The VCU College of Engineering, an innovation front-runner in academics and research, brings real-world education to Central Virginia. Our collaborative and multidisciplinary partnerships prepare undergraduate, master’s and doctoral students for leadership. Part of a premier research university, the VCU College of Engineering enhances regional and global prosperity through cutting-edge developments in tissue engineering, drug delivery, bioinformatics, cybersecurity, mechanical systems and particle science. We make it real by turning great ideas into breakthrough technologies. Our facilities are hubs of discovery, powered by an expanding student body and faculty committed to excellence.

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Fellowship DEGP, UNAM, Mexico

Fellowship PAEP, UNAM, Mexico

Fellowship DGEP, Georgia Institute of Technology

National Research Prize in Dentistry by GlaxoSmithKline

Young Investigator Award, International Conference on the Chemistry and Biology of Mineralized Tissues

International Association for Dental Research

Society for Biomaterials

Orthopeadic Research Society

The American Society for Bone and Mineral Research

Biomedical Engineering Society

Enhancing the osteoblastic differentiation through nanoscale surface modifications.

Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli.

Osteogenic response of human MSCs and osteoblasts to hydrophilic and hydrophobic nanostructured titanium implant surfaces

Hydrogels derived from cartilage matrices promote induction of human mesenchymal stem cell chondrogenic differentiation

Differential spatial regulation of BMP molecules is associated with single-suture craniosynostosis

Dental implant surface chemistry and energy alter macrophage activation in vitro

Titanium surface characteristics, including topography and wettability, alter macrophage activation

Role of integrin subunits in mesenchymal stem cell differentiation and osteoblast maturation on graphitic carbon-coated microstructured surfaces

Osteoblast maturation on microtextured titanium involves paracrine regulation of bone morphogenetic protein signaling

Coordinated regulation of mesenchymal stem cell differentiation on microstructured titanium surfaces by endogenous bone morphogenetic proteins

Implant materials generate different peri-implant inflammatory factors: poly-ether-ether-ketone promotes fibrosis and microtextured titanium promotes osteogenic factors

Role of integrin α7β1 signaling in myoblast differentiation on aligned polydioxanone scaffolds

Craniosynostosis and Resynostosis: Models, Imaging, and Dental Implications

Comparable responses of osteoblast lineage cells to microstructured hydrophilic titanium-zirconium and microstructured hydrophilic titanium

Characterization of osteoarthritic human knees indicates potential sex differences

Influence of the Periodontal Status on the Initial-Biofilm Formation on Titanium Surfaces

A review of 1α,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling

Role of integrin α2 β1 in mediating osteoblastic differentiation on three-dimensional titanium scaffolds with submicron-scale texture

Role of α2β1 integrins in mediating cell shape on microtextured titanium surfaces

Regulation of Osteoblast Differentiation by Acid-Etched and/or Grit-Blasted Titanium Substrate Topography Is Enhanced by 1,25(OH)2D3 in a Sex-Dependent Manner

Osteoblast lineage cells can discriminate microscale topographic features on titanium-aluminum-vanadium surfaces

Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model

Impaired bone formation in Pdia3 deficient mice

Signaling components of the 1α,25(OH)2D3-dependent Pdia3 receptor complex are required for Wnt5a calcium-dependent signaling

Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants

Superposition of nanostructures on microrough titanium-aluminum-vanadium alloy surfaces results in an altered integrin expression profile in osteoblasts

Characterization of distinct classes of differential gene expression in osteoblast cultures from non-syndromic craniosynostosis bone

Role of the N-terminal peptide of amelogenin on osteoblastic differentiation of human mesenchymal stem cells

Mechanical stiffness as an improved single-cell indicator of osteoblastic human mesenchymal stem cell differentiation

Electrical polarization of titanium surfaces for the enhancement of osteoblast differentiation

Rough titanium alloys regulate osteoblast production of angiogenic factors

Chaperone properties of pdia3 participate in rapid membrane actions of 1α,25-dihydroxyvitamin d3

The roles of titanium surface micro/nanotopography and wettability on the differential response of human osteoblast lineage cells

Biphasic fusion of the murine posterior frontal suture

Microstructured titanium regulates interleukin production by osteoblasts, an effect modulated by exogenous BMP-2

Rapid re-synostosis following suturectomy in pediatric mice is age and location dependent

Differential responses of osteoblast lineage cells to nanotopographically-modified, microroughened titanium-aluminum-vanadium alloy surfaces

Effects of resveratrol on enrichment of adipose-derived stem cells and their differentiation to osteoblasts in two-and three-dimensional cultures

The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors

Interrelationship of cranial suture fusion, basicranial development, and resynostosis following suturectomy in twist1(+/-) mice, a murine model of Saethre-Chotzen syndrome

BMP2 induces osteoblast apoptosis in a maturation state and noggin-dependent manner

Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

Algorithm to assess cranial suture fusion with varying and discontinuous mineral density

Use of polyelectrolyte thin films to modulate osteoblast response to microstructured titanium surfaces

Osteogenic differentiation of stem cells alters vitamin D receptor expression

Effect of cleaning and sterilization on titanium implant surface properties and cellular response

Membrane estrogen signaling enhances tumorigenesis and metastatic potential of breast cancer cells via estrogen receptor-α36 (ERα36)

Influence of topography and hydrophilicity on initial oral biofilm formation on microstructured titanium surfaces in vitro

Osteoblasts exhibit a more differentiated phenotype and increased bone morphogenetic protein production on titanium alloy substrates than on poly-ether-ether-ketone

Effects of structural properties of electrospun TiO2 nanofiber meshes on their osteogenic potential

Electrical implications of corrosion for osseointegration of titanium implants

Mediation of osteogenic differentiation of human mesenchymal stem cells on titanium surfaces by a Wnt-integrin feedback loop

Role of non-canonical Wnt signaling in osteoblast maturation on microstructured titanium surfaces

Enhancement of surface wettability via the modification of microtextured titanium implant surfaces with polyelectrolytes

The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation

Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1,25-dihydroxyvitamin D3 in osteoblasts

Sex dependent regulation of osteoblast response to implant surface properties by systemic hormones

Use of molecular beacons to image effects of titanium surface microstructure on beta1 integrin expression in live osteoblast-like cells.

Regulation of angiogenesis during osseointegration by titanium surface microstructure and energy

The role of phospholipase D in osteoblast response to titanium surface microstructure

Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage

The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces

Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces

Integrin alpha2beta1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates

Beta-1 integrins mediate substrate dependent effects of 1alpha,25(OH)2D3 on osteoblasts

Integrin beta1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3

In vitro cytotoxicity of amorphous carbon films

mplant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation

Olivares-Navarrete’s research at VCU focuses on Tissue Engineering and Regenerative Medicine approaches for Craniofacial and Orthopaedic needs. His lab uses different approaches such as biomaterial surface modifications, 3D bioprinting, decellularized tissue hydrogels, etc., aimed for immunomodulation, speed up healing process, and tissue regeneration. His lab also is constantly developing animal models that resemble disease conditions such smoking, e-cigarette use, diabetes, aging, obesity, etc., to implement tissue engineering and regenerative medicine approaches created in his lab.  He is a member of the International Association for Dental Research, Society for Biomaterials, Biomedical Engineering Society, Orthopaedic Research Society, and The American Society for Bone and Mineral Research.

Tissue Engineering

Stem Cell Biology and Engineering

Biomaterials for Craniofacial and Musculoskeletal Tissues

Immunomodulation and Immunoengineering

Wnt Signaling in Morphogenesis  Healing  and Regeneration

Craniofacial Development and Abnormalities

Olivares-Navarrete Lab

Google Scholar profile

Jeremy Meeks' Pregnant Girlfriend Chloe Green Caught Vaping

Are E-Cigarettes Safe While Pregnant?

Some E-Cigarette Flavors May Be More Harmful Than Others

Would-be moms, beware: Smoking e-cigarettes during pregnancy could cause birth defects

Smoking e-cigarettes while pregnant could increase risk of birth defects, study suggests

Vaping while pregnant could cause craniofacial birth defects, study shows

VCU study: Vaping while pregnant could lead to birth defects

Interdisciplinary research team studies whether using e-cigarettes while pregnant causes craniofacial birth defects

Developing technologies to improve the treatment of craniosynostosis in children

Associate Professor, Department of Biomedical Engineering | D.D.S, National Autonomous University of Mexico | Ph.D., National Autonomous University of Mexico

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