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Sweeteners may be linked to increased cancer risk – new research

Apr 13, 2022

4 min



Sweeteners have long been suggested to be bad for our health. Studies have linked consuming too many sweeteners with conditions such as obesity, type 2 diabetes and cardiovascular disease. But links with cancer have been less certain.


An artificial sweetener, called cyclamate, that was sold in the US in the 1970s was shown to increase bladder cancer in rats. However, human physiology is very different from rats, and observational studies failed to find a link between the sweetener and cancer risk in humans. Despite this, the media continued to report a link between sweeteners and cancer.


But now, a study published in PLOS Medicine which looked at over 100,000 people, has shown that those who consume high levels of some sweeteners have a small increase in their risk of developing certain types of cancer.


To assess their intake of artificial sweeteners, the researchers asked the participants to keep a food diary. Around half of the participants were followed for more than eight years.


The study reported that aspartame and acesulfame K, in particular, were associated with increased cancer risk – especially breast and obesity-related cancers, such as colorectal, stomach and prostate cancers. This suggests that removing some types of sweeteners from your diet may reduce the risk of cancer.


Cancer risk

Many common foods contain sweeteners. These food additives mimic the effect of sugar on our taste receptors, providing intense sweetness with no or very few calories. Some sweeteners occur naturally (such as stevia or yacon syrup). Others, such as aspartame, are artificial.


Although they have few or no calories, sweeteners still have an effect on our health. For example, aspartame turns into formaldehyde (a known carcinogen) when the body digests it. This could potentially see it accumulate in cells and cause them to become cancerous.


Our cells are hard-wired to self-destruct when they become cancerous. But aspartame has been shown to “switch off” the genes that tell cancer cells to do this. Other sweeteners, including sucralose and saccharin, have also been shown to damage DNA, which can lead to cancer. But this has only been shown in cells in a dish rather than in a living organism.



Sweeteners can also have a profound effect on the bacteria that live in our gut. Changing the bacteria in the gut can impair the immune system, which could mean they no longer identify and remove cancerous cells.


But it’s still unclear from these animal and cell-based experiments precisely how sweeteners initiate or support cancerous changes to cells. Many of these experiments would also be difficult to apply to humans because the amount of sweetener was given at much higher doses than a human would ever consume.


The results from previous research studies are limited, largely because most studies on this subject have only observed the effect of consuming sweeteners without comparing against a group that hasn’t consumed any sweeteners. A recent systematic review of almost 600,000 participants even concluded there was limited evidence to suggest heavy consumption of artificial sweeteners may increase the risk of certain cancers. A review in the BMJ came to a similar conclusion.


Although the findings of this recent study certainly warrant further research, it’s important to acknowledge the study’s limitations. First, food diaries can be unreliable because people aren’t always honest about what they eat or they may forget what they have consumed. Although this study collected food diaries every six months, there’s still a risk people weren’t always accurately recording what they were eating and drinking. Though the researchers partially mitigated this risk by having participants take photos of the food they ate, people still might not have included all the foods they ate.


Based on current evidence, it’s generally agreed that using artificial sweeteners is associated with increased body weight – though researchers aren’t quite certain whether sweeteners directly cause this to happen. Although this recent study took people’s body mass index into account, it’s possible that changes in body fat may have contributed to the development of many of these types of cancers – not necessarily the sweeteners themselves.


Finally, the risk of developing cancer in those who consumed the highest levels of artificial sweeteners compared with those who consumed the lowest amounts was modest – with only at 13% higher relative risk of developing cancer in the study period. So although people who consumed the highest amounts of sweetener had an increased risk of developing cancer, this was still only slightly higher than those with the lowest intake.


While the link between sweetener use and diseases, including cancer, is still controversial, it’s important to note that not all sweeteners are equal. While sweeteners such as aspartame and saccharin may be associated with ill health, not all sweeteners are. Stevia, produced from the Stevia rebaudiana plant, has been reported to be useful in controlling diabetes and body weight, and may also lower blood pressure. The naturally occurring sugar alcohol, xylitol, may also support the immune system and digestion. Both stevia and xylitol have also been shown to protect from tooth decay, possibly because they kill bad oral bacteria.


So the important choice may be not the amount of sweetener you eat but the type you use.

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Twin earthquakes in Venezuela raise serious concerns over humanitarian, health and infrastructure impacts featured image

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Dr Komal Raj Aryal, lecturer in crisis and disaster management at Aston Business School, has expressed serious concern following the powerful twin earthquakes that struck northern Venezuela on 24 June 2026. "The back-to-back earthquakes, measuring magnitude 7.2 and 7.5 and occurring within less than a minute of each other at an approximate depth of 22 km, represent an exceptionally severe seismic event," said Dr Aryal, who has more than 26 years of international research experience in earthquakes, landslides, extreme weather events and disaster risk governance. "The combination of two major earthquakes occurring in rapid succession, their relatively shallow depths, and the repeated strong ground shaking is likely to have substantially increased damage to buildings, transport networks and other critical infrastructure. Scientifically, a magnitude 7.5 earthquake releases approximately three times more energy than a magnitude 7.2 event. Experiencing both events within seconds creates an extremely complex emergency response situation." Dr Aryal highlighted particular concern for San Felipe, an important industrial, commercial and transportation centre with a population of more than 300,000 people. Built across hilly terrain, with steep streets and dense urban development, the city could face significant challenges for emergency access, search and rescue operations, evacuation and humanitarian assistance. Around 10% of the city's population is aged 65 or older, making older adults particularly vulnerable during prolonged emergency situations. "If widespread power outages occur while temperatures remain between 32°C and 35°C, communities will face compounded risks including heat stress, disruption to healthcare services, shortages of clean water, communication failures and interruptions to essential public services. These cascading impacts often become as significant as the direct earthquake damage itself." Based on the available seismic information and preliminary footage shared on social media, Dr Aryal noted that it will likely take days or even weeks before authorities fully understand the extent of structural damage across northern Venezuela. "Initial seismic information suggests a rupture along a major fault system parallel to Venezuela's northern coastline, with areas experiencing extremely intense ground shaking. If confirmed, significant cascading impacts may extend well beyond the epicentral area, affecting multiple urban centres, transport corridors and regional supply chains." Dr Aryal also expressed concern about the resilience of Venezuela's healthcare system. "Northern Venezuela contains a large concentration of hospitals and healthcare facilities. At present, it remains unclear how many medical facilities have been affected by the earthquakes. Any disruption to hospitals, combined with existing pressures on healthcare capacity, medicine supplies and emergency logistics, could significantly affect the delivery of healthcare services for both acute injuries and patients with chronic illnesses." He added that damage to airports, major highways, bridges and other transport infrastructure could delay humanitarian assistance, emergency logistics and economic recovery. "The humanitarian consequences of this disaster will depend not only on the severity of the ground shaking, but also on the resilience of critical infrastructure, the effectiveness of emergency coordination, the availability of healthcare services and the country's broader socioeconomic capacity to recover." Dr Aryal further warned that the immediate earthquake sequence is unlikely to mark the end of the crisis. "Strong aftershocks are highly likely following earthquakes of this magnitude. These may continue for months, and some could themselves be damaging. They increase risks to already weakened buildings, complicate search and rescue operations, trigger additional landslides in mountainous areas, and prolong humanitarian needs." He concluded that while casualty figures and the full extent of the damage remain uncertain, the event has the potential to become one of the most significant seismic disasters in the region in recent years, requiring sustained national and international humanitarian support.

The world is burning useful waste, and cleaner alternatives are needed featured image

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The world is burning useful waste, and cleaner alternatives are needed

When we talk about clean air, the conversation usually turns to traffic: exhaust fumes, congestion, school runs and the air people breathe on busy streets. That focus is understandable because road transport remains one of the most visible sources of poor air quality in everyday life. But Clean Air Day should also draw attention to a less visible question: why are useful materials still being burned as waste? Clean air is about more than traffic Around the world, huge quantities of leftover straw are still treated as waste to be cleared quickly, with rice straw one of the clearest examples. More than 700 million tonnes of rice straw are produced globally every year, and around 80% is burned. That contributes directly to air pollution and greenhouse gas emissions, while also destroying material that could have value. 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That is particularly relevant when residues are burned in the open, as smoke and fine particles can travel beyond the field where burning takes place, affecting nearby communities and wider air quality. There is a practical issue as well as an environmental one. If burning is the fastest and cheapest way to clear land, it can easily become the default, which is why any cleaner alternative has to work for farmers and communities in practice. It is not enough to tell people to stop burning; they need practical alternatives that make sense economically and locally. Turning waste into cleaner alternatives Biochar and bioenergy are two examples of how waste crop material can be treated differently. Instead of being burned in the open, residues can be converted into useful products or sources of renewable energy. Biochar can also offer practical benefits for farmers when it is produced and applied appropriately. Studies have shown that addition of biochar to the soil can improve its structure, help retain nutrients and, in some cases, reduce the need for synthetic fertilisers, which will lower associated emissions and economic demands. The water-holding capacity of biochar can also support crops during dry periods, potentially reducing irrigation demand in drought-prone seasons. Work connected to rice straw has shown that cleaner alternatives to burning can produce measurable environmental benefits while supporting local economies. Community-scale rice straw bioenergy systems, for example, can avoid 2.7–3.5 tonnes of CO₂ equivalent emissions per hectare each year, while creating fuel savings and reducing post-harvest losses for rice farming communities. Research and interviews have shown that farmers and local stakeholders are willing to participate in these transitions when alternatives are designed around their needs and priorities. During community engagement activities, participants consistently highlighted cleaner air as an important benefit, not only for environmental reasons but also because of concerns about the health impacts of smoke and the financial burden of illness. For many households, avoiding respiratory problems and expensive hospital bills was seen as just as important as generating additional income from agricultural residues. That matters because cleaner air is linked to more than one policy area. Transport is important, but so are farming, energy and waste. Research can help identify what works, where the trade-offs are, and how promising ideas can move beyond the lab. It can also support industry, policymakers and local partners to develop alternatives that are practical rather than theoretical. For policymakers, the lesson is that air quality cannot be improved by focusing only on the most visible sources of pollution. Transport matters, but so do homes, industry, farming, waste and energy systems. There is no single answer. Agricultural residues vary, local conditions vary, and technologies need to be assessed carefully, but cleaner air will require better options than burning. Clean Air Day should prompt us to ask why useful materials are still being burned in the first place. If we want cleaner air, we need to reduce what we burn and get smarter about what we waste. This article was written by Dr Samuel Sogbesan and Thea Mae Baltazar from Aston University’s Energy and Bioproducts Research Institute. (Photo by Sandie Peters on Unsplash)

Major trial shows increasing bone density fails to cut fracture risk in brittle bone disease featured image

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Major trial shows increasing bone density fails to cut fracture risk in brittle bone disease

An international clinical trial involving Aston University researchers has challenged long held assumptions about how brittle bone disease is treated in adults, after finding that substantially increasing bone density did not reduce the risk of fractures. The study, published in the Journal of the American Medical Association (JAMA), examined whether a two stage treatment using the bone building drug teriparatide followed by the bone preserving drug zoledronic acid could reduce fractures in adults with osteogenesis imperfecta, often referred to as brittle bone disease, a rare genetic condition that causes bones to break easily throughout life. Researchers followed 349 adults treated at 27 specialist centres across the UK and Europe. While the treatment led to clear increases in bone density in the spine and hip, fracture rates were no lower than among patients receiving standard care, suggesting that bone quality may matter more than bone density alone in preventing fractures in people with the condition. The findings underline a key distinction between brittle bone disease and more common bone conditions such as osteoporosis, where increasing bone density is known to reduce fracture risk. In osteogenesis imperfecta, the study suggests that bones can become denser without becoming less likely to break, indicating that the underlying quality and structure of bone tissue may play a greater role in fracture risk than density alone. Dr Zaki Hassan Smith, an endocrinologist at Aston Medical School who contributed to the research, said: “This study shows that in osteogenesis imperfecta, simply increasing bone density doesn’t necessarily translate into fewer fractures. That’s important, because it tells us that the disease is more complex than what we see on a scan. The findings help shift the focus towards understanding bone quality and how bones behave in real life, which is essential if we are to develop more effective treatments that genuinely reduce harm for patients.” Osteogenesis imperfecta is a genetic condition that affects collagen, leaving bones fragile and prone to fracture throughout life. There is currently no licensed treatment specifically approved to prevent fractures in adults with the condition, and patients often experience repeated fractures, chronic pain and long term disability. The trial tested a sequential treatment strategy commonly used in osteoporosis, where a bone building drug is followed by a treatment designed to preserve gains in bone strength. Although this approach successfully increased bone density in people with osteogenesis imperfecta, it did not reduce fracture rates, suggesting that treatment strategies effective in osteoporosis may not directly translate to rare bone diseases. Researchers did observe improvements in some quality of life measures among participants receiving the treatment, including reduced pain interference and improved mobility. However, fracture prevention remained unchanged, reinforcing the need for new approaches that target the fundamental properties of bone in osteogenesis imperfecta rather than density alone. The study was led by the University of Edinburgh and funded by the Medical Research Council and the National Institute for Health and Care Research. Aston University contributed clinical and academic expertise through Aston Medical School as part of the large international collaboration, which involved specialist centres across the UK and Europe. The study was led by the University of Edinburgh, with Aston University contributing clinical and academic expertise as part of a wider international collaboration involving multiple specialist centres across the UK and Europe. The research was funded by the Medical Research Council and the National Institute for Health and Care Research. Researchers say the findings provide important guidance for future research, helping to steer efforts towards treatments that focus on bone quality, strength and resilience in everyday life. They also highlight the value of large scale clinical trials in rare diseases, where learning what does not reduce harm is an essential step towards better care. The paper, Teriparatide Plus Zoledronic Acid for Osteogenesis Imperfecta, is published in JAMA. https://doi.org/10.1001/jama.2026.6889

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