Dr Afzal-Ur-Rahman Mohammed's research interests include: formulation development and optimization of orally disintegrating tablets; formulation and stability testing of oral liquid nano medicines; particle engineering through controlled dry particle coating technology; development of cell culture based models - buccal absorption, intestinal absorption, taste assessment, gene expression using microarrays.
Areas of Expertise (5)
Dry Particle Coating Technology
Aston University: PhD 2004
Supervisor, Prof Yvonne Perrie
Sheffield Hallam University: MSc 2001
- Academy of Pharmaceutical Sciences, UK : Fellow
- Nature Scientific Reports : Editorial Board Member
- Journal of Pharmaceutics : Founding Associate Editor
- BMC Journal of Pharmacology and Toxicology : Associate Editor
- Journal of Therapeutic delivery : Editorial Board Member
- Letters in Drug Delivery : Editorial Board Member
- Pharmaceutica Analytica Acta : Editorial Board Member
Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
Coating apparatus and method
Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating drums
Multimodal Role of Amino Acids in Microbial Control and Drug DevelopmentAntibiotics
2020 Amino acids are ubiquitous vital biomolecules found in all kinds of living organisms including those in the microbial world. They are utilised as nutrients and control many biological functions in microorganisms such as cell division, cell wall formation, cell growth and metabolism, intermicrobial communication (quorum sensing), and microbial-host interactions.
Evaluation of anti-biofilm activity of acidic amino acids and synergy with ciprofloxacin on Staphylococcus aureus biofilmsScientific Reports
2020 Acidic amino acids, aspartic acid (Asp) and glutamic acid (Glu) can enhance the solubility of many poorly soluble drugs including ciprofloxacin (Cip). One of the mechanisms of resistance within a biofilm is retardation of drug diffusion due to poor penetration across the matrix. To overcome this challenge, this work set to investigate novel counter ion approach with acidic amino acids, which we hypothesised will disrupt the biofilm matrix as well as simultaneously improve drug effectiveness.
Conceptualisation, Development, Fabrication and In Vivo Validation of a Novel Disintegration Tester for Orally Disintegrating TabletsScientific Reports
2019 Disintegration time is the key critical quality attribute for a tablet classed as an Orally Disintegrating Tablet (ODT). The currently accepted in vitro testing regimen for ODTs is the standard United States Pharmacopeia (USP) test for disintegration of immediate release tablets, which requires a large volume along with repeated submergence of the dosage form within the disintegration medium.
Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and Thermal ProfilesPharmaceutics
2019 Among the many methods available for solubility enhancement, mesoporous carriers are generating significant industrial interest. Owing to the spatial confinement of drug molecules within the mesopore network, low solubility crystalline drugs can be converted into their amorphous counterparts, which exhibit higher solubility.
High‐throughput screening of excipients with a biological effect: a kinetic study on the effects of surfactants on efflux‐mediated transportJournal of Pharmacy and Pharmacology
2019 In this study, we develop and apply a high‐throughput screening protocol to investigate the activity of non‐ionic surfactants, with a broad range of hydrophilic–lipophilic balance values, against ABCB1‐mediated efflux transport and ABCC2‐mediated efflux transport.