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"The Manner in Which Equilibrium Surfactant Adsorption Determines Surface Tension Evolution"

James K. Ferri is Professor and Associate Department Chair of Chemical and Life Science Engineering (CLSE) at Virginia Commonwealth University (VCU) in Richmond, Virginia.  James came to VCU CLSE, after sixteen years at Lafayette College in Easton, Pennsylvania, where he was the James T. Marcus ’50 Professor of Chemical and Biomolecular Engineering.  At Lafayette, he served as the Department Head of Chemical and Biomolecular Engineering, the Robert Adenbaum ’49 Director of the IDEAL Center for Innovation, and the Dean of Curriculum and Resources.  His teaching and research at Lafayette were recognized with the Jones Faculty lecture award and the Marquis Distinguished Teaching award.  He has taught across the chemical engineering curriculum in more than (20) different courses and in a wide range of inter- and transdisciplinary courses focusing on the intersections of economic development, cultural heritage conservation, environmental science, and engineering.

His research focuses on the stability of disperse systems, interfacial phenomena, additive manufacturing, and continuous process intensification.  His research has been funded by the National Science Foundation, the National Aeronautics and Space Administration, and the U.S. Department of Education, as well as through industrial partnerships.  He has received awards from the Deutscher Akademischer Austauschdienst (DAAD), the Max Planck Society, the Alexander von Humboldt Foundation, and the Camille and Henry Dreyfus Foundation.  He is an appointed member of a number of editorial and scientific advisory boards of academic and industrial enterprises.  

James has been a guest and visiting scientist at the Max Planck Institute for Colloids and Interfaces, Potsdam, Germany; the Consorzio per lo Sviluppo dei Sistemi a Grande Interfase and the Department of Chemistry at the University of Florence, Florence, Italy; the Suzhou Institute for Biomedical Technology, Chinese Academy of Science, Suzhou, China; and the Future Industries Institute, University of South Australia, Adelaide, SA, Australia.  He received his BS and PhD both in Chemical Engineering from Johns Hopkins in 1995 and 2000.

Advanced Manufacturing

Stability in disperse systems

Interfacial Phenomena

Process intensification

PubMed Profile

Google Scholar Profile

Digitizing the supply network could jump-start America’s ability to produce crucial medicines

'The Alexa of chemistry': NSF puts VCU and partners on fast track to build open network

darpa-awards-vcu-4875-million-for-development-of-modular-drug-manufacturing-platform

Virginia Commonwealth University College of Engineering professor James Ferri, Ph.D. applies continuous manufacturing technology to address critical drug shortages

Professor and Associate Chair, Department of Chemical and Life Science Engineering

The Defense Advanced Research Projects Agency (DARPA) is funding a $13M grant for  a Rutgers University and Virginia Commonwealth University (VCU) partnership through the EQUIP-A-Pharma program, with $4.175 million to James Ferri, Ph.D., professor in the Department of Chemical and Life Science Engineering at VCU, to develop a modular manufacturing platform for sterile liquid drug products.

The 24-month grant supports Ferri’s project, “Modular Manufacturing of Sterile Liquid Drug Products,” which develops a continuous manufacturing platform capable of producing highly potent drug substances such as albuterol sulfate and bupivacaine hydrochloride. These drug substances are for use in sterile liquid products, where compliance with purity of the active pharmaceutical ingredient (API) and impurity profiles are characterized and controlled in real time throughout the manufacturing process.

“This work enables agile continuous manufacturing of drug substance and end-to-end drug product manufacturing of several highly potent drug substances with real time quality control,” Ferri said. “The combination of dynamic modular operation and real-time quality control will increase the supply of critical medicines in the United States.”

Drug shortages continue to receive national attention, with albuterol sulfate and bupivacaine hydrochloride both appearing on the U.S. Food and Drug Administration drug shortage list within the past year. The project develops technologies that enable distributed manufacturing approaches to essential medicines currently in shortage in the United States.

The platform incorporates several innovative features including continuous flow synthesis for improved process performance, online spectroscopy for real-time quality control, and modular unit operations that can be rapidly configured for different drug products. Key technologies include heterogeneous catalytic flow reactors, in-line purification systems and advanced process analytical technologies.

The continuous manufacturing approach offers significant advantages over traditional batch manufacturing, including improved process control, reduced waste and the ability to produce medicines closer to the point of care. The modular design enables rapid deployment and flexible manufacturing of multiple drug products using the same platform.

Ferri is collaborating with researchers from Rutgers University on the project, which began in August 2024. The platform is designed to fit within a standard shipping container, enabling distributed manufacturing capabilities.

The research directly addresses national security concerns about pharmaceutical supply chain vulnerabilities while advancing the field of continuous pharmaceutical manufacturing. Students involved in the project gain experience in cutting-edge manufacturing technologies that are increasingly important in addressing global health challenges.


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