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Could Popular Weight-Loss Drugs Be Affecting Your Oral Health? Augusta University Researcher Investigates
GLP-1 medications such as Ozempic, Wegovy and Zepbound are transforming treatment for obesity and diabetes, with some now being used to treat obstructive sleep apnea. But could these increasingly popular medications also affect your teeth and gums? A researcher at Augusta University's Dental College of Georgia is investigating that question, highlighting a potential connection between GLP-1 medications, sleep apnea treatment and oral health. John C. Comisi, DDS, DMD, interim chair and professor in the Department of General Dentistry, recently published a review in Clinical Oral Investigations examining how obstructive sleep apnea and GLP-1 medications may influence the oral microbiome — the complex community of bacteria that helps maintain healthy teeth and gums. A New Question About GLP-1 Medications Obstructive sleep apnea can affect oral health through repeated oxygen disruptions, inflammation, mouth breathing and dry mouth. Treating the condition could improve some of these problems, but GLP-1 medications may introduce additional considerations. “OSA affects much more than sleep,” Comisi said. “The changes that occur throughout the body can also change the environment in the mouth. As we increasingly use medications to treat OSA, we need to understand what those treatments may mean for oral health.” Comisi's review suggests that successful treatment of sleep apnea could improve the oral environment by reducing mouth breathing, acid reflux and other contributing factors. However, reports involving semaglutide have also raised questions about dry mouth and changes in saliva, which plays an important role in protecting against tooth decay and gum disease. “There are potentially competing effects happening at the same time,” Comisi said. “Treating sleep apnea could improve several conditions that contribute to an unhealthy oral environment, while the medication itself could potentially affect salivary function. We simply do not have the prospective human studies yet to know what the overall effect will be.” The review, featured in an Oct. 6 Augusta University Jagwire article, calls for additional research tracking patients using GLP-1 medications, including changes in saliva, oral bacteria, cavities and gum disease. It also highlights the importance of communication between dentists and other health care providers, particularly when patients taking GLP-1 medications require dental procedures involving sedation or general anesthesia. With GLP-1 medications becoming increasingly common, understanding their broader effects on oral health is an emerging area of research with important implications for patients and dental professionals. John C. Comisi, DDS, DMD, is interim chair and professor in the Department of General Dentistry at Augusta University's Dental College of Georgia. His expertise provides a valuable perspective on the intersection of dental health, medication use and emerging approaches to patient care. If you're interested in speaking with Dr. John Comisi about GLP-1 medications, sleep apnea, dry mouth, oral health and the implications of these treatments for dental care, contact AU's External Communications Team mediarelations@augusta.edu to arrange an interview today.





