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Aston University hosts event to foster innovation in crisis and disaster research

The two-day conference brought together academics and policy experts Its aim was to strengthen crisis and disaster research cooperation between institutions in Taiwan and Nepal with Hounslow Borough Council and Birmingham City Council The event laid the groundwork for ongoing cooperation and knowledge exchange in disaster management. Aston University has welcomed a delegation of global disaster management experts to a two-day conference aimed at fostering collaboration and innovation in crisis and disaster research. The event held at Conference Aston from 12 to 14 May 2024 brought together leading academics, policy experts and industry professionals, with a particular focus on strengthening cooperation between institutions in Taiwan and Nepal together with Hounslow Borough Council and Birmingham City Council. Since mid-2019, a concerted effort has been underway to harness innovative technologies for geoclimatic hazards monitoring in Nepal, the Philippines and Bhutan. Supported by the National Science and Technology Center for Disaster Reduction in Taiwan, this initiative has seen meaningful partnerships between British and Taiwanese stakeholders, driving advancements in real-time data capture for earthquake activity, rainfall patterns and wind dynamics crucial for effective crisis and disaster governance. Dr Komal Aryal, a lecturer in crisis and disaster management at Aston University, said: “I was wonderful to welcome such esteemed experts and colleagues to campus for this important event. “Sharing success stories and addressing implementation challenges to emerging technologies in local crisis and disaster management is vital in strengthening digital research infrastructure and networks at the grassroots level in countries like Nepal, Bhutan, the Philippines and other Himalayan regions. “The event served as a nexus for fostering partnerships among academia, policymakers, industries, emergency services and humanitarian volunteers across the UK, Nepal and Taiwan. “These collaborations are essential for driving impactful solutions and strategies in disaster management.” Professor Zoe Radnor, Pro-Vice-Chancellor and Executive Dean of the College of Business and Social Sciences at Aston University, said: “I’d like to thank everyone who attended this important event around disaster management. “It was wonderful to see the renewed commitment to enhancing crisis and disaster research cooperation which are integral to developing comprehensive and sustainable disaster response frameworks. “I am delighted to see draft plans produced for future joint collaborative activities, laying the groundwork for ongoing cooperation and knowledge exchange in disaster management.” Rev. Weilien Lin, programme secretary, Church and Society Committee, the Presbyterian Church in Taiwan, said: “This conference marks a significant step forward in our collective efforts to enhance global resilience to disasters. “By bringing together diverse expertise and fostering meaningful partnerships, we are better equipped to address the complex challenges posed by natural and man-made crises.” Professor Yie-Ru, from Chiu Tzu Chi University, Taiwan, said: “Aston University and Tzu Chi universities have entered into a Memorandum of Understanding (MoU) to collaborate more closely in addressing disaster and crisis management studies not only in Taiwan and the United Kingdom but also abroad. “This partnership marks a significant step forward in our shared commitment to enhancing global preparedness and response to emergencies, fostering cooperation and knowledge exchange across borders.” Mayor Narulal Chaudhary, general secretary of Municipal Association of Nepal elected mayor of Ghorahi Sub Metropolitan City, said: “This relationship with Aston University stands as a testament to how collaboration can foster disaster resilience and fortify crisis management efforts, especially in regions like the Himalayas in South Asia where vulnerability to natural disasters like earthquakes is significant. “As someone elected as the mayor of Ghorahi Sub Metropolitan City, a region highly susceptible to earthquakes, I believe that such collaborations are crucial in equipping communities with the knowledge and resources needed to mitigate risks and respond effectively in times of crises.”

MEDIA RELEASE: CAA Manitoba Urges Drivers to Slow Down and Move Over

A recent study conducted by CAA Manitoba revealed a knowledge gap in how drivers understand and comply with Slow Down Move Over (SDMO) laws. According to the study, 85 per cent of drivers claim they are aware of the SDMO law – however, only 41 per cent have a clear understanding of its definition. The survey also found that a third of drivers (30 per cent) confuse the SDMO law with the one that requires drivers to give emergency vehicles the right of way and clear passage when stopped on the side of the road. “This data shows us that there is a big divide and misunderstanding between the law in theory and the law in practice,” says Ewald Friesen, manager of government and community relations CAA Manitoba. “Lack of understanding of the Slow Down Move Over law poses a significant safety risk for tow truck operators and emergency vehicles on the province's roads." To help keep tow operators safe, CAA Manitoba is using National Slow Down Move Over Day to remind drivers of the law, its purpose and penalties for non-compliance. On May 14, all CAA Clubs across Canada are coordinating a National Slow Down Move Over Day, part of a broader campaign to remind motorists to be mindful and cautious around truck operators assisting others on the roadside. Across North America, more than 100 tow truck drivers have been killed in the last decade after being struck by oncoming traffic while helping stranded motorists with flat tires, breakdowns, and collisions. Given the lack of data collection on these types of deaths, this number is very conservative. Add to that the significant number of injuries and near misses demonstrates just how important it is to educate the public about the Slow Down Move Over law. “Tow truck operators face a high risk of injury when on the side of the road or in a live lane helping stranded drivers. “These are real people with friends, families and loved ones,” says Friesen. “CAA Manitoba will always advocate for their safety to create safer roads across Manitoba for everyone, including those working alongside it.” In Manitoba, the SDMO law requires drivers to slow down when a vehicle is working along the roadside. If the posted speed limit is less than 80 km/h, drivers are required to slow down to 40 km/h. If the posted speed limit is 80 km/h or higher, drivers are required to slow down to 60 km/h. Drivers are not as concerned for the safety of tow truck operators as they should be. The survey also found that when compared to other types of emergency vehicles, Manitoban drivers tend to slow down less for tow truck operators. While motorists say they will reduce their speed and fully change lanes when they encounter emergency vehicles like police (95 per cent), ambulances (93 per cent) and fire trucks (89 per cent) only 70 per cent will slow down and move over for a tow operator. “Everyone deserves a safe place to work, including tow truck operators who are working in extremely unsafe conditions, "says Friesen. “ CAA Manitoba will continue to educate the public on road safety, and bring awareness to the laws that have been put in place to protect tow operators along with other emergency roadside assistance.” CAA Manitoba is encouraging motorists to get informed on the laws put in place to protect tow operators and other emergency roadside assistance on National Slow Down, Move Over Day. To learn more about Slow Down, Move Over, visit: https://www.caamanitoba.com/advocacy/government-relations/slow-down DIG Insights conducted an online survey on behalf of CAA Manitoba between October 26th –November 6th, 2023, of 758 Manitoba drivers aged 18-75 years. Based on the sample size and the confidence level (95 per cent), the margin of error for this study was +/- 3 per cent

This Is a Critical Moment: Delaware Must Not Go Backward in Health Equity

The proposed Delaware House Bill 350 is well-intended but would have terrible consequences for Delaware’s most vulnerable populations. There is a better way. By LeRoi S. Hicks, M.D., MPH, FACP As a Black physician who has dedicated his 25-year career to understanding and addressing health equity, I am deeply concerned about Delaware’s proposed House Bill 350, which aims to address rising health care costs by establishing a body of political appointees that would oversee the budgets of Delaware’s nonprofit hospitals. While the goal of bending the cost curve in health care may be well-intentioned, this bill will have horrific consequences for Delaware’s most vulnerable populations, including Black people, Hispanic people and other groups that have been traditionally underserved in health care. We can and must work together to solve this problem and provide the right care, in the right place, at the right time. A tale of two cities To borrow a phrase from Charles Dickens, Delaware, like much of America, is a tale of two cities. The experience of life—including a healthy, safe environment and access to good-quality health care—is vastly different depending on where you live and your demographic background. In the city of Wilmington, for example, ZIP codes that are just a few miles apart represent more than 20 years difference in life expectancy. This is not OK—it’s a sign that we have serious structural problems in our communities that are causing harm to people and making their lives shorter. Importantly, chopping $360 million out of Delaware’s hospital budgets, as House Bill 350 would do in year one, is not going to help this problem—it’s going to make it worse. And in doing so, it would ultimately make health care in Delaware more expensive—not less expensive. The key to lowering health care costs is to improve quality, access and equity Data show that about 5% of patients in the United States account for more than 50% of all health care costs. These are primarily patients who have complex and poorly managed chronic conditions that cause them to end up in the most expensive care settings—hospitals, operating rooms, emergency departments. The key to driving down health care costs is to improve quality and equity so that everyone is supported in achieving their best health, and these high users of the most expensive kinds of care are better supported in managing their health conditions such as diabetes or heart failure in the appropriate way. In doing so, they prevent the need for costly emergency or “rescue” care. Let’s do more—not less—of what we already know works Health care is not a one-size-fits-all industry. The delivery of care for patients across a diverse population requires multiple interventions at the same time. These interventions are designed not only to improve the quality of care but also to close the gap in terms of health care disparities. That’s important, because when we improve care and outcomes for the most vulnerable populations, we tend to get things right for everyone. One type of intervention is about doing exactly the right things for a patient based on the evidence of what will help—and doing nothing extra that will cause harm or generate additional costs without providing additional benefit. An example of this might be ensuring that every patient who has a heart attack gets a certain drug called a beta blocker right after their heart attack, and they receive clear guidance and support on the actions they must take to reduce their risk of a second heart attack, such as regular exercise and good nutrition. The second type of intervention is for the highest-risk populations. These are patients who live in poor communities where there are no gyms and no grocery stores, and people commonly have challenges with transportation and lack of access to resources that makes it difficult—sometimes impossible—to follow their plan for follow-up care. They lack access to high-nutrient food that reduces their risk of a second heart attack. They also live in areas where there are fewer health care providers compared to more affluent areas. These interventions tend to be very intensive and do not generate income for health systems; in fact, they require significant non-reimbursed investment, but they are necessary to keep our most vulnerable patients healthy. The medical community has developed interventions for these populations that are proven to work. A local example is the Delaware Food Pharmacy program, which connects at-risk patients with healthy food and supports their ability to prepare it. The program helps patients improve their overall health and effectively manage their chronic conditions so they can prevent an adverse event that would put them back in the hospital or emergency department. When we work together, we succeed We’ve seen incredible examples of how this work can be successful right here in Delaware. Delaware was the first state in the country to eliminate a racial disparity in colorectal cancer, and we did this by expanding cancer services, including making it easy for vulnerable people to get preventive cancer care and screenings. This is an incredible success story that continues to this day, and it was the result of thoughtful, detail-oriented partnerships among the state and the health care community. The work continues as we collaborate to reduce the impact and mortality of breast cancer in our state. Unfortunately, these kinds of interventions are the first thing to go when health care budgets get slashed, because they don’t generate revenue and are not self-sustaining. These kinds of activities need to be funded—either through grants or an external funder, or by the hospitals and health care systems. By narrowly focusing on cost, we risk losing the progress we have made Delaware House Bill 350, as it’s proposed, would cause harm in two ways: First, it would compromise our ability to invest in these kinds of interventions that work. Second, it increases the risk that higher-cost health services and programs that are disproportionately needed by people in vulnerable communities could become no longer available in Delaware. In states where the government has intervened in the name of cutting costs, like Vermont and Massachusetts, we see the consequences–less quality and reduced equitable access to much-needed services. House Bill 350 will widen the gap between those who have means and those who are more vulnerable. These changes will lead to increased disease burden on these populations. They will end up in the emergency room more and hospitalized more, which is by far the most expensive kind of care. That’s not what anyone wants—and it’s the opposite of what this bill was intended to accomplish. At this moment, in Delaware, we have an opportunity to put our state on a sustainable path to better health for all Delawareans. House Bill 350 is not that path. However, the discussion that House Bill 350 has started is something that we can build on by bringing together the stakeholders we need to collaborate with to solve these complicated problems. That includes Delaware’s government and legislators, the hospitals and health centers, the insurance, pharmacy and medical device industries, and most importantly, patients and the doctors who care for them. LeRoi Hicks, M.D., is the campus executive director for ChristianaCare, Wilmington Campus.

Innovative EEG Brain Monitoring Program Provides Optimal Care for Critically Ill Patients

ChristianaCare has launched an innovative electroencephalogram (EEG) brain monitoring program that represents a significant leap forward in the diagnosis and management of neurological conditions. The easy-to-use EEG program is the first of its kind that can be performed at the bedside to measure the electrical activity of the brain, providing a vital sign for brain function to help diagnose seizures more quickly. ChristianaCare is the first hospital system in Delaware to use the Ceribell point-of-care EEG monitoring system, which can reduce the time it takes to diagnose certain neurological conditions from hours to mere minutes. Using the system, clinicians have immediate access to EEG information so they can triage at-risk patients in just five minutes and monitor patients for treatment optimization. “With this new program, our team of expert clinicians will have the diagnostic information they need to provide high-risk patients with the right care at the right time, ensuring the best outcomes for our patients and their families,” said Kim Gannon, M.D., Ph.D., service line leader for Neurosciences at ChristianaCare. New technology detects ‘silent seizures’ Critically ill patients are at high risk of harmful brain electrical discharges called seizures. Some of these patients experience a type of “silent seizure” with no noticeable symptoms (non-convulsive) that can only be detected using EEG. If prolonged, non-convulsive seizures can lead to permanent brain injury and higher risk of morbidity and mortality. Demonstration of EEG device on patient at ChristianaCare Newark Campus. As a result, guidelines from the Neurocritical Care Society recommend EEG should be initiated within 15-60 minutes when these seizures are suspected. Meeting these guidelines has proven difficult due to the limitations of conventional EEG systems, which were not designed for use in emergency situations. Even top academic centers that have 24/7 EEG capabilities may experience wait times of four hours or more for conventional equipment. When relying on clinical judgement alone while waiting for these conventional EEG systems, diagnostic accuracy has been shown to be only slightly better than chance (65%). The value of this new technology for patients is that it provides accurate results quickly so that the care team can intervene early. “The neuroscience and critical care teams at ChristianaCare believe that ‘time is brain’ not only applies to stroke but also when dealing with seizure,” Gannon said. Gannon is referring to the fact that for every minute that passes when someone is having a stroke, 1.9 million brain cells are lost, increasing the chance of disability or death. That same kind of speed and urgency can now more easily be brought to bear for patients when a seizure is suspected. “This monitoring system is easy to use and can be set up in about five minutes,” said Richard Choi, D.O., medical director of the Neurocritical Care Unit at Christiana Hospital. “It consists of a simple headband, pocket-sized recorder with intuitive software and an on-line portal for remote viewing. Using the system, we can review EEG data, assess response to treatment and optimize care, all in real-time.” Neurosciences at ChristianaCare ChristianaCare’s multidisciplinary neurosciences team provides comprehensive and advanced care for neurologic illnesses across the acute and ambulatory settings. As the largest and most comprehensive neurology practice in Delaware with more than 55,000 patient visits last year, ambulatory subspecialties include stroke, epilepsy, multiple sclerosis, movement disorders, neuromuscular disorders, headaches/migraines, pediatric neurology and Botox specialists. The inpatient team of experts includes neurosurgeons, neurointerventional surgeons, neurocritical care physicians and vascular neurologists. The Newark Campus serves as the only comprehensive stroke center in the state and includes the only Epilepsy Monitoring Unit in Delaware.

Climate change research trailblazer elected to prestigious list of AAAS Fellows

University of Delaware professor Rodrigo Vargas has been elected as a fellow of the American Association for the Advancement of Science (AAAS) — one of the largest scientific societies in the world and publisher of the Science family of journals. The new class of AAAS Fellows includes 502 scientists, engineers and innovators across 24 disciplines, who are being honored for their scientifically and socially distinguished achievements. Vargas, professor of ecosystem ecology and environmental change in UD’s College of Agriculture and Natural Resources, is recognized "for distinguished contributions to carbon dynamics across the terrestrial-aquatic interface, development of environmental networks, novel data analysis tools and his leadership in creating a more diverse scientific workforce." Deborah Allen, who retired from UD in 2019 as a professor of biological sciences, was also names as a fellow. She was cited “for transformational contributions to STEM education nationally and internationally, particularly for developments in problem-based learning and faculty development.” Vargas is an ecosystem ecologist who studies how nature-based solutions can help address global environmental change in both terrestrial and coastal ecosystems, Vargas uses a variety of research methods, including data mining, machine learning, remote sensing, measurements of greenhouse gas fluxes and modeling techniques for forecasting applications.

Veterinary deal would increase UK agrifood exports to EU by more than a fifth, research shows

A veterinary deal would increase agri-food exports from the UK to the EU by at least 22.5%, say researchers Agri-food exports overall are worth £25 billion to the UK economy, but the two years since the new trading rules were put in place have seen a fall of 5% in exports to the EU from 2019 levels, during a period where the sector has otherwise grown. Team from Aston University and University of Bristol have analysed trade deals and export figures worldwide to estimate impact of a new veterinary deal on UK–EU exports A veterinary deal with the European Union could increase UK agricultural and food exports by over a fifth, according to new research. The team, from Aston University’s Centre for Business Prosperity and the University of Bristol, analysed the agricultural and veterinary aspects of trade deals around the world to estimate their impact on exports. They then modelled the potential impact of different types of agreement on UK exports to the EU. Veterinary Agreements specifically focus on regulations and standards related to animal health and welfare, as well as to the safety of animal-derived products such as meat, dairy, and seafood. They aim to align, harmonise, or recognise veterinary requirements and certifications, and reduce the number of inspections between countries to facilitate the safe and efficient trade of live animals and animal products. The EU–UK Trade and Cooperation Agreement (TCA), implemented in January 2021, eliminates tariffs and quotas but does not remove non-tariff barriers to trade. These can be particularly burdensome for agricultural and animal-derived food (agri-food) exports, involving complex rules and requirements, production of extensive documentation and veterinary checks. The UK agri-food sector is a cornerstone of the UK economy, with exports worth £25 billion and employing 4.2million people. Although the sector is growing overall, exports to the EU shrank in 2022 by 5% compared to 2019, in part due to the new trade arrangements. This has led to calls for an EU–UK veterinary agreement from business and agri-food organisations, including the Confederation of British Industry, British Chambers of Commerce, UK Food and Drink Federation, Chartered Institute of Environmental Health and British Veterinary Association. Analysing data from the World Bank on 279 trade agreements and export statistics from over 200 countries, the researchers found that shallow agreements, that went little further than provisions already covered by World Trade Organisation (WTO) rules, had significant negative impacts on agri-food exports. However, where trade agreements went beyond WTO provisions to include more commitments on sanitary and phytosanitary (SPS) measures (which aim to protect countries against risks relating to pests, diseases and food safety) and were legally enforceable, they had a robust, positive impact on exports, particularly exports of animal products and food. Applying this to the UK–EU relationship, the team estimate that a veterinary agreement that went beyond the existing TCA provisions would increase agri-food exports from the UK to the EU by at least 22.5%. Imports from the EU would also increase by 5.6%. In the 203 countries studied for the research, positive effects of deep trade deals that included provisions on agriculture took between 10 and 15 years to manifest. But the UK might not have to wait so long, according to report co-author Professor Jun Du, Director of Aston University’s Centre for Business Prosperity. “There is no blueprint out there that mirrors the UK–EU relationship. Most veterinary agreements are agreed as part of a trade deal between countries that haven’t previously had close alignment and it takes a while for the benefits to take effect. “Until recently, the UK had frictionless agri-food exports to the EU, so it’s possible that a supplementary veterinary agreement to reduce some of the frictions created by Brexit could allow trade that previously existed to pick up again quite quickly.” However clear the economic arguments, the legal and political barriers to a veterinary agreement still remain. The researchers address these in their report, suggesting that the best format for the additional measures would be as a supplementary agreement to the TCA. The key question for the UK government in negotiating such an agreement would be what the EU demanded in return. “The closest model is the EU-Swiss relationship, which sees Switzerland largely follow EU law,” said report co-author from the University of Bristol, Dr Greg Messenger. “That’s unlikely to be an option for the UK. As we wouldn’t expect to eliminate all paperwork, we could both agree that our rules meet each other’s standard for phytosanitary protection. As most of our rules are still essentially the same as the EU, that wouldn’t require any major change, though we’d have to agree a greater level of coordination in relation to the development of new rules.” The report was written jointly by Professor Du, Dr Messenger and Dr Oleksandr Shepotylo, senior lecturer in economics, finance and entrepreneurship at the Centre for Business Prosperity, Aston Business School.

World-leading scientist gives annual Aston University Distinguished Lecture on the wonder of smart gels

Dr Raghunath Anant Mashelkar delivered the 2024 Aston University Annual Distinguished Lecture He has been president of the Indian National Science Academy and director general of the Indian Council of Scientific and Industrial Research and has received multiple honours and awards He was also presented with an honorary professorship in recognition of his outstanding contribution to academia and beyond. Dr Raghunath Anant Mashelkar delivered Aston University’s 2024 Annual Distinguished Lecture to more than 70 invited guests on 22 April. One of the world’s renowned figures in polymer science, research leadership and intellectual property rights, Dr Mashelkar, a chemical engineer, is a global leader and inspiration in his native India and the wider international research community. In recognition of his outstanding contribution to the research community, Dr Mashelkar was bestowed with an honorary professorship at the end of the lecture by Professor Aleks Subic, Vice-Chancellor and Chief Executive of Aston University. The title of Dr Mashelkar’s lecture was ‘Trapeze Artistry in Biomimetic Smart Gels’. ‘Smart gels’, made from synthetic polymers (types of plastics), can be developed with specific functional properties, such as reacting to changes in temperature and pH. Whilst Director at India’s National Chemical Laboratories, Dr Mashelkar led work which discovered smart gels which can mimic biological functions (biomimetic), including being self-healing, self-organising, and acting as enzymes in chemical and biological processes. Their properties can be reversibly switched on or off, or they can change volume or shape, through the use of pH or temperature, the ‘trapeze artistry’ of the title, giving them many uses. This included temperature-responsive comfortable insoles for diabetic feet, drilling fluids which can quickly, but reversibly, plug an oil well, and medical devices for the digestive system, which resist the acidic environment of the stomach to deliver drugs, but dissolve harmlessly in the alkaline environment when they leave the stomach. One of the defining factors of Dr Mashelkar’s work has been serendipity. He told the story of a smart gel that dried to become a completely different shape when dried in his laboratory’s old oven rather than the new oven. One of his research team discovered this was due to the presence of copper ions from corrosion in the oven, which changed the way the molecules arranged themselves and led to a whole new area of research on polymer self-assembly. As he said: “Eyes do not see what the mind does not know. Look at the 'failed' experiment very carefully, maybe the next big breakthrough is waiting there!” Dr Mashelkar also spoke on his life story, from a young boy in India, attending the local municipal school, to addressing thousands of the world’s best minds at places like the World Economic Forum and the World Bank. His great passion now is ‘Gandhian Engineering’ based on the principle of more performance, from fewer resources, for more people. He created the Anjani Mashelkar Award, named after his mother, for the best low-cost, high-technology innovations. Winners have included an Internet of Things-based maternal healthcare system for rural areas and a smartphone app to assess lung health. Dr Mashelkar is proud of his work on Gandhian Engineering. Speaking after the lecture he said: “Rising inequalities create social disharmony. Now, you can’t make the inequalities vanish because you can’t make poor people rich overnight. What is needed is access. Can we give access equality, despite the income inequality? And that’s the principle of Gandhian Engineering. In my lecture I showed a photograph of a poor lady in a hut with a mobile, and a rich lady from a city who also had a mobile. This is equal access. It was not possible previously when mobiles were so expensive. In India now we have good public infrastructure. Data is now Rs 4 per GB and wireless is free. Once you start giving access, there is a parity.” Professor Subic said: “It was a privilege and a pleasure to welcome such a celebrated scientist as Dr Mashelkar to give the Aston University Annual Distinguished Lecture this year. Once again, we have brought a renowned international leader to engage with our community and present some of the most exciting research going on in our world today, while also inspiring the next generation of researchers and international citizens. I am deeply honoured that Dr Mashelkar has accepted an honorary professorship from Aston University in recognition of his international standing and significant contributions to scientific research and innovation.” The distinguished lecture series was established by Professor Subic in 2023. It brings influential speakers to the University to address major scientific breakthroughs, as well as social, cultural and policy issues. The first distinguished lecture was given by Nobel Laureate Peter Agre in 2023. Speaking after the lecture, Dr Mashelkar said: “I am absolutely honoured to get this honorary professorship from Aston University. Aston University is excelling in a number of areas. In terms of its future, I consider that to be very bright for the simple reason that the University’s dynamic Vice-Chancellor is making big changes with speed and skill, with expansion, inclusion and excellence. To be honoured with an honorary professorship is one of the greatest satisfactions and fulfilments of my life.” The lecture was followed by a drinks reception to allow guests to meet Dr Mashelkar and further discuss his work. A video recording of the 2024 Annual Distinguished Lecture will be made available on the University website at a later date.

Kelly Banas, Ph.D., To Present Her Latest Discovery at CRISPR Medicine’s First International Conference

Global audience in Copenhagen, Denmark, will learn of Gene Editing Institute research targeting the NRF2 gene in cancer cells Kelly Banas, Ph.D., principal investigator at ChristianaCare’s Gene Editing Institute, will present her latest research discovery related to targeting the NRF2 gene in cancer cells at the first CRISPR Medicine Conference held in Copenhagen, Denmark, April 22 to 25. The Gene Editing Institute’s research has focused on the NRF2 gene and the strong immune response it causes within cancer cells, allowing them to grow resistant to chemotherapy and leading cancer treatments to fail. By disrupting the NRF2 gene in cancer cells while allowing healthy cells to continue producing it, chemotherapy treatment becomes more effective. Gene Editing Institute principal investigators Kelly Banas, Ph.D., and Natalia Rivera-Torres, Ph.D., in the lab. Banas’ latest research delves into the mechanism of DNA repair following the removal of NRF2, ensuring that surrounding DNA in healthy cells is not affected and that the repair does not produce an unexpected outcome. “I’m extremely honored to be invited to this conference to highlight the work that all of our researchers at the Gene Editing Institute have put into this study,” Banas said. “The work we have done to characterize the impact of CRISPR on the NRF2 gene has changed how we approach new cancer targets. “This has influenced how we design experiments and analyze our data,” she said, “so it’s got a big impact on not just our work, but the work of anyone we collaborate with in the future. This community is full of phenomenal voices, and we’re committed to sharing our work in contexts like this to continue building a foundation of CRISPR research that will uplift treatment for some of the deadliest and most resilient cancers and diseases.” Read about Banas’ earlier research here.

NASA selects University of Delaware’s CubeSat spacecraft for upcoming mission

It’s safe to say that not many students expect to lead a NASA-supported mission during their undergraduate studies. But at least a dozen from the University of Delaware will have done that by the time they collect their diplomas in the next few years. All are part of a team creating Delaware’s first orbital spacecraft, which was selected by NASA for launch in 2026 as part of its CubeSat Launch Initiative. The NASA program, which started in 2011, aims to give students an opportunity to be part of real missions and gain extraordinary experience in what it takes to do space research. CubeSats are small, modular, inexpensive satellites that carry experiments for science investigations and/or technology demonstrations. About 160 CubeSats have been launched in the NASA program over the years, many deployed from the International Space Station (ISS). Delaware’s mission — the Delaware Atmospheric Plasma Probe Experiment (DAPPEr) — will launch its CubeSat spacecraft from the ISS and orbit independently through Earth’s upper atmosphere. The CubeSat will be about the size of a loaf of bread, according to the team’s faculty mentor, Bennett Maruca, associate professor of physics and astronomy. It will gather data about the density and temperature of electrons in Earth’s upper atmosphere, recording changes observed at different latitudes and times of day. This data will inform future research on how the sun affects conditions there. Understanding the sun’s interaction with the Earth’s atmosphere is critical to development of satellite communications networks, global positioning systems (GPS) and national security. But the real objective is educational, Maruca said. The students are the “deliverables.” They’ll emerge from this work with an insider’s view of what it’s like to develop and work on a NASA mission. To arrange an interview with Maruca, contact UD's media relations team at mediarelations@udel.edu.

MEDIA RELEASE: CAA Manitoba Survey Reveals Alarming Data on Cannabis-Impaired Driving in Manitoba

CAA Manitoba (CAA MB) is encouraging Manitoba drivers to remain vigilant this month by driving responsibly – and sober. In a recent survey conducted by CAA Manitoba, alarming data highlights concerns related to cannabis-impaired driving, particularly involving edibles. Key findings from the 2023 survey found that since legalization, a third of cannabis-impaired drivers (27 per cent) in Manitoba have driven a vehicle after consuming an edible form of cannabis. “The data shows us that there is a significant number of impaired drivers under the influence of edible cannabis, which poses a great risk to road safety,” says Ewald Friesen, community and government relations manager at CAA Manitoba. “Edibles pose a greater risk for impairment and road safety since they can often take up to two hours for the effects to kick in.” According to the survey, 61 per cent of cannabis-impaired drivers in Manitoba wait less than three hours before getting behind the wheel. Due to the prolonged absorption of edible cannabis, the potential for drivers to get behind the wheel before they even realize they are beginning to feel the effects poses a serious risk to road safety. The data shows that 89 per cent of Manitoba drivers agree that driving under the influence of cannabis is a serious risk to road safety. However, 67 per cent of cannabis-impaired drivers feel confident in their ability to drive. “While some believe that cannabis doesn’t impair their driving ability, it has been proven to affect coordination, reaction time, decision-making and the ability to pay attention. We would like to see more public education and awareness on the risks of cannabis-impaired driving,” says Friesen. More than half of Manitoba drivers (64 per cent) believe that cannabis-impaired driving is the most important public education topic related to cannabis – more than education on health risks (63 per cent) and health risks for youth under 25 (59 per cent). Despite the concern for road safety and driving impairment, 21 per cent of Manitoba drivers are not aware of the penalties that could be faced for any type of impaired driving. According to Manitoba Public Insurance, this can include an immediate 24-hour licence suspension with a maximum of 60 days upon further testing, a $400 vehicle impoundment of three days, a mandatory Impaired Driver Assessment at the driver’s expense and potential charges under the Criminal Code of Canada. CAA is encouraging motorists to get informed, know the rules, and make the right choices – don’t get behind the wheel when impaired. Instead, make alternate arrangements, such as utilizing rideshare services, to ensure a safe journey home. Dig Insights conducted an online survey on behalf of CAA Manitoba between June 22 to July 5, 2023, of 500 Manitoba drivers aged 19-75 who had access to a vehicle. Based on the sample size and the confidence level (95 per cent), the margin of error for this study was +/- 3 per cent.