Jon Doering
Assistant Professor Louisiana State University
- Baton Rouge LA
Dr. Doering has more than 15 years of experience in the aquatic toxicology of anthropogenic chemicals.
Areas of Expertise
Research Focus
Species-Specific Chemical Sensitivity & Environmental Toxicology
Dr. Doering’s research centers on species-specific chemical sensitivity and the mechanisms behind it. He integrates in silico, in vitro, and in vivo assays with toxicogenomic tools to build objective ecological risk-assessment frameworks for fish, amphibians, reptiles, and birds of regulatory concern.
Accomplishments
Exceptional Paper Award from Environmental Toxicology and Chemistry
2025
LSU Outstanding Faculty Research Award (Tenure-Track)
2025
Exceptional Reviewer Award from Environmental Toxicology and Chemistry
2025
Gulf Research Program Early-Career Research Fellowship, National Academies of Sciences, Engineering, and Medicine
2024
Top Cited Article 2022-2023 (Top 10) for Environmental Toxicology and Chemistry
2024
Education
University of Saskatchewan
Ph.D.
Toxicology
2016
University of Saskatchewan
B.S.
2008
Articles
Chlorination and Bromination of Anthracene Affects Aryl Hydrocarbon Receptor Activation and Early Life Stage Mortality in Zebrafish (Danio rerio)
Environmental Science & Technology2025
Polycyclic aromatic hydrocarbons (PAHs) are known to adversely affect fish through activation of aryl hydrocarbon receptor 2 (AhR). Most studies have focused on 16 priority PAHs, but chlorinated and brominated PAHs are more potent than the parent PAHs in studies using mammalian AhRs. Despite being detected in fish species in situ, no studies have examined their toxicity. The present study investigated the effect of positioning and degree of chlorination and bromination on potency relative to an unsubstituted PAH for in vitro activation of zebrafish (Danio rerio) AhR2 and potency for zebrafish early life-stage mortality. Anthracene did not activate the AhR2, but chlorination and bromination strongly affected potency in a position-dependent manner. Seven of 11 halogenated PAHs activated the AhR2 with potency generally increasing with number of substitutions.
A Quantitative Adverse Outcome Pathway for Embryonic Activation of the Aryl Hydrocarbon Receptor of Fishes by Polycyclic Aromatic Hydrocarbons Leading to Decreased Fecundity at Adulthood
Environmental Toxicology and Chemistry2024
uantitative adverse outcome pathways (qAOPs) describe the response–response relationships that link the magnitude and/or duration of chemical interaction with a specific molecular target to the probability and/or severity of the resulting apical‐level toxicity of regulatory relevance. The present study developed the first qAOP for latent toxicities showing that early life exposure adversely affects health at adulthood. Specifically, a qAOP for embryonic activation of the aryl hydrocarbon receptor 2 (AHR2) of fishes by polycyclic aromatic hydrocarbons (PAHs) leading to decreased fecundity of females at adulthood was developed by building on existing qAOPs for (1) activation of the AHR leading to early life mortality in birds and fishes, and (2) inhibition of cytochrome P450 aromatase activity leading to decreased fecundity in fishes.
Far from Their Origins: A Transcriptomic Investigation on How 2,4‐Di‐tert‐butyl‐6‐(5‐chloro‐2H‐benzotriazol‐2‐yl) Phenol Affects Rainbow Trout Alevins
Environmental Toxicology and Chemistry2024
Benzotriazole ultraviolet stabilizers (BUVSs) are a group of widely used chemicals added to a variety of consumer (e.g., plastics) and industrial (e.g., metal coating) goods. Although detected globally as an environmentally persistent pollutant, BUVSs have received relatively little toxicological attention and only recently have been acknowledged to affect development and the endocrine system in vivo. In our previous study, altered behavior, indicative of potential neurotoxicity, was observed among rainbow trout alevins (day 14 posthatching) that were microinjected as embryos with a single environmentally relevant dose of 2,4‐di‐tert‐butyl–6‐(5‐chloro‐2H‐benzotriazol‐2‐yl) phenol (UV‐327).
Embryonic Exposure to Benzotriazole Ultraviolet Stabilizer 327 Alters Behavior of Rainbow Trout Alevin
Environmental Toxicology and Chemistry2024
Benzotriazole ultraviolet (UV) stabilizers (BUVSs) are used in great quantities during industrial production of a variety of consumer and industrial goods. As a result of leaching and spill, BUVSs are detectable ubiquitously in the environment. As of May 2023, citing concerns related to bioaccumulation, biomagnification, and environmental persistence, (B)UV(S)‐328 was recommended to be listed under Annex A of the Stockholm Convention on Persistent Organic Pollutants. However, a phaseout of UV‐328 could result in a regrettable substitution because the replacement chemical(s) could cause similar or unpredicted toxicity in vivo, relative to UV‐328.
Assessing the Toxicity of Benzotriazole Ultraviolet Stabilizers to Fishes: Insights into Aryl Hydrocarbon Receptor-Mediated Effects
Environmental Science & Technology2023
Benzotriazole ultraviolet stabilizers (BUVSs) are chemicals used to mitigate UV-induced damage to manufactured goods. Their presence in aquatic environments and biota raises concerns, as certain BUVSs activate the aryl hydrocarbon receptor (AhR), which is linked to adverse effects in fish. However, potencies of BUVSs as AhR agonists and species sensitivities to AhR activation are poorly understood. This study evaluated the toxicity of three BUVSs using embryotoxicity assays. Zebrafish (Danio rerio) embryos exposed to BUVSs by microinjection suffered dose-dependent increases in mortality, with LD50 values of 4772, 11 608, and 56 292 ng/g-egg for UV-P, UV-9, and UV-090, respectively.
