Researchers reveal CBD can counter epileptic seizures in children

Mar 6, 2023

3 min

Gavin WoodhallDr Stuart Greenhill



• Aston University epilepsy model used to illustrate the mechanisms of seizure activity

• Results suggest how CBD can be useful in the treatment of childhood epilepsy

• New insight into potential future interventions for hard-to-treat epilepsy.


Researchers at Aston University have contributed to the discovery of a previously unknown way in which cannabidiol (CBD), a non-psychoactive component of cannabis, can reduce seizures in many treatment-resistant forms of childhood epilepsy.


A group of international collaborators, led by scientists at NYU Grossman School of Medicine, including a team from the Aston Institute of Health and Neurodevelopment at Aston University, found that CBD blocked signals carried by a molecule called lysophosphatidylinositol (LPI).


LPI is found in our brain’s neurons and is thought to amplify nerve signals as part of normal function but can be hijacked by some epilepsies to promote seizures.

The study, published in the journal Neuron, expanded on previous findings showing that CBD blocks the ability of the molecule LPI to amplify nerve signals in a brain region called the hippocampus.


The current study argues that, for the first time, the molecule also weakens signals that counter seizures, further explaining the value of CBD treatment and the generation of seizure activity in epileptic people.


As part of the research group, the Aston University team used a leading model of epilepsy, developed by Professor Gavin Woodhall, to perform recordings of electrical signals in brain cells taken from epileptic rodents, some of which had been treated with CBD. By doing this, they were able to pinpoint the molecular mechanisms by which CBD acts to prevent seizure activity in epileptic brains.


Professor Woodhall, co-director of Aston Institute for Health and Neurodevelopment, said: “These new insights into epilepsy and the mechanism by which CBD works to stop seizures is the fruit of years of collaboration between neuroscientists in the UK and USA and our industry partner, GW Pharma. We are hopeful that it will lead to even better treatments in future”.


Dr Stuart Greenhill, senior lecturer in neuroscience, Aston Institute for Health and Neurodevelopment added: "We are delighted that our epilepsy model is being used to make such meaningful breakthroughs in the mechanisms of epilepsy and is paving the way for a wider range of future treatments".



Corresponding author Richard W Tsien, chair of the Department of Physiology and Neuroscience at NYU Langone Health, said: “Our results deepen the field’s understanding of a central seizure-inducing mechanism, with many implications for the pursuit of new treatment approaches.

“The study also clarified, not just how CBD counters seizures, but more broadly how circuits are balanced in the brain. Related imbalances are present in autism and schizophrenia, so the paper may have a broader impact.”


The results build on how each neuron “fires” to send an electrical pulse down an extension of itself until it reaches a synapse, the gap that connects it to the next cell in a neuronal pathway, and how this activity can change in a network which is likely to generate epileptic seizures.


For more information about Aston Institute of Health and Neurodevelopment (IHN) please visit our website.


Connect with:
Gavin Woodhall

Gavin Woodhall

Professor, Aston Pharmacy School

Professor Woodhall researches electrophysiological studies on neurones of the entorhinal cortex (EC) and the hippocampus.

Neuronal Network DynamicsSchizophreniaEpilepsyHippocampus
Dr Stuart Greenhill

Dr Stuart Greenhill

Senior Lecturer in Neuroscience

Dr Greenhill's research is focussed on neuroscience, epilepsy and synaptic plasticity.

SchizopreniaPharmacologyElectrophysiologyNeuroscienceEpilepsy

You might also like...

Check out some other posts from Aston University

4 min

People still trust scientists: Aston University psychologists contribute to largest post-pandemic study on public trust

Researchers looked at trust in scientists in 68 countries and found relatively high levels of trust everywhere The TISP Many Labs study of 71,922 people included those living in under-researched nations of the Global South The majority of survey participants believe that scientists should be more involved in society and policymaking. Public trust in scientists is still high, according to a survey carried out in 68 countries by an international team of 241 researchers, led by Dr Viktoria Cologna (Harvard University, ETH Zurich) and Dr Niels Mede (University of Zurich). The study found no evidence of the oft-repeated claim of a crisis of trust in science. The team, which included Aston University School of Psychology’s Dr James Reynolds and Dr Charlotte Pennington, also found that the majority of survey participants believed that scientists should be more involved in society and policymaking. This study is the result of the Trust in Science and Science-Related Populism (TISP) Many Labs study, a collaborative effort that allowed the authors to survey 71,922 people in 68 countries, including many under-researched countries in the ‘Global South’. For the first time since the COVID-19 pandemic, the study provides global, representative survey data on the populations and regions of the world in which researchers are perceived to be most trustworthy, the extent to which they should engage with the public and whether science is prioritising important research issues. Dr Mede said: “The study is the most comprehensive post-pandemic snapshot of trust in scientists, societal expectations of their involvement in society and policymaking and public views on research priorities.” Across 68 countries, the study finds that the majority of the public has a relatively high level of trust in scientists (mean trust level = 3.62, on a scale of 1 = very low trust to 5 = very high trust). The majority of respondents also perceive scientists as qualified (78%), honest (57%) and concerned about people’s wellbeing (56%). However, the results also reveal some areas of concern. Globally, less than half of respondents (42%) believe that scientists pay attention to the views of others. Additionally, many people felt that the priorities of science are not always well-aligned with their own priorities. The researchers call upon scientists to take the results seriously and find ways to be more receptive to feedback and more open to dialogue. The findings confirm the results of previous studies that show significant differences between countries and population groups. In particular, people with right-wing political views in Western countries tend to have less trust in scientists than those with left-wing views. This suggests that attitudes toward science tend to polarise along political lines. In most countries, however, political orientation and trust in scientists were not related. A majority of respondents want science to play an active role in society and policymaking. Globally, 83% of respondents believe that scientists should communicate with the public about science, providing an impetus for increased science communication efforts. Only a minority (23%) believe that scientists should not actively advocate for specific policies. 52% believe that scientists should be more involved in the policymaking process. Participants gave high priority to research to improve public health, solve energy problems and reduce poverty. On the other hand, research to develop defence and military technology was given a lower priority. In fact, participants explicitly believe that science is prioritising the development of defence and military technology more than they would like, highlighting a potential misalignment between public and scientific priorities. Dr Cologna said: “Our results show that most people in most countries have relatively high trust in scientists and want them to play an active role in society and policymaking”. Dr Reynolds, a senior lecturer at Aston University School of Psychology, said: “This research demonstrates that people from all around the globe still have high trust in science and want scientists involved in policymaking. When we face great challenges, such as threats to public health or energy crises, the public recognise the importance that scientists can play and want us involved. This is also true of the UK where levels of public trust in science is one of the highest globally.” Dr Pennington, a senior lecturer at Aston University School of Psychology, said: “This project showcases the importance and power of big team science to answer fundamental questions about human behaviour. By pooling our expertise and resources, we were able to reach over 70,000 people and improve sample diversity and representation by recruiting from 68 countries. Overall, the study resulted in an optimistic finding – that people generally trust scientists and agree that they should engage more in society and policymaking. Such trust is important because it allows people to make research-informed decisions about their own lives.” Find out more about the research in Nature Human Behaviour by visiting https://www.nature.com/articles/s41562-024-02090-5.

4 min

Aston University-led project finds simple ways to improve the wellbeing of paediatric critical care staff

The Staff Wellbeing (SWell) project was carried out in conjunction with Birmingham Children’s Hospital and NHS England Paediatric critical care (PCC) staff experience high levels of moral distress, post-traumatic stress disorder and burnout Two simple, low-resource wellbeing sessions can be delivered by staff for staff without specialist training. The Staff Wellbeing (SWell) project, led by Aston University researchers in collaboration with Birmingham Children’s Hospital and NHS England, has developed two simple, easy-to-deliver sessions to improve the wellbeing of staff in paediatric critical care (PCC) units in UK hospitals. PCC staff are known to experience high levels of moral distress, symptoms of post-traumatic stress disorder (PTSD) and burnout, but often feel little is offered to help them with their mental health. The SWell team at Aston University, led by Professor Rachel Shaw from the Institute of Health and Neurodevelopment, realised following a literature review that there are no existing, evidence-based interventions specifically designed to improve PCC staff wellbeing. Initial work by SWell identified the ‘active ingredients’ likely to create successful intervention designs. Together with a team from NHS England, the Aston University researchers set up the SWell Collaborative Project: Interventions for Staff Wellbeing in Paediatric Critical Care, in PCC units across England and Scotland. The aim of the project was to determine the feasibility and acceptability of implementing wellbeing interventions for staff working in PCC in UK hospitals. In total, 14 of the 28 UK PCC units were involved. One hundred and four intervention sessions were run, attended by 573 individuals. Professor Shaw said: “The significance of healthcare staff wellbeing was brought to the surface during the COVID-19 pandemic, but it’s a problem that has existed far longer than that. As far as we could see researchers had focused on measuring the extent of the problem rather than coming up with possible solutions. The SWell project was initiated to understand the challenges to wellbeing when working in paediatric critical care, to determine what staff in that high-pressure environment need, and what could actually work day-to-day to make a difference. Seeing PCC staff across half the paediatric critical care units in the UK show such enthusiasm and commitment to make the SWell interventions a success has been one of the proudest experiences in my academic career to date.” The two wellbeing sessions tested are low-resource and low-intensity, and can be delivered by staff for staff without any specialist qualifications. In the session ‘Wellbeing Images’, a small group of staff is shown images representing wellbeing, with a facilitated discussion using appreciative inquiry - a way of structuring discussions to create positive change in a system or situation by focusing on what works well, rather than what is wrong. In the ‘Mad-Sad-Glad’ session, another small group reflective session, participants explore what makes them feel mad, sad and glad, and identify positive actions to resolve any issues raised. The key ingredients in both sessions are social support – providing a psychologically safe space where staff can share their sensitive experiences and emotions without judgement, providing support for each other; self-belief – boosting staff’s self-confidence and ability to identify and express their emotions in response to work; and feedback and monitoring – encouraging staff to monitor what increases their stress, when they experience challenging emotions, and what might help boost their wellbeing in those scenarios. Feedback from staff both running and participating in the SWell interventions was very positive, with high satisfaction and feasibility ratings. Participants like that the session facilitated open and honest discussions, provided opportunities to connect with colleagues and offered opportunities for generating solutions and support. One hospital staff member responsible for delivering the sessions said: “Our staff engaged really well, and it created a buzz around the unit with members of the team asking if they could be ‘swelled' on shift. A really positive experience and we are keeping it as part of our staff wellbeing package.” The team concluded that even on busy PCC units, it is feasible to deliver SWell sessions. In addition, following the sessions, staff wellbeing and depression scores improved, indicating their likely positive impact on staff. Further evaluations are needed to determine whether positive changes can be sustained over time following the SWell sessions. The work was funded by Aston University Proof of Concept Fund and NHS England. Donna Austin, an advanced critical care practitioner at University Hospital Southampton paediatric intensive care unit, said: “We were relatively new to implementing wellbeing initiatives, but we recognised the need for measures to be put in place for an improvement in staff wellbeing, as staff had described burnout, stress and poor mood. SWell has enabled our unit to become more acutely aware of the needs of the workforce and adapt what we deliver to suit the needs of the staff where possible. Staff morale and retention has been the greatest outcomes from us participating in the SWell study and ongoing SWell related interventions.” Read the paper about the SWell interventions in the journal Nursing in Critical Care at https://onlinelibrary.wiley.com/doi/10.1111/nicc.13228. For more information about SWell, visit the website.

2 min

Expert comment available - the Government's announcement for the AI Opportunities Action Plan

Expert comment is available on the the Government's announcement for the AI Opportunities Action Plan in which it is aims to roll out AI across the UK. In a speech setting out the government's plans to use AI across the UK to boost growth and deliver services more efficiently, the Prime Minister said the government had a responsibility to make AI "work for working people". The government claims that the AI Opportunities Action Plan is backed by leading tech firms, some of which have committed £14bn towards various projects, creating 13,250 jobs. It includes plans for growth zones where development will be focused, and the technology will be used to help tackle issues such as potholes. Expert comment: "The plan is a necessary step in the right direction with appropriate investment. It should be coupled with a major training programme at business and public levels to bridge the skill gap and develop essential capabilities. "It is important to specify the role that the higher education sector will play in the delivery of such a plan particularly with regards to innovation and knowledge transfer partnerships. "The government used stated that the technology will be used to help tackle issues such as potholes, however AI should be used not only in the detection of potholes, but also in their prediction. Using predictive analytics would significantly reduce the number of cameras that must be deployed to monitor road surface conditions up and down the country." Professor Abdul Hamid Sadka, Professor of Visual Media Technologies, Director, The Sir Peter Rigby Digital Futures Institute, Aston University For further details contact Nicola Jones, Head of Press & Communications (interim) on (+44) 7825 342091 or email: n.jones6@aston.ac.uk

View all posts