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The popularity -- and price -- of brand-name injectable drugs like Ozempic, Wegovy, Mounjaro, and Zepbound has skyrocketed.
But the soaring demand for these drugs -- used for weight loss as well as to control blood sugar levels and reduce the risk of heart disease -- and the limited supply as well as lack of generic options has also led to a flood of non-brand alternatives in the market.
In a recent article for The Conversation, UConn expert C. Michael White, Distinguished Professor of Pharmacy Practice, issued a warning to consumers about the potential undisclosed risks of these off-brand products:
High demand is driving GLP-1 wannabes The dietary supplement market has sought to cash in on the GLP-1 demand with pills, teas, extracts and all manner of other products that claim to produce similar effects as the brand names at a much lower price. Products containing the herb berberine offer only a few pounds of weight loss, while many dietary supplement weight loss products contain stimulants such as sibutramine and laxatives such as phenolphthalein, which increase the risk of heart attacks, strokes and cancer. The role of compounding pharmacies Unlike the dietary supplements that are masquerading as GLP-1 weight loss products, compounding pharmacies can create custom versions of products that contain the same active ingredients as the real thing for patients who cannot use either brand or generic products for some reason. These pharmacies can also produce alternative versions of brand-name drugs when official drug shortages exist. Since the demand for GLP-1 medications has far outpaced the supply, compounding pharmacies are legally producing a variety of different semaglutide and tirzepatide products. These products may come in versions that differ from the brand-name companies, such as vials of powder that must be dissolved in liquid, or as tablets or nasal sprays. Just like the brand-name drugs, you must have a valid prescription to receive them. The prices range from $250-$400 a month – still a steep price for many consumers. Compounding pharmacies must adhere to the FDA’s sterility and quality production methods, but these rules are not as rigorous for compounding pharmacies as those for commercial manufacturers of generic drugs. In addition, the products compounding pharmacies create do not have to be tested in humans for safety or effectiveness like brand-name products do. Proper dosing can also be challenging with compounded forms of the drugs. Companies that work the system For people who cannot afford a compounding pharmacy product, or cannot get a valid prescription for semaglutide or tirzepatide, opportunistic companies are stepping in to fill the void. These include “peptide companies,” manufacturers that create non-FDA approved knockoff versions of the drugs. From November 2023 to March 2024, my team carried out a study to assess which of these peptide companies are selling semaglutide or tirzepatide products. We scoured the internet looking for these peptide companies and collected information about what they were selling and their sales practices. We found that peptide sellers use a loophole to sell these drugs. On their websites, the companies state that their drugs are for “research purposes only” or “not for human consumption,” but they do nothing to verify that the buyers are researchers or that the product is going to a research facility. By reading the comments sections of the company websites and the targeted ads on social media, it becomes clear that both buyers and sellers understand the charade. Unlike compounding pharmacies, these peptide sellers do not provide the supplies you need to dissolve and inject the drug, provide no instructions, and will usually not answer questions. Peptide sellers, since they allegedly are not selling to consumers, do not require a valid prescription and will sell consumers whatever quantity of drug they wish to purchase. Even if a person has an eating disorder such as anorexia nervosa, the companies will happily sell them a semaglutide or tirzepatide product without a prescription. The average prices of these peptide products range from $181-$203 per month. Skirting regulations Peptide sellers do not have to adhere to the rules or regulations that drug manufacturers or compounding pharmacies do. Many companies state that their products are 99% pure, but an independent investigation of three companies’ products from August 2023 to March 2024 found that the purity of the products were far less than promised. One product contained endotoxin – a toxic substance produced by bacteria – suggesting that it was contaminated with microbes. In addition, the products’ promised dosages were off by up 29% to 39%. Poor purity can cause patients to experience fever, chills, nausea, skin irritation, infections and low blood pressure. In this study, some companies never even shipped the drug, telling the buyers they needed to pay an additional fee to have the product clear customs. If a consumer is harmed by a poor-quality product, it would be difficult to sue the seller, since the products specifically say they are “not for human consumption.” Ultimately, consumers are being led to spend money on products that may never arrive, could cause an infection, might not have the correct dose, and contain no instructions on how to safely use or store the product. Dr. C. Michael White is an expert in the areas of comparative effectiveness and preventing adverse events from drugs, devices, dietary supplements, and illicit substances.
Dr. White is available to speak with media -- click on his icon now to arrange an interview today.
In the aftermath of last week's school shooting in Georgia, Jennifer Necci Dineen and Kerri M. Raissian from UConn’s ARMS Center contributed this compelling piece to The Atlanta Journal-Constitution. The entirety of the article is available here:
On Sept. 4, the United States experienced its 45th school shooting of 2024, this time at Apalachee High School in Winder, Georgia. Barrow County Sheriff Jud Smith called the shooting “pure evil” and reported the suspected shooter would be tried as an adult. Since then, the shooter’s father has also been charged. A criminal justice response is vital, but it cannot be our only response. Gun laws need an overhaul. The failure to do so means that we will continue charging shooters and their families and attending the funerals of those senselessly killed. Laws are the role of government. Should elected officials fail to act (again), we think it is also fair to hold them responsible for the firearm violence killing our nation’s children. Georgia lawmakers have passed legislation to protect children in other ways. Georgia requires that children be at least 16 years old and to have held a learner’s permit for a year before they can drive: minors under 16 cannot be employed in dangerous or harmful jobs; and those under 17 cannot marry. These restrictions recognize that children’s prefrontal cortex, the part of their brain responsible for reasoning, impulse control and decision-making, is not yet fully formed. Yet, despite firearms being the leading cause of death for children in the United States, Georgia has minimal regulations governing children’s firearm access. There is no minimum age for purchasing or possessing rifles or shotguns, no permit required for carrying firearms in public (whether open or concealed) and no mandate for secure firearm storage (such as unloading, locking and storing ammunition separately). Details of the shooting in Winder continue to emerge, but let’s start with what we know. Reports indicate that the shooter and his father were questioned by the Jackson County Sheriff’s Office in May 2023 following multiple anonymous tips about online threats, including images of guns. The suspect’s father claimed that his child did not have unfettered access to the guns. The authorities did not have probable cause for an arrest, and so they left and the guns stayed. And, in fact, the father bought his son a new gun — an AR-15 — as a Christmas present. Perhaps more disturbing is that this kind of negligence and indifference is not an anomaly. A similar set of facts surround the Nashville Waffle House shooter and the Michigan Oxford High School Shooter. In both cases, parents ignored warning signs and helped their sons keep or procure firearms that were used in mass shootings. Moreover, almost three-quarters of guns used in gun-related incidents at schools come from the home or someone the shooter knows. It’s fair to ask: Where are the parents? However, we also want to know where are the elected officials charged with keeping us and our children safe when they are at school, the movies, a parade or otherwise living their lives? Laws mandating secure firearm storage, permitting, minimum age requirements and background checks have been proven to lower firearm homicide rates. Emergency risk protection orders, or red-flag laws, which temporarily prevent individuals deemed a danger to themselves or others from possessing or purchasing firearms, have also been effective in reducing firearm homicides. Georgia’s failure to implement such regulations, allowing a child with underdeveloped decision-making skills to access a gun, means the state shares the blame for the gun-related injuries and deaths at Apalachee High School. Georgia Gov. Brian Kemp is right. It’s not the time to “talk about safety and policy.” The time was years ago, but it’s never too late to do the right thing. Kerri Raissian is an associate professor in the School of Public Policy at the University of Connecticut; director of the University of Connecticut's UConn’s Center for Advancing Research, Methods, and Scholarship (ARMS) in Gun Violence Prevention; and co-director of the Institute for Collaboration on Health, Intervention, and Policy (InCHIP) Gun Violence Prevention Research Interest Group.
Her research focuses on child and family policy, with an emphasis on understanding how policies affect fertility, family formation, and family violence.
She is available to speak to media about this important topic - simply click on her icon now to arrange an interview today.
It's being called a "once in a lifetime" opportunity - and Monday's solar eclipse has almost everybody on the continent talking as well as planning and preparing to get a glimpse of this rare astronomical moment.
Amid the excitement is a need for people to view the event safely, which is why NBC Connecticut recently caught up with UConn Associate Professor of Physics Jonathan Trump to explain what's happening and, if you're going to be gazing upwards, what you need to know and how to do it without getting hurt.
An astronomical celebration is just around the corner. But if you want to see the solar eclipse for yourself, there are steps you need to take to do so safely. First and foremost: to watch this out-of-this-world display April 8, don’t even think about looking right at the sun. “Most important thing, do not look directly at the solar eclipse with your eyes,” said UConn associate professor of physics Jonathan Trump. “Here in Connecticut the eclipse will be about 90% which is pretty spectacular, but even 10% of the sun’s light is a lot of the sun’s light.” UConn is one of many organizations around the state holding a celebration and viewing event. “The next one is not going to be for another 20 years, so yeah this is a special event,” said Trump. Sunglasses aren’t strong enough to protect your retinas from these UV rays. “The ultraviolet light is what give us sunburns and it can severely damage the retina in the back of your eye and permanently scar your vision. So do not look directly at the sun,” said Trump. You can view the solar eclipse safely with certified solar eclipse glasses. If you wear eyeglasses, put the solar eclipse glasses on top of your glasses. And if you have solar eclipse glasses from the last phenomena visible stateside, which was seven years ago, you should get a new pair. Experts we spoke to say they have no more than a three-year shelf life. Looking to know more?
Jonathan Trump is an observational astronomer and is available to speak with reporters about Monday's eclipse. Simply click on his icon now to arrange a time to talk today.
