Aileen Anderson
Director of the Sue and Bill Gross Stem Cell Research Center UC Irvine
- Irvine CA
Dr. Anderson is an expert on stem cell research, with a focus on spinal cord and traumatic brain injury.
Media
Biography
Areas of Expertise
Accomplishments
UCI Chancellor's Award for Excellence in Research Mentorship
2006
Education
University of California, Irvine
PhD
Biology, Neurobiology
1996
University of Illinois, Urbana
BS
Bioengineering
1987
Affiliations
- Society for Neuroscience
- American Association for the Advancement of Science
- International Society for Stem Cell Research
Links
Media Appearances
Advancing regenerative medicine therapies
Newswise online
2024-06-26
University and community guests recently gathered to celebrate the 7,700 square-foot Good Manufacturing Practice facility’s grand opening in Hewitt Hall’s basement on the UC Irvine campus. … “This facility is not just a building; it is a powerhouse of innovation and hope, meticulously designed and equipped to produce FDA-compliant cell and gene therapies, which are at the forefront of medical science’s promise for the future,” says Dr. Michael J. Stamos, dean of the UC Irvine School of Medicine. … “Our commitment to taking a multidisciplinary approach to integrating groundbreaking research with clinical applications was also recognized and supported by the California Institute for Regenerative Medicine,” says Aileen Anderson, Ph.D., director of the UC Irvine Stem Cell Research Center and professor of physical medicine & rehabilitation.
Can We Rebuild the Spinal Cord? These Scientists Are Redefining What's Possible
Inverse online
2023-03-02
After someone experiences a spinal cord injury, doctors set off on a race against the clock. … “The dominant thinking was that you should focus on acute injuries,” Aileen Anderson, a stem cell researcher [and professor] at the University of California, Irvine, tells Inverse. “If you could just hit a magic bullet at that stage and minimize the amount of damage that’s happening because it kind of rolls out over days and a couple of weeks … this was the place to target.” … Some teams, including Anderson and her colleagues, are trying to put specialized materials into people’s spinal cords, such as scaffolds made of hydrogels, as another method to help the spinal cord reconnect itself. It could also help to combine scaffolding and stem cells, Anderson says, an idea currently in the early stages of development.
$5.5M grant awarded for spinal stem cell research
Becker's Spine Review online
2021-12-01
"In the U.S., there are about 285,000 individuals living with paralysis due to traumatic spinal cord injury, and there are no FDA-approved treatments," Dr. Anderson said in a Nov. 30 news release. "Integrating transplanted human neural stem cells is likely to direct improved locomotor function, and increasing a single level of spine function can make a significant positive impact on both quality of life and the economic burden of disease for these patients."
Campus labs produce sample-preserving fluid for COVID-19 test kits
University of California online
2020-04-16
“We set up a mini task force of related medical investigators and faculty from various schools,” says Aileen Anderson, professor of physical medicine & rehabilitation and director of the Sue & Bill Gross Stem Cell Research Center. “We sourced all the reagents needed for the media and set up a system to manage production in Gross Hall with social distancing measures in place to protect our staff.”
Campus labs making sample-preserving fluid for COVID-19 test kits
UCI News online
2020-04-07
“We set up a mini task force of related medical investigators and faculty from various schools,” says Aileen Anderson, professor of physical medicine & rehabilitation and director of the Sue & Bill Gross Stem Cell Research Center. “We sourced all the reagents needed for the media and set up a system to manage production in Gross Hall with social distancing measures in place to protect our staff.”
Articles
Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model
Tissue Engineering Part ADominique R. Smith, Courtney M. Dumont, Jonghyuck Park, Andrew J. Ciciriello, Amina Guo, Ravindra Tatineni, Brian J. Cummings, Aileen J. Anderson, and Lonnie D. Shea
2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge. The complex, dynamic, inhibitory microenvironment postinjury, which is characterized by proinflammatory signaling from invading leukocytes and lack of sufficient factors that promote axonal survival and elongation, limits regeneration.
PLG Bridge Implantation in Chronic SCI Promotes Axonal Elongation and Myelination
ACS Biomaterials Science & EngineeringDominique R. Smith, Courtney M. Dumont, Andrew J. Ciciriello, Amina Guo, Ravindra Tatineni, Mary K. Munsell, Brian J. Cummings, Aileen J. Anderson, and Lonnie D. Shea
2019
Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and loss of bladder, bowel, and sexual function. Patients are rarely treated immediately, and this delay is associated with tissue loss and scar formation that can make regeneration at chronic time points more challenging. Herein, we investigated regeneration using a poly(lactide-co-glycolide) multichannel bridge implanted into a chronic SCI following surgical resection of necrotic tissue.
Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury
Proceedings of the National Academy of SciencesJonghyuck Park, Yining Zhang, Eiji Saito, Steve J. Gurczynski, Bethany B. Moore, Brian J. Cummings, Aileen J. Anderson, and Lonnie D. Shea
2019
Inflammatory responses, such as those following spinal cord injury (SCI), lead to extensive tissue damage that impairs function. Here, we present nanoparticles that target circulating immune cells acutely, with nanoparticles reprogramming the immune cell response. The polymeric nanoparticles are formed without an active pharmaceutical ingredient that can have off-target effects, and internalization redirects some immune cells to the spleen, with modest numbers at the SCI.
Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis
J Immunol2017
Inflammatory processes play a key role in pathophysiology of many neurologic diseases/trauma, but the effect of immune cells and factors on neurotransplantation strategies remains unclear. We hypothesized that cellular and humoral components of innate immunity alter fate and migration of human neural stem cells (hNSC).
Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury
Stem Cell Reports2017
We previously showed the efficacy of multiple research cell lines (RCLs) of human CNS neural stem cells (HuCNS-SCs) in mouse and rat models of thoracic spinal cord injury (SCI), supporting a thoracic SCI clinical trial. Experts recommend in vivo preclinical testing of the intended clinical cell lot/line (CCL) in models with validity for the planned clinical target.
Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair
J Neurosci2017
The interaction of transplanted stem cells with local cellular and molecular cues in the host CNS microenvironment may affect the potential for repair by therapeutic cell populations. In this regard, spinal cord injury (SCI), Alzheimer's disease, and other neurological injuries and diseases all exhibit dramatic and dynamic changes to the host microenvironment over time.
Achieving Informed Consent for Cellular Therapies: A Preclinical Translational Research Perspective on Regulations Versus a Dose of Reality
J Law Med Ethics2016
A central principle of bioethics is "subject autonomy," the acknowledgement of the primacy of the informed consent of the subject of research. Autonomy requires informed consent - the assurance that the research participant is informed about the possible risks and benefits of the research. In fact, informed consent is difficult when a single drug is being tested, although subjects have a baseline understanding of the testing of a pharmacological agent and the understanding that they can stop taking the drug if there were an adverse event.
Biomaterial Bridges Enable Regeneration and Re-Entry of Corticospinal Tract Axons Into the Caudal Spinal Cord After SCI: Association With Recovery of Forelimb Function
Biomaterials2015
Severed axon tracts fail to exhibit robust or spontaneous regeneration after spinal cord injury (SCI). Regeneration failure reflects a combination of factors, including the growth state of neuronal cell bodies and the regeneration-inhibitory environment of the central nervous system. However, while spared circuitry can be retrained, target reinnervation depends on longitudinally directed regeneration of transected axons.
