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Joshua Grill - UC Irvine. Irvine, CA, US

Joshua Grill Joshua Grill

Director of the Institute for Memory Impairments and Nerological Disorders at UCI | UC Irvine


Joshua Grill directs a major Alzheimer's disease research institute helps lead the national strategy for AD clinical trial recruitment.






Maximizing Healthy Brain Aging- Joshua Grill, PhD & Ruobing Li, MA Research-Promising Therapies for Dementia Patients | Joshua D. Grill, PhD - UCLA Health UCI C2C Registry - Joshua Grill, PhD




Dr. Grill has been the recipient of the National Alzheimer’s Coordinating Center Junior Investigator Award, the Alzheimer’s Association Turken Research Prize, the Community Spirit Award from OPICA Adult Day Services, and the P. Gene and Elaine Smith Term Chair in Alzheimer’s Disease Research. He has been funded by the National Institute on Aging, the National Institute of Neurological Disorders and Stroke, the Alzheimer’s Association, the Hartford Foundation, the BrightFocus Foundation, the American Federation for Aging Research, and the University of California. He is the co-leader of the Recruitment Unit and the Internal Ethics Committee for the NIH-funded Alzheimer’s Clinical Trial Consortium. He is a member of the Scientific Advisory Board for Maria Shriver’s Women’s Alzheimer’s Movement and for Lauren Rogen Miller and Seth Rogan's HfC. In 2017, he co-chaired a workgroup as part of the NIH’s Inclusion Across the Lifespan workshop, a congressional mandate in the 21st Century Cures Act (P.L. 114-255). He was part of a working group sponsored by the National Institute on Aging and the Alzheimer’s Association charged with creating a national strategy for recruitment to Alzheimer’s disease clinical research.

Areas of Expertise (5)


Clinical Trials

Alzheimer’s Disease

Neurodegenerative disorders

Recruitment and Retention

Accomplishments (4)

Community Spirit Award (professional)

OPICA Adult Day Services

Junior Investigator Award (professional)

National Alzheimer’s Coordinating Center

Turken Research Prize (professional)

Alzheimer’s Association

P. Gene and Elaine Smith Term Chair (professional)

Alzheimer’s Disease Research

Education (1)

Wake Forest University School of Medicine: PhD, Neuroscience 2004

Media Appearances (5)

Former California First Lady Maria Shriver gives UC Irvine gender-related research on Alzheimer’s disease another boost

The Orange County Register  online


Her organization’s outreach included Shriver’s presence in November at the opening of a senior living and memory care center in Redondo Beach, an appearance highlighted by a Q&A with leading researchers that included UCI MIND’s director, Dr. Joshua Grill.

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Should Alzheimer's Prevention Trials Include Disease-Modifying Therapies? Experts Weigh the Risks and Benefits

Neurology Today  online


“The evidence suggesting problematic safety profiles for BACE inhibitors is mounting. Yet, there are still more questions than answers about BACE inhibitors, especially in preclinical AD,” Joshua Grill, PhD, associate director of the Alzheimer's Disease Research Center and director of the Institute for Memory Impairments and Neurological Disorders at the University of California in Irvine, told Neurology Today.

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Don't Be Taken In by Dementia 'Pseudomedicine'

AARP  online


In addition, there's concern that by falling for pseudomedicine, people are delaying the care they truly need. “A common situation is an older adult becoming concerned about their memory and taking a supplement to try to ward off dementia,” says Joshua Grill, director of the Institute for Memory Impairments and Neurological Disorders at the University of California, Irvine. “But in reality, if they saw their doctor, they might find out that another medical condition such as hypothyroidism, or a certain prescription medication, is causing symptoms and can be easily treated. They're just making things worse.”

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What America's Corporations Can Do To Tackle Alzheimer's

Forbes  online


This past week, thousands of the world's leading Alzheimer's disease researchers gathered in London to discuss and debate the latest research. Among the questions that captured much attention was: what's the right kind of study to discover the best treatments?

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Alzheimer’s research ramps up

UCI News  online


And under the leadership of Joshua Grill, co-director of UCI MIND and associate professor of psychiatry & human behavior, the institute’s portfolio of clinical trials to identify new preventions or cures is growing.

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Articles (5)

Study partner types and prediction of cognitive performance: implications to preclinical Alzheimer’s trials

Alzheimer's Research & Therapy

Michelle M. Nuño, Daniel L. Gillen, Joshua D. Grill & for the Alzheimer’s Disease Cooperative Study

2019 Alzheimer’s disease (AD) clinical trials require enrollment of a participant and a study partner, whose role includes assessing participant cognitive and functional performance. AD trials now investigate early stages of the disease, when participants are not cognitively impaired. This gives rise to the question of whether study partners or participants provide more information in these trials.

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Participant and study partner prediction and identification of cognitive impairment in preclinical Alzheimer’s disease: study partner vs. participant accuracy

Alzheimer's Research & Therapy volume

Mary M. Ryan, Joshua D. Grill, Daniel L. Gillen & for the Alzheimer’s Disease Neuroimaging Initiative

2019 Preclinical Alzheimer’s disease (AD) clinical trials require participants to enroll with a study partner, a person who can attend visits and report changes in the participant’s cognitive ability. Whether study partners, compared to participants themselves, provide added information about participant cognition in preclinical AD trials is an open question. We tested the hypothesis that study partners provide meaningful information related to participant cognition cross-sectionally and longitudinally, and assessed whether amyloid status modified observed effects.

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Response to “Avoiding Methodological Bias in Studies of Amyloid Imaging Results Disclosure”

Alzheimer's Research & Therapy

Joshua D. Grill, Chelsea G. Cox, Kristin Harkins & Jason Karlawish

2019 The goal of “Reactions to learning a ‘not elevated’ amyloid PET result in a preclinical Alzheimer’s disease trial” was to study how learning one is not eligible for a trial based on an Alzheimer’s disease (AD) biomarker result affects willingness to be in subsequent trials, as well as how it affects other behaviors [1]. Answering this question fills a critical gap in the literature, as preclinical AD trials are increasingly common but the ideal criteria for participant inclusion remains an area of active research. Thus, a person ineligible for one trial may be eligible for another.

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Retention of Alzheimer Disease Research Participants

Alzheimer Disease & Associated Disorder

Joshua D Grill, Jimmy Kwon, Merilee A Teylan, Aimee Pierce, Eric D Vidoni, Jeffrey M Burns, Allison Lindauer, Joseph Quinn, Jeff Kaye, Daniel L Gillen, Bin Nan

2019 Participant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research.

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Which MCI Patients Should be Included in Prodromal Alzheimer Disease Clinical Trials?

Alzheimer Disease & Associated Disorders

Joshua D Grill, Michelle M Nuño, Daniel L Gillen

2019 Prodromal Alzheimer disease (AD) clinical trials enroll patients with mild cognitive impairment (MCI) meeting biomarker criteria, but specific enrollment criteria vary among trials.

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