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Aston University develops novel bone cancer therapy which has 99% success rate

Bioactive glasses, doped with gallium developed to create a potential treatment for bone cancer Lab tests have a 99 percent success rate of killing cancerous cells Method could also regenerate diseased bones. Bioactive glasses, a filling material which can bond to tissue and improve the strength of bones and teeth, has been combined with gallium to create a potential treatment for bone cancer. Tests in labs have found that bioactive glasses doped with the metal have a 99 percent success rate of eliminating cancerous cells and can even regenerate diseased bones. The research was conducted by a team of Aston University scientists led by Professor Richard Martin who is based in its College of Engineering and Physical Sciences. In laboratory tests 99% of osteosarcoma (bone cancer) cells were killed off without destroying non-cancerous normal human bone cells. The researchers also incubated the bioactive glasses in a simulated body fluid and after seven days they detected the early stages of bone formation. Gallium is highly toxic, and the researchers found that the ‘greedy’ cancer cells soak it up and self-kill, which prevented the healthy cells from being affected. Their research paper Multifunctional Gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma has been published in the journal Biomedical Materials. Osteosarcoma is the mostly commonly occurring primary bone cancer and despite the use of chemotherapy and surgery to remove tumours survival rates have not improved much since the 1970s. Survival rates are dramatically reduced for patients who have a recurrence and primary bone cancer patients are more susceptible to bone fractures. Despite extensive research on different types of bioactive glass or ceramics for bone tissue engineering, there is limited research on targeted and controlled release of anti-cancer agents to treat bone cancers. Professor Martin said: “There is an urgent need for improved treatment options and our experiments show significant potential for use in bone cancer applications as part of a multimodal treatment. “We believe that our findings could lead to a treatment that is more effective and localised, reducing side effects, and can even regenerate diseased bones. “When we observed the glasses, we could see the formation of a layer of amorphous calcium phosphate/ hydroxy apatite layer on the surface of the bioactive glass particulates, which indicates bone growth.” The glasses were created in the Aston University labs by rapidly cooling very high temperature molten liquids (1450o C) to form glass. The glasses were then ground and sieved into tiny particles which can then be used for treatment. In previous research the team achieved a 50 percent success rate but although impressive this was not enough to be a potential treatment. The team are now hoping to attract more research funding to conduct trials using gallium. Dr Lucas Souza, research laboratory manager for the Dubrowsky Regenerative Medicine Laboratory at the Royal Orthopaedic Hospital, Birmingham worked on the research with Professor Martin. He added: “The safety and effectiveness of these biomaterials will need to be tested further, but the initial results are really promising. “Treatments for a bone cancer diagnosis remain very limited and there’s still much we don’t understand. Research like this is vital to support in the development of new drugs and new methodologies for treatment options.” Notes to Editors Multifunctional Gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma Shirin B. Hanaei1, Raghavan C. Murugesan1, Lucas Souza1, Juan I.C. Miranda1, Lee Jeys2,3, Ivan B. Wall3, and Richard A. Martin1 1. College of Engineering and Physical Sciences. Aston University, Aston Triangle, Birmingham, B4 7ET, UK 2. Oncology Department, The Royal Orthopaedic Hospital, Birmingham, B31 2AP, UK 3. College of Health and Life Sciences. Aston University, Aston Triangle, Birmingham, B4 7ET, UK DOI 10.1088/1748-605X/ad76f1 About Aston University For over a century, Aston University’s enduring purpose has been to make our world a better place through education, research and innovation, by enabling our students to succeed in work and life, and by supporting our communities to thrive economically, socially and culturally. Aston University’s history has been intertwined with the history of Birmingham, a remarkable city that once was the heartland of the Industrial Revolution and the manufacturing powerhouse of the world. Born out of the First Industrial Revolution, Aston University has a proud and distinct heritage dating back to our formation as the School of Metallurgy in 1875, the first UK College of Technology in 1951, gaining university status by Royal Charter in 1966, and becoming The Guardian University of the Year in 2020. Building on our outstanding past, we are now defining our place and role in the Fourth Industrial Revolution (and beyond) within a rapidly changing world. For media inquiries in relation to this release, contact Nicola Jones, Press and Communications Manager, on (+44) 7825 342091 or email: n.jones6@aston.ac.uk

ExpertSpotlight: The History of American Football

American football holds a special place in the cultural fabric of the United States, evolving into one of the most popular and celebrated sports in the country. Its history, marked by innovation, athleticism, and deep-rooted rivalries, reflects broader societal changes such as commercialization, media influence, and evolving notions of teamwork and competition. As one of the most-watched sports globally, its impact on American culture, from college football Saturdays to Super Bowl Sundays, goes beyond the field. This story matters because it highlights the connection between sports, community identity, and the evolution of American pastimes. Key story angles of interest include: The origins and early development of American football The impact of college football rivalries on American sports culture The rise of the NFL and its influence on modern sports entertainment The role of football in fostering a sense of community and national identity The effects of media and technology on the commercialization of football Health concerns and how they’ve shaped the future of the sport, particularly in relation to player safety and concussions Connect with an expert about the The History of American Football: To search our full list of experts visit www.expertfile.com

ExpertSpotlight: The History of America's Steel Industry

The steel industry has been a cornerstone of American industrialization, shaping the nation's economy, infrastructure, and workforce. As the backbone of major industries from construction to transportation, the history of steel production in America is more than just a tale of technological advancement—it's a story of social transformation, labor movements, and global competition. This topic is crucial as it offers insights into the evolution of American manufacturing, the rise and decline of industrial cities, and the ongoing challenges in maintaining domestic production in a globalized economy. The relevance of the steel industry today is underscored by its connection to contemporary issues such as trade policies, environmental sustainability, and the future of American manufacturing. Potential story angles for journalists include: The role of the steel industry in shaping American cities and communities The impact of global trade policies on the American steel industry The evolution of labor movements within the steel industry Technological innovations and their influence on steel production Environmental challenges and sustainability efforts in steel manufacturing The future of the steel industry in the context of American infrastructure projects Connect with an expert about the History of America's Steel Industry: To search our full list of experts visit www.expertfile.com

Industry and researchers call for action to tackle climate impact of organic, carbon-based chemicals

Call led by members of Supergen Bioenergy Hub, based at Aston University They highlight that carbon-based chemicals cannot be decarbonised but can be defossilised They want a transition to renewable carbon sources such as biomass, recycled carbon, and carbon dioxide. Director of Supergen Bioenergy Hub, Professor Patricia Thornley Industry experts and university researchers have joined together to ask the government to address the climate impact of organic, carbon-based chemicals. While demand for fossil fuels as energy is expected to fall in the coming decades, the petrochemicals sector is set to grow significantly according to experts and is set out in a 2018 report by the International Energy Agency. Members of the Supergen Bioenergy Hub which is based at Aston University and the Biomass Biorefinery Network believe the issue has yet to receive proper attention and is calling for a strategy that addresses this key component of our greenhouse gas emissions. They want a move to a more circular economy, managing supply and demand levels and transitioning away from fossil feedstocks which are raw materials required for some industrial processes. In their paper Carbon for chemicals How can biomass contribute to the defossilisation of the chemicals sector? they highlight that carbon-based chemicals cannot be decarbonised but can be defossilised through a transition to renewable carbon sources such as biomass, recycled carbon and carbon dioxide. Many products in modern society contain carbon such as pharmaceuticals, plastics, textiles, food additives, cosmetics, and cleaning products. These chemicals are derived from fossil feedstocks, so they are classed as petrochemicals. As a result, they contribute to global greenhouse gas emissions and climate change. Carbon is embedded in organic chemical products and released when they break down at end-of-life, for example through incineration. To address the emissions from carbon in chemicals and accelerate the development of bio-based chemicals, the group want a cross-party consensus to support a sustainable chemical system. Director of Supergen Bioenergy Hub, Professor Patricia Thornley, said: “We need to consider the UK’s future feedstock and chemicals production and use, and how it relates to net zero, agriculture, environment, economy, trade, and just transition policy objectives. There are opportunities here for the UK to lead the way on sustainable chemical production, but we need to carefully plan a roadmap for the transition, that delivers opportunities around jobs and the economy as well as sustainable greenhouse gas reductions. “There is a definite role for biomass here. But it is essential that any future use of biomass in the chemicals sector is underpinned by rigorous, trusted, and enforceable sustainability governance to build confidence, deliver sustainability benefits, and minimise negative impacts. That requires improvements in sustainability governance and regulation. “We think there are real economic and trade opportunities by the UK accelerating sustainable chemicals. At the moment bio-based chemicals, and chemicals derived from other renewable carbon sources, are not being expanded in the UK because there are no explicit incentives that prioritise them over fossil-based production.” The group argues that the UK has significant academic and industrial research expertise to underpin the development of sustainable bio-based products and could be a global leader in bio-based products and sustainability governance. They believe that to date little of this has manifested as UK-based scale-up and manufacturing, whilst there are numerous examples of UK-led research being scaled up elsewhere. The paper was delivered at a webinar on 7 August. Notes to Editors Carbon for chemicals How can biomass contribute to the defossilisation of the chemicals sector? https://www.supergen-bioenergy.net/output/carbon-for-chemicals-how-can-biomass-contribute-to-the-defossilisation-of-the-chemicals-sector-policy-briefing/ Author: Joanna Sparks (formerly Aston University) With contributions from: Cristiane Scaldaferri (formerly Aston University), Andrew Welfle (University of Manchester), Patricia Thornley (Aston University), Ashley Victoria (University of Leeds), Caspar Donnison (Lawrence Livermore National Laboratory), Jason Hallett (Imperial College London), Nilay Shah (Imperial College London), Mirjam Rӧder (Aston University), Paul Mines (Biome Bioplastics), David Bott (Society of Chemical Industry), Adrian Higson (NNFCC), Neil Bruce (University of York) 2018 International Energy Agency report https://www.iea.org/reports/the-future-of-petrochemicals https://www.supergen-bioenergy.net/ The Supergen Bioenergy Hub works with academia, industry, government, and societal stakeholders to develop sustainable bioenergy systems that support the UK’s transition to an affordable, resilient, low-carbon energy future. The Hub is funded jointly by the Engineering and Physical Sciences Research Council (EPSRC) and the Biotechnology and Biological Sciences Research Council (BBSRC) under grant EP/Y016300/1 and is part of the wider Supergen Programme. www.bbnet-nibb.co.uk The Biomass Biorefinery Network (BBNet), a phase II Network in Industrial Biotechnology & Bioenergy funded by the Biotechnology and Biological Sciences Research Council (BBSRC-NIBB) under grant BB/S009779/1. The aim of the Biomass Biorefinery Network is to act as a focal point to build and sustain a dynamic community of industrial and academic practitioners who work together to develop new and improved processes for the conversion of non-food biomass into sustainable fuels, chemicals and materials. About Aston University For over a century, Aston University’s enduring purpose has been to make our world a better place through education, research and innovation, by enabling our students to succeed in work and life, and by supporting our communities to thrive economically, socially and culturally. Aston University’s history has been intertwined with the history of Birmingham, a remarkable city that once was the heartland of the Industrial Revolution and the manufacturing powerhouse of the world. Born out of the First Industrial Revolution, Aston University has a proud and distinct heritage dating back to our formation as the School of Metallurgy in 1875, the first UK College of Technology in 1951, gaining university status by Royal Charter in 1966, and becoming the Guardian University of the Year in 2020. Building on our outstanding past, we are now defining our place and role in the Fourth Industrial Revolution (and beyond) within a rapidly changing world. For media inquiries in relation to this release, contact Nicola Jones, Press and Communications Manager, on (+44) 7825 342091 or email: n.jones6@aston.ac.uk

The History of Labor Day

Labor Day, celebrated on the first Monday in September, is more than just a long weekend marking the end of summer—it is a day dedicated to honoring the social and economic achievements of American workers. The history of Labor Day is deeply intertwined with the labor movement and the fight for fair working conditions, making it a day of both reflection and celebration. This event is significant not only because it recognizes the contributions of workers to the nation's prosperity but also because it sheds light on ongoing issues such as workers' rights, labor laws, and the future of work in an increasingly automated and globalized economy. Potential story angles: The origins of Labor Day and the labor movement in the United States The evolution of labor laws and workers' rights since the 19th century The impact of automation and globalization on the American workforce The role of unions in modern-day labor movements The intersection of labor rights and social justice issues How Labor Day is celebrated across different regions and industries in the U.S. Connect with an expert about the History of Labour Day: To search our full list of experts visit www.expertfile.com

ExpertSpotlight: Today is Women’s Equality Day

Women’s Equality Day on August 26 marks a pivotal moment in history, celebrating the anniversary of the 19th Amendment’s adoption, which granted women the right to vote in the United States. This day is not just a commemoration of past achievements but a call to address the ongoing challenges women face in achieving full equality. From wage gaps and representation in leadership to reproductive rights and gender-based violence, the fight for women’s equality continues to be a crucial issue in today’s society. This topic is significant as it highlights both the progress made and the work still needed to ensure true equality for all women. Key story angles that journalists might explore include: The evolution of women’s rights since the 19th Amendment and the ongoing struggle for gender equality. Current challenges women face in the workforce, including wage disparity and underrepresentation in leadership roles. The role of women in politics and the importance of female representation in government. Intersectionality in the women’s rights movement: how race, class, and other identities intersect with gender. The impact of recent legal decisions and legislation on women’s reproductive rights. Celebrations and events surrounding Women’s Equality Day across the country. This alert emphasizes the importance of reflecting on both historical achievements and current challenges, making it a compelling topic for coverage. Connect with an expert about Women’s Equality Day: To search our full list of experts visit www.expertfile.com

The History of the Electoral College

As one of the most debated and misunderstood components of American democracy, the Electoral College plays a crucial role in determining the outcome of U.S. presidential elections. Understanding the history and purpose of the Electoral College is essential for grasping how American elections work and why this system continues to generate controversy. This topic is newsworthy not only because of its impact on election results but also due to ongoing discussions about its relevance in a modern democracy, potential reforms, and its influence on campaign strategies. The Electoral College intersects with broader societal issues such as representation, voter equity, and the balance of power between states, which include: The origins of the Electoral College and the Founding Fathers’ intentions How the Electoral College has influenced the outcomes of past presidential elections The ongoing debate over whether the Electoral College should be reformed or abolished The impact of the Electoral College on voter turnout and representation The role of swing states and how they shape campaign strategies Legal challenges and Supreme Court decisions related to the Electoral College Covering the election? Let us help! Connect with a political expert about the History of the Electoral College: To search our full list of experts visit www.expertfile.com Photo Credit: Clay Banks

Amid Detainees' Release, Putin Flaunts Power and Flouts Western Influence

On August 1, the United States, Russia, Germany and three other European nations engaged in an historic 24-person East-West prisoner exchange. The largest such swap since the end of the Cold War, the multi-country deal secured the release of three prominent American detainees: Wall Street Journal correspondent Evan Gershkovich, corporate security executive Paul Whelan and Radio Free Europe/Radio Liberty editor Alsu Kurmasheva. It also freed a dozen Russian opposition leaders, incarcerated in their native country for challenging Vladimir Putin and his authoritarian regime. Lynne Hartnett, PhD, is the chair of Villanova University’s Department of History and an expert on modern Russia, protest movements and dissidents in exile. Recently, she shared some insights on the Kremlin's decision to release the American and Russian prisoners—as well as the egotism, oppressive tendencies and political posturing that drove their detention. Q: The arrests and sentencings of Gershkovich, Whelan and Kurmasheva have been described as "outrageous," "a mockery of justice" and reflective of "a total disregard for basic freedoms." What prompted Putin and the Russian government to detain these individuals? Dr. Hartnett: For Putin, seizing Gershkovich, Whelan and Kurmasheva was a power play. They were pawns for him to use when he deemed it convenient. If they could be used in a prisoner swap, they would be. But if that time never arrived, their incarceration, suffering and even potential deaths were inconsequential to him. Their arrests were also a signal that, in Russia, Putin's authority is uncontested. These were American citizens, and around the world, a U.S. passport opens doors: It holds power; it provides access; and it affords its holder protection. But the arrests of Gershkovich, Whelan and Kurmasheva were Putin’s attempt to demonstrate the limits of American influence. They were meant as a signal that, in Russia, a U.S. passport becomes meaningless if it serves Putin to make it so. Q: In recent years, the Russian government has seemingly worked to rehabilitate the reputations of figures like Josef Stalin, who infamously used the Soviet Gulag to stifle opposition and criticism. Is Putin's use of detentions as a political cudgel similar? DH: The show trials of the Stalinist era are frequently referenced. However, it should be stressed that those were largely intended for domestic consumption. They were used to justify the Communist elites' repression of fellow citizens by broadcasting "evidence" that enemies lurked within. The trials of Americans like Gershkovich and Brittney Griner [a professional basketball player detained on smuggling charges] were designed to show the world, not just Russians, that Putin's regime would not be cowed—even if the person being tried had fame and a powerful enterprise, like the Wall Street Journal or the WNBA, supporting them. Q: The New York Times recently ran a piece on the Russian dissidents released, claiming "hopes are high [they] will breathe new life into a fragmented opposition force." What do you anticipate these political players' activism will look like in the coming years, especially in exile? DH: As in the Imperial and Soviet periods, Russian censorship prevents any news or opinions that are not the government's from coming to light. As Putin has dismantled political opposition in Russia and tightened his grip on any vestiges of civil society in the country, there is little hope that a powerful opposition movement can gain momentum without outside support. This is where the Russian dissidents living abroad come in. They will ensure that a vision for another type of Russia is articulated. At the end of the 19th and the beginning of the 20th centuries, political exiles smuggled illegal newspapers and journals into the Russian empire to instill hope in their compatriots, to give them some indication that a nation beyond the autocracy was achievable. This, in my opinion, is the role that Russian dissidents living in exile must have today. They must provide the vision. They must provide the hope. While they cannot change the system on their own—they need a movement en masse—the dissidents abroad are needed to demonstrate that a nation without Putin and his repressive regime is possible. This is certainly not an easy venture, and it will require extraordinary sacrifices to be made a reality. However, it may be the Russian people's only hope.

#ExpertSpotlight: The History of DNC Conventions in America

As one of the most significant political events in American history, the Democratic National Convention (DNC) has shaped the political landscape and influenced presidential elections for over a century. Understanding the history of DNC conventions offers a window into the evolution of American politics, party ideologies, and electoral strategies. This topic is newsworthy not only because of its historical significance but also due to its ongoing impact on contemporary political discourse, party unity, and voter mobilization. Furthermore, the DNC conventions reflect broader societal changes, such as shifts in public opinion, the role of media in politics, and the influence of grassroots movements, which include: The evolution of the DNC’s role in shaping party platforms and political agendas Key historical moments from past DNC conventions that defined U.S. politics The impact of DNC conventions on voter engagement and turnout The role of media coverage in shaping public perceptions of the DNC How grassroots movements and protests have influenced DNC outcomes The significance of keynote speeches and how they have launched political careers By covering these angles, journalists can provide their audiences with a comprehensive look at the history of these important conventions and topics readers, listeners and viewers want to know more about. Connect with a political expert about the History of DNC Conventions: To search our full list of experts visit www.expertfile.com Photo Credit: Kelly Sikkema

Why Japan Issued a "Megaquake" Advisory Following Last Week's Tremor

The magnitude 7.1 earthquake that struck Japan's southern islands on August 8 left some residents of the country in panic. Not from the tremor itself, which caused only a handful of minor injuries and quick-expiring tsunami alerts, but rather the unprecedented advisory from the Japanese Meteorological Agency warning of an elevated risk of a "megaquake" in the region over the coming weeks. A "megaquake," short for a megathrust earthquake, is a type of temblor that occurs at a subduction zone, where one tectonic plate slips under another. A release of the tension that forms the thrust fault where the two plates meet can trigger some of the strongest earthquakes on the planet, measuring 9.0 or higher on the Richter scale, and produce large tsunamis. It may sound a bit alarmist, but Isabel Hong, PhD, assistant professor in Villanova University's Department of Geography and the Environment, assures that "even though it is not possible to predict earthquakes, the advisory comes from a place of prior knowledge." "We can't say for certain [when these earthquakes will happen]," she reiterated. "But probability suggests it could be more likely, in part because this smaller earthquake event occurred." The acute event—last week's earthquake—is indeed the root of the alert, which was issued in the following hours. The quake's epicenter was located close to the end of the Nankai Trough, a subduction zone off the coast of Japan where the Philippine Sea Plate slips under the Eurasian Plate. The Nankai Trough has historically produced strong earthquakes, most recently an 8.0 tremor in 1946. "Oftentimes, a large earthquake event can then trigger subsequent earthquakes," Dr. Hong said. "It can transfer stress to other faults that can make it more conducive for other earthquakes to then rupture, and that's the general belief of what's happening with the Nankai Trough right now." To compound the acute disturbance last week, Japanese government officials had already previously warned of a 70-80 percent likelihood of a Nankai Trough earthquake measuring 8-9 on the scale within the next 30 years. That warning was the product of extensive research into the region's seismic history. "All of the data that goes into [an advisory like that] is pulled from the work of dedicated scientists looking at past earthquake and tsunami deposits," said Dr. Hong, who herself studies prehistoric geohazards by analyzing their geologic trails along coasts. "This allows us to refine our understanding of the frequency of such events in a region. In this case, scientists can say, 'These happen about every 100 years, and it's already been over 70. Therefore, there's a higher probability another will occur in the next 30.'" If it does, officials fear that a strong earthquake could trigger a massive tsunami that would reach the coast of Japan within minutes due to its proximity, threatening the lives of hundreds of thousands of individuals. "Tsunamis occur along active subduction zones like the Nankai Trough," Dr. Hong said. "They do have to be generated by a strong earthquake, yes, but more important in their impact to coastal communities is the shape of the coastline offshore. If they go from deep to shallow water very fast, the tsunami builds tall." So, whether it appears alarmist or not, having the ability to study these seismic events in a way that can warn individuals of heightened risks should not be taken for granted, says Dr. Hong. Early warning signs and advisories for potential geohazards can save lives. "One of the reasons we dig into the geologic past is to help inform people what could happen in the future."