Dr Lissette Sanchez Aranguren
Lecturer in Bioenergetics Aston University
- Birmingham B4 7ET
Dr. Lissette Sanchez Aranguren studies how blood vessels and the brain work together & which medications boost brain function.
Media
Social
Biography
Lissette's research focuses on how blood vessels and the brain work together, specifically looking at the role of mitochondria (the energy producers in cells) in keeping the cells lining blood vessels healthy. Her work aims to understand how problems with these mitochondria might lead to brain diseases like Alzheimer’s or Parkinson’s.
Her lab has two main goals: first, to figure out how mitochondria problems in blood vessels are connected to brain disorders, and second, to explore new or existing drugs that could improve blood vessel health and, in turn, help treat brain-related conditions.
Areas of Expertise
Accomplishments
BBSRC IAA Award
2023
Sir Halley Stuart Small Grant Award
2020
Education
Aston University
MEd
Education
2023
Universidad del Valle
PhD
Biomedical Sciences
2017
Universidad de Carabobo
Degree
Biochemistry and Clinical Laboratory Science
2009
Affiliations
- Committee Member British Society for Cardiovascular Research, UK
- Fellow Higher Education Academy, UK
- British Journal of Biomedical Sciences (BJBS) : Editorial Board
Links
Articles
MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment
Redox Biology2021
Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disease, stroke and vascular dementia.
Cholesterol and oxysterol sulfates: Pathophysiological roles and analytical challenges
British Journal of Pharmacology2020
Cholesterol and oxysterol sulfates are important regulators of lipid metabolism, inflammation, cell apoptosis, and cell survival. Among the sulfate-based lipids, cholesterol sulfate (CS) is the most studied lipid both quantitatively and functionally. Despite the importance, very few studies have analysed and linked the actions of oxysterol sulfates to their physiological and pathophysiological roles.
Bioenergetic effects of hydrogen sulfide suppress soluble Flt-1 and soluble endoglin in cystathionine gamma-lyase compromised endothelial cells
Scientific Reports2020
Endothelial dysfunction is a hallmark of preeclampsia, a life-threatening complication of pregnancy characterised by hypertension and elevated soluble Fms-Like Tyrosine Kinase-1 (sFlt-1). Dysregulation of hydrogen sulfide (H2S) by inhibition of cystathionine γ-lyase (CSE) increases sFlt-1 and soluble endoglin (sEng) release.
Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia
Frontiers in Physiology2018
Preeclampsia is a maternal hypertensive disorder that affects up to 1 out of 12 pregnancies worldwide. It is characterized by proteinuria, endothelial dysfunction, and elevated levels of the soluble form of the vascular endothelial growth factor receptor-1 (VEGFR-1, known as sFlt-1). sFlt-1 effects are mediated in part by decreasing VEGF signaling.
Endothelial dysfunction and preeclampsia: role of oxidative stress
Frontiers in Physiology2014
Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries.
