Featured Post from University of East Anglia

Novel coronavirus discovered in British bats

Apr 26, 2021

5 min

A coronavirus related to the virus that causes Covid-19 in humans has been found in UK horseshoe bats – according to new collaborative research from the University of East Anglia, ZSL (Zoological Society of London), and Public Health England (PHE).


However, there is no evidence that this novel virus has been transmitted to humans, or that it could in future, unless it mutates.


UEA researchers collected faecal samples from more than 50 lesser horseshoe bats in Somerset, Gloucestershire and Wales and sent them for viral analysis at Public Health England.


Genome sequencing found a novel coronavirus in one of the bat samples, which the team have named ‘RhGB01’.


Due to the rapid response nature of this research, it has not yet been peer reviewed.

It is the first time that a sarbecovirus (SARS-related coronavirus) has been found in a lesser horseshoe bat and the first to be discovered in the UK.


The research team say that these bats will almost certainly have harboured the virus for a very long time. And it has been found now, because this is the first time that they have been tested.


Importantly, this novel virus is unlikely to pose a direct risk to humans, unless it mutates.


A mutation could happen if a human infected with Covid-19 passes it to an infected bat, so anyone coming into contact with bats or their droppings, for example those engaged in caving or bat protection, should wear appropriate PPE.

Prof Diana Bell, an expert in emerging zoonotic diseases from UEA’s School of Biological Sciences, said: “Horseshoe bats are found across Europe, Africa, Asia and Australia and the bats we tested lie at the western extreme of their range.
“Similar viruses have been found in other horseshoe bat species in China, South East Asia and Eastern Europe.
“Our research extends both the geographic and species ranges of these types of viruses and suggests their more widespread presence across more than 90 species of horseshoe bats.
“These bats will almost certainly have harboured this virus for a very long time – probably many thousands of years. We didn’t know about it before because this is the first time that such tests have been carried out in UK bats.
“We already know that there are different coronaviruses in many other mammal species too,” she said. “This is a case of ‘seek and you will find’.
“Research into the origins of SARS-CoV-2, the virus that causes Covid-19 in humans, has focussed on horseshoe bats - but there are some 1,400 other bat species and they comprise 20 per cent of known mammals.
“Our findings highlight the need for robust genotype testing for these types of viruses in bat populations around the world. And it raises an important question about what other animals carry these types of viruses.”


Prof Andrew Cunningham, from the Zoological Society of London, said: “Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection have been underestimated.


“This UK virus is not a threat to humans because the receptor binding domain (RBD) – the part of the virus that attaches to host cells to infect them - is not compatible with being able to infect human cells.


“But the problem is that any bat harbouring a SARS-like coronavirus can act as a melting pot for virus mutation. So if a bat with the RhGB01 infection we found were to become infected with SARS-CoV-2, there is a risk that these viruses would hybridise and a new virus emerge with the RBD of SARS-CoV-2, and so be able to infect people.


“Preventing transmission of SARS-CoV-2 from humans to bats, and hence reducing opportunities for virus mutation, is critical with the current global mass vaccination campaign against this virus.”


Prof Bell added: “The main risks would be for example a bat rehabilitator looking after a rescued animal and infecting it with SARS-CoV2 - which would provide an opportunity for genetic recombination if it is already carrying another sarbecovirus.
“Anyone coming into contact with bats or their droppings, such as bat rescuers or cavers, should wear appropriate PPE – in order to reduce the risk of a mutation occurring.
“We need to apply stringent regulations globally for anyone handling bats and other wild animals,” she added.


The new virus falls within the subgroup of coronaviruses called sarbecoviruses which contains both SARS-CoV-2 (responsible for the current pandemic) and SARS-CoV (responsible for the initial 2003 SARS outbreak in humans).


Further analysis compared the virus with those found in other horseshoe bat species in China, South East Asia and Europe and showed that its closest relative was discovered in a Blasius’s bat from Bulgaria in 2008.


Ivana’s story


The UK discovery was made by undergraduate ecology student Ivana Murphy, from UEA’s School of Biological Sciences, who collected bat droppings as part of her final year research dissertation. Jack Crook conducted the genetic analyses in partnership with other researchers at PHE.


A total of 53 bats were captured, and their faeces collected in sterile bags. The research was conducted under strict Health and Safety protocols. Full PPE was worn and Ivana was regularly tested for Covid-19 to avoid any chance of cross contamination. The bats were released immediately after their droppings had been collected.


Ivana said: “I am very fortunate to be surrounded by so many experts in their fields, which has allowed me access to resources that many undergraduates wouldn’t have. I feel extremely lucky to have been able to conduct such an advanced study.”


“We weren’t shocked by the results, but I am extremely eager to carry out further research.


“I chose to study ecology at UEA as I have a passion for trying to protect and conserve nature. I wanted a better understanding of the global situation and so chose UEA to study ecology and conservation.


“The plan after graduation is to do an extended study of viruses in UK bats, very similar to the one I carried out as an undergraduate. There is still a lot more to understand and I am extremely excited to see what else we can find out.”


But she says that she doesn’t want her research to turn people against bats.

“More than anything, I’m worried that people may suddenly start fearing and persecuting bats, which is the last thing I would want and would be unnecessary. As like all wildlife, if left alone they do not pose any threat.”


‘Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe’ is published on the Research Square pre-print server.


Read the full story, including a Q&A with all you need to know.



You might also like...

Check out some other posts from University of East Anglia

3 min

Major study reveals the lasting impact of Covid lockdowns

New research from the University of East Anglia reveals first-hand the lasting impact that lockdowns may have had on people’s mental and physical health. The UK’s first Covid lockdown was announced by Prime Minister Boris Johnson exactly two years ago today. Just a few days later, researchers at UEA launched a major project to track the mental and physical health of the nation through lockdowns and beyond. More than 1,000 participants carried out daily surveys – with questions on a range of lifestyle behaviours including physical activity, diet, sleep, smoking, drinking, and drug use. Some of the participants were then interviewed by the research team, to try to understand what was happening for people from their own viewpoints. Listen to what they had to say in our oral history project Lockdown Voices. New findings published today show how people responded very differently to social restrictions depending on their existing circumstances. For those who were less well-off to start with, adapting to lockdown was more difficult, and health behaviours typically worsened to a greater extent. In contrast, those who were better off at the start of the pandemic demonstrated faster adaptation and were more able to respond positively to restrictions, for example by taking to online exercise classes. It is likely that any lasting impact to mental and physical health will therefore be much greater for those who were worse off to start with. Those with good social links and healthy behaviours already in place described in their interviews how they were able to adapt to lockdown and thrive, whereas some of the more vulnerable in our communities had fallen into unhealthy spirals. Prof Caitlin Notley, from UEA's Norwich Medical School, said: “When the first lockdown was announced back in 2020, we started surveying participants from around the UK daily. Our initial results showed that people were eating less fruit and veg, getting less exercise and drinking more alcohol. “It quickly became apparent that lockdown may have lasting consequences for the physical and mental health of the nation. “We wanted to see whether people’s lifestyles changed in the long-term so we continued the study by carrying out regular surveys with the participants, and interviewing some people to find out more.” Now, two years on, the team’s results show how health inequalities are likely to have widened. Prof Notley said: “Social restrictions imposed as a result of the coronavirus pandemic have had a significant impact on health behaviours at the individual and population level. “It’s fair to say that all of our participants’ lives were disrupted by lockdown and they were forced to adapt. “But people responded to the lockdowns very differently and their experiences of social restrictions varied considerably. “Fundamentally, people were hindered or helped by their existing support structures and resources, such as access to technology to engage with the outside world, or private outdoor space. “Those people who had good friends, community links and who were already health conscious, were able to respond positively and better able to cope. “They were able to adapt to the ‘new normal’, use technology to keep in touch with friends and relatives, order veg boxes, carry on with a healthy diet and take part in healthy pursuits in new and innovative ways such as online fitness classes or ‘doing Joe Wicks’. “But lockdowns are very likely to have caused a sustained widening of social and health inequalities. “Those who remained in work outside the home, or who were retired, were the least impacted overall. But those who were unemployed, younger, on a lower income, clinically unwell or told to fully shield were particularly impacted by strict restrictions. “For these more vulnerable people, supportive social factors were taken away or severely restricted. Anxiety and depression worsened, and unhealthy behaviours like exercising less, drinking more alcohol, and eating a poor diet increased. “As we work through the ‘roadmap to recovery’, emphasis needs to be placed on a collaborative, community-based approach, with a focus on what makes us well. “Encouraging membership of community exercise groups, for example, may help those most impacted to engage again with healthy behaviours to keep them well. We also need to pay attention to how those who are less well-off responded more negatively to the policy of lockdown, so that lessons can be learnt for the future,” she added. ‘Disruption and adaptation in response to the coronavirus pandemic – assets as contextual moderators of enactment of health behaviours’ is published in the British Journal of Health Psychology.

2 min

'Tangled Up' reveals science and history of Alzheimer's

A new book from leading University of East Anglia dementia expert Prof Michael Hornberger investigates the science and history of Alzheimer's disease. 'Tangled Up - The science and history of Alzheimer's disease' is available as a paperback or e-book. Prof Hornberger researches groups that are at higher risk of developing dementia (because of genetics, lifestyle or their other health condition) and works to help reduce this risk or delay the symptoms of dementia. He also explores the nature of support for those who have been diagnosed with dementia and helping the patients and their families and carers prepare for the future. His background is as a neuroscientist and his work involves using innovative techniques (such as online games and driver behaviour) to identify the spatial or navigation issues that can occur long before before diagnosis of dementia and before the traditional impacts on memory arise. He developed the mobile game Sea Hero Quest that can detect people at risk of Alzheimer's. His work enables early prediction of the likelihood of dementia (sometimes a decade ahead) and the opportunity to manage the onset and reduce risk by as much as 30 per cent. Prof Michael Hornberger, from UEA’s Norwich Medical School, said: “Alzheimer's disease is the most common cause of dementia in the UK. It affects around one in 14 people over the age of 65 and one in every six people over the age or 80 – and it can affect memory, thinking skills and other mental abilities. “I wanted to write a book to help people better understand the science and history of Alzheimer’s disease. “It covers everything from the causes of Alzheimer’s, through to why people with Alzheimer’s ‘live in the past’ and practical advice for how people can reduce the risk of developing it. “At the end of the book, you will have become an Alzheimer’s disease science expert and can use your newfound knowledge to untangle this devastating disease,” he added.

2 min

Flavoured vapes less harmful to young people than smoking, could help teen smokers quit

Flavoured vapes are much less harmful to young people than smoking, and could help teen smokers quit tobacco – according to new research from the University of East Anglia. A new study published today looks at young peoples’ use of vape flavours, reporting the views and experiences of more than 500,000 under 18s. It finds that flavours are an important aspect of vaping that young people enjoy, suggesting that flavoured products may help them switch away from harmful tobacco smoking. But the researchers warn that more needs to be done to make sure that youngsters who have never smoked are not attracted to vaping. Lead researcher, Prof Caitlin Notley, from UEA’s Norwich Medical School, said: “There has been a lot of concern that young people may start vaping because they are attracted to e-liquid flavours, and that it could potentially lead them to start smoking tobacco. “We wanted to find out more about the links between vape flavours, the uptake of vaping among young people, and whether it leads to regular vaping and, potentially, tobacco smoking.” The research team studied all available evidence (58 studies) on young peoples’ use of e-liquid flavours. Prof Notley said: “We found that flavoured e-liquids are an important aspect of vaping that young people enjoy. This suggests that flavoured products may encourage young people to switch away from harmful tobacco smoking towards less harmful vaping. “Flavours may be an important motivator for e-cigarette uptake – but we found no evidence that using flavoured e-liquids attracted young people to go on to take up tobacco smoking. “And we also found no adverse effects or harm caused by using liquid vape flavours. “However, there is also a need to monitor flavour use to ensure that young people who have never smoked are not attracted to taking up vaping. “Ensuring the continued availability of a range of e-liquid flavours is likely to be important in encouraging young people who smoke to switch to vaping as a less harmful alternative,” she added. The team found that the overall quality of the evidence on use of e-cigarette flavours by young people was low. In particular, many studies did not clearly define e-liquid flavours and could not therefore be included within the review. The study was led by UEA in collaboration with researchers at University College London, the University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust. ‘Youth Use of E-Liquid Flavours – A systematic review exploring patterns of use of e liquid flavours and associations with continued vaping, tobacco smoking uptake, or cessation’ is published in the journal Addiction on November 17, 2021.

View all posts
Powered by