Featured Post from Aston University

Aston University researchers collaborate with biotechnology start-up to develop drugs to tackle irreversible lung disease

Jan 23, 2023

3 min



• Researchers in the School of Biosciences partner with preclinical-stage biotechnology start-up company to develop drugs for fibrotic diseases

• Professor Martin Griffin and team develop TG2 inhibitors to help treat a serious chronic lung disease called idiopathic pulmonary fibrosis.

• Isterian Biotech is part of Cambrian BioPharma who have been working with Aston University since 2019.


Aston University scientists are working with start-up company, Isterian Biotech, part of Cambrian BioPharma, to develop novel drugs to treat fibrotic diseases such as lung disease.


The focus of preclinical-stage biotechnology company Isterian Biotech is on developing novel drugs to stop or reverse the pathological accumulation of crosslinked proteins commonly observed in all major organs with age.


As we age a chronic increase of crosslinked proteins occurs in the extracellular matrix (ECM), that surround, support, and give structure to the cells and tissues in the body. These crosslinked proteins are difficult for the body to degrade and over time can make organs stiff and dysfunctional, ultimately resulting in fibrosis. Reversing the accumulation of these pathological crosslinks will greatly contribute to reducing fibrosis.


The start-up is working to develop small molecule inhibitors of transglutaminase 2 also known as TG2, which is one of the major crosslinking enzymes in the human body, that becomes more active during ageing - thus resulting in fibrotic diseases such as a type of lung disease known as idiopathic pulmonary fibrosis (IPF).


Isterian President and Chairman of the Board, Georg C Terstappen, PhD said:


"Isterian's strategy of combining rational drug design with efficient multiparametric profiling of synthesized small molecules has been both impressive and highly productive. Notably, for one of our highly potent and selective TG2 inhibitors, we have recently demonstrated efficacy in a mouse model of lung fibrosis for the first time.

"Using this state-of-the-art approach to drug discovery combined with an impressive team gives us great confidence in the future of this novel company."


IPF is a progressive, irreversible disease that is characterized by pathological crosslinking of extracellular matrix (ECM) proteins (a large network of proteins and other molecules that surround, support, and give structure to the cells and tissues in the body) leading to excessive deposition of collagen. This means that in IPF scar tissue or fibrosis builds up around the air sacs (alveoli) in the lungs and reduces the ability to transfer oxygen that is breathed into the blood, resulting in severe restriction of lung capacity and function.


IPF is the most common form of pulmonary fibrosis. The disease affects between 200,000 and 300,000 people globally. Statistics from the charity Action for Pulmonary Fibrosis suggest there are about 30,000 people living with IPF in the UK with an estimated 6,000 new cases of the condition each year. The disease usually develops in people aged 70 and older and is more common in men. But it can occur in younger individuals, particularly if there is a family history of idiopathic pulmonary fibrosis.


The company was founded by capitalizing on over 35 years of scientific research from the laboratory of Professor Martin Griffin and his team Dr Dan Rathbone and Dr Vivian Wang at Aston University.


Their work with small molecule inhibitors selective for TG2 has demonstrated reduction of fibrosis in multiple organs in a number of animal models. In 2019, Aston University partnered with Cambrian to form Isterian Biotech with a mission to develop safe and effective TG2 inhibitors to treat Idiopathic pulmonary fibrosis (IPF), a devastating fibrotic disease of the lung.


Professor Martin Griffin, Biosciences Research Group, Aston University said: “We are delighted to continue our work with Isterian researching how we can further develop TG2 inhibitors to help tackle this awful disease.”


CEO of Cambrian BioPharma, James Peyer, commented: "As Cambrian continues on its mission to build medicines that will redefine healthcare in the 21st century, we are very thankful to find brilliant scientists such as Martin and his team that are willing to break the mold. Isterian and its work to reduce fibrosis are a perfect fit alongside the other pipeline companies our team has announced in 2022."


The company's current pipeline includes an advanced preclinical-stage TG2 inhibitor for inhaled administration and several structurally unrelated back-up compounds for the treatment of IPF.


For more information about the School of Biosciences at Aston University, please visit our website.



Powered by

You might also like...

Check out some other posts from Aston University

3 min

New research partnership to develop biodegradable gloves from food waste for healthcare sector

Knowledge Transfer Partnership between Aston University and PFE Medical to develop a biodegradable clinical glove from food waste The gloves will provide a low-cost, convenient and sustainable alternative to the 1.4bn disposable gloves used in the NHS each year The innovation will reduce clinical waste and costs and help the NHS reach its net zero goals. Aston University and Midlands-based company PFE Medical are teaming up to create biodegradable gloves made from food waste for use in the NHS. They will offer a low-cost, convenient alternative to disposable gloves without compromising patient safety. More than 1.4bn disposable gloves are used by the NHS each year. They create large volumes of clinical waste which has both an environmental and economic cost. The Knowledge Transfer Partnership (KTP) project will develop a more sustainable alternative made from polymers derived from food waste such as orange peel, able to degrade naturally. The gloves will initially be for use during low-risk tasks such as ultrasound scans, rather than in more critical situations such as operating theatres. The gloves would be designed to not only reduce clinical waste and costs in the NHS, but also carbon emissions, helping the NHS reach its goal to be the world’s first net-zero health service. With most personal protective equipment (PPE) currently sourced from Chinese manufacturers, the goal is to develop a biodegradable glove that can be manufactured using a UK supply chain. The challenging project draws on Aston University’s expertise in sustainable polymer chemistry, centred at Aston Institute for Membrane Excellence (AIME). Aston University has one of the largest research groups of polymer chemists in the UK. The project will be led at the University by Professor Paul Topham, director of AIME, and Dr James Wilson, AIME associate member. The research team have chosen to focus on polymers from food waste in order to ensure that the final product can be manufactured sustainably. Most polymers are currently made from petroleum. Polymers made from food waste, ranging from fruit waste to corn or dairy products, have the potential for antioxidant and antibacterial properties if designed appropriately. The team will manipulate the polymer molecules so that they include the right monomers (the smaller units which make up the molecules) in the right location to achieve the properties they require. Critical to the success of the project will be PFE Medical’s commercial and clinical experience of taking new innovations into medical use. It will be the third KTP between Aston University and PFE, following on from successful projects to develop an automated endoscope cleaner, now in use across University Hospitals Birmingham NHS Foundation Trust (UHB). Professor Topham said: “At Aston University, we have a long history of working with industry, of translating fundamental research into solutions for real world problems. This project with PFE Medical provides us with that route, to take our science and engineering and make a difference to peoples’ lives. That’s exactly where, as researchers, we want to be.” Rob Hartley, CEO of PFE Medical, said: “Our previous KTP with Aston University was a phenomenal success, thanks to the brilliant team we had on board. I’m just as excited by this project, which is looking to solve an equally long-standing problem. If we can achieve our goal, then the implications are huge, going far beyond the NHS to all the other situations where people are wearing disposable gloves.” KTPs, funded by Innovate UK, are collaborations between a business, a university and a highly qualified research associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is a sector-leading KTP provider, ranked first for project quality, and joint first for the volume of active projects. For further details about this KTP, visit the webpage: www.aston.ac.uk/business/collaborate-with-us/knowledge-transfer-partnership/at-work/pfe-medical.

2 min

Aston University’s Professor Gina Rippon wins British Psychological Society book award for The Lost Girls of Autism

Gina Rippon, professor emeritus of cognitive neuroimaging at Aston University, has won an award for her book, The Lost Girls of Autism The book won the 2025 British Psychological Society Popular Science Award It explores the emerging science of female autism, and examines why it has been systematically ignored and misunderstood for so long. The Lost Girls of Autism, the latest book from Gina Rippon, professor emeritus of cognitive neuroimaging at Aston University Institute of Health and Neurodevelopment (IHN), has won the 2025 British Psychological Society (BPS) Popular Science Award. The annual BPS Book Awards recognise exceptional published works in the field of psychology. There are four categories – popular science, textbook, academic monograph and practitioner text. With the subtitle ‘How Science Failed Autistic Women and the New Research that’s Changing the Story’, The Lost Girls of Autism explores the emerging science of female autism, and examines why it has been systematically ignored and misunderstood for so long. Historically, clinicians believed that autism was a male condition, and simply did not look for it in girls and women. This has meant that autistic girls visiting a doctor have been misdiagnosed with anxiety, depression or personality disorders, or are missed altogether. Many women only discover they have the condition when they are much older. Professor Rippon said: “It's such a pleasure and an honour to receive this award from the BPS. It’s obviously flattering to join the great company of previous winners, but I’m also extremely grateful for the attention drawn to the issues raised in the book. “Over many decades, due to autism’s ‘male spotlight’ problem, autistic girls and women have been overlooked, deprived of the help they needed, and even denied access to the very research studies that could widen our understanding of autism. This book tells the stories of these girls and women, and I’m thrilled to accept this prize on their behalf.”

3 min

New book from Aston University academic shows that Christmas tasks mostly fall on women

New book by Dr Emily Christopher shows differences in how household tasks are divided by men and women Book highlights that women tend to buy the Christmas presents and send cards Men often see women as being more thoughtful or having better knowledge of what people would like. A new book from Aston University’s Dr Emily Christopher reveals that when it comes to sending Christmas cards and buying Christmas presents, women are still mostly doing the work as they are perceived to have better knowledge of what people would like. Dr Emily Christopher, a lecturer in sociology and policy at Aston School of Law and Social Sciences, has recently published her book Couples at Work: Negotiating Paid Employment, Housework and Childcare, which look at how household tasks are divided by men and women and the reasons behind these divisions. The data for the book has been collated over an eight-year period with couples being interviewed twice to provide a robust set of results. It looks at how different sex parent couples combined paid work, housework and childcare. The research revealed how gender norms continue to shape how certain daily household jobs are divided. Women were more likely than men to clean the house, especially bathrooms, wash clothes and put clothes away. Men still tend to do tasks like mowing the lawn and DIY but now are also more likely to do the cooking and the grocery shopping. The research shows that the key to understanding how household tasks are divided lies in the meaning they hold for partners. With the festive season upon us, the book reveals that woman are largely responsible for the Christmas present buying and sending cards with 100% of those taking part in the research saying that women mostly carried out these tasks. This also included buying for the male partner's relatives. In instances where men had a 'helping' role in these tasks, this included being involved in the discussion or consulting on choice of presents, especially for children, with only a small minority buying presents for their own family. The data revealed that where women didn't choose and buy presents for their partners family, they were still involved in reminding their partners that this needed to be done or advising on choice of gifts, showing that women were still taking on the mental load of planning for the festive season. The book reveals that when men were questioned about why they didn't get involved in present buying, they drew on gender norms. Women were often described, by the men, as being more thoughtful or having better knowledge of what people would like. Men often described how family members wouldn’t receive presents at all if it relied on them. Although much of the gift giving and organising represented love and affection for the women, which many found enjoyable, many still saw it as work and expressed that they would like their partners' to be more involved. Dr Christopher said: “This book takes an in-depth look at the way in which everyday roles around the household are divided between men and women. “The research shows that over a period of eight years fathers increased their role in childcare tasks but this did not always extend to housework. “The pandemic was an opportunity to change how couples share housework but women were still more likely to carry out tasks like cleaning, washing clothes and putting clothes away and overwhelmingly remained responsible for the mental orchestration of family work.”

View all posts
Powered by