Roslyn Bill

Professor of Biotechnology Aston University

  • Birmingham

Professor Bill's research on water flow in the body has revealed how to develop drugs that prevent brain swelling after injury or disease.

Contact

Aston University

View more experts managed by Aston University

Spotlight

2 min

Professor Roslyn Bill selected for the inaugural cohort of the Big if True Science accelerator

Professor Roslyn Bill is the director of Aston Institute for Membrane Excellence (AIME) The Big if True Science (BiTS) accelerator aims to bridge the gap between cutting-edge lab science and multi-million-dollar collaborative projects Professor Bill’s research is focused on the brain’s plumbing system and developing drugs against traumatic brain injury and cognitive decline. Professor Roslyn Bill, director of Aston Institute for Membrane Excellence (AIME), has been selected as an inaugural fellow of the new Big if True Science (BiTS) accelerator. BiTS was set up by a non-profit organisation, Renaissance Philanthropy, to support its scientist and innovator fellows in developing groundbreaking research initiatives and equip them with the tools, skills, and networks needed to design high-impact, collaborative research programmes and technical projects with multi-million-dollar budgets beyond their own laboratories. The first cohort of 12 fellows was selected after a highly competitive process. The cohort represents diverse fields including neuroscience, environmental engineering, biomedical research, and materials science. Over a 15-week period, they will transform their breakthrough concepts into fundable eight-figure R&D programmes, before pitching their ideas to funders on 10 December 2025. Professor Bill’s research focuses on the glymphatic system, the brain’s ‘plumbing’ system, which facilitates the movement of fluid and clears waste products. Water moves in and out of brain cells through tiny protein channels in the cell membrane called aquaporins. Uncontrolled water entry, for example, after a head injury, can cause catastrophic swelling and severe brain injuries of the type suffered by racing driver Michael Schumacher after a skiing accident. When the flow is impeded, for example, as we age, waste products can build up, leading to diseases like Alzheimer’s. In 2020, Professor Bill was lead author on a paper published in the prestigious journal Cell on how the flow of water through aquaporin-4 is controlled. She is now researching drugs to affect this process, which could have a huge impact on the treatment of traumatic brain injury and cognitive decline. Professor Bill said: “Every year, tens of millions of people are affected by injuries to their brains. Every three seconds, someone in the world develops dementia. There are no medicines that can fix these terrible conditions. Being an inaugural member of BiTS is a great honour, and I am delighted to be in the company of truly inspiring people. This exciting programme offers hope to patients for whom no medicines are available!”

Roslyn Bill

5 min

Aston University and Birmingham Women and Children’s Hospital developing new devices to improve drug treatment safety

The new device is designed to reduce the risk of injuries when medicines being delivered into a vein enter the surrounding tissues It detects this problem at the earliest stages, before it is visible to the human eye The project is being supported by SPARK The Midlands at Aston University, a network to support technology development for unmet clinical needs. Clinicians at Birmingham Women’s and Children's NHS Foundation Trust (BWC) have joined with academics at Aston University to create an innovative sensor to reduce the risk of injuries caused when drugs being delivered into a vein enter the surrounding tissue. This complication, called extravasation, can cause harm and, in the most severe cases, life-changing injuries and permanent scarring. It happens most often when infusing medicines into peripheral intravenous (IV) devices, such as a cannula, but can also occur when infusing into a central venous access device. By joining together, BWC and Aston University are combining clinical, academic and engineering expertise to create a sensor that can detect extravasation at its earliest stages. Karl Emms, lead nurse for patient safety at BWC, said: “We've done lots of work across our Trust that has successfully reduced incidents. While we've made fantastic progress, there is only so much we can do as early signs of extravasation can be difficult to detect with the human eye. “The next step is to develop a technology that can do what people can't detection as it happens. This will make a huge impact on outcomes as the faster we can detect extravasation, the less likely it is that it will cause serious harm.” The focused work to date addressing the issue has recently been recognised by the Nursing Times Awards 2024, winning the Patient Safety Improvement title for this year. This new project is supported by SPARK The Midlands, a network at Aston University dedicated to providing academic support to advance healthcare research discoveries in the region. SPARK The Midlands is the first UK branch of Stanford University's prestigious global SPARK programme. It comes as a result of Aston University’s active involvement in the delivery of the West Midlands Health Tech Innovation Accelerator (WMHTIA) – a government-funded project aimed at helping companies drive their innovations towards market success. The SPARK scheme helps to provide mentorship and forge networks between researchers, those with technical and specialist knowledge and potential sources of funding. SPARK members have access to workshops led by industry experts, covering topics such as medical device regulations, establishing good clinical trials, and creating an enticing target product profile to engage future funders. Luke Southan, head of research commercialisation at Aston University and SPARK UK director, said: “I was blown away when Karl first brought this idea to me. I knew we had to do everything we could to make this a reality. This project has the potential to transform the standard of care for a genuine clinical need, which is what SPARK is all about.” Work on another potentially transformative project has also begun as the team are working to develop a medical device that detects the position of a nasogastric feeding tube. There is a risk of serious harm and danger to life if nasogastric tubes move into the lungs, rather than the stomach, and feed is passed through them. Emms explained: “pH test strips can usually detect nasogastric tube misplacement, but some children undergoing treatment can have altered pH levels in the stomach. This means this test sometimes does not work. “A medical device that can detect misplacement can potentially stop harm and fatalities caused by these incidents.” SPARK will bring together engineers, academics and clinicians for both projects to develop the devices for clinical trial, with a goal of the technologies being ready for clinical use in three to five years. Southan said: “BWC is one of our first partners at SPARK and we're really excited to work with them to make a vital impact on paediatric healthcare in the Midlands and beyond." Notes to editors About Aston University For over a century, Aston University’s enduring purpose has been to make our world a better place through education, research and innovation, by enabling our students to succeed in work and life, and by supporting our communities to thrive economically, socially and culturally. Aston University’s history has been intertwined with the history of Birmingham, a remarkable city that once was the heartland of the Industrial Revolution and the manufacturing powerhouse of the world. Born out of the First Industrial Revolution, Aston University has a proud and distinct heritage dating back to our formation as the School of Metallurgy in 1875, the first UK College of Technology in 1951, gaining university status by Royal Charter in 1966, and becoming the Guardian University of the Year in 2020. Building on our outstanding past, we are now defining our place and role in the Fourth Industrial Revolution (and beyond) within a rapidly changing world. For media inquiries in relation to this release, contact Helen Tunnicliffe, Press and Communications Manager, on (+44) 7827 090240 or email: h.tunnicliffe@aston.ac.uk About Birmingham Women’s and Children’s NHS Foundation Trust Birmingham Women’s and Children’s NHS Foundation Trust (BWC) brings together the very best in paediatric and women’s care in the region and is proud to have many UK and world-leading surgeons, doctors, nurses, midwives and other allied healthcare professionals on its team. Birmingham Children’s Hospital is the UK’s leading specialist paediatric centre, caring for sick children and young people between 0 and 16 years of age. Based in the heart of Birmingham city centre, the hospital is a world leader in some of the most advanced treatments, complex surgical procedures and cutting-edge research and development. It is a nationally designated specialist centre for epilepsy surgery and also boasts a paediatric major trauma centre for the West Midlands, a national liver and small bowel transplant centre and a centre of excellence for complex heart conditions, the treatment of burns, cancer and liver and kidney disease. The hospital is also home to one of the largest Child and Adolescent Mental Health Services in the country, comprising of a dedicated inpatient Eating Disorder Unit and Acute Assessment Unit for regional referrals of children and young people with the most serious of problems (Tier 4) and Forward Thinking Birmingham community mental health service for 0to 25-year-olds. Birmingham Women’s Hospital is a centre of excellence, providing a range of specialist health care services to over 50,000 women and their families every year from Birmingham, the West Midlands and beyond. As well as delivering more than 8,200 babies a year, it offers a full range of gynaecological, maternity and neonatal care, as well as a comprehensive genetics service, which serves men and women. Its Fertility Centre is one of the best in the country, while the fetal medicine centre receives regional and national referrals. The hospital is also an international centre for education, research and development with a research budget of over £3 million per year. It also hosts the national miscarriage research centre – the first of its kind in the UK in partnership with Tommy’s baby charity. For interview requests please email the Communications Team on bwc.communications@nhs.net

Roslyn Bill

2 min

Podcast: Aston University researchers discuss how brain injury research led to a better understanding of dementia causes

Professor Roslyn Bill discusses her research into brain cell membranes with Dr Matt Derry Serious brain injuries and dementia are affected by the flow of water through a protein called aquaporin-4 in brain cell membranes Aquaporins are responsible for clearing the build-up of waste products in brain cells in a process Professor Bill likens to a ‘dishwasher for your brain’. Professor Roslyn Bill, co-founder of Aston Institute for Membrane Excellence (AIME), joins Dr Matt Derry to discuss her research into brain cell membranes in the latest Aston Originals podcast. Water moves in and out of brain cells through tiny protein channels in the cell membrane called aquaporins. One in particular, aquaporin-4, is the focus of Professor Bill’s research. In 2020, she was lead author on a paper published in prestigious journal Cell on how the channels open and close and how this can be controlled. Uncontrolled water entry into brain cells can occur after head trauma, causing swelling which leads to severe brain injuries of the type suffered by racing driver Michael Schumacher after a skiing accident. Finding drugs to control this water movement could lead to treatments to prevent brain swelling in the first place. This research into brain swelling and the contribution of aquaporins led Professor Bill to research into Alzheimer’s, a common form of dementia, which is also related to the action of aquaporins. Alzheimer’s is caused by a build-up of waste products in brain cells. In a process Professor Bill likened to a ‘dishwasher for your brain’, aquaporins are responsible for clearing this waste as we sleep. Professor Bill was selected for an Advanced Grant by the European Research Council (ERC) in 2023, which is being funded by UK Research and Innovation (UKRI). The funded project will further investigate the process, and whether it might be possible to develop a drug to boost the ‘brain dishwasher’, which could be taken to slow or even prevent cognitive decline due to ageing. Bringing together this biological research with the polymer research of AIME, chemists like Dr Derry will help in the drug development and could also lead to totally different applications. Professor Bill said in the podcast to Dr Derry: “We can take the knowledge that we have of how these proteins work in cells and try and apply them to interesting applications in biotechnology. And this is where the sort of work that you (Dr Derry) do comes in, where you can develop plastic membranes, polymer membranes, and then take learning from the biology and try and make really, really good ways of purifying water, for example.” For more information about AIME, visit the webpage. The website also includes links to the previous AIME podcast and details about open positions.

Roslyn BillDr Matthew Derry
Show More +

Media

Social

Biography

Membrane proteins are the targets of over half of all prescription pharmaceuticals. I am an international authority on the synthesis and characterization of membrane proteins for biochemical, biophysical and structural analysis, which is the basis of modern drug discovery. My scientific focus is on aquaporin water channels (AQP), G protein-coupled receptors and tetraspanins.

In 2009, I led the multidisciplinary team that discovered a novel pathway that controls the permeability of cells to water. I have published a suite of articles describing this regulatory mechanism for human AQP1, 3, 4 and 5. These findings provide the foundation of understanding the mechanistic basis of water imbalance.

After a stroke or a traumatic head injury, the brain swells. This affects tens of millions of people every year. This swelling, known as ‘cytotoxic oedema’, can lead to death, disability and an increased risk of neurodegeneration with ageing. This is what happened to Michael Schumacher after his skiing accident in 2013. Current clinical treatments are crude and limited to symptom management. They include removal of part of the skull to allow the brain space to swell or the use of chemicals to draw water out of the brain tissue; these treatments are risky, especially for older patients. My team has discovered how water enters the brain and how to stop this happening after an injury. This means we can develop medicines to stop cytotoxic oedema developing and therefore reduce the need for life-threatening surgery. Excitingly, we have identified a compound that is already licenced in humans for another purpose. I am actively working towards testing whether it can be used as an anti-cytotoxic oedema medicine in a clinical trial.

Areas of Expertise

Membrane Proteins
Brain Swelling
Water Balance
Healthy Ageing
Brain Injury

Education

University of Oxford

DPhil

1994

Wellcome Trust Prize Student

University of Oxford

MA

Natural Science (Chemistry)

1993

University of Oxford

BA

Natural Science (Chemistry)

1990

Affiliations

  • BBSRC Research Committee E: Chair
  • Biotechnology Letters : Editorial Board Member
  • Molecular Biotechnology : Editorial Board Member
  • BBA-Biomembranes : Editorial Board Member
  • Membranes : Editorial Board Member
Show All +

Media Appearances

Michael Schumacher: Miracle treatment gives 'full recovery' hope for brain injury patients

Expres  online

2020-06-11

Professor Roslyn Bill of the Biosciences Research Group at Aston University said: "Every year, millions of people of all ages suffer brain and spinal injuries, whether from falls, accidents, road traffic collisions, sports injuries or stroke.

View More

Study uncovers new applications for schizophrenia drug

BBC  online

2020-05-15

"Rats who had not been given the treatment were still disabled after six weeks, but those who had a single injection, can walk normally after just two weeks," lead scientist Prof Roslyn Bill, at Aston University, said.

View More

'Cell pores' discovery gives hope to millions of brain and spinal cord injury patients

University of Birmingham  online

2020-05-14

Professor Roslyn Bill of the Biosciences Research Group at Aston University said: “Every year, millions of people of all ages suffer brain and spinal injuries, whether from falls, accidents, road traffic collisions, sports injuries or stroke. To date, their treatment options have been very limited and, in many cases, very risky.

View More

Show All +

Articles

Purification and immobilization of engineered glucose dehydrogenase: a new approach to producing gluconic acid from breadwaste

Biotechnology for Biofuels

2020

Platform chemicals are essential to industrial processes. Used as starting materials for the manufacture of diverse products, their cheap availability and efficient sourcing are an industrial requirement. Increasing concerns about the depletion of natural resources and growing environmental consciousness have led to a focus on the economics and ecological viability of bio-based platform chemical production. Contemporary approaches include the use of immobilized enzymes that can be harnessed to produce high-value chemicals from waste.

View more

Expression of eukaryotic membrane proteins in eukaryotic and prokaryotic hosts

Methods

2020

The production of membrane proteins of high purity and in satisfactory yields is crucial for biomedical research. Due to their involvement in various cellular processes, membrane proteins have increasingly become some of the most important drug targets in modern times. Therefore, their structural and functional characterization is a high priority. However, protein expression has always been more challenging for membrane proteins than for soluble proteins.

View more

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Cell

2020

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers.

View more

Show All +