Dr Sukhvir Wright
Clinical Research Career Development Fellow Aston University
- Birmingham B4 7ET
Dr Sukhvir Wright leads a multidisciplinary translational neuroscience research team focussing on neuro-immunological diseases of childhood.
Media
Social
Biography
Areas of Expertise
Accomplishments
Honorary Consultant Paediatric Neurologist
Birmingham Children's Hospital
Education
University of Oxford
PhD
Autoimmune epilepsies and encephalopathies of childhood
2015
Royal Free and University College Medical School
MBBS
2001
University College London
BSc
Physiology and Pharmacology
1998
Affiliations
- Honorary Consultant Neurologist, Birmingham Children's Hospital
Links
Media Appearances
Birmingham to Derby scooter challenge to raise £50,000 for rare epilepsy research kicks off at Aston University
ATV Today online
2024-09-05
Aston University is to host the start of a charity kick scooter challenge from Birmingham to Derby which aims to raise £50,000 for research into a rare and catastrophic form of epilepsy. Sam’s Big Scoot, which begins on 20 September 2024, is being organised by the charity Sam’s Superheroes Foundation, which was set up in 2021 by Rachel Liew in memory of her son Sam.
Can we extinguish the seizures in FIRES?
Epilepsy Research Institute UK online
2024-05-23
Febrile infection-related epilepsy syndrome, or “FIRES”, is a condition characterised by sudden onsets of relentless, difficult-to-treat seizures – sometimes hundreds a day. Dr Sukhvir Wright is developing a new method to study the underlying causes of FIRES and test treatments to counteract it. Sukhvir will also collect information on current FIRES treatments to help her develop new treatment guidelines. In this blog, Sukhvir discusses how she hopes her work could transform the lives of children and adults affected by FIRES.
Articles
Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models
Brain, Behavior, and Immunity2024
Anti-contactin associated protein receptor 2 (CASPR2) encephalitis is a severe autoimmune encephalitis with a variable clinical phenotype including behavioral abnormalities, cognitive decline, epileptic seizures, peripheral nerve hyperexcitability and neuropathic pain. The detailed mechanisms of how CASPR2 autoantibodies lead to synaptic dysfunction and clinical symptoms are largely unknown. Aiming for analyses from the molecular to the clinical level, we isolated antibody-secreting cells from the cerebrospinal fluid of two patients with CASPR2 encephalitis.
Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures
Journal of Experimental Medicine2021
Autoantibodies targeting the GABAA receptor (GABAAR) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with further autoantibodies and the lack of patient-derived mAbs.
Early predictors of epilepsy and subsequent relapse in children with acute disseminated encephalomyelitis
Multiple Sclerosis Journal2019
To identify predictors of epilepsy and clinical relapses in children presenting with acute disseminated encephalomyelitis (ADEM).
Disease Course and Treatment Responses in Children With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
JAMA Neurology2018
Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are consistently identified in a range of demyelinating disorders in adults and children. Current therapeutic strategies are largely center specific, and no treatments have been formally evaluated.
Myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies are highly specific in children with acquired demyelinating syndromes
Developmental Medicine & Child Neurology2018
Our objectives were to evaluate the utility of measuring myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies (Ab) in clinical practice and describe their associated neurological phenotypes in children.
