Zvi Schwartz, D.M.D., Ph.D.
Professor, Department of Biomedical Engineering | VCU College of Engineering
Engineering West Hall, Room 397, Richmond, VA, UNITED STATES
Doctor of dental medicine and periodontal expert; skilled program developer
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Industry Expertise (4)
Research
Education/Learning
Program Development
Public Policy
Areas of Expertise (6)
Bone Cartilage and mineralization and their relation to Vitamin D sex hormones and local factors.
Implant and bone substitute mechanism of action and clinical use
Steroid hormone
Periodontal diseases etiology and treatment
The Effect of Vitamin D on Cartilage Cells in Vitro
The Effect of Sex Hormones on Endochondral Bone Formation
Accomplishments (21)
Fellow, American Institute for Medical and Biological Engineering
2009
First Prichard Competition, Southwestern Society for Periodontology Annual Meeting in Dallas
2004
Excellence in Teaching Hebrew University
2000
Albert-Hoffa-Prize, Die Nordeutsche Orthopdenreingung e.V\ (North German Orthopaedic Society) Research Prize
2001
American Academy of Periodontology, R. Earl Robinson Regeneration Award
2001
IADR Award for Basic Research in Biological Mineralization
2000
American Academy of Periodontology, R. Earl Robinson Regeneration Award
1999
American Academy of Periodontology, R. Earl Robinson Regeneration Award
1997
Mentor, Two Students Winner American Hatton Award
1994
Mentor, Pritchard Award Winner
1994
Mentor, Israel Hatton Award Winner
1993
Mentor, Second Place Orban Award
1993
Mentor, Second Place Hatton IADR Winner (worldwide)
1991
Mentor, Israel Hatton Award Winner
1991
Awarded Young Investigator Award
1989
Awarded Young Investigator Award, Third International Conference on the Chemistry and Biology of Mineralized Tissues, Chatham, Massachusetts
1988
Awarded Prize of Excellence for studies toward obtaining D.M.D. Thesis from the Israel Dental Association
1982
Best Student Award in Endodontics
1980
President elect, Israel Society of Periodontics
Present
President, Israel Association for Dental Research
1991
Secretary, Israel Association for Dental Research
1988
Education (3)
The Hebrew University, Hadassah Faculty of Dental Medicine: Ph.D., Experimental Pathology 1988
The Hebrew University, Hadassah Faculty of Dental Medicine: Graduate training, Periodontics 1986
The Hebrew University, Hadassah Faculty of Dental Medicine: D.M.D., Dentistry 1981
Affiliations (10)
- Professor Emeritus : Hebrew University
- Professor of Periodontics : UTHCSA
- Organization for the Study of Sex Differences
- International Association of Dental Research
- The Israel Dental Association
- The Israel Society of Periodontics
- The Israel Calcified Tissues Society
- The European Calcified Tissues Society
- American Society of Bone and Mineral Research
- Orthopaedic Research Society
Selected Articles (7)
Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli
PLoS ONE2017-01-02
Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response. Studies have used polymers to mimic the stiffness of extracellular matrix as well as of individual tissues and shown mesenchymal stem cells (MSCs) could be directed along specific lineages. In this study, we examined the role of stiffness in MSC differentiation to two closely related cell phenotypes: osteoblast and chondrocyte.
Characterization of osteoarthritic human knees indicates potential sex differences
Biology of Sex Differences2016-12-05
The prevalence of osteoarthritis is higher in women than in men in every age group, and overall prevalence increases with advancing age. Sex-specific differences in the properties of osteoarthritic joint tissues may permit the development of sex-specific therapies. Sex hormones regulate cartilage and bone development and homeostasis in a sex-dependent manner. Recent in vitro studies show that the vitamin D3 metabolite 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] also has sex-specific effects on musculoskeletal cells, suggesting that vitamin D3 metabolites may play a role in osteoarthritis-related sex-specific differences. The purpose of this study was to determine if sex-specific differences exist in synovial fluid and knee tissues isolated from male and female patients with severe knee osteoarthritis.
Effects of low‐frequency ultrasound treatment of titanium surface roughness on osteoblast phenotype and maturation
Clinical Oral Implants Research2016-09-05
Low-frequency ultrasound is widely used in the treatment of chronically infected wounds. To investigate its feasibility as a method for in situ restoration of metal implant surfaces in cases of peri-implantitis, we evaluated how low-frequency ultrasound affected surface properties of and response of human osteoblast-like MG63 cells to titanium (Ti). Material and methods: Three Ti surfaces [hydrophobic/smooth (pretreatment, PT); hydrophobic/rough (sandblasted/acid-etched, SLA); and hydrophilic/rough (SLA processed and stored hydrophilicity, mSLA)] were subjected to 25 kHz ultrasound for 10 min/cm(2) . Substrate roughness, chemical composition, and wettability were analyzed before and after ultrasound application. Osteoblastic maturation of cells on sonicated disks was compared to cells on untreated disks.
24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats
PLoS ONE2016-08-16
Osteoarthritis (OA) in humans is associated with low circulating 25-hydroxyvitamin D3 [25(OH)D3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] accumulates in articular cartilage following injection of [3H]-25(OH)D3. Previously, we showed that 24R,25(OH)2D3 blocks chondrocyte apoptosis via phospholipase D and p53, suggesting a role for 24R,25(OH)2D3 in maintaining cartilage health. We examined the ability of 24R,25(OH)2D3 to prevent degenerative changes in articular cartilage in an OA-like environment and the potential mechanisms involved.
Stiffness modulates chondrogenic osteogenic differentiation of human mesenchymal stem cells
Society for Biomaterials2011-04-13
Current regenerative medicine strategies aim to incorporate stem cells and biomaterials to restore structure and function to injured or diseased tissues. Stem cell differentiation can be affected by chemical, mechanical, and topographical cues provided by the biomaterial. It has been shown that physical cues such as microroughness and stiffness can influence stem cell fate. However, it has been difficult to determine the effect of material stiffness on stem cell differentiation since decoupling substrate stiffness and chemistry presents a challenge.
VEGF-A has an autocrine role in cell response to titanium substrate features
Society for Biomaterials2011-04-13
The initial interaction between cells and a biomaterial surface plays a significant role in determining the overall success of an implant. In orthopaedics and dentistry, success is typically determined by osseointegration of the implant with the surrounding bone tissue. It has been demonstrated that microrough Ti substrates support greater bone to implant contact and have higher removal torque values in vivo than do smooth surfaces. Critical to this process is the establishment of a patent vasculature at the bone-implant interface.
Differential regulation of suture closure in metopic and lambdoid craniosynostosis
International Association for Dental Research2011-03-16
Non-syndromic craniosynostosis is poorly understood and the molecular mechanisms are not known. We hypothesized that cells in fused suture express higher levels of osteogenic genes and produce paracrine factors that stimulate mesenchymal stem cells (MSCs) to differentiate into osteoblasts. To test this, we compared osteogenesis-related signaling pathways in cells isolated from normal bone (NB) and patent (PAT) and fused (FUS) sutures from human craniosynostosis patients.
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