Featured Post from University of Rochester

'Brain-on-a-chip': Engineering tomorrow’s breakthroughs today

Biomedical engineering expert demonstrates how healthy brains can break down.

Oct 10, 2025

1 min

A “brain-on-a-chip” technology might sound like science fiction, but it’s real-world hope.

James McGrath, a biomedical engineer at the University of Rochester, leads a team that develops micro-scale tissue chips to study diseases in lieu of conducting animal experiments. The team’s “brain-on-a-chip” model replicates the blood-brain barrier — the critical membrane separating the brain from the bloodstream — to mimic how the barrier functions under healthy conditions and the duress of infections, toxins, and immune responses that can weaken it.

Recent findings from McGrath’s team show how systemic inflammation, such as that caused by sepsis, can compromise the barrier and harm brain cells. The researchers also demonstrated how pericytes — supportive vascular cells — can help repair barrier damage, an insight that could guide new therapies for Alzheimer’s and Parkinson’s.

The research culminated in a pair of recent studies published in Advanced Science and Materials Today Bio.

“We hope that by building these tissue models in chip format, we can arrange many brain models in a high-density array to screen candidates for neuroprotective drugs and develop brain models with diverse genetic backgrounds,” McGrath says.

McGrath aims to transform how scientists test drugs and predict neurological side effects before they occur — helping rewrite how we study, and one day safeguard, the brain.

Contact McGrath by clicking on his profile

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James McGrath

William R. Kenan, Jr. Professor of Biomedical Engineering at the Hajim School of Engineering & Applied Sciences

James McGrath and his team focus on the basic science of ultrathin membranes, including studies of transport and mechanics.

Tissue on ChipCell MotilityNanomembranesQuantitative Light Microscopy

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Mar 26, 2026

1 min

Target Can’t Seem to Escape the Crosshairs

The on-again-off-again nationwide boycott of Target has the retailer’s new chief executive, Michael Fiddelke, officer facing relentless pressure from activists on both sides of the issue. David Primo, a professor of political science and business administration at the University of Rochester, says Fiddelke can’t seem to move Target from the crosshairs despite slashing prices on thousands of products and investing in stores, workers, and technology. “Target remains a battleground for activists on the left and the right, and its new CEO hasn’t yet figured out how to extricate the company from this role,” Primo recently told USA Today. “Fiddelke already faces a huge challenge in turning around a company with significant operational issues. This certainly doesn’t help matters.” Target has reported 13 straight quarters of sluggish sales. Company officials have admitted that shopper anger has contributed. Activists in Minneapolis, where Target is based, organized a nationwide boycott last year over the company’s rollback of diversity, equity, and inclusion policies. From church pulpits to community gatherings, the policy about-face was widely viewed as a betrayal of Black Americans who had propped up the retail giant’s bottom line. Primo studies corporate political strategies, among other areas, and regularly shares his insights with business journalists and political reporters. His essays have appeared in The New York Times and The Wall Street Journal, and he’s been interviewed by many radio and television outlets, including Bloomberg and National Public Radio. Contact him by clicking on his profile.

Feb 25, 2026

1 min

The truth behind federal disclosure of alien life

With the recent presidential comments on potential alien life, UFO enthusiasts have new hope that finally we’re going to get federal “disclosure” of UFOs, aliens and the great government conspiracy surrounding both. But, as a scientist who studies the search for life in the Universe, the question I have is much simpler: What would disclosure really need to disclose? What is required for actual, factual proof that aliens exist and they’ve been visiting Earth? We’ve already had three years of Congressional hearings on UFOs that have produced zero proof of anything. What we need now is simple: hard physical evidence. That is what disclosure needs to deliver. Not stories about alien spaceships being held by the government, but the actual spaceships themselves. Not stories about alien bodies but the actual icky, gooey bodies with their icky gooey tentacles. If disclosure provides physical evidence that independent laboratories and independent scientists all over the world can verify, then it will live up to its hype. That would make “Disclosure Day” truly history-making.

Feb 13, 2026

1 min

Parents — Stop Trying to Be Your Teen's BFF

As teenagers push for independence, many parents respond by trying to become their friends and confidants. University of Rochester psychologist Judi Smetana says blurring the line between warmth and authority can backfire. “It’s great if kids want to disclose to you,” Smetana explains. “But it would be weird for parents to talk about their private lives with their kids. When parents start revealing things about themselves, it’s slippery. Your child should not be your confidant.” Smetana, an expert in adolescent development and parent-teen relationships, emphasizes that closeness and trust are essential — but they are not the same as “friendship.” Teenagers need structure, limits, and clear boundaries as they test autonomy. When parents overshare they risk shifting roles in ways that reduce parental influence. That doesn’t mean parent-child relationships remain rigid forever. The dynamics naturally evolve as children mature into early adulthood. “Let the child take the lead,” Smetana says. “There may show a willingness to become more like friends when parents don’t have the same authority. But there will still be some boundaries.” Her research underscores that healthy parent-teen relationships balance openness with guidance. Trust grows not from collapsing boundaries, but from maintaining them with consistency and care. For reporters covering parenting and adolescent behavior, Smetana is available to discuss: • Healthy boundaries in parent-teen relationships • Oversharing and role confusion in families • Adolescent autonomy and authority • How parent-child dynamics shift in early adulthood Click her profile to connect with her.