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UF team develops AI tool to make genetic research more comprehensive

University of Florida researchers are addressing a critical gap in medical genetic research — ensuring it better represents and benefits people of all backgrounds. Their work, led by Kiley Graim, Ph.D., an assistant professor in the Department of Computer & Information Science & Engineering, focuses on improving human health by addressing "ancestral bias" in genetic data, a problem that arises when most research is based on data from a single ancestral group. This bias limits advancements in precision medicine, Graim said, and leaves large portions of the global population underserved when it comes to disease treatment and prevention. To solve this, the team developed PhyloFrame, a machine-learning tool that uses artificial intelligence to account for ancestral diversity in genetic data. With funding support from the National Institutes of Health, the goal is to improve how diseases are predicted, diagnosed, and treated for everyone, regardless of their ancestry. A paper describing the PhyloFrame method and how it showed marked improvements in precision medicine outcomes was published Monday in Nature Communications. Graim, a member of the UF Health Cancer Center, said her inspiration to focus on ancestral bias in genomic data evolved from a conversation with a doctor who was frustrated by a study's limited relevance to his diverse patient population. This encounter led her to explore how AI could help bridge the gap in genetic research. “If our training data doesn’t match our real-world data, we have ways to deal with that using machine learning. They’re not perfect, but they can do a lot to address the issue.” —Kiley Graim, Ph.D., an assistant professor in the Department of Computer & Information Science & Engineering and a member of the UF Health Cancer Center “I thought to myself, ‘I can fix that problem,’” said Graim, whose research centers around machine learning and precision medicine and who is trained in population genomics. “If our training data doesn’t match our real-world data, we have ways to deal with that using machine learning. They’re not perfect, but they can do a lot to address the issue.” By leveraging data from population genomics database gnomAD, PhyloFrame integrates massive databases of healthy human genomes with the smaller datasets specific to diseases used to train precision medicine models. The models it creates are better equipped to handle diverse genetic backgrounds. For example, it can predict the differences between subtypes of diseases like breast cancer and suggest the best treatment for each patient, regardless of patient ancestry. Processing such massive amounts of data is no small feat. The team uses UF’s HiPerGator, one of the most powerful supercomputers in the country, to analyze genomic information from millions of people. For each person, that means processing 3 billion base pairs of DNA. “I didn’t think it would work as well as it did,” said Graim, noting that her doctoral student, Leslie Smith, contributed significantly to the study. “What started as a small project using a simple model to demonstrate the impact of incorporating population genomics data has evolved into securing funds to develop more sophisticated models and to refine how populations are defined.” What sets PhyloFrame apart is its ability to ensure predictions remain accurate across populations by considering genetic differences linked to ancestry. This is crucial because most current models are built using data that does not fully represent the world’s population. Much of the existing data comes from research hospitals and patients who trust the health care system. This means populations in small towns or those who distrust medical systems are often left out, making it harder to develop treatments that work well for everyone. She also estimated 97% of the sequenced samples are from people of European ancestry, due, largely, to national and state level funding and priorities, but also due to socioeconomic factors that snowball at different levels – insurance impacts whether people get treated, for example, which impacts how likely they are to be sequenced. “Some other countries, notably China and Japan, have recently been trying to close this gap, and so there is more data from these countries than there had been previously but still nothing like the European data," she said. “Poorer populations are generally excluded entirely.” Thus, diversity in training data is essential, Graim said. "We want these models to work for any patient, not just the ones in our studies," she said. “Having diverse training data makes models better for Europeans, too. Having the population genomics data helps prevent models from overfitting, which means that they'll work better for everyone, including Europeans.” Graim believes tools like PhyloFrame will eventually be used in the clinical setting, replacing traditional models to develop treatment plans tailored to individuals based on their genetic makeup. The team’s next steps include refining PhyloFrame and expanding its applications to more diseases. “My dream is to help advance precision medicine through this kind of machine learning method, so people can get diagnosed early and are treated with what works specifically for them and with the fewest side effects,” she said. “Getting the right treatment to the right person at the right time is what we’re striving for.” Graim’s project received funding from the UF College of Medicine Office of Research’s AI2 Datathon grant award, which is designed to help researchers and clinicians harness AI tools to improve human health.

Staying Sober and on the Path to Recovery During the Holidays

The holidays can be a joyous time full of celebrations and they also can be a time of intense stress. Individuals with substance and alcohol use disorders can experience additional stress during the holidays, which can interfere with their recovery, and they may need additional support to abstain from substance use. What can people in recovery do to both abstain and enjoy the holidays? And what can loved ones do to support them? “Holidays can be difficult for anyone, but those with substance use and mental health disorders may have a more difficult time coping with those difficulties,” said Baylor University substance use disorder treatment expert Sara Dolan, Ph.D., professor of psychology and neuroscience. “The holidays can be – on one hand – a time rife with loneliness, and on the other hand, a time where family conflict might be more present,” Dolan said. “Both of these situations are hard for many of us to cope with, but we may want to be more sensitive to those who struggle more with these situations.” Dolan is a nationally known researcher on how neuropsychological dysfunction, including problems with memory and executive functions, affects how people cope with alcohol and substance use disorders and how these issues affect the treatment process and outcome. Dolan offers the following suggestions for individuals in recovery to help them get through the holidays and how family and friends can offer support. Stay active in recovery If the individual already has a recovery plan in place such as a 12-step program or Celebrate Recovery, make sure to continue attending meetings and appointments during the holiday season. “There are numerous virtual and in-person resources for people who are struggling, including mutual aid support groups like Alcoholics Anonymous, Narcotics Anonymous and Smart Recovery,” Dolan said. “People can also call the SAMHSA national helpline at 1-800-662-HELP.” Even when traveling, it is a good idea to know local meeting schedules, use virtual resources and consider attending extra meetings to stay on top of your recovery. Have a coping plan “It is important for people to have a solid coping plan before they go into potentially distressing situations,” Dolan said. Are there places or events to just stay away from? Dolan said it is “okay to keep yourself safe by leaving or even avoiding places that may be unsafe.” By having a plan to handle stressors ahead of time, you can manage it better in the moment. Preparation is key to feeling safe and enjoying the holidays. Avoid triggers and stressors Understanding personal triggers, which can be different for different people, can help us avoid them ahead of time. “For some people, it’s family conflict, for some, it’s loneliness, and for some it’s feelings of anxiety or depression,” Dolan said. “It’s important to know your own stress points before you go into situations that may trigger them.” Once you know what leads to urges to use alcohol or other substances, you can determine how to counteract those circumstances or avoid them if necessary. Reach out for support Reach out to family and friends who will most likely offer positive support. Letting your loved one know what you need – and how to support you in your recovery – can help you abstain from substance use during stressful situations. In fact, Dolan said you may even want to let them know ahead of time that you may need extra support. How to support someone with a substance use disorder Be as open, direct and caring as you can be. Dolan suggests talking to your loved one directly about what may – or may not be helpful – during the holidays. “Some people in recovery may feel more comfortable in alcohol-free environments,” she said, “but some may not want their loved ones altering their behavior. “Ask – don’t assume – and let your loved one tell you what might work best for them,” Dolan added. Using these suggestions can help both individuals with substance and alcohol use disorders and their families have a healthy and happy holiday season.

Why 48 Hours Outdoors Does More Than a Week of Scrolling Breaks

When people feel burned out from their phones, the default solution is often a “digital detox”: delete the apps for a week, set a screen-time limit, maybe move social icons off the home screen. Then work, group chats and FOMO pull them right back in. Personal Development Coach Mark Diamond, an expert in the Offline.now directory who ran a tech-free summer camp for 25 years, says the real reset button isn’t a slightly less frantic version of the same life. It’s 48 hours of real-world experience outdoors. “I’ve watched kids and adults go from wired and anxious to relaxed and connected in a matter of days — not because we lectured them about screens, but because they were hiking, cooking over a fire, laughing with friends, actually living,” Diamond says. “Nature gives your nervous system something it can’t get from a feed.” The science backs up what he sees at camp. A large meta-analysis of nature exposure in adults found that as little as 10 minutes in natural settings improves markers of mental health — including mood and stress — with larger benefits for longer doses of time outside. A broad review on nature and health reports that regular contact with green and blue spaces is associated with: Better mental health and reduced stress Improved cognitive function and attention Higher levels of physical activity Better sleep quality Experimental work using brain imaging has also shown that short visits to green spaces can boost positive affect and change patterns of brain activation in ways consistent with reduced rumination and improved emotional regulation, the opposite of what many people experience after long periods of doomscrolling. Diamond’s camp experience maps directly onto these findings: after even a weekend of tech-free outdoor time, he sees kids and adults become more patient, more playful and more able to tolerate “boredom”: a key ingredient for real focus and creativity. Offline.now integrates this into its digital balance approach by treating offline, outdoor experiences as a core intervention, not a reward you earn after perfect screen behavior. Instead of asking, “How can I use my phone less?” the question becomes, “What can I do offline that naturally displaces my screen time?” “You don’t have to move to the woods,” Diamond says. “Two days of walks, parks, backyard projects, or local trails can do more for your brain than seven days of white-knuckling your way through a ‘detox’ while you stay indoors thinking about your phone.” For journalists covering digital wellness, mental health, or lifestyle resets, this story connects the dots between nature research, digital fatigue, and why a simple 48-hour outdoor reset might be more realistic and more powerful than yet another all-or-nothing break from apps. Featured Expert Mark Diamond – Personal Development Coach and longtime director of a tech-free outdoor camp. He specializes in outdoor wellness, sustainable behavior change, and helping families and individuals swap abstract “detox” goals for concrete, nature-based experiences that restore mood, focus and connection. Expert interviews can be arranged through the Offline.now media team.

Playing "Ketchup": Kraft Heinz, Food Industry Work to Meet Evolving Consumer Trends

In September, the Kraft Heinz Company revealed its intention to split into two smaller entities—one focused on in-demand products, like shelf-stable meals, spreads and sauces, and the other on slower-growth businesses, such as the Oscar Mayer, Kraft Singles and Lunchables brands. The move is among the latest in a series of breakups and spinoffs announced by major "Big Food" conglomerates, including Kellogg's, Keurig Dr Pepper Inc. and Unilever, and experts speculate more divvying and downsizing are bound to follow. Beth Vallen, PhD, a professor in the Villanova School of Business who studies consumer behavior and food marketing, contends these demergers and restructurings are the direct result of a recent yet significant shift in shoppers' spending habits. "It is certainly a possibility that we are moving away from 'Big Food,'" says Dr. Vallen. "The companies are likely to be more agile as smaller entities, and the more targeted businesses will allow them to focus on their different market segments as we face increasingly complex consumer and macro trends in the food industry." Among the more noteworthy factors the professor cites are changes in how shoppers evaluate products and how often they make purchases, particularly amid rising costs, economic pressures and increased competition in the marketplace. When it comes to groceries, a LendingTree survey from earlier this year found that nearly nine in 10 Americans are reassessing what items they cart to the checkout lane. "Inflation and uncertainty have driven consumers to look for more value when they shop," says Dr. Vallen. "This might result in behaviors like switching to lower-cost alternatives, and along these lines, consumers are seeking out retailers with high-quality store brand offerings that might replace their typical, branded items. "Consumers are also shopping less frequently. This could be due to reliance on technology, like online grocery purchases, which requires more planning, as well as a desire to make groceries stretch between purchases to save money." Another development affecting the industry is a broader drive across the population toward health-conscious options and low-calorie meals, heightened to a degree by the rise of GLP-1 drugs like Ozempic. A recent KFF Health Tracking Poll evidences that these medications, which have been shown to promote weight loss, are taken by roughly one in eight American adults; and households with users are expected to account for more than a third of food and beverage sales by 2030. According to Rebecca Shenkman, MPH, RDN, LDN, the director of the MacDonald Center for Nutrition Education and Research at Villanova's M. Louise Fitzpatrick College of Nursing, the impact of these drugs' usage on consumers' eating habits should not be underestimated. "GLP-1 receptor agonists reduce appetite and food intake through multiple mechanisms, and evidence suggests both a reduction in snacking frequency and a shift toward healthier choices among users," shares Shenkman. "They report fewer cravings for sweet, salty and fatty snacks, particularly during the first 12 to 24 weeks of treatment. In addition, consumer surveys and clinical trials indicate increased intake of fruits, vegetables and water, and decreased consumption of processed foods and sugary beverages. "With millions of users and average daily reductions of 700 to 900 calories, demand for calorie-dense snacks could decline significantly." Among the brands and businesses at greatest risk, in Dr. Vallen and Shenkman's respective estimations, are "packaged and processed foods" as well as "sugary beverages and high-fat treats." In turn, with shoppers increasingly moving away from these "unhealthy" options and expressing an openness to dispensing with long-term staples, companies in the sector will need to emphasize adaptability in the coming years, making a conscious effort to understand customers' distinct preferences and needs. "Altogether, there are numerous trends that are seemingly pulling consumers in different directions—between health, taste, value and convenience," concludes Dr. Vallen. "Looking ahead, it will be important for firms to understand how these trends impact different consumers—and in different categories. Health likely means something different to Gen X and Gen Z and may vary further based on whether we are talking about a family dinner or a late-night treat. Taking efforts to understand consumer motivations will be crucial for companies to appropriately respond to current trends."

Tinsel, Tears, and Turkey: How Seniors Really Feel About the Holidays

Ah, the holidays. That magical season when cinnamon fills the air, grandkids are glued to their phones, and you're wondering if it's too early to spike the eggnog. (Answer: it's 5 o'clock somewhere, and that somewhere is your kitchen.) For many older adults, the season is a cocktail of nostalgia, joy, and melancholy—served in a glass rimmed with memories of when the house was full, and the turkey wasn't store-bought. Dealing With The Ghosts of Christmas Past The holidays used to mean full houses, laughter echoing off the walls, and more food than a Costco freezer aisle. Now? Smaller gatherings, missing faces, and a nagging feeling that you're somehow in the way at your own celebration. There's a certain ache that comes with the holidays as we age. It's not just arthritis—it's memory. The people who made our holidays special might no longer be around, and while their photos still grace the mantle, their absence can hit harder than a fruitcake to the forehead. It's the quiet that gets you. The stillness of a home that used to hum with chaos. The microwave hums where the oven once sang. The Christmas card list has ghosted us—literally—replaced by e-cards that can't be hung on the fridge or hugged. And yet, despite the ache, many seniors keep the traditions alive. They polish the silver, bake the cookies, and set the table—because ritual matters. It's a way to say, I'm still here, and this still matters. Loneliness: The Fear No One Talks About Let's name the holiday elephant in the room. Yes, it turns out that one really is the loneliest number. It's that heavy feeling that sneaks in right around the time commercials start showing perfect families in matching pajamas (who, let's be honest, probably fought about those pajamas in the parking lot). The numbers tell a sobering story: A report by the National Institute on Ageing, finds that as many as 41 per cent of Canadians aged 50 years and older are at risk of social isolation and up to 58 per cent have experienced loneliness before. The holidays often bring additional pressure for many.  It's important to note, you don't have to live alone to feel lonely.  Seniors often fear being forgotten—left out of the group chat, the dinner invite, or even the conversation at dinner. Some feel like a burden, convinced their presence is more "obligation" than "invitation." That fear of irrelevance can creep up faster than fruitcake at a church bake sale. The internal dialogue doesn't help: "They're busy." "They have their own lives." "I don't want to be a bother." But here's the truth: you're not a bother. You're the keeper of stories, the family's living archive, and—let's face it—the only one who actually knows how to carve a turkey without creating a crime scene. The health stakes are real: According to a 2023 research report from the U.S. Surgeon General, loneliness and social isolation have a profound effect on mortality, equal to smoking 15 cigarettes per day. That’s more impact than obesity or sedentary lifestyles. It's associated with increased risk of heart disease, stroke, dementia, depression, and anxiety. This isn't just about feeling blue; it's about actual health outcomes. When Depression Wears a Santa Hat Holiday depression doesn't always look like tears and tissues. Sometimes it's withdrawing from events, skipping meals, or not bothering to decorate. It's saying "I'm fine" with a smile that doesn't reach your eyes. A prominent research study of seniors in the UK over a 12-year period published in The Lancet,  confirms what many seniors experience: loneliness is a significant predictor of depression in older adults. The study found that higher loneliness scores were consistently associated with increased depression severity. The relationship works both ways—people with mental health conditions are more than twice as likely to experience loneliness. It can also show up physically—fatigue, poor sleep, or that vague feeling that something's just... off. The sparkle of the season fades under the weight of grief, change, or just the exhausting pressure to be merry when you're not feeling it. A few sad moments are natural. We all get a little misty when "White Christmas" plays for the 47th time. But if the blues linger past Boxing Day, it might be time for a gentle check-in—with a friend, a doctor, or someone who actually listens (not just nods while scrolling). Remember: asking for help isn't a weakness. It's wisdom. And honestly? It's badass. The Magic of Rituals and Traditions For seniors, traditions aren't just habits—they're anchors. The same decorations, the favorite songs, the "don't touch that, it's Grandma's angel" moment that happens every. Single. Year. Research shows that rituals and traditions provide crucial psychological benefits for older adults, including a sense of stability, purpose, and belonging. They offer structure and comfort during challenging times, helping seniors feel grounded and connected to their roots. Studies have found that maintaining traditions contributes to overall mental well-being and can even reduce symptoms of anxiety and depression.  These rituals offer stability in a world that keeps changing at warp speed (seriously, when did voice-activated ornaments become a thing?). But when traditions fade—when no one asks for the shortbread recipe or the ornaments stay boxed—it can feel like being erased in real time. So here's the trick: Evolve the traditions. Pass the torch, not the guilt. Let the grandkids lead carols (even if they insist on adding Mariah Carey). Use the good china. Pull out the silverware stored in the wooden case under the china cabinet that hasn't been opened since 1987. Keep the spirit alive, even if it looks different now. How Seniors Can Create a Joyful Holiday (Yes, Really!) Reach Out First: Don't wait for others to make the first move. Call, text, or—even better—show up with cookies. People are often grateful for the invitation but also afraid to impose. Be the one who breaks the ice. Host a Mini Gathering: Even if it's just tea with a neighbor, connection is the best seasoning of all. Bonus: smaller gatherings mean less cleanup and more actual conversation. Volunteer: Nothing lifts the spirit like helping someone else. Food banks, shelters, and local schools welcome extra hands. Plus, it's a great reminder that you're still needed—and you are. Laugh on Purpose: Watch old comedies. Tell those same stories (again). Laughter really is medicine—no prescription, no co-pay required. Decorate Anyway: Even if no one's visiting, do it for you. Light up your space, and your mood might just follow. And if the neighbors think you're overdoing it? Even better. What Families Can Do (Besides Show Up Hungry) Here's your holiday homework, families: Visit More, Scroll Less. You can't hug over FaceTime. And honestly, Grandma's WiFi probably can't handle it anyway. Listen Like It's a Gift. Because it is. Let seniors share their stories without rushing them or checking your phone. They're not just repeating themselves—they're reliving joy. (And yes, you've heard it before. Listen again.) Include Them in the Chaos. Let Grandma wrap presents, Grandpa set the playlist, or Aunt Sue take charge of... okay, maybe not the gravy. But give them a role. Purpose is the best present. Check In Regularly. A quick "thinking of you" text can mean more than an expensive gift. Though, to be fair, both are nice. Respect Their Pace. Big gatherings can be overwhelming. Sometimes small and meaningful beats loud and crowded. Not everyone wants to do the Macarena at Christmas dinner. (Looking at you, Uncle Bob.) Remember: the greatest present you can give an older adult is presence—yours. The Importance of Joy (and How to Find It Again) Joy doesn't always come in grand gestures. Sometimes it's hiding in the small stuff: • The smell of pine needles • The first snowflake (before it turns into gray slush) • That old ornament you swore you'd throw out • The laughter of family—even if it's at your expense Joy isn't found lying around like loose change. It's made. Sometimes it's coaxed out with a memory, a song, or a well-timed bad joke about Aunt Sue's lumpy gravy. And if all else fails, remember this: you've survived decades of holidays. Burnt turkeys. Broken ornaments. That unfortunate incident with the glue gun in 2003. You've earned the right to laugh through the tears and dance in your slippers if you damn well feel like it. The Real Gift The holidays remind us that connection—not perfection—is the true magic. For seniors, it's about being seen, heard, and loved. For families, it's about showing up, listening, and laughing together. Because one day, those elders' stories will become yours. And you'll want someone to care enough to hear them, too. So let's make this season count. Let's call more, visit more, and laugh more. Let's honor the past while making new memories. And let's remember that the best traditions aren't the ones that stay the same—they're the ones that adapt, evolve, and keep bringing us together. Now pass the eggnog. The spiked kind. Let's All Sit Under the Mistletoe and Sing the Retired Remix of "Jingle Bells" (To the tune of "Jingle Bells") Dashing through the snow, With a walker all in tow, To the mall we go, Moving nice and slow! Family's out of sight, Texting through the night, Oh, what fun it is to Zoom My grandkids once a night—hey! Chorus: Jingle bells, jingle bells, jingle all the way, Oh, what fun it is to chat With friends who won't delay—hey! Jingle bells, jingle bells, laughter saves the day, Lonely hearts can still feel joy— If love just finds a way. Happy holidays, everyone. May your turkey be moist, your family be present, and your eggnog be strong. Want more insights like this? Subscribe to my free newsletter here, where I share practical strategies, real-world stories, and straight talk about navigating retirement with confidence—not confusion. Plus, all subscribers get exclusive early access to advance chapters from my upcoming book. For Canadians 55+: Get actionable advice on making your home equity work for you, understanding your options, and living retirement on your terms. For Mortgage Brokers and Financial Professionals: Learn how to become the trusted advisor your 55+ clients—it's your opportunity to build lasting relationships in Canada's fastest-growing demographic. Sue Don’t Retire…Re-Wire! References & Resources for You or a Loved One On Loneliness and Social Isolation: • U.S. Surgeon General. (2023). Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General's Advisory on the Healing Effects of Social Connection and Community. https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdf • Medicare FAQ. (2024). Loneliness in Seniors Statistics: Combating Social Isolation. https://www.medicarefaq.com/blog/senior-loneliness-statistics/ • Mayo Clinic. (2023). Loneliness and Social Isolation Through the Holidays. https://newsnetwork.mayoclinic.org/discussion/loneliness-and-social-isolation-through-the-holidays/ On Depression and Mental Health: • Kok, R.M., & Reynolds, C.F. (2020). The association between loneliness and depressive symptoms among adults aged 50 years and older: A 12-year population-based cohort study. The Lancet Psychiatry. https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30383-7/fulltext • Cigna. (2021). The Loneliness Epidemic Persists: A Post-Pandemic Look at the State of Loneliness Among U.S. Adults. On Traditions and Rituals: • Oregon Counseling. Why Traditions Matter to Mental Health. https://oregoncounseling.com/article/why-traditions-matter-to-mental-health/ • Care365. Maintaining Traditions with Seniors. https://www.care365.care/resources/maintaining-traditions-with-seniors Additional Support: • National Council on Aging. Four Steps to Combat Loneliness in Seniors During the Holidays. https://www.ncoa.org/article/four-steps-to-combat-loneliness-in-seniors-during-the-holiday-and-beyond/ Emergency Services If the situation is urgent or someone is in immediate danger: Call 911. Canada Suicide Prevention Service (CSPS) • Call: 1-833-456-4566 (available nationwide, 24/7) • Text: 45645 (evenings) • Chat: available at 988.ca

Built-In Backup System Helps Muscles Counteract Fatigue

When you're running up stairs or out on a jog, your muscles eventually start to feel heavy and weak. That's fatigue setting in, a sign that the muscles’ energy reserves are becoming depleted. But a team of researchers led by Rensselaer Polytechnic Institute (RPI) biology professor Doug Swank, Ph.D., have discovered something surprising: certain muscle fibers have a built-in backup system that fights back against fatigue, potentially helping us keep going when we'd otherwise have to stop. The secret lies in a phenomenon called "stretch activation": when a muscle is stretched just before it contracts, it can produce a short burst of extra force. Stretch activation has been studied extensively in the context of insect flight muscle and heart muscle contraction in mammals, but its effects have long been assumed to be physiologically irrelevant for the big skeletal muscles we use for day-to-day activities like walking around. The new study, published in the Journal of General Physiology, shows that assumption was wrong, at least when it comes to certain fast-twitch muscle fibers used to produce quick, powerful movements. “For decades, stretch activation in skeletal muscle was considered physiologically insignificant because it contributes a relatively small amount of force under normal conditions," Swank said. "But we realized no one had tested what happens during fatigue, when the chemical environment inside muscle fibers changes significantly." The researchers tested individual muscle fibers from mice under three conditions: normal, early fatigue (with chemical changes that mimic the state of tired muscles), and severe fatigue. They found that while the fibers' normal force production dropped dramatically as expected, in certain fibers the stretch-activated force stayed the same or even increased. In the most fatigued state, stretch activation contributed up to 30% of the total force these fast-twitch fibers were generating. “What was dismissed as too small to matter may actually be an important fatigue-fighting mechanism that's been hiding in plain sight,” Swank said. The effect was specific to fast-twitch fibers, which are used to generate rapid, powerful movements like sprinting and jumping. Slow-twitch fibers, which are used during endurance tasks like long-distance running or cycling, are more fatigue-resistant to begin with, and showed almost no stretch activation response. Understanding how muscles naturally combat fatigue could eventually inform strategies for improving strength and endurance, whether for athletes, people with muscular disorders, or patients recovering from injury. Swank and his colleagues are following up on their findings by conducting more detailed explorations of how stretch activation contributes to force generation in both low-intensity and high-intensity exercise. The research is funded by a five-year, $2.7 million National Institutes of Health grant to Professor Swank.

Stress-Free Holiday Gatherings Made Simple

Holiday gatherings often bring a mix of joy and challenges, especially when navigating complex family dynamics. Anticipating potential hurdles, such as sensitive topics or interpersonal tensions, can help family members approach these events with confidence and clarity. Baylor University communication expert Allison M. Alford, Ph.D., researches adult daughtering, invisible labor and family relationships and emphasizes the importance of preparation to ensure a more relaxed and enjoyable experience for everyone over the holidays. She shares five practical tips to help families navigate the holidays with ease: Dr. Allison Alford’s Five Family Tips for a Stress-free Holiday 1.Work out known hurdles before you arrive to the holiday event. Family dynamics often have predictable friction points – whether it’s a difference in political views, sibling rivalries or unresolved conflicts. Identify these hurdles in advance and decide how to approach them. “For instance, if you anticipate a certain topic will come up, plan a calm response or rehearse setting a boundary,” Alford said. “If you’re traveling with a partner or children, discuss how you’ll handle challenging moments as a team. The goal is to minimize surprises and feel equipped to manage potential stressors.” 2.Come prepared with a list of topics you’re ready and willing to talk about (and off-limits subjects, too!). Having a mental (or physical!) list of neutral or positive conversation topics can keep the mood light and engaging, Alford said. “Think about shared hobbies, family memories or recent accomplishments,” she said. “At the same time, identify subjects that are off-limits for you – like contentious debates or sensitive personal matters – and practice polite ways to redirect or deflect those conversations. For example, you could say, ‘I’d rather not get into that today. Tell me about your new garden!’ Preparation is key to feeling in control of the dialogue.” 3.Set a mantra for your intention. Repeat often. Alford suggests anchoring yourself with a phrase or saying that aligns with your values and goals for the event. For example, “I will stay calm and kind,” or “I am here to connect, not to control.” Repeat this mantra to yourself whenever you feel stress creeping in. “It acts as a mental reset and helps you respond intentionally rather than react impulsively. Over time, this practice can shift your mindset and create a buffer against family tension,” Alford said. View her profile 4.Take breaks when you feel things going off the rails. Recognizing when you’re overwhelmed is a vital skill. If emotions are running high, excuse yourself for a breather. A short walk, stepping outside for fresh air, or even taking an extended “bathroom break” can provide the time you need to decompress and regroup. “Use this break to practice deep breathing, text a supportive friend or simply enjoy a few moments of solitude. Returning with a clearer head can prevent escalation and help you maintain your composure,” Alford said. 5.Stand up for your needs. Don’t abandon yourself! While family gatherings often involve compromise, Alford said it’s important not to sacrifice your emotional well-being. If a situation feels uncomfortable or hurtful, express your needs calmly but firmly, she said. For example, “I feel uncomfortable when this is discussed. Let’s talk about something else.” “Prioritize your mental health and remember that it’s okay to say no, step away or leave early if necessary. Standing up for yourself sends a clear message that your feelings matter and reinforces healthy boundaries,” Alford said. By addressing known hurdles in advance, curating conversation topics, setting personal intentions and taking mindful breaks when needed, Alford said family members can create a buffer against tension and foster meaningful connections. “At the same time, standing up for your needs and setting boundaries helps preserve your emotional well-being,” she said. “With these strategies, you’ll be better equipped to approach holiday events with confidence and calm.”

AI Can’t Replace Therapists – But It Can Help Them

For a young adult who is lonely or just needs someone to talk to, an artificial intelligence chatbot can feel like a nonjudgmental best friend, offering encouragement before an interview or consolation after a breakup. AI’s advice seems sincere, thoughtful and even empathic – in short, very human. But when a vulnerable person alludes to thoughts of suicide, AI is not the answer. Not by itself, at least. Recent stories have documented the heartbreak of people dying by suicide after seeking help from chatbots rather than fellow humans. In this way, the ethos of the digital world – sometimes characterized as “move fast and break things” – clashes with the health practitioners’ oath to “first, do no harm.” When humans are being harmed, things must change. As a researcher and licensed therapist with a background in computer science, I am interested in the intersection between technology and mental health, and I understand the technological foundations of AI. When I directed a counseling clinic, I sat with people in their most vulnerable moments. These experiences prompt me to consider the rise of therapy chatbots through both a technical and clinical lens. AI, no matter how advanced, lacks the morality, responsibility and duty of care that humans carry. When someone has suicidal thoughts, they need human professionals to help. With years of training before we are licensed, we have specific ethical protocols to follow when a person reveals thoughts of suicide. Read the full article from US News & World Report here

Navigating Grief During the Holiday Season

The holiday season is a time of joy, togetherness and celebration, but for many – especially those who are grieving the death of a loved one or a deep loss – it can bring a complex mix of emotions, ranging from sadness and sorrow to gratitude and joy. Baylor University professors Candi Cann, Ph.D., a death scholar and associate professor of religion in the Honors College, and Jo-Ann Tsang, Ph.D., a leading gratitude researcher and associate professor of psychology, offer four strategies for people experiencing difficult emotions and grief during the holidays. Embrace the spectrum of emotions Both Tsang and Cann say the key to maintaining balance and authenticity – even while deep in grief – is understanding and accepting where you are emotionally. “It’s possible and normal to feel different emotions at one time,” Tsang said. “You can feel happiness during the holidays, but also sad that you miss someone who you wish were present. Being grateful does not rule out feeling other emotions; we can cultivate gratitude, but that does not necessitate running away from other emotions.” Cann pointed out that grief can be complicated if the death or loss is from a difficult relationship. “It is okay to feel relief in addition to grief and it is important to validate all of your feelings – it’s a complicated grief because it was a complicated relationship,” Cann said. The importance of self-care Self-care is vital during this time, Cann said. She encourages grieving people to stay active, eat healthy, go outside to be in nature and get enough sleep. “It’s totally normal to need more sleep when you're depressed and grieving. You just have to be gracious with yourself about that,” Cann said. Allowing ourselves to feel emotions like stress, sadness or grief gives us insight into what we value and “can motivate us to take some time for self-care,” Tsang said. Acknowledging that we are stressed might lead us to reach out to others for help with tasks that overwhelm us or to let go of things to reduce stress. In addition to taking care of your physical health, staying engaged in your community or church and being in community with others is beneficial for mental health, Cann said. But at the same time, be honest with yourself about what you want to do and only accept invitations or participate in activities that you feel you can handle, she added. The place of gratitude Tsang suggests approaching challenging emotions with gratitude as it “might also provide context and perspective for our loss and potentially transform our negative emotions.” “As an example, I might feel frustrated that I am sad but then feel grateful that I have good family and neighbors to check on me and coworkers to help me finish the tasks that I can’t do while I’m down,” Tsang said. “This gratitude might help reduce my frustration by helping me see the support that is present in my life, on which I had not previously reflected.” At the same time, she reiterated that, in addition to cultivating gratitude, it’s important for people to permit themselves to experience negative emotions such as grief and sadness in response to life circumstances. “It’s okay if it’s hard to experience gratitude. God meets us where we are,” Tsang said. Evaluate traditions and embrace memories Cann suggests evaluating family traditions, choosing those that are most important to continue and starting new traditions that include their loved one. “A lot of people feel like when that person is gone, the love is gone too, but the love is still there,” Cann said. “You wouldn't feel the grief or the big hole that you now have if you didn't have all of this love in the first place.” She suggests embracing their loved one’s presence by including a place at the table for Christmas dinner, making their favorite recipe or finding other ways to continue the bonds. By doing these things, “you're including them in your conversation, and you're making space for that person, both literally and symbolically,” Cann said. Supporting someone who is grieving Being supportive of someone grieving requires patience and vulnerability. “Engage with the person and ask how you can best support them, and let them know that you are thinking about them during this time,” Cann said. Sometimes, friends or family members don’t want to bring up death during the holidays because they don't want to make people sad at a joyful time. “But the point is, they already are sad, so bringing it up allows them to express it” and feel accepted in their pain, Cann said. It also is important to remember that not all grief is related to death. There are many types of loss that people experience such as divorce or disease. The Baylor researchers note that we can’t decide or predict what defines another person's grief, but we can offer love and support. Approaching the holidays when experiencing grief over a death or a deep loss may be painful at first, but using these strategies can help us face the future by celebrating with gratitude what we had in the past. Ultimately, the holidays are a time for reflection, connection and self-compassion. Allow yourself to feel your emotions fully – whether joyful, challenging or a mix of both – and use them as guides for meaningful action. Looking to know more or arrange an interview? Simply click on the expert's icon below or contact: Shelby Cefaratti-Bertin today.

National Cancer Institute Renews Wistar—ChristianaCare Cancer Center Support Grant with Exceptional Score

The National Cancer Institute (NCI) has renewed the Cancer Center Support Grant (CCSG) for The Wistar Institute and ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, awarding $16.3 million over the next five years. The renewal received an “exceptional” rating — the highest possible — recognizing the strength and impact of a partnership that combines world-class basic science with leading community-based cancer care. A One-of-a-Kind National Model This collaboration is the only one of its kind in the nation, joining Wistar, an NCI-Designated Basic Cancer Center, with ChristianaCare, one of the country’s premier academic community cancer centers and a National Cancer Institute Community Oncology Research Program. Together, they focus on driving advances against some of the most challenging cancers, including pancreatic, melanoma, breast, lung and ovarian cancers. The grant supports shared infrastructure, scientific resources and programs that enable researchers and clinicians to work seamlessly across both institutions. By connecting laboratory breakthroughs at Wistar with ChristianaCare’s ability to rapidly apply new approaches in a diverse patient population, the partnership accelerates the path from discovery to care. NCI highlighted the collaboration’s effectiveness, noting that “the ongoing alliance with the Helen F. Graham Cancer Center & Research Institute is where most clinical translation into active oncology trials is occurring, supported by productive collaboration between Wistar investigators and Graham Cancer Center oncologists.” Impact on Patients and Community “At ChristianaCare, we are committed to bringing innovation directly to the people we serve. Our collaboration with Wistar connects the best of basic science with the realities of patient care,” said Thomas Schwaab, M.D., Ph.D., Bank of America Endowed Medical Director of the Helen F. Graham Cancer Center & Research Institute. “The NCI’s exceptional score recognizes the promise of this work and the progress we are making together. It is a powerful affirmation that our patients are benefiting from research at the highest level.” “This renewal from the NCI is proof that we are building a model for how cancer research and community care can come together,” said Nicholas J. Petrelli, M.D., director of the Cawley Center for Translational Cancer Research at the Helen F. Graham Cancer Center & Research Institute and associate director of Translational Research at The Wistar Institute Cancer Center. “Through our partnership with Wistar, patients in Delaware and beyond are gaining access to cutting-edge research and therapies for some of the toughest cancers we face.” Dario Altieri, M.D., president and CEO of The Wistar Institute and director of its Ellen and Ronald Caplan Cancer Center, added: “An exceptional rating from the NCI is a reflection of the scientific excellence and real-world impact of this partnership. What makes this collaboration unique is its ability to take discoveries in areas such as melanoma and ovarian cancer and bring them rapidly into clinical practice through ChristianaCare.” NCI underscored the alliance’s reach, noting that “the partnership with the Graham Cancer Center brought cutting-edge cancer research to the community and advanced groundbreaking discoveries to first-in-human oncology clinical trials.” A Pipeline of Research Advancing Faster Than Ever Research achievements supported by the Wistar—ChristianaCare partnership include: Advancing multiple Wistar discoveries into investigator-initiated, first-in-human oncology clinical trials, including studies in pancreatic, melanoma, lung, breast and ovarian cancers. Launching joint research programs across several cancer types, with expanding efforts in cancer risk and population health. Increasing access to high-quality biospecimens — including tumor tissue, biopsies and blood samples — that fuel translational research. Strengthening shared scientific infrastructure supporting immunotherapy research, organoid development, xenograft models and molecular profiling. The Wistar—ChristianaCare partnership, established in 2011, has grown into a nationally recognized alliance that bridges science and medicine. With this CCSG renewal, the collaboration will expand research in pancreatic, melanoma, breast, lung and ovarian cancers and continue advancing prevention, early detection and training programs for the next generation of physician—scientists. The Helen F. Graham Cancer Center & Research Institute depends on grants and community support to keep this work moving forward. To learn more or make a gift, visit Support the Helen F. Graham Cancer Center & Research Institute.