyday activities like grocery shopping, puzzles and scavenger hunts Andrea Glowatz, expert in special education and child development can comment on: Why boredom is actually good for children – and how it builds creativity, problem-solving and independence How summer routines help children, particularly those with learning differences or neurodivergence Why chores, calendars and family routines strengthen executive functioning, not just responsibility Sara Goldstein, expert in adolescent development and parent-teen relationships can comment on: Why teenagers experience a version of the summer slide through increased screen time, disrupted sleep and reduced activity Healthy ways parents can encourage independence before college, from managing money to building life skills Research showing that strengthening parent-teen relationships during the summer benefits both parents and young adults These experts can also comment on broader parenting topics including screen time, executive functioning, preparing children for the new school year, supporting neurodivergent learners, and helping teens transition to college. If you're planning back-to-school or parenting coverage and want to speak with any of these experts, click on their profiles or email mediarelations@udel.edu.

Jul 17, 2026

1 min

Food safety expert available to discuss emerging health risks

The University of Delaware’s Kalmia Kniel can discuss foodborne parasites and food safety risks, including the ongoing cyclosporiasis outbreak spreading across the United States. Kniel, a professor of microbial food safety, can explain how foodborne parasites spread, why outbreaks (particularly those involving the Cyclospora parasite) can be challenging to investigate and what consumers should know about reducing their risk of illness. She co-authored a study published in December 2025 that examined challenges researchers face in detecting, studying and controlling Cyclospora cayetanensis, including gaps in understanding the parasite and improving prevention strategies. Kniel can also discuss why fresh produce and water are often a focus during investigations and the steps consumers can take to improve food safety. Kniel’s expertise includes: • Foodborne parasites and illness outbreaks • Produce and microbial food safety • Food contamination and prevention • Food safety research Kniel discussed the biology of this specific pathogen in detail at a recent presentation on cyclospora. To arrange an interview with Kniel, visit her profile page and click the contact button. Interested journalists can else email MediaRelations@udel.edu.