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Farm but no fowl: How Florida aquaculture is growing the economy
Florida’s thriving aquaculture industry is a vital part of the state’s economy, generating more than $165 million in sales annually and supporting jobs across rural and coastal communities. Recognized as agriculture by the Florida Legislature in 1993, aquaculture contributes to food security, environmental sustainability and economic resilience. “Just like terrestrial, land-based agriculture, aquaculture is the process of growing or raising a product,” said Shirley Baker, UF/IFAS professor of aquaculture and associate director of the School of Forest, Fisheries and Geomatics Sciences. “The people who do the work consider themselves farmers. Their products are simply plants and animals grown or raised underwater.” Overseen by the Florida Department of Agriculture & Consumer Services (FDACS), the industry includes an estimated 1,500 varieties of food fish, bait fish, mollusks, aquatic plants, alligators, turtles, crustaceans, amphibians, caviar and ornamental fish. With proper regulatory support, aquaculture can continue to be a driving force in Florida’s economy and environmental stewardship. The hallmark of Florida aquaculture is ornamental, or tropical fish, the saltwater and freshwater species bred for aquariums. In 2023, the sector generated more than $57 million, making the state the country’s top pet fish producer. In fact, 95% of ornamental fish in the United States come from the Sunshine State. About 90% of Florida’s ornamental fish are freshwater varieties. Farmers primarily raise live-bearing species in sterilized earthen ponds dug into loam or bedrock. They fill ponds with sexually mature fish called broodstock and harvest offspring using baited traps. Most egg-laying fish are grown in commercial hatcheries. Like ornamental fish, the demand for farmed seafood has grown as wild-caught sources are increasingly depleted. Globally, more than 50% of all seafood for human consumption is produced through aquaculture. “Seafood is considered one of the most in-demand sources of lean protein in the world, and it has to come from somewhere,” said Matthew DiMaggio, director of the UF/IFAS Tropical Aquaculture Laboratory in Ruskin. “The ocean can't produce any more than it already has, so aquaculture has to make up the deficit.” In Florida, as the number of fish farms and the scale of their operations have grown, the value of food fish sales has skyrocketed. Between 2018 and 2023, sales rose from $4 million to $26 million, a 550% increase. Some of the most common Florida food fish are tilapia, striped bass, cobia, pompano and red drum. They’re housed in various ways. Operations can include fiberglass ponds, vats and tanks inside greenhouses and recirculating systems occupying entire warehouses. Farmers typically start with fingerlings, or juvenile fish, purchased from reputable suppliers. Aquaculture farmers share their experiences Evans Farm of Pierson, Florida, is among the pioneering food fish farms in the state. Originally cattle farmers, the company expanded to sell tilapia, striped bass and caviar harvested from sturgeon. Fish are kept in filtered, recirculating ponds and long tanks known as raceways. They’re transported live to grocery stores and markets in vans outfitted with tanks and filtration systems. “Our fish are thriving, and they’re healthy. We grow them with great water quality, and we feed them excellent food,” said Jane Davis, who owns the business with her mother and brothers. “Although they’re raised in water, they’re no different than other agriculture crops, whether it's cattle, chickens or anything else.” Mollusks are another significant contributor to Florida aquaculture. While the sector includes oysters and scallops, clams are the dominating commodity; in 2023, they brought in $32 million of the state’s $43 million in mollusk sales. Clam farmers generally obtain grain-sized seed clams from hatcheries. The smallest varieties are initially cared for in nursery systems. Once the shells become large enough, they’re transferred to bags submerged off the coast. Cedar Key resident Heath Davis, no relation to Jane Davis, transitioned from fishing to clam farming in the mid-1990s. He and his father, Mike Davis, own Cedar Key Seafarms, one of the state’s leading wholesale clam distributors. “Before, as fishermen, we would go out and place nets wherever we thought the fish were,” Heath Davis said. “But clamming is like farming. We lease a 2-acre, underwater plot from the state and harvest the product from our designated field.” The Florida Aquaculture Plan In November, the Florida Aquaculture Review Council, the official conduit between FDACS and farmers, published the latest revision of the Florida Aquaculture Plan, a detailed list of research and development priorities. Florida’s climate, infrastructure, streamlined regulations and positive business environment have positioned the state to become the national leader in aquaculture, but innovation is required to remain competitive, according to the document. It’s a message Heath Davis echoed. “Aquaculture farming is such a huge part of Florida’s economy,” he said. “It could hold some of the answers needed to sustain the growing number of people living on this peninsula.”
Why 48 Hours Outdoors Does More Than a Week of Scrolling Breaks
When people feel burned out from their phones, the default solution is often a “digital detox”: delete the apps for a week, set a screen-time limit, maybe move social icons off the home screen. Then work, group chats and FOMO pull them right back in. Personal Development Coach Mark Diamond, an expert in the Offline.now directory who ran a tech-free summer camp for 25 years, says the real reset button isn’t a slightly less frantic version of the same life. It’s 48 hours of real-world experience outdoors. “I’ve watched kids and adults go from wired and anxious to relaxed and connected in a matter of days — not because we lectured them about screens, but because they were hiking, cooking over a fire, laughing with friends, actually living,” Diamond says. “Nature gives your nervous system something it can’t get from a feed.” The science backs up what he sees at camp. A large meta-analysis of nature exposure in adults found that as little as 10 minutes in natural settings improves markers of mental health — including mood and stress — with larger benefits for longer doses of time outside. A broad review on nature and health reports that regular contact with green and blue spaces is associated with: Better mental health and reduced stress Improved cognitive function and attention Higher levels of physical activity Better sleep quality Experimental work using brain imaging has also shown that short visits to green spaces can boost positive affect and change patterns of brain activation in ways consistent with reduced rumination and improved emotional regulation, the opposite of what many people experience after long periods of doomscrolling. Diamond’s camp experience maps directly onto these findings: after even a weekend of tech-free outdoor time, he sees kids and adults become more patient, more playful and more able to tolerate “boredom”: a key ingredient for real focus and creativity. Offline.now integrates this into its digital balance approach by treating offline, outdoor experiences as a core intervention, not a reward you earn after perfect screen behavior. Instead of asking, “How can I use my phone less?” the question becomes, “What can I do offline that naturally displaces my screen time?” “You don’t have to move to the woods,” Diamond says. “Two days of walks, parks, backyard projects, or local trails can do more for your brain than seven days of white-knuckling your way through a ‘detox’ while you stay indoors thinking about your phone.” For journalists covering digital wellness, mental health, or lifestyle resets, this story connects the dots between nature research, digital fatigue, and why a simple 48-hour outdoor reset might be more realistic and more powerful than yet another all-or-nothing break from apps. Featured Expert Mark Diamond – Personal Development Coach and longtime director of a tech-free outdoor camp. He specializes in outdoor wellness, sustainable behavior change, and helping families and individuals swap abstract “detox” goals for concrete, nature-based experiences that restore mood, focus and connection. Expert interviews can be arranged through the Offline.now media team.
Playing "Ketchup": Kraft Heinz, Food Industry Work to Meet Evolving Consumer Trends
In September, the Kraft Heinz Company revealed its intention to split into two smaller entities—one focused on in-demand products, like shelf-stable meals, spreads and sauces, and the other on slower-growth businesses, such as the Oscar Mayer, Kraft Singles and Lunchables brands. The move is among the latest in a series of breakups and spinoffs announced by major "Big Food" conglomerates, including Kellogg's, Keurig Dr Pepper Inc. and Unilever, and experts speculate more divvying and downsizing are bound to follow. Beth Vallen, PhD, a professor in the Villanova School of Business who studies consumer behavior and food marketing, contends these demergers and restructurings are the direct result of a recent yet significant shift in shoppers' spending habits. "It is certainly a possibility that we are moving away from 'Big Food,'" says Dr. Vallen. "The companies are likely to be more agile as smaller entities, and the more targeted businesses will allow them to focus on their different market segments as we face increasingly complex consumer and macro trends in the food industry." Among the more noteworthy factors the professor cites are changes in how shoppers evaluate products and how often they make purchases, particularly amid rising costs, economic pressures and increased competition in the marketplace. When it comes to groceries, a LendingTree survey from earlier this year found that nearly nine in 10 Americans are reassessing what items they cart to the checkout lane. "Inflation and uncertainty have driven consumers to look for more value when they shop," says Dr. Vallen. "This might result in behaviors like switching to lower-cost alternatives, and along these lines, consumers are seeking out retailers with high-quality store brand offerings that might replace their typical, branded items. "Consumers are also shopping less frequently. This could be due to reliance on technology, like online grocery purchases, which requires more planning, as well as a desire to make groceries stretch between purchases to save money." Another development affecting the industry is a broader drive across the population toward health-conscious options and low-calorie meals, heightened to a degree by the rise of GLP-1 drugs like Ozempic. A recent KFF Health Tracking Poll evidences that these medications, which have been shown to promote weight loss, are taken by roughly one in eight American adults; and households with users are expected to account for more than a third of food and beverage sales by 2030. According to Rebecca Shenkman, MPH, RDN, LDN, the director of the MacDonald Center for Nutrition Education and Research at Villanova's M. Louise Fitzpatrick College of Nursing, the impact of these drugs' usage on consumers' eating habits should not be underestimated. "GLP-1 receptor agonists reduce appetite and food intake through multiple mechanisms, and evidence suggests both a reduction in snacking frequency and a shift toward healthier choices among users," shares Shenkman. "They report fewer cravings for sweet, salty and fatty snacks, particularly during the first 12 to 24 weeks of treatment. In addition, consumer surveys and clinical trials indicate increased intake of fruits, vegetables and water, and decreased consumption of processed foods and sugary beverages. "With millions of users and average daily reductions of 700 to 900 calories, demand for calorie-dense snacks could decline significantly." Among the brands and businesses at greatest risk, in Dr. Vallen and Shenkman's respective estimations, are "packaged and processed foods" as well as "sugary beverages and high-fat treats." In turn, with shoppers increasingly moving away from these "unhealthy" options and expressing an openness to dispensing with long-term staples, companies in the sector will need to emphasize adaptability in the coming years, making a conscious effort to understand customers' distinct preferences and needs. "Altogether, there are numerous trends that are seemingly pulling consumers in different directions—between health, taste, value and convenience," concludes Dr. Vallen. "Looking ahead, it will be important for firms to understand how these trends impact different consumers—and in different categories. Health likely means something different to Gen X and Gen Z and may vary further based on whether we are talking about a family dinner or a late-night treat. Taking efforts to understand consumer motivations will be crucial for companies to appropriately respond to current trends."
School’s Out, Screens Are In: Why Your Kids Copy Your Phone Habits on Winter Break
When the bell rings for winter break, most parents worry their kids will “disappear into their phones.” What often goes unmentioned? The adults usually disappear into theirs first. New behavioral data from Offline.now, the digital wellness platform founded by author Eli Singer, shows we now spend about 10 of our 16 waking hours on screens, roughly 63% of our day. Kids off school are simply mirroring the digital norms they see at home. Executive Function Coach and child development specialist Craig Selinger says winter break is less a test of kids’ willpower and more a test of family norms: “If you want behavior change in kids, start with the parent model. A 12-year-old will not put their phone away at dinner if their parents won’t.” Selinger points to what he calls the “mobility problem”: what used to be a TV in the living room is now a device in your child’s pocket. “Mobility makes tech sticky - there’s no natural ‘show’s over’ when Minecraft and TikTok never end.” Offline.now’s experts note that high, especially late screen use is tied to disrupted sleep and next-day behavior in children and teens, exactly when parents say, “They’re monsters over break.” Selinger’s work with families suggests the answer isn’t banning devices outright, but changing what kids see adults do with theirs. When parents put phones in a basket at meals, leave devices out of bedrooms, and actually join “old school” activities: cooking, board games, hands-on hobbies, kids’ attention and confidence start to rebound: “Micro-independence beats micromanagement. If you engineer small wins off-screen - a 20-minute task kids can complete without their phone - you rebuild their real-world confidence one brick at a time.” Key message for journalists: Over winter break, the real story isn’t just “kids are on their phones all day.” It’s that adult behavior quietly sets the ceiling on what’s realistic for children. The most effective “screen-time rule” is the one parents are willing to follow themselves. Featured Expert Craig Selinger, M.S., CCC-SLP - Executive Function Coach and child development specialist (Brooklyn Letters), focused on how kids actually learn and how digital dependency affects attention, writing, family systems, and school success. Expert interview availability can be arranged through Offline.now’s media team.
The National Cancer Institute (NCI) has renewed the Cancer Center Support Grant (CCSG) for The Wistar Institute and ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, awarding $16.3 million over the next five years. The renewal received an “exceptional” rating — the highest possible — recognizing the strength and impact of a partnership that combines world-class basic science with leading community-based cancer care. A One-of-a-Kind National Model This collaboration is the only one of its kind in the nation, joining Wistar, an NCI-Designated Basic Cancer Center, with ChristianaCare, one of the country’s premier academic community cancer centers and a National Cancer Institute Community Oncology Research Program. Together, they focus on driving advances against some of the most challenging cancers, including pancreatic, melanoma, breast, lung and ovarian cancers. The grant supports shared infrastructure, scientific resources and programs that enable researchers and clinicians to work seamlessly across both institutions. By connecting laboratory breakthroughs at Wistar with ChristianaCare’s ability to rapidly apply new approaches in a diverse patient population, the partnership accelerates the path from discovery to care. NCI highlighted the collaboration’s effectiveness, noting that “the ongoing alliance with the Helen F. Graham Cancer Center & Research Institute is where most clinical translation into active oncology trials is occurring, supported by productive collaboration between Wistar investigators and Graham Cancer Center oncologists.” Impact on Patients and Community “At ChristianaCare, we are committed to bringing innovation directly to the people we serve. Our collaboration with Wistar connects the best of basic science with the realities of patient care,” said Thomas Schwaab, M.D., Ph.D., Bank of America Endowed Medical Director of the Helen F. Graham Cancer Center & Research Institute. “The NCI’s exceptional score recognizes the promise of this work and the progress we are making together. It is a powerful affirmation that our patients are benefiting from research at the highest level.” “This renewal from the NCI is proof that we are building a model for how cancer research and community care can come together,” said Nicholas J. Petrelli, M.D., director of the Cawley Center for Translational Cancer Research at the Helen F. Graham Cancer Center & Research Institute and associate director of Translational Research at The Wistar Institute Cancer Center. “Through our partnership with Wistar, patients in Delaware and beyond are gaining access to cutting-edge research and therapies for some of the toughest cancers we face.” Dario Altieri, M.D., president and CEO of The Wistar Institute and director of its Ellen and Ronald Caplan Cancer Center, added: “An exceptional rating from the NCI is a reflection of the scientific excellence and real-world impact of this partnership. What makes this collaboration unique is its ability to take discoveries in areas such as melanoma and ovarian cancer and bring them rapidly into clinical practice through ChristianaCare.” NCI underscored the alliance’s reach, noting that “the partnership with the Graham Cancer Center brought cutting-edge cancer research to the community and advanced groundbreaking discoveries to first-in-human oncology clinical trials.” A Pipeline of Research Advancing Faster Than Ever Research achievements supported by the Wistar—ChristianaCare partnership include: Advancing multiple Wistar discoveries into investigator-initiated, first-in-human oncology clinical trials, including studies in pancreatic, melanoma, lung, breast and ovarian cancers. Launching joint research programs across several cancer types, with expanding efforts in cancer risk and population health. Increasing access to high-quality biospecimens — including tumor tissue, biopsies and blood samples — that fuel translational research. Strengthening shared scientific infrastructure supporting immunotherapy research, organoid development, xenograft models and molecular profiling. The Wistar—ChristianaCare partnership, established in 2011, has grown into a nationally recognized alliance that bridges science and medicine. With this CCSG renewal, the collaboration will expand research in pancreatic, melanoma, breast, lung and ovarian cancers and continue advancing prevention, early detection and training programs for the next generation of physician—scientists. The Helen F. Graham Cancer Center & Research Institute depends on grants and community support to keep this work moving forward. To learn more or make a gift, visit Support the Helen F. Graham Cancer Center & Research Institute.
Violence alters human genomes for generations, researchers discover
In February of 1982, the Syrian government besieged the city of Hama, killing tens of thousands of its own citizens in sectarian violence. Four decades later, rebels used the memory of the massacre to help inspire the toppling of the Assad family that had overseen the operation. But there is another lasting effect of the attack, hidden deep in the genes of Syrian families. The grandchildren of women who were pregnant during the siege — grandchildren who never experienced such violence themselves — nonetheless bear marks of it in their genomes. Passed down through their mothers, this genetic imprint offers the first human evidence of a phenomenon previously documented only in animal models. The genetic transmission of stress across multiple generations. “The idea that trauma and violence can have repercussions into future generations should help people be more empathetic, help policymakers pay more attention to the problem of violence,” said Connie Mulligan, Ph.D., a professor of Anthropology and the Genetics Institute at the University of Florida and co-senior author of the new study. “It could even help explain some of the seemingly unbreakable intergenerational cycles of abuse and poverty and trauma that we see around the world, including in the U.S.” While our genes are not changed by life experiences, they can be tuned through a system known as epigenetics. In response to stress or other events, our cells can add small chemical flags to genes that may quiet them down or alter their behavior. These changes may help us adapt to stressful environments, although the effects aren’t well understood. It is these tell-tale chemical flags that Mulligan and her team were looking for in the genes of Syrian families. While lab experiments have shown that animals can pass along epigenetic signatures of stress to future generations, proving the same in people has been nearly impossible. “Resilience and perseverance is quite possibly a uniquely human trait.” —Connie Mulligan Mulligan worked with Rana Dajani, Ph.D., a molecular biologist at Hashemite University in Jordan and co-senior author, as well as anthropologist Catherine Panter-Brick, Ph.D., of Yale University, to conduct the unique study. Dajani envisioned the research project; because of her intimate knowledge of the Syrian population and its tragic history, she designed the study to cover three generations of Syrian refugees to Jordan. Some families had lived through the Hama attack before fleeing to Jordan. Other families avoided Hama, but lived through the recent civil war against the Assad regime. The team collected samples from grandmothers and mothers who were pregnant during the two conflicts, as well as from their children. This study design meant there were grandmothers, mothers and children who had each experienced violence at different stages of development. A third group of families had immigrated to Jordan before 1980, avoiding the decades of violence in Syria. These early immigrants served as a crucial control to compare to the families who had experienced the stress of civil war. Study coauthor Dima Hamadmad, a Syrian researcher and the daughter of refugees, led the search for families that met the study criteria and collected cheek swabs from 138 people across 48 families. "The participants took part in the research out of love for their children and concern for future generations,” she said. “But more than that, they wanted their stories of trauma to be heard and acknowledged.” Back in Florida, Mulligan’s lab scanned the DNA for epigenetic modifications and looked for any relationship with the families’ experience of violence. In the grandchildren of Hama survivors, the researchers discovered 14 areas in the genome that had been modified in response to the violence their grandmothers experienced. These 14 modifications demonstrate that stress-induced epigenetic changes may indeed appear in future generations in humans, just as they can in animals. The study also uncovered 21 epigenetic sites in the genomes of people who had directly experienced violence in Syria. In a third finding, the researchers reported that people exposed to violence while in their mothers’ wombs showed evidence of accelerated epigenetic aging, a type of biological aging that may be associated with susceptibility to age-related diseases. Most of these epigenetic changes showed the same pattern after exposure to violence, suggesting a kind of common epigenetic response to stress – one that can not only affect people directly exposed to stress, but also future generations. “We think our work is relevant to many forms of violence, not just refugees. Domestic violence, sexual violence, gun violence: all the different kinds of violence we have in the U.S,” said Mulligan. “We should study the effects of violence. We should take it more seriously.” It’s not clear what, if any, effect these epigenetic changes have in the lives of people carrying them inside their genomes. But some studies have found a link between stress-induced epigenetic changes and diseases like diabetes. One famous study of Dutch survivors of famine during World War II suggested that their offspring carried epigenetic changes that increased their odds of being overweight later in life. While many of these modifications likely have no effect, It’s possible that some have functional effects that can affect our health, Mulligan said. The researchers published their findings, which were supported by the National Science Foundation, Feb. 27 in the journal Scientific Reports. While carefully searching for evidence of the lasting effects of war and trauma stamped into our genomes, Mulligan and her collaborators were also struck by the perseverance of the families they worked with. Their story was much bigger than merely surviving war, Mulligan said. “In the midst of all this violence we can still celebrate their extraordinary resilience. They have persevered,” Mulligan said. “That resilience and perseverance is quite possibly a uniquely human trait.”
A Roadmap or a Rift? Examining Trump’s 28-Point Ukraine Peace Proposal
As negotiations around the war in Ukraine continue to dominate global headlines, a newly surfaced 28-point peace proposal associated with former U.S. President Donald Trump has triggered intense debate across NATO capitals, Kyiv, and Moscow. The document — described in reporting by Reuters, Axios, Sky News, Al Jazeera and other outlets — outlines a framework aimed at ending the conflict but includes provisions that many analysts say could significantly reshape Europe’s security landscape. A Plan Built Around Ceasefire, Guarantees, and Reconstruction At its core, the plan calls for a formal ceasefire, a non-aggression pact between Russia, Ukraine, and European states, and a set of “security guarantees” meant to deter future conflict. Reporting indicates that Ukraine would receive assurances that any renewed Russian offensive would trigger a coordinated international response. The plan also proposes the creation of a major reconstruction program — potentially financed in part with frozen Russian assets — to rebuild infrastructure and modernize Ukraine’s economy. The proposal references pathways for deeper Ukrainian integration with Europe, including support for progressing toward EU membership and providing enhanced access to European markets. A large “Ukraine Development Fund” is also mentioned in multiple summaries of the plan. Provisions Driving the Most Global Pushback The most controversial elements relate to Ukraine’s territorial integrity and long-term security posture. Outlets such as Sky News and Al Jazeera report that the draft would recognize Russian control over Crimea and large parts of Donetsk, Luhansk, Zaporizhzhia, and Kherson — areas currently occupied by Russian forces. Ukraine would also be required to formally abandon NATO membership and cap its military at 600,000 personnel. Additional provisions include restrictions on the presence of foreign troops in Ukraine, phased lifting of sanctions on Russia, full amnesty for war-related actions, and the reintegration of Russia into global economic and political structures. These components have drawn sharp responses, particularly from European leaders who argue the plan could reward aggression and undermine international legal norms. Dr. Glen Duerr is a citizen of three countries. He was born in the United Kingdom, moved to Canada as a teenager, and then to the United States to obtain his Ph.D. His teaching and research interests include nationalism and secession, comparative politics, international relations theory, sports and politics, and Christianity and politics. View his profile. What Remains Unclear or Still Under Discussion Reporting from Reuters and AP notes that many sections of the plan remain undefined or are still in flux. The exact mechanism behind the proposed security guarantees is not detailed. Oversight of reconstruction funds, timelines for reintegration of Russia, and the legal handling of frozen assets also require further clarification. Some reporting suggests parts of the plan draw from a prior informal Russian “non-paper,” raising questions about the provenance and intent of specific provisions. Why the Proposal Matters With the war approaching four years of fighting, any formal proposal for ending hostilities carries significant geopolitical weight. Supporters of the plan frame it as a pragmatic attempt to halt loss of life and begin rebuilding. Critics argue it risks legitimizing territorial conquest and weakening the broader post-Cold-War security order. As governments evaluate the implications, journalists covering defense, diplomacy, and international law will find this evolving proposal central to understanding where U.S., European, Russian, and Ukrainian negotiators may — or may not — be willing to go next.
Nandi A. Marshall, DrPH, professor and associate dean for Georgia Southern University’s Jiann-Ping Hsu College of Public Health, has been named president of the American Public Health Association (APHA), the nation’s oldest and largest organization of public health professionals. Marshall began her presidential term on Nov. 5, following a year as president-elect. She will serve a three-year term on APHA’s executive board, including her current presidential year and a subsequent year as immediate past president. With more than two decades of experience in community-engaged public health, Marshall is widely recognized for her leadership in advancing maternal and child health equity, and for her dedication to preparing the next generation of the public health workforce. She holds a bachelor’s in religious studies from Spelman College, a master’s in public health from East Stroudsburg University and a Doctor of Public Health from Georgia Southern. “Dr. Marshall’s appointment to lead APHA is a tremendous national recognition of her contribution to public health — and a reflection of Georgia Southern’s growing impact on the global public health landscape,” said Avinandan Mukherjee, Ph.D., provost and executive vice president for Academic Affairs. “Her commitment to community partnership, workforce development and health equity exemplifies the values we strive to instill in every graduate of our distinctive public health college.” Marshall’s work has centered on bridging lived experience and scientific research to drive equitable health outcomes. “I’m deeply honored to serve as APHA president,” Marshall said. “Public health calls us to listen to communities, honor their wisdom and work together to build the equitable systems that recognize health as a human right. Equity is not an outcome — it’s a commitment. And I’m grateful to continue this work with purpose, courage and love alongside partners across the country.” Founded in 1872, APHA represents more than 25,000 members nationwide, serving as a convener, catalyst and advocate for equitable health and well-being for all. The association connects practitioners, researchers, educators and policymakers to advance evidence-based public health initiatives. Looking to know more about Georgia Southern University or connect with Dr. Marshall — simply contact Georgia Southern's Director of Communications Jennifer Wise at jwise@georgiasouthern.edu to arrange an interview today.
Proteins, often called the building blocks of life, play a central role in drug development. When scientists develop new treatments, they must understand how drugs interact with proteins involved in disease mechanisms and with proteins in the human body that influence drug response. Scientists commonly use cryo-electron microscopy (cryo-EM) 3D imaging data to study proteins. While recent advances have enabled higher-resolution images that are easier to analyze, medium-resolution images—which are more difficult to interpret—are still the most common for larger protein complexes. Salim Sazzed, Ph.D., an assistant professor in the computer science department of Georgia Southern University’s Allen E. Paulson College of Engineering and Computing, has been awarded a two-year National Science Foundation grant of about $175,000 to lead a groundbreaking project to develop novel Artificial Intelligence (AI) techniques for determining protein secondary structures from medium-resolution cryo-electron microscopy (cryo-EM) images. Improved modeling from medium-resolution images will help researchers study more proteins efficiently, giving new insights into diseases and potentially guiding the development of new treatments and future drugs. At its core, this research will combine biology and machine learning to study protein structures. The multidisciplinary approach and potential impacts on public health are what most excite Sazzed. “The impetus behind this research is the positive impact on public health and possibly contributing to the biomedical workforce,” he said. “Seeing biology and computer science combine for that kind of impact is incredibly moving.” As the Principal Investigator (PI) for the project, Sazzed will use his expertise in deep learning computer models to focus on a major challenge in structural biology: identifying the two main secondary structures of proteins—the alpha helix and the beta sheet. These structures are critical for a protein’s overall shape and function, but in medium-resolution cryo-EM images they often appear indistinct or lack clear detail, making them particularly difficult to analyze. Sazzed’s research will focus on two main goals. First, he will quantify the variability of alpha helices and beta sheets in medium-resolution images, comparing them to idealized structures. Second, by integrating this structural variability with the image data in a deep learning model, he will aim to generate more precise and accurate representations of protein secondary structures. “When we feed this information into a deep learning model along with the image data, the model should be able to determine protein secondary structures more precisely,” Sazzed elaborated. Sazzed believes students will greatly benefit from this multi-disciplinary approach. In addition to a Ph.D. student, several undergraduate students will be directly engaged in the research. A full-day workshop will also be organized, allowing Georgia Southern students from diverse disciplines to participate. This initiative will build on Georgia Southern’s strong tradition of involving undergraduates in research and will support the University’s recent focus on biomedical and health sciences. “There are many different knowledge areas coming together in this work,” Sazzed said. “It involves computer science, biology, chemistry, and even public health. I look forward to students following the research and exploring these different fields themselves.” Allen E. Paulson College of Engineering & Computing Interim Associate Dean of Research, Masoud Davari, Ph.D., echoes this sentiment and emphasizes its importance to the University’s research profile. “Sazzed’s interdisciplinary research, which bridges the gap between biology and computer science, will foster multidisciplinary research in our college—as it is cutting-edge and potentially groundbreaking in drug development to impact people’s lives nationally and globally,” Davari said. “It’s also well aligned with the college’s strategic research plan—as we make the move to R1 status to be aligned with ‘Soaring to R1,’ which is among the transformational initiatives for the University.” Looking to know more about Georgia Southern University or connect with Salim Sazzed — simply contact Georgia Southern's Director of Communications Jennifer Wise at jwise@georgiasouthern.edu to arrange an interview today.
The University of Florida’s ‘AI Queen’ is using AI technology to help prevent dementia
To help the 50 million people globally who live with dementia, the National Institute on Aging is finding researchers to develop tech-based breakthroughs that target the disease — researchers like the University of Florida’s “AI Queen.” It’s a fitting nickname for Aprinda Indahlastari Queen, Ph.D., who is applying artificial intelligence technology to study transcranial direct current stimulation, or tDCS — a technique that involves placing electrodes on the scalp to deliver a weak electrical current to the brain — as a possible way to prevent dementia. The assistant professor in the UF College of Public Health and Health Professions’ Department of Clinical and Health Psychology is using UF’s supercomputer, HiPerGator, to perform neuroimaging and machine learning analyses to study how anatomical differences may affect tDCS outcomes. “Investigating working memory in patients with mild cognitive impairment offers an opportunity to understand how cognitive processes are disrupted in the early stages of Alzheimer’s disease,” said Queen, whose study — funded by a National Institute on Aging research career development grant — integrates neuroimaging with information on brain structure that is unique to older adults and those with mild cognitive impairment. Refining the treatment with AI Using neuroimaging, Queen captures real-time changes during tDCS to the parts of the brain associated with working memory, which is the type of memory that allows humans to temporarily keep track of small amounts of information. Think of this as a mental “scratchpad.” Her study includes older adults with mild cognitive impairment as well as individuals who are cognitively healthy. In tDCS, a safe, weak electrical current passes through electrodes placed on a person’s head. The stimulation is being used in research and clinical settings for a variety of conditions and has shown partial success as a nonpharmaceutical intervention that can improve cognitive and mental health in older adults. But tDCS results can vary across individuals, and the suspected cause is both simple and complex: Everyone’s head is different. “One potential reason tDCS may not work for some individuals is the variation in head tissue anatomy, including differences in brain structure,” Queen said. “Since electrical stimulation must travel through multiple layers of tissue to reach the brain, and every individual’s anatomy is unique, these differences likely affect outcomes.” To address this further, Queen is using AI. “Artificial intelligence will play a major role in the modeling pipeline, including constructing individualized head models, conducting predictive analyses to identify which participants will respond to the stimulation, and disentangling multiple individual factors that may contribute to these outcomes,” Queen said. An estimated 10 to 20% of adults over age 65 have memory or thinking problems characterized as mild cognitive impairment. Their symptoms are not as severe as Alzheimer’s disease and other dementias, but they may be at increased risk for developing dementia. “The fact that not all individuals with mild cognitive impairment progress to Alzheimer’s disease emphasizes the need to identify effective interventions that can slow the progression to dementia,” Queen said. “This project presents an opportunity to differentiate between multiple types of mild cognitive impairment and investigate how tDCS affects the brain across these subtypes.” An AI visionary Queen, who joined the UF faculty under the university’s AI hiring initiative, is an instructor in the College of Public Health and Health Professions’ undergraduate certificate program in AI and public health and health care, and the co-chair of the college’s AI Workgroup. She is also the assistant director for computing and informatics at the UF Center for Cognitive Aging and Memory Clinical Translational Research and a member of UF’s McKnight Brain Institute. Queen received her Ph.D. training in engineering with a focus on building and running computational models to investigate medical devices. She experienced a career “a-ha” moment as a postdoc, when she was a co-investigator on a large clinical trial that paired brain stimulation with cognitive training to enhance cognition in older adults. “This experience was transformative for me. I had the chance to interact directly with participants, which was both fulfilling and eye-opening. These interactions allowed me to see the immediate, real-world implications of my work and sparked a passion for pursuing aging research,” Queen said. “I realized that, through this type of research, I could have a more direct impact on addressing age-related challenges, which prompted a shift in my career plans.” The new grant will help Queen further improve her understanding of the neurobiology and progression of Alzheimer’s disease and other dementias. “These experiences will ultimately prepare me to become a well-rounded aging investigator, capable of making meaningful contributions to the field of aging research,” Queen said. She also credits her mentors and collaborators — Ronald Cohen, Ph.D.; Adam Woods, Ph.D.; Steven DeKosky, M.D.; Ruogu Fang, Ph.D.; Joseph Gullett, Ph.D.; and Glenn Smith, Ph.D. — with supporting her as an early career scientist. “It really takes a village to get here!” Queen said.
