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ChristianaCare and The Wistar Institute advance partnership with new cancer research strategies

Mar 16, 2022

4 min

ChristianaCare’s Helen F. Graham Cancer Center & Research Institute is advancing its historic partnership with the Ellen and Ronald Caplan Cancer Center of The Wistar Institute in Philadelphia with three new research projects under way.


The new research projects consist of a population health study targeting triple negative breast cancer. Other projects focus on a new therapeutic target for epithelial ovarian cancer, the most lethal gynecologic cancer in the developed world, and the development of “mini organs” derived from stem cells.


Targeting triple negative breast cancer

Delaware has one of the highest incidence rates of triple-negative breast cancer in the United States. This highly aggressive cancer has few treatment options, because the cells test negative for three known treatment targets – estrogen, progesterone and HER2 protein receptors.


Working with patient data from the Graham Cancer Center, researchers are investigating potential contributing factors such as diet, alcohol use and genetic variants among women, and the effects of these on cancer metabolism. The team will also examine spatial relationships between cancer “hot spots”—geographic areas with a higher-than-expected prevalence—and modifiable risk factors.


Key resources for the study are blood and tissue samples from the Graham Cancer Center’s Tissue Procurement Center and its statewide High-Risk Family Cancer Registry.


The research team will be led by Director of Population Health Research at ChristianaCare Scott Siegel, Ph.D., and Lead Research Scientist Jennifer Sims Mourtada, Ph.D., at the Graham Cancer Center’s Cawley Center for Translational Cancer Research (CTCR). They will join Zachary Schug, Ph.D., at Wistar’s Molecular and Cellular Oncogenesis Program.


Researching novel therapy for ovarian cancer

The latest study supported by the Graham Cancer Center’s Tissue Procurement Program targets KAT6A expression as a novel therapy for ovarian cancer caused by a specific genetic mutation, called PP2R1A.


Epithelial ovarian cancer is the most common form of ovarian cancer and the leading cause of gynecologic cancer deaths in the United States. Chemoresistance to currently available platinum-based drugs like cisplatin represents a major treatment challenge, as more than 50 percent of affected women ultimately relapse and die from this disease.


Wistar’s Rugang Zhang, Ph.D., leader of the Immunology, Microenvironment and Metastases Program, is focused on developing novel therapeutics for subtypes of ovarian cancer that currently have no effective therapies and on improving the current standard of care. Dr. Zhang’s previous work suggests that KAT6A signaling plays a critical role in ovarian cancer progression. Targeting this signaling pathway could be an effective strategy for treating ovarian cancer.


Working with Dr. Zhang on this project are Graham Cancer Center gynecologic oncologists Mark Cadungog, M.D., director of Robotic Surgery, and Sudeshna Chatterjee-Paer, M.D., and Cawley CTCR’s Stephanie Jean, M.D., director of Gynecologic Oncology Research. Also collaborating with the team is Wistar’s Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program.


‘Mini organs’ offer hope for therapeutics

Dr. Sims-Mourtada at the Cawley CTCR will lead a new program to culture organ-specific tissue from stem cells that could change the way diseases are studied and treated.


These so called “mini organs” or “organoids” are three-dimensional tissue cultures grown in the lab that replicate the complexity and functions of a specific tissue or organ found in the body. Organoids offer scientists a better model for how drugs and other therapeutics might interact with a patient’s particular type of tumor, opening new avenues for precision medicine.


“The ability to grow each patient’s tumor in a three-dimensional organoid along with our capability to create patient-derived xenograft or animal models as part of our PDX core, will allow us to fully capture the effects of genetic as well as gene altering behavioral and environmental influences that are lacking in current research models,” said Dr. Sims-Mourtada. “Our collaboration with Wistar to build these programs raises our clinical platform to the next level for studying new cancer biomarkers and treatments.”


Advancing a Pioneering Partnership

The Graham Cancer Center made history when it signed a first-of-its-kind agreement in 2011 with The Wistar Institute, pairing a National Cancer Institute, NCI-designated basic research institution with a community cancer center that is also an NCI Community Oncology Research Program (NCORP).


“Our partnership with Wistar has attracted national recognition as a model of collaboration that leverages cutting-edge research to benefit cancer prevention and therapy statewide,” says Nicholas J. Petrelli, M.D., Bank of America endowed medical director of ChristianaCare’s Helen F. Graham Cancer Center and Research Institute. “With Wistar, our productive collaborations over the last decade continue to drive discovery research toward clinical trials to benefit patients here at the Graham Cancer Center and in communities everywhere.”


“The Graham Center has been an ideal partner in our mission,” said Dario C. Altieri, M.D., Wistar president and CEO and director of the Ellen and Ronald Caplan Cancer Center. “Our scientists at Wistar have access to clinically-annotated primary patient specimens of the highest quality. As the majority of patients at the Graham Cancer Center are treatment naïve, this collaboration affords an opportunity to conduct unique, high impact mechanistic and correlative studies that will ultimately advance important scientific discoveries that hopefully will lead to better cancer therapies.”

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A dedicated team of geriatricians, nurses, social workers and other professionals collaborates with patients and their families to offer support, education and guidance throughout the diagnosis and treatment process. “ChristianaCare has consistently been at the forefront of providing excellent patient care, and the Swank Center for Memory Care is another opportunity for us to enhance support for people 65 and older,” said Steven Huege, M.D., MSEd, The Swank Foundation Endowed Chair in Memory Care and Geriatrics at ChristianaCare. “By designing care that meets the specific needs of older adults, we can create a better experience and achieve improved outcomes for everyone involved. 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It is the leading provider of in-home nursing care and assistance in Delaware. “ChristianaCare HomeHealth designs a plan of care that is personalized for those we serve,” said Donna Antenucci, MHA, BSN, RN, interim president, ChristianaCare HomeHealth. “Treating older adults in their own home is a privilege and brings comfort physically and emotionally to those served and their family. “It is truly rewarding for us as providers of home health services to enhance people’s quality of life and improve their overall well-being. We are truly honored to be a part of their journey to wellness and healing while respecting the dignity of those we serve.” These services are available throughout the entire state and provide comprehensive care through skilled nursing, home health aides, rehabilitative services, and medical social workers. Specially trained professionals offer home care, including physical and speech therapy, to help individuals live independently and safely. 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1 min

ChristianaCare Appoints Ashley Panichelli, M.D., Vice Chair, Department of Family and Community Medicine

Ashley Panichelli, M.D., has been appointed vice chair of the Department of Family and Community Medicine at ChristianaCare. In this role, Panichelli will support the department’s clinical and academic missions. She will help guide quality and safety initiatives and promote a culture of accountability, learning and psychological safety. She will advance education and professional development across faculty and residency programs, assist with strategic planning, mentorship and peer review, and strengthen collaboration across department leadership, faculty and staff. A Delaware native, Panichelli earned her medical degree from Sidney Kimmel Medical College at Thomas Jefferson University and completed her residency and chief residency in Family Medicine at ChristianaCare in 2018. She joined the residency program’s core faculty that same year and has since held several leadership roles, including clinical lead and associate program director. In 2022, she was named clinical director of Academic and Complex Primary Care, a role she continues to support. Panichelli is a clinical assistant professor at Sidney Kimmel Medical College and has been recognized with several honors, including the Delaware Academy of Family Physicians’ Teacher of the Year award and the Department’s Rising Star award. She completed ChristianaCare’s ACT course, the LEED-R elective, and the Harvard Medical Director Leadership Institute. She was an Emerging Leaders Institute scholar with the American Academy of Family Physicians Foundation. She reports to Erin Kavanaugh, M.D., FAAFP, chair of the Department of Family and Community Medicine.

3 min

Delaware INBRE Summer Scholars Complete Biomedical Research Projects at ChristianaCare

Eight undergraduate scholars recently completed a 10-week immersion in biomedical research through the Delaware IDeA Network of Biomedical Research Excellence (INBRE) Summer Scholars Program at ChristianaCare. Their projects, spanning oncology, emergency medicine and community health, culminated in a capstone presentation and celebration on August 13 at Christiana Hospital. This year’s cohort included students from University of Delaware, Delaware State University and Delaware Technical Community College, as well as Delaware residents attending college out of state. Each student was paired with expert mentors from across ChristianaCare, contributing to research designed to improve patient care and outcomes. In addition to their primary projects, the scholars explored ChristianaCare’s advanced facilities such as the Gene Editing Institute Learning Lab, gaining hands-on exposure to cutting-edge methods in biomedical research. “This year’s DE-INBRE program at ChristianaCare was a one-of-a-kind experience,” said Susan Smith, Ph.D., RN, program director of Technology Research & Education at ChristianaCare and the INBRE site principal investigator. “We brought together undergraduates from various academic backgrounds and immersed them in real, hands-on biomedical research with some of our most accomplished investigators. “Watching these students go from a little unsure on day one to confidently presenting their own findings by the end of the summer was inspiring, and proof that programs like this are building the next generation of biomedical researchers in Delaware.” Delaware INBRE is a statewide initiative funded by the National Institutes of Health to strengthen Delaware’s biomedical research infrastructure. It supports undergraduate research training, faculty development and core facility investments across partner institutions. At ChristianaCare, the program offers students immersive, hands-on research experiences guided by seasoned investigators, equipping them with the skills, mentorship and exposure essential for careers in science and medicine. Madeline Rowland, a Delaware resident and rising senior at Williams College in Massachusetts, collaborated with Hank Chen, senior medical physicist at the Helen F. Graham Cancer Center & Research Institute, to evaluate tattoo-free, surface-guided radiation therapy for breast cancer patients. She also worked with leaders of ChristianaCare’s Center for Virtual Health to explore how different patient populations experience virtual primary care. Rowland praised the program for the research skills and knowledge she gained as well as the meaningful relationships she built with mentors, health care professionals and fellow scholars she might not have otherwise met. “Dr. Chen and the whole Radiation team really adopted me into the department,” Rowland said. “From sitting on the CT simulation table in my first week to working on my project, I felt fully welcomed. I’ve learned so much, and the people I’ve met made this summer unforgettable.” Chen was recognized as the program’s inaugural “Mentor of the Summer” for his exceptional dedication and thoughtful approach to teaching. Having now mentored INBRE scholars for three years, Chen has a personal connection to the program. His own daughter participated as an undergraduate and recently began her general surgery residency after graduating from Sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia. For Chen, mentoring represents an investment in health care’s future. “The greatest asset of any institution is its talent,” he explained. “When you welcome students into your environment, you draw good people to your field, and patients ultimately benefit from that.” Naana Twusami, a rising senior at Delaware State University, spent her summer with the Oral & Maxillofacial Surgery and Hospital Dentistry Department. She examined social determinants of health in facial trauma patients, analyzing how factors like income, education, transportation and insurance status influence recovery. “Being here showed me that things like income or transportation can matter just as much as the medical care itself,” she said. “The INBRE Summer Scholars Program gave me a real look at how health care works, and how places like ChristianaCare are helping shape where it’s headed.” Amy Minsker, continuing medical education manager, Academic Affairs, served as manager of the summer scholars program. Read more on news.christianacare.org.

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