Featured Post from Aston University

Melatonin’s role in protecting the heart – the evidence so far

Apr 13, 2022

3 min



Many people know of melatonin as the sleep hormone – and, indeed, that’s what most of the research on melatonin has focused on. However, melatonin is also an antioxidant, protecting cells from harmful “free radicals” that can damage DNA – and this includes protecting cells in the heart and blood vessels.


Given that heart disease is the leading cause of death in the world, killing around 17.9 million people each year, this action is of particular interest to researchers.


Research shows that people with cardiovascular disease have lower levels of melatonin in their blood compared with healthy people. And there is a strong inverse relationship between melatonin levels and cardiovascular disease. In other words, the lower a person’s melatonin level, the higher their risk of cardiovascular disease.


Melatonin supplements (2.5mg taken one hour before sleep) have been shown to reduce blood pressure. And, of course, high blood pressure (hypertension) is a known risk factor for cardiovascular disease. Also, so-called cardiovascular events, including heart attacks and sudden cardiac death (unexpected death caused by a change in heart rhythm), occur at a higher rate in the early morning when melatonin is at its lowest. These studies strongly suggest that melatonin protects the heart and blood vessels.


Importantly, patients who have had a heart attack have reduced nighttime melatonin levels. This observation has led to the theory that melatonin may be able to improve recovery from a heart attack and form part of the standard treatment given immediately after a heart attack occurs.


Laboratory studies of heart attack (using rats’ hearts kept alive outside of their bodies) have shown that melatonin does indeed protect the heart from damage after a heart attack. Similar studies have shown that when rats’ hearts are deprived of oxygen, as occurs in a heart attack, providing the heart with melatonin had a protective effect.


Evidence less certain in people

In humans, the evidence is less clear. A large trial where melatonin was injected into patients’ hearts after a heart attack showed no beneficial effects. A later analysis of the same data suggested that melatonin reduced the size of damage caused to the heart by being starved of oxygen during a heart attack. And a similar clinical trial suggested no beneficial effects of giving melatonin to people who had suffered a heart attack. So the evidence is contradictory and no clear picture of melatonin’s role in helping to prevent damage to the heart during a heart attack has emerged so far.


It has been suggested that giving melatonin orally after a heart attack, rather than directly to the heart, could explain the contradictory findings in clinical trials.


Trials looking at the effect of melatonin on heart attack are still in the relatively early stages, and it is clear further studies are needed to look at how and when melatonin could be administered after a heart attack.


However, it is clear that melatonin levels decline as we get older, and this may lead to an increased risk of heart disease.


As melatonin pills are only available on prescription in the UK, EU and Australia, melatonin levels can’t be topped up with a supplement – as can be done with other hormones, such as vitamin D. Ultimately, eating a diet that contains foods rich in melatonin, such as milk, eggs, grapes, walnuts and grains, may help protect you from cardiovascular disease. Melatonin is also found in wine, and some suggest that this may explain red wine’s heart-protective effects.



You might also like...

Check out some other posts from Aston University

3 min

Aston University-led report exposes persistent barriers for Black professionals in the UK television industry

L to R: Professor Helen Wood, Annika Allen and Nadia Afiari (Image: Simon Roberts Photography) Aston University’s Professor Helen Wood led the research for Black Leaders in TV, a company championing Black TV professionals Black in Focus is the first report of its kind and highlights the prevalence, with 92% of respondents reporting prejudicial or discriminatory experiences Recommendations for improvements include mid-career support, changing how Black stories are commissioned and tackling racism and bullying. Black television professionals in the UK’s television industry continue to face persistent barriers to career progression, with progress towards equity and inclusion very slow, according to new research led by Aston University academics. The report, Black in Focus, was produced in partnership with Black Leaders in TV, a company set up to champion Black professionals in the UK television and content creation industry, committed to bridging the representation gap and creating a more inclusive and innovative industry. The research group was led by Professor Helen Wood, a professor of media and cultural studies at Aston University. It also included Aston University’s Dr Killian Mullen and Dr Priya Sharma, alongside Dr Jack Newsinger, associate professor in cultural industries and media at the University of Nottingham. The researchers surveyed 164 Black mid-career television professionals to learn about their experiences. While entry-level diversity efforts have sparked positive change, the researchers say that respondents generally see this as performative, with little genuine progress at mid and senior levels. Of those surveyed, 92% reported experienced microaggressions at work, defined as subtle, often unintentional, comments or actions that express prejudice or discrimination towards them, such as being mistaken for a taxi driver or colleagues continually mispronouncing a name. 80% stated that their careers in television have negatively impacted wellbeing. Almost three-quarters (74%) of respondents said they had been ignored or excluded at work One of the biggest problems highlighted is a persistent ‘club’ culture with career progression often based on informal networks and hires. 91% of the survey respondents reported having no friends or family in the industry, blocking wider access and opportunity. Many Black television professionals still report being labelled as ‘diversity hires’, which negatively impacts their confidence and feeling of belonging in the industry. Black-Caribbean respondents and those from working-class backgrounds report heightened feelings of exclusion. Another major problem found by the report is in programme commissioning, with Black stories often viewed as commercially risky, leading to missed opportunities for richer, more authentic storytelling. The recommendations for improvement are grouped into four categories - breaking the mid-career bottleneck, commission, diversity initiatives, and racism, bullying and inclusion failures. To help with career bottlenecks, the authors’ suggestions include developing a national fellowship scheme to offer structured leadership training, shadowing, and commissioning exposure for Black professionals, setting up a centralised database for Black talent and supporting Black creatives though industry showcases. The television industry could tackle the problems with commissioning for example by incentivising Black-led narratives and requiring commissioning teams to complete anti-bias training. Diversity initiatives should move away from entry-level programmes towards structural change. This includes moving away from informal, network-based recruitment to structured, clear processes, and formalising promotion pathways. The television industry can tackle racism and bullying through zero-tolerance harassment policies, independent reporting mechanisms and sanctions, inclusive leadership training and developing mental health resources specifically tailored to Black professionals. Professor Wood said: “We can hear the voices of frustration in this survey and the data is clear about the problems. It’s time for the industry to use this evidence to take the next steps to deliver real, systemic change.” Black Leaders in TV founders Nadia Afiari and Annika Allen Gray said: “The findings make clear that, for UK television to truly reflect its diverse audiences and unlock creative innovation, the industry must move beyond surface-level diversity efforts. There needs to be support in place for Black professionals, greater transparency in recruitment and progression, and a fundamental shift towards inclusive, equitable workplace cultures.” Visit https://www.aston.ac.uk/sites/default/files/2025-07/Black_in_Focus_report.pdf to read Black in Focus in full.

3 min

Aston University research: Parents should encourage structure and independence around food to support children’s healthy eating

Dr Katie Edwards studied the feeding practices of parents of children with ‘avid’ eating traits, which can lead to obesity Focusing on health or deciding when it is time for a meal or snack helps parents to use supportive feeding practices. Supportive feeding practices could include involving children in decisions about food, or sitting together for mealtimes New research from Aston University has shone a light on the best ways for parents to encourage healthy eating in their children. The team of academics from Aston University’s School of Psychology, led by Professor Jacqueline Blissett, with Dr Katie Edwards as the lead researcher, looked at the meal- and snack-time practices of parents of children with ‘avid’ eating behaviours. ‘Avid’ eaters, who make up around 20% of children, particularly love food, are often hungry and will eat in response to food cues in the environment and their emotions, not just when they are hungry. They are the most susceptible to obesity and therefore encouraging a healthy, balanced diet is vital. Feeding children with avid eating behaviours can be challenging and the researchers wanted to understand how factors in everyday life, such as parent mood or eating situations, influence the feeding practices that parents use. Understanding this can help to create better support for families around meal and snack times and reduce the risk of children developing obesity. Dr Edwards says that the research shows that when parents prioritise children’s health or decide when it is time for a meal or snack, parents are more likely to use supportive feeding practices which create structure around meal or snack times or encourage children to be independent with their food choices. For example, parents could sit and eat with their children, choose what food is available for their children, or involve children in decisions about what food to eat. She adds that there are three main things that parents can do to help encourage healthy eating behaviour. The first is to focus on health, by providing nutritious and balanced meals. The second is to ensure a calm and positive atmosphere during eating occasions. The final recommendation is that parents should take the lead on setting meal- and snack-times, with a good structure being three meals and two snacks a day. These recommendations are linked to parents’ use of supportive feeding practices which are known to encourage children’s healthy eating. To carry out the research, the team recruited parents of children aged 3-5 with avid eating behaviour and asked them to download an app to their smartphones. The app sent four semi-random reminders per day for a 10-day period, asking them to complete a survey with information about mood and stress levels. Every time a child had a meal or a snack, or asked for food, parents completed another survey to give information about feeding practices (including those which give children structure, or independence, around food), mealtime goals (such as prioritising healthy eating), and information about the mealtime setting (such as the atmosphere). Previous research from this team at Aston University identified four main eating traits in children. As well as ‘avid’, the other traits, not studied here, are ‘typical’ eaters, who have no extreme behaviours, ‘avoidant’ eaters, who are extremely fussy, and ‘emotional’ eaters, who eat in response to emotions but do not necessarily enjoy food in the way that avid eaters do. Dr Edwards was also involved in the team’s research at Aston University that showed that parents’ eating behaviour influences that of their children. Dr Edwards said: “Given the challenges that parents may face and the risk of childhood obesity, we will use these findings to develop feeding support for families. Encouraging parents to use feeding practices which provide structure around meal and snack times, or promote children’s independence with food, could be helpful for supporting children’s healthy eating. Read the full paper in the International Journal of Behavioral Nutrition and Physical Activity at https://doi.org/10.1186/s12966-025-01768-x.

3 min

Aston University optometrist develops app with the best easy blinking exercises to improve dry eye symptoms

Dry eye disease is a common condition affecting one-third of the adult population and one-in-five children Professor James Wolffsohn researched the most effective blinking exercises to reduce discomfort, involving a close-squeeze-blink cycle He developed the MyDryEye app in collaboration with Alec Kingsnorth and Mark Nattriss to help sufferers An Aston University optometrist, Professor James Wolffsohn, has determined an optimum blinking exercise routine for people suffering with dry eye disease, and has developed a new app, MyDryEye, to help them complete the routine to ease their symptoms. Dry eye disease is a common condition which affects one-third of the adult population and one-in-five children, in which the eyes either do not make enough tears, or produce only poor-quality tears. It causes the eyes to become uncomfortable, with gritty- or itchy-feeling eyes, watery eyes and short-term blurred vision. It is more common in older adults and can be exacerbated by factors including dry air caused by air conditioning, dust, windy conditions, screen use and incomplete blinks, where the eye does not fully close. Professor Wolffsohn is head of Aston University’s School of Optometry and a specialist in dry eye disease. While it has long been known that blinking exercises can ease the symptoms of dry eye disease, the optimum technique, number of repetitions and necessary repeats per day are unclear. Professor Wolffsohn set out to determine the best exercises. His team found that the best technique for a dry eye blinking exercise is a close-squeeze-blink cycle, repeated 15 times, three times per day. Participants found that while they were doing their exercises symptom severity and frequency decreased, and the number of incomplete blinks decreased. Within two weeks of stopping the exercises, their symptoms returned to normal levels, showing the efficacy of the exercises. To carry out the work, Professor Wolffsohn’s team ran two studies. For the first, they recruited 98 participants, who were assessed for dry eye symptoms before and after the two weeks of blinking exercises. Participants were randomly allocated different blinking exercises to determine the most effective. A second study with 28 people measured the efficacy of the blinking exercise. Once the optimum blinking routine had been developed, Professor Wolffsohn worked withAlec Kingsnorth, an engineer and former Aston undergraduate and PhD student, and Mark Nattriss, business manager of his spin-out company, Wolffsohn Research Ltd, to develop the app, MyDryEye, which is freely available on Android and iOS operating systems. The app allows users to monitor their dry eye symptoms, assess their risk factors, add treatment reminders and monitor their compliance, complete the science-based blink exercises and find a specialist near them. Professor Wolffsohn says that the blinking exercises should be carried out as part of a treatment programme which could also include the use of lipid-based artificial tears, omega-3 supplements and warm compresses. Professor Wolffsohn said: “This research confirmed that blink exercises can be a way of overcoming the bad habit of only partially closing our eyes during a blink, that we develop when using digital devices. The research demonstrated that the most effective way to do the exercises is three times a day, 15 repeats of close, squeeze shut and reopen – just three minutes in total out of your busy lifestyle. To make it easier, we have made our MyDryEye app freely available on iOS and Android so you can choose when you want to be reminded to do the exercises and for this to map your progress and how it affects your symptoms.” Read the full paper, ‘Optimisation of Blinking Exercises for Dry Eye Disease’, in Contact Lens and Anterior Eye at https://doi.org/10.1016/j.clae.2025.102453.

View all posts
Powered by