Featured Post from University of Delaware

Researcher develops microrobots to battle cancer with unique precision

May 1, 2024

4 min

Sambeeta Das


Magnetic robots that can target cancer cells are nothing new. But the patented microrobots developed by the University of Delaware's Sambeeta Das can be guided with a magnetic field to deliver medication to cells – or to destroy infectious cells, such as cancer – inside the body.


To mark the launch of National Inventors Month, Das, assistant professor of mechanical engineering, shared her journey toward invention.


Q: Tell us about your patented invention on microrobots for cancer research. What problem were you trying to solve?


Das: One of the biggest issues with cancer research is the ability to target cancer cells without harming healthy cells. Cancer cells are sneaky, and they have evolved ways of hiding from the body’s immune cells.


A big part of our research focuses on targeting, specifically precision targeting. We want to be able to target a single cell in a mass of cells, whether that is a single cell in a mass of cancer cells or whether it is a single abnormal cell surrounded by healthy cells. To do this, we use magnetic microrobots that can be driven inside the body by magnetic fields to a particular cell location. Magnetic fields are biocompatible, meaning they are not harmful to biological tissues, and our microrobots are very small, around 20 microns, which is about the size of a single bacteria cell. We can load our microrobots with various drugs and modify their surface in such a way that when the robots come in contact with the cells we are targeting, they can kill the target cell or perform some other function.


Q: How is this solution unique?


Das: Other people have made magnetic microrobots, but our system is unique since it allows us to do automatic targeting with a lot of precision. For example, a person operating our microrobots can just point to a cell and our system will drive the microrobot there. Additionally, the instrument we have made and patented is an all-in-one portable device that can be used anywhere. We don’t need a separate microscope, camera or software, it is all built in and very user friendly. Anyone can use it. This makes it super portable, which means quick solutions for health practitioners. In addition, poor and resource challenged areas can also be accessed with this portable solution.

Q: What drives you toward invention?


Das: I like to solve problems, and I like seeing something come together from nothing. I am very interested in problems that affect human health and longevity, particularly those that affect the common person.


Q: How do you approach solving a problem, and whose support has been critical along the way?


Das: One thing I have realized is that it is imperative to ask the right question to solve a problem. You must really get to the core of the issue. The second thing is to always keep the end user in mind. So, it’s kind of a two-pronged approach—looking from both ends of the problem.


For support, I would say my team members and my collaborators. Their support has been invaluable in helping me solve the problems that I want to solve. In fact, my graduate students keep a running list of crazy ideas that they have come up with. It helps us look at problems in a unique way and come up with innovative solutions.


Q: Not every invention makes it. How do you deal with failure?


Das: The way that I start working on a problem is to assume that whatever we do, we are going to fail. I always tell my students that their first couple of experiments or designs will always fail. But failure is essential because it will teach you what not to do. And knowing what not to do is sometimes the critical part of the invention process. The failures inform us about the ways of not doing something which means now there is another way of doing something.


Q: What is the best advice you’ve ever received?


Das: The best career advice I’ve ever received is that there is always another way. If you run into roadblocks there is always another answer, there is always another opportunity. So we just need to keep going and trying new and crazy ideas.


Q: How are inventive minds created – is it innate or can it be developed? How do you encourage innovation among your students?


Das: That’s an interesting question and honestly, I am not sure. I do believe in what Edison said, “Genius is 1% inspiration and 99% perspiration.” He is a known inventor, so I would go with his interpretation on this.


As for my students, I give them lots of freedom. I think freedom is essential in encouraging innovation. The freedom to come up with crazy ideas without anyone saying that won't work and the freedom to fail—multiple times.


Das is available for interviews to talk about her microrobots and other projects at UD. To reach her, visit her profile and click the "contact" button.

Connect with:
Sambeeta Das

Sambeeta Das

Assistant Professor of Mechanical Engineering

Prof. Das’s research spans robotics, autonomous systems, physics, organic chemistry and materials engineering.

Biomechanical EngineeringClean Energy & EnvironmentMaterials EngineeringBiomechanicsFluid Mechanics
Powered by

You might also like...

Check out some other posts from University of Delaware

2 min

How corporate competition can spur collaborative solutions to the world's problems

Why can’t large competitive companies come together to work on or solve environmental challenges, AI regulation, polarization or other huge problems the world is facing? They can, says the University of Delaware’s Wendy Smith. While it's difficult, the key is to have these companies collaborate under the guise of competition. Smith, a professor of management and an expert on these types of paradoxes, co-authored a recent three-year study of one of the most profound collaborations. Her team looked at the unlikely alliance of 13 competitive oil and gas companies that eventually formed Canada’s Oil Sands Innovation Alliance (COSIA), which works with experts worldwide to find innovative solutions for environmental and technical challenges in the region. Smith and her co-authors found that those companies were willing to collaborate, but only when collaboration was cast in the language, practices and goals of competition. Given the scope of our global problems, companies must continually work together to offer solutions. Creating that collaboration becomes critical, Smith said. This research offers important insight about how these collaborations are possible. Among the study's key findings: Competition can drive cooperation — if leaders harness it. It would make sense to assume that competition undermines collaboration. But the study finds that those who championed alliances used competitive dynamics to strengthen cooperation among rival firms. Rather than suppressing rivalry, leaders leveraged competition as a mechanism to enable joint action toward shared environmental goals. This reframes how organizations can manage tensions between competition and cooperation in partnerships. For example, COSIA leaders created competition between partners to see who would contribute the most valuable environmental innovations. Partners could only gain as much benefit from other company’s innovations commensurate with what they shared. A “Paradox Mindset” is key to complex collaborative success. The research identifies the importance of what the authors call a paradox mindset, which sees competition and cooperation not as opposites to be balanced but as interrelated forces that can be used in tandem. Leaders in the study who adopted this mindset were more thoughtful and creative about how to engage both competitive and collaborative practices in the same alliance. Traditional balance isn’t the goal — process over stability. Instead of pursuing a simplistic “balance” between competing and cooperating, the study shows that effective alliances evolve through process, where competition remains visible and even useful throughout the lifecycle of the alliance. To connect with Smith directly and arrange an interview, visit her profile and click on the "contact" button. Interested journalists can also send an email to MediaRelations@udel.edu.

1 min

Why homelessness is more than a housing issue for students

More than 4,400 students in Delaware were identified as experiencing homelessness during the 2022–23 school year, a number that continues to rise.  Ann M. Aviles, associate professor in the University of Delaware’s College of Education and Human Development, studies education equity, social policy and services for children and families. She is co-author of a new book, "Serving Students Who Are Homeless: A Resource Guide for Schools, Districts, Educational Leaders, and Community Partners", which offers practical guidance for educators navigating the challenges of student homelessness. Nationwide, more than 1.3 million school-aged children experience homelessness annually. While housing instability is often viewed as a social services issue, research shows it has direct and profound consequences for student learning, engagement and well-being. Housing instability affects every aspect of a student’s daily life. Students may be worried about where they will sleep, whether they will have food or how they’ll get home after school. That uncertainty makes it much harder to focus on learning, Aviles said. A key recommendation in Aviles’ new book is stronger collaboration between schools and community organizations. She encourages districts to develop community resource maps that identify local food pantries, shelters, health providers and other support services. She also emphasizes the importance of public understanding of homelessness as a systemic issue shaped by policy, affordability and access to services. To speak with Aviles further, email mediarelations@udel.edu. 

2 min

Maduro is gone; expert details potential impact on the Caribbean

Globally, the ousting of Nicolás Maduro in Venezuela has been met with a mix of reactions and cautious optimism. The University of Delaware’s Kalim Shah can discuss how regime change will play across the Caribbean and the spillover effect that will ripple throughout the region – and the world – in the years and decades to come. Shah, professor of energy and environmental policy and an expert on the island nations of the Caribbean, says that although public statements have been muted and restrained, there is a shared understanding. “For small island states that have absorbed the effects of Venezuelan collapse for more than two decades, this moment represents the possible end of a long and destabilizing chapter,” Shah said. Caribbean governments are not celebrating regime change, Shah said. Rather, they are responding to the prospect of reduced systemic risk. “A Venezuela that no longer exports large-scale displacement, opaque energy leverage and permissive criminal governance is objectively preferable for the region.” Shah can discuss several aspects of Venezuela’s political history, how the nation has arrived where it is, where it might be headed and the impact this will have on the Caribbean as a whole. Those include: • Venezuela’s political and economic deterioration during the Chávez–Maduro era and how that has translated directly into pressures felt across the Caribbean in the form of migration, fiscal exposure, security risks and regional uncertainty. • How the nation’s institutional collapse coincided with deepening organized crime activity across the Caribbean basin. Data from the United Nations Office on Drugs and Crime consistently places the region within major cocaine trafficking corridors linking South America with North American and European markets. For Caribbean governments, this meant higher interdiction costs, increased exposure to transnational criminal networks and growing pressure on already limited security institutions. • This moment invites a reassessment of China’s expanding footprint in the Caribbean, Shah says. He can discuss the ways in which Beijing has deepened its presence throughout the region. Shah says that as this transition unfolds, five policy developments will determine whether the cautious optimism proves warranted: • The impact on Venezuelan outward migration to the Caribbean. • Whether Caribbean public systems receive durable support rather than short-term humanitarian fixes. • Organized crime and drug trafficking pressures in the Caribbean basin. • External security engagement in the Caribbean. • Whether the region avoids a return to dependency-driven energy and infrastructure politics. “For the Caribbean, hope today is not naïve. It is conditional. The Chávez–Maduro years imposed real costs on the region. Their end creates an opening…but only if policy follows through,” Shah said. To contact Shah directly for interviews, visit his expert page and click on the "contact" button. Interested reporters can also send an email to mediarelations@udel.edu.

View all posts
Powered by