Dr. Prasanta Kumar Dey is a professor in Operations and Information Management at Aston Business School, Aston University, UK. Prior to joining Aston University in 2004, he worked for 4 and half years with the University of West Indies in Barbados as a Director of a graduate project management program and 13 years in Indian Oil Corporation Limited, India as a project executive. He has a bachelor in mechanical engineering from Jadavpur University, Kolkata, India, Master’s in Industrial engineering and management from Asian Institute of Technology, Bangkok, Thailand, and Doctoral degree in Production engineering from Jadavpur University. He specializes in low carbon supply chain management and project management. He has extensively published in the international refereed journals (e.g. IEEE Transactions in Engineering Management, International Journal of Production and Operations Management, International Journal of Production Economics, European Journal of Operation Research, Supply Chain Management International Journal, Energy). He is a visiting professor of Rouen Business School and Toulouse Business School in France, University of Deusto in Spain, University of South Australia, University of Bamberg in Germany, and University of Vienna in Austria. He is the founder co-editor of the International Journal of energy Sector Management. He has published more than one hundred research papers in the leading international refereed journals. He has accomplished several research projects funded by Ford Foundation, Research Council, UK, British Council, and West Midlands Manufacturing Advisory Services. His industry clients include Jaguar Land Rover, Rolls Royce, JCB, L’Oreal, NHS, Britons Carpet, Cemex, Indian Oil Corporation Limited, Kuwait National Petroleum Company and Unocal.
Areas of Expertise (5)
Total Quality Management
Service Operations Management
Supply Chain Management
Jadavpur University: PhD, Production Engineering 1997
Asian Institute of Technology: MS, Industrial Engineering 1992
Jadavpur University: BS, Mechanical Engineering 1985
- International Journal of Energy Sector Management : Chief Editor
- Journal of Advances in Management Research : Editorial Review Board Member
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker RatsCells
Amit Kundu, Prasanta Dey, Jae Hyeon Park, In Su Kim, Seung Jun Kwack, Hyung Sik Kim
Sirtuin (SIRT) is known to prevent nonalcoholic fatty liver disease (NAFLD); however, the role of SIRT4 in the progression of hepatic fibrosis remains unknown. We hypothesize that EX-527, a selective SIRT1 inhibitor, can inhibit the progression of high-fat diet (HFD)-induced hepatic fibrosis. We found that SIRT4 expression in the liver of NAFLD patients is significantly lower than that in normal subjects. In this study, EX-527 (5 µg/kg), administered to HFD rats twice a week for ten weeks, reduced the serum levels of triglyceride (TG), total cholesterol, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) and attenuated hepatic fibrosis evidenced by Masson’s trichrome and hepatic fat by oil red-O staining. EX-527 upregulated SIRT2, SIRT3, and SIRT4 expression in the liver of HFD fed rats but downregulated transforming growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA) expression. It decreased proinflammatory cytokine production and hydroxyproline levels in the serum and SMAD4 expression and restored apoptotic protein (Bcl-2, Bax, and cleaved caspase-3) expression. These data propose a critical role for the SIRT4/SMAD4 axis in hepatic fibrogenesis. SIRT4 upregulation has the potential to counter HFD-induced lipid accumulation, inflammation, and fibrogenesis. We demonstrate that EX-527 is a promising candidate in inhibiting the progression of HFD-induced liver fibrosis.
Healthcare supply chain management: Application in the Maltese Healthcare SystemHealth Services Management Research
Sandra C Buttigieg, Frank Bezzina, Andrew Xuereb, Prasanta K Dey
Hospital supply chains are complex systems ensuring flow of products/services to satisfy patients. The aim of this exploratory study is to improve the Maltese health care system’s efficiency using supply chain management principles in three hospital settings. The theoretical basis underlying the study is the supply chain decision-making framework.
Circular economy to enhance sustainability of small and medium‐sized enterprisesBusiness Strategy and the Environment
Prasanta Kumar Dey, Chrisovaladis Malesios, Debashree De, Pawan Budhwar, Soumyadeb Chowdhury, Walid Cheffi
The circular economy (CE) represents a major paradigm shift of moving from the concepts of linear to circular supply chains across multiple industries. Although some aspects of CE adoption within industrial supply chains have been researched extensively (particularly addressing challenges of design, implementation, and operations), the research that relates CE practices with sustainability performance to reveal the current state of CE practices within small and medium‐sized enterprises (SMEs) is scant. The aim of this research was to facilitate SMEs to achieve greater sustainability through CE implementation. This research addresses three research questions—How are CE fields of action related to sustainability performance? What are the issues, challenges, and opportunities of adopting CE in SMEs? And what key strategies, resources, and competences facilitate effective implementation of CE in SMEs? This study adopts a mixed method approach (qualitative and quantitative) using survey research, focus group, and case studies; 130 randomly selected SMEs within the Midlands of the United Kingdom have been surveyed, and the responses are analysed using statistical tools along with findings from focus groups and case studies. The study reveals that all CE fields of action (take , make , distribute , use , and recover ) of SMEs are correlated to economic performance, but only make and use are related to environmental and social performance. The study further derives strategies, resources, and competences for achieving sustainability across all the CE field of actions. Additionally, this research reveals the issues and challenges, strategies, resources, and competences required for implementing CE in SMEs.
Adverse health risk from prolonged consumption of formaldehyde-preserved carps in eastern region of Indian populationEnvironmental Science and Pollution Research
Amit Kundu, Prasanta Dey, Rammohan Bera, Ratul Sarkar, Boomin Kim, Sam Kacew, Byung Mu Lee, Sanmoy Karmakar & Hyung Sik Kim
Presence of formaldehyde as a preservative in commonly available fishes (Labeo rohita, Catla catla, Anabas testudineus and Clarias gariepinus) has become a serious health concern in the public health of eastern region of India. Formaldehyde content was determined using high-performance liquid chromatography (HPLC). Results showed high formaldehyde content in frozen carp (19.66 and 23.3 mg/kg in Labeo rohita and Catla catla, respectively); however, the amount of formaldehyde was significantly reduced in boiled and fried fish (80 °C and 100 °C for 5 min) in mustard, coconut, and sesame oils. However, formaldehyde contents in non-carp fishes (Anabas testudineus and Clarias gariepinus) were almost negligible, compared to those in L. rohita and C. catla. In vivo toxicity studies showed a time-dependent increase in blood formaldehyde levels in rats after they were fed formaldehyde-contaminated fish (23.3 mg/kg) for 7 days. Histopathological analysis of the stomach of rats fed contaminated fish showed destruction and granulation of the protective mucus layer and detachment from the secretory layer. Taken together, our results indicated that continuous consumption of formaldehyde-contaminated carps commonly available in the eastern region of India may be associated with adverse health effects.
Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker ratsToxicology and Applied Pharmacology
Amit Kundu, Sachan Richa, Prasanta Dey, Kyeong Seok Kim, Ji Yeon Son, Hae Ri Kim, Seok-Yong Lee, Byung-Hoon Lee, Kwang Youl Lee, Sam Kacew, Byung Mu Lee, Hyung Sik Kim
High-fat diet (HFD)-induced obesity is implicated in diabetic nephropathy (DN). EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, has multiple biological functions; however, its protective effect against DN is yet to be properly understood. This study was aimed to explore the protective effect of EX-527 against DN in HFD-induced diabetic Zucker (ZDF) rats. After 21 weeks of continually feeding HFD to the rats, the apparent characteristics of progressive DN were observed, which included an increase in kidney weight (~160%), hyperglycemia, oxidative stress, and inflammatory cytokines, and subsequent renal cell damage. However, the administration of EX-527 for 10 weeks significantly reduced the blood glucose concentration and kidney weight (~59%). Furthermore, EX-527 significantly reduced the serum concentration of transforming growth factor-β1 (49%), interleukin (IL)-1β (52%), and IL-6 in the HFD-fed rats. Overall, the antioxidant activities significantly increased, and oxidative damage to lipids or DNA was suppressed. Particularly, EX-527 significantly reduced blood urea nitrogen (81%), serum creatinine (71%), microalbumin (43%), and urinary excretion of protein-based biomarkers. Histopathological examination revealed expansion of the extracellular mesangial matrix and suppression of glomerulosclerosis following EX-527 administration. EX-527 downregulated the expression of α-SMA (~64%), TGF-β (25%), vimentin, α-tubulin, fibronectin, and collagen-1 in the kidneys of the HFD-fed rats. Additionally, EX-527 substantially reduced claudin-1 and SIRT1 expression, but increased the expression of SIRT3 in the kidneys of the HFD-fed rats. EX-527 also inhibited the growth factor receptors, including EGFR, PDGFR-β, and STAT3, which are responsible for the anti-fibrotic effect of SIRT-1. Therefore, the administration of EX-527 protects against HFD-induced DN.