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In new study in journal Gene Therapy, researchers at ChristianaCare’s Gene Editing Institute describe how the advance is validating the safety and efficacy of their novel approach for using CRISPR to improve lung cancer treatments A new study from scientists at ChristianaCare’s Gene Editing Institute is advancing the safety and efficacy of using CRISPR gene editing in patient treatments by demonstrating how to identify and evaluate the broad-based biological impact of gene editing on targeted tissues, where the edits are designed to fully disable or “knock out” a specific sequence of genetic code. The work, published today in the Nature journal Gene Therapy, supports the Institute’s efforts to improve lung cancer treatments by using CRISPR to disable or alter a master regulator gene to prevent it from producing a protein that blunts the impact of chemotherapy. “We found that when you use CRISPR, the edits sometimes end up altering rather than completely disabling the target gene, so we developed a process to gain a more complete understanding of what that means for patients,” said Eric Kmiec, Ph.D., executive director and chief scientific officer of ChristianaCare’s Gene Editing Institute and the principal author of the study. Dr. Kmiec said that for his team’s lung cancer work, “We discovered that even when our CRISPR-based genetic manipulation did not completely disable the targeted gene, it altered it in ways that appear to make lung cancer tumors more sensitive to chemotherapy. Validating lung cancer research using CRISPR “We were fortunate that our strategy for using CRISPR to improve lung cancer treatments has been validated once again,” he added. “But our commitment to conducting an unbiased assessment of our approach highlights the importance of examining all potential outcomes of an attempt to use CRISPR to knock out a specific gene. Specifically, anyone developing CRISPR therapies needs to be on the lookout for edits that don’t fully knock out a section of DNA code—and evaluate the potential impacts for patients. They could be positive, as they were in our case, negative or neutral, but they need to be known.” Much of the excitement around medical applications of CRISPR involves using the tool to disable harmful genes by editing or “knocking out” a specific sequence of DNA code. But there is increasing evidence that in the wake of a CRISPR edit, cells may remain that contain merely an altered form of the targeted code that allows the gene to continue to produce biologically active proteins. Scientists at the Gene Editing Institute are investigating the potential of using CRISPR to disable a gene called NRF2 to alter production of the protein that protects squamous cell carcinoma lung cancer tumors from the effects of chemotherapy or radiation. They already have shown, in studies with tumor cells and in animals, that they can selectively target the NRF2 gene without affecting normal cells, where the gene confers health benefits. In the present study they wanted to go further. They wanted to fully understand the implications of a CRISPR gene edit that allowed the NRF2 gene to retain enough DNA code to continue making a version of the protein, albeit in an altered or truncated form. The team is laying the groundwork for a clinical trial that would use CRISPR to improve the efficacy of conventional chemotherapy and radiation treatments. Dr. Kmiec said that before proceeding, he wanted his team to develop a clear process for identifying and evaluating all outcomes of CRISPR edits. Identifying and understanding the diversity of genetic outcomes produced by CRISPR-directed gene editing has been a centerpiece of the foundational research programs established by the Gene Editing Institute. Using CRISPR in a safe way “We carry out experiments in an unbiased fashion, not hoping for a particular outcome, but with patient safety and efficacy serving as the true north for our scientific endeavors,” Dr. Kmiec said. “No matter what we uncover or elucidate, the insights will help both ChristianaCare and the entire field use CRISPR in a safer and more efficacious manner.” The researchers found multiple cells where the targeted strand of DNA code in the NRF2 gene was not completely knocked out. Rather, following the CRISPR edit, cells emerged that had retained enough of the original code to continue producing a different form of the protein. Tests revealed that cancer tumor cells generating these altered proteins may be more vulnerable to chemotherapy drugs. "For the work we are doing with NRF2, the truncated proteins generated by the CRISPR edit appear to be beneficial for making tumors more sensitive to treatment,” said lead author Kelly Banas, Ph.D. “But the key point is these proteins were clearly biologically active. And that means we needed to determine their potential impact on the safety and efficacy of using CRISPR to treat lung cancer patients.” Dr. Banas noted that the study points to the limits of considering a CRISPR edit to be successful simply by testing for the absence of a targeted protein in its original form. She said by that standard, their edit was successful. The edited NRF2 genes were no longer producing the same protein. But she said if that’s all the ChristianaCare team had looked for, they would have missed the altered proteins coming from the NRF2 gene—and overlooked an important outcome that, in this case, strengthens the original hypothesis and experimental approach: that using CRISPR to target the NRF2 gene holds promise for improving outcomes for lung cancer patients. Importance of due diligence “The process we describe in this study is a template that should be followed in any effort to develop CRISPR as a medical treatment,” Dr. Kmiec said. “We’re part of a health care organization where patient safety is the top priority. We also are working at the vanguard of an exciting area of cutting-edge medicine, where a failure to conduct due diligence could cause tragic outcomes that would set back this field for decades. With this study, we have validated a process that can help this field move forward rapidly but safely.” CRISPR stands for “clustered regularly interspaced short palindromic repeats.” It is a defense mechanism found in bacteria that can recognize and slice up the DNA of invading viruses. Scientists have learned how to modify this mechanism so it can be directed to “edit” specific sequences of DNA code. About ChristianaCare’s Gene Editing Institute The Gene Editing Institute, a worldwide leader in CRISPR gene editing technology and the only institute of its kind based within a community health care system, takes a patient-first approach in all its research to improve the lives of people with life-threatening disease. Since 2015, researchers at the Gene Editing Institute have been involved in several ground-breaking firsts in the field, including the development of the first CRISPR gene editing tool to allow DNA repairs outside the human cell which will rapidly speed therapies to patients and the ExACT ™pathway of single-stranded DNA repair, which increased the on-target efficacy of CRISPR and paved the way for new CRISPR breakthroughs in precise DNA edits. Its researchers created CRISPR in a Box™, the leading educational toolkit to teach gene editing, DECODR™, recognized as the most user-friendly and precise analytical tool to understand the diversity of genetic outcomes of gene editing and are currently developing a patient trial for lung cancer using CRISPR.
Market jitters making you anxious? Our expert might have the remedy to calm your nerves.
So far, 2022 has been, in a word, volatile. With the emergence of omicron, supply chain issues choking the economy, inflation the highest it has been in decades and now the war drums beating in Europe, investors are getting nervous and the markets are showing the strain. As political guru James Carville once said, "It's the economy, stupid!" Following that sage advice, Augusta University’s Wendy Habegger is here to offer expert perspective to journalists looking to figure out just what’s going on with the markets and what investors and the public can expect in the coming months. Q: What's the best advice to give people when the stock market is on such a roller coaster ride? “Frankly put, if one can't stomach when the roller coaster drops, don't get on the ride. If one does not have much tolerance for risk, they should not invest in the stock market. If one is already invested in the stock market and breaking into a cold sweat every time they look at their stocks, then they need to take a cash position, meaning cash out of the stock market. The market does not reward anyone based upon their level of anxiety. What good is making gains on stocks if one will turn around and spend those gains treating their ulcers? I liken it to pro sports athletes who don't retire when they are still healthy. What good is all the money they earned if they are only going to be spending it on medical treatments for the rest of their lives? What kind of quality of life is that?" Q: With the market trending down right now, if people can invest, is this the best time to do so? “Whenever the market trends down, it is always a great time to buy stable companies with solid cash flows and certain commodities. Look for those companies and commodities that always do well regardless of what is happening in the economy. But remember my response to the above question. One should do this if and only if they can tolerate risk.” Q: Should people look at safer places to put their money for the time being, and what would some of those places be? “Again, this depends upon their level of risk tolerance. If they are risk tolerant, they should shift into less risky investments. If they are not risk tolerant, cash out and put it in their savings accounts or CDs.” Q: Does the emergency fund rule of thumb still come in to play, maybe now more than ever? “Yes, but I don't go by the standard rule of thumb for emergency savings – having three to six months of expenses saved. I teach students their goal should be to have 12 months of expenses saved. The three to six months rule is obsolete. We saw this with the recession of 2007-09 and with the pandemic. People need to be able to live without employment longer because there is no definitive time frame for when one will find gainful employment and the government should not be relied upon to support the mass population in the meantime. Also, even when the government does provide assistance, not everyone receives it and some still never recover from the aftermath. “ The economy is front and center for just about every American business, investor and household – and if you’re a reporter looking to know more, then let us help. Wendy Habegger is a respected finance expert available to offer advice on making the right money moves during volatile times. If you’re looking to arrange an interview, simply click on her icon now to arrange an interview today.
$100K student scholarship pool available for 2022 summer courses in Ireland Six professors from Georgia Southern University’s College of Education (COE) recently broadened their horizons during a trip to Ireland as they learned from and shared insight with instructors and educational leaders in the Wexford County community. Led by Howard Keeley, Ph.D., director of the University’s Center for Irish Research and Teaching, COE faculty traveled to Georgia Southern’s learning center in Wexford, Ireland, to observe Irish educational settings and exchange ideas with local leaders just ahead of a summer study abroad program opportunity for Georgia Southern students in which $100,000 of scholarship funding is available. “The main thing we did was get in front of leaders in the education space in Ireland,” stated Keeley. “We spoke to a number of folks who are either principals or vice principals or, in some way, senior administrators in a variety of schools including all-boys, all-girls, religious, secular and mixed schools.” The group included Catherine Howerter, Ph.D., associate professor of elementary and special education; Kip Sorgen, Ph.D., assistant professor of leadership, technology and human development; Alex Reyes, Ph.D., assistant professor of middle grades and secondary education; Amanda Wall, Ph.D., associate professor of middle grades and secondary education; Betsy Barrow, Ed.D., assistant professor of middle grades and secondary education; and Dan Calhoun, Ph.D., professor of leadership, technology and human development. Reyes, who trains pre-service and in-service teachers to work with culturally and linguistically diverse students, was excited to travel to Wexford after a study abroad program in Czech Republic she spearheaded with Wall was canceled in March 2020 due to the pandemic. Intrigued by Ireland, a plurilingual country, she was curious to see how Wexford’s environment might benefit students culturally. “I thought it was really exciting,” said Reyes. “All of the street signs are in Irish, even though English is the main language spoken. That prioritizing of that cultural heritage is fascinating. It was great to learn that the students in their primary and secondary schools take Irish language and culture as a subject every year.” She was especially motivated by a field trip to an Irish-language school, Meanscoil Gharman, which serves middle and high school students. With the exception of one daily class in English, teachers and students conducted all lessons in Irish. “It was really interesting to see that perspective,” she said. “There has been a revitalization of that culture. I thought that was fascinating to see how that can be handled in school.” In addition, Reyes was duly impressed with the country’s prioritization of social and emotional literacy for children, and the mandated well-being hours that are incorporated into daily school routines as a result of the pandemic. A program that promotes hygiene and an anti-bullying campaign also fit into the wellness curriculum. “It really impressed me that as a nation they prioritize the wellness of students, and how language and cultures can really be supported in a meaningful way,” Reyes said. “It’s affirming to see a proactive approach that has positive outcomes. Now, thinking ahead, we can look at how we can create opportunities for our students to experience this kind of approach.” Sorgen, who teaches in the educational leadership program at Georgia Southern, was interested in Ireland’s professional preparation. “None of them had advanced degrees, like what we offer at Georgia Southern,” noted Sorgen. “Learning about how to be a principal in Ireland is on-the-job training. In Georgia, there are specific educational requirements for our school administrators guided by professional standards. In Ireland, they generally ascend through the ranks, which makes professional mentoring essential to their success. We are exploring ways our educational leadership students could learn from Irish administrators about their experience, specifically with mentoring.” He also foresees the international partnership as a two-way exchange. “Given educational leadership programs are not common in Ireland, our faculty are considering ways in which we could use our expertise to foster leadership development of principals and teachers in Wexford,” said Sorgen. “We would utilize the Georgia Southern Wexford campus to host some of these sessions, furthering Georgia Southern’s relationship within the Wexford community.” Keeley also arranged meetings with education policy makers, including an extended meeting with an Irish congressman who is a representative for the County of Wexford in the Irish national parliament and chairs the joint committee for the Irish equivalent of the House and Senate Committee on education and higher education. “That was a tremendous opportunity for our faculty to talk to somebody at the highest level of government in Ireland, creating Irish state policy on education,” said Keeley. “And I know from the feedback we got from our College of Education colleagues that particularly for those in higher education, that to them was a really useful, next-step experience.” The trip exceeded expectations. “It was a fantastic learning experience for everyone,” said Keeley. “We had lots of high-level and also very practical experiences, and I could see our College of Education team thinking, ‘How can I bring what I’m learning, what I’m experiencing in this moment, into my classroom, into my curriculum, into my prospective study abroad courses in a way to build student success for our Georgia Southern folks.’ I think it was a great visit.” Complementing the faculty’s trip, a COE Irish study abroad program on diverse education in Ireland was recently approved for Summer 2022 and will give education students the opportunity to take one or two courses with the study abroad component. This will be a part of a broader study abroad program in Wexford, presented by the Honors College and the Center for Irish Research and Teaching, with assistance from the Office of the Provost and the Office of Global Engagement. The costs for undergraduate students at Georgia Southern’s Wexford campus will be offset by a $100,000 scholarship fund with awards of $1,000 for each student accepted into the program. “For students traveling to Wexford, Ireland, this summer, we will be able to defray the cost of the program through a generous travel scholarship through the Georgia Southern University Foundation,” said Dustin Anderson, Ph.D., associate provost for Student Success. “The donation makes these the most affordable multi-week programs that we ever have been able to offer.” Keeley is thrilled the gifts from generous donors will enable a number of students to earn valuable global experiences. “For students to have an opportunity to have international lives is powerful, and it’s powerful in ways that sometimes we can’t even predict,” he said. “Just the very fact of being abroad is going to change any of us, right? It can have a really transformative effect to feel a sense that, you know, as a student, ‘I can do this,’ and then a sense after the fact, ‘I did this,’ and just that in itself is educational. Giving students a safe space in Wexford, Ireland, to grow and feel that they are in a sense global citizens and bring the best of America, bring the best of Georgia, bring the best of the states from Savannah to Ireland, and learn to be an ambassador. That’s wonderful.” In addition to the education courses, students will also be able to choose from a Wexford-Savannah honors inquiry and an interdisciplinary program open to all students on human migration with courses in geography, religious studies, public health and a CORE study abroad course. Students interested can learn more about the program by clicking here and can email Kristin Karam in the Office of Global Engagement for more information about the scholarships. Georgia Southern University-Wexford is a global hub for learning housed in a historic building constructed in 1812. The space now features state-of-the-art classrooms and student apartments. Georgia Southern is the first public university in the United States to open an outreach learning facility in Ireland. If you're a reporter looking to know more about this initiative, then let our experts help. Howard Keeley, Ph.D., is the director of the Center for Irish Research and Teaching at Georgia Southern University. He is available - simply click on his icon now to arrange an interview today.
Dr. Janice Nevin named among Modern Healthcare’s 2022 ‘Top 25 Women in Health Care’
Nevin praised for her work expanding ChristianaCare’s efforts in health equity, value-based care and emerging technology ChristianaCare President and CEO Janice E. Nevin, M.D., MPH, has been named one of Modern Healthcare’s Top 25 Women in Healthcare for 2022. This is the second time Dr. Nevin has received this distinction. Modern Healthcare chose awardees – female executives from different sectors of the health care industry – who are guiding health care improvement by influencing policy and care delivery models across the country. A panel of judges and the top editors of Modern Healthcare made the selections. The publication focused on Dr. Nevin’s leadership in ChristianaCare’s use of innovation and technology to aid in the battle against COVID-19 and improve health equity. It also called attention to her leadership in ChristianaCare’s collaboration with Highmark Health; through a new joint venture company, ChristianaCare and Highmark are combining their expertise and capabilities to create better health and to make health care more affordable for everyone by taking costs out of the system. “I am deeply gratified by this award, but it is even more so a recognition of the incredible work all of ChristianaCare’s caregivers do every day to create better health,” said Dr. Nevin. “Living our values of love and excellence, we are transforming care and becoming not just a health system—but a system that truly impacts health.” Dr. Nevin has overseen growth at ChristianaCare during the past year that includes a joint venture with AccentCare (formerly Seasons Hospice & Palliative Care) to expand in-home hospice and palliative care services throughout Delaware and a recently announced letter of intent to acquire Crozer Health, as well as the continued integration into the health system of Union Hospital in Cecil County, Maryland, which joined ChristianaCare in January 2020. At the same time, she has worked tirelessly to ensure the system continued its tradition of clinical excellence while maintaining financial health and stability. This year, ChristianaCare was recognized for the second consecutive year by Healthgrades as one of America’s 50 Best Hospitals and by Forbes as one of the best health systems to work for in the United States. Dr. Nevin continues to promote caregiver wellbeing and health equity. For the work of ChristianaCare’s Center for WorkLife Wellbeing to support its caregivers, ChristianaCare earned a 2021 Joy in Medicine recognition from the American Medical Association. The American Hospital Association’s Institute for Diversity and Health Equity named ChristianaCare a 2021 Carolyn Boone Lewis Equity of Care Award honoree for demonstrating health equity as a priority across the organization. “ChristianaCare is lucky to have Dr. Nevin’s leadership,” said Nicholas M. Marsini, Jr., chair of the ChristianaCare board of directors. “Having Modern Healthcare recognize her extraordinary efforts and passion is a wonderful acknowledgement of what we see on an ongoing basis. Dr. Nevin is incredibly invested in the wellbeing of ChristianaCare’s workforce, the communities we serve and the future of the U.S. healthcare system.” The recognition also highlighted Dr. Nevin’s work in promoting gender equity – from building an executive cabinet evenly split between women and men to the creation of ChristianaCare’s Gender Equity Taskforce, which focuses on issues like pay equity and leadership access. The profiles of all the winners were featured in the February 21 issue of Modern Healthcare.
ChristianaCare and The Wistar Institute advance partnership with new cancer research strategies
ChristianaCare’s Helen F. Graham Cancer Center & Research Institute is advancing its historic partnership with the Ellen and Ronald Caplan Cancer Center of The Wistar Institute in Philadelphia with three new research projects under way. The new research projects consist of a population health study targeting triple negative breast cancer. Other projects focus on a new therapeutic target for epithelial ovarian cancer, the most lethal gynecologic cancer in the developed world, and the development of “mini organs” derived from stem cells. Targeting triple negative breast cancer Delaware has one of the highest incidence rates of triple-negative breast cancer in the United States. This highly aggressive cancer has few treatment options, because the cells test negative for three known treatment targets – estrogen, progesterone and HER2 protein receptors. Working with patient data from the Graham Cancer Center, researchers are investigating potential contributing factors such as diet, alcohol use and genetic variants among women, and the effects of these on cancer metabolism. The team will also examine spatial relationships between cancer “hot spots”—geographic areas with a higher-than-expected prevalence—and modifiable risk factors. Key resources for the study are blood and tissue samples from the Graham Cancer Center’s Tissue Procurement Center and its statewide High-Risk Family Cancer Registry. The research team will be led by Director of Population Health Research at ChristianaCare Scott Siegel, Ph.D., and Lead Research Scientist Jennifer Sims Mourtada, Ph.D., at the Graham Cancer Center’s Cawley Center for Translational Cancer Research (CTCR). They will join Zachary Schug, Ph.D., at Wistar’s Molecular and Cellular Oncogenesis Program. Researching novel therapy for ovarian cancer The latest study supported by the Graham Cancer Center’s Tissue Procurement Program targets KAT6A expression as a novel therapy for ovarian cancer caused by a specific genetic mutation, called PP2R1A. Epithelial ovarian cancer is the most common form of ovarian cancer and the leading cause of gynecologic cancer deaths in the United States. Chemoresistance to currently available platinum-based drugs like cisplatin represents a major treatment challenge, as more than 50 percent of affected women ultimately relapse and die from this disease. Wistar’s Rugang Zhang, Ph.D., leader of the Immunology, Microenvironment and Metastases Program, is focused on developing novel therapeutics for subtypes of ovarian cancer that currently have no effective therapies and on improving the current standard of care. Dr. Zhang’s previous work suggests that KAT6A signaling plays a critical role in ovarian cancer progression. Targeting this signaling pathway could be an effective strategy for treating ovarian cancer. Working with Dr. Zhang on this project are Graham Cancer Center gynecologic oncologists Mark Cadungog, M.D., director of Robotic Surgery, and Sudeshna Chatterjee-Paer, M.D., and Cawley CTCR’s Stephanie Jean, M.D., director of Gynecologic Oncology Research. Also collaborating with the team is Wistar’s Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program. ‘Mini organs’ offer hope for therapeutics Dr. Sims-Mourtada at the Cawley CTCR will lead a new program to culture organ-specific tissue from stem cells that could change the way diseases are studied and treated. These so called “mini organs” or “organoids” are three-dimensional tissue cultures grown in the lab that replicate the complexity and functions of a specific tissue or organ found in the body. Organoids offer scientists a better model for how drugs and other therapeutics might interact with a patient’s particular type of tumor, opening new avenues for precision medicine. “The ability to grow each patient’s tumor in a three-dimensional organoid along with our capability to create patient-derived xenograft or animal models as part of our PDX core, will allow us to fully capture the effects of genetic as well as gene altering behavioral and environmental influences that are lacking in current research models,” said Dr. Sims-Mourtada. “Our collaboration with Wistar to build these programs raises our clinical platform to the next level for studying new cancer biomarkers and treatments.” Advancing a Pioneering Partnership The Graham Cancer Center made history when it signed a first-of-its-kind agreement in 2011 with The Wistar Institute, pairing a National Cancer Institute, NCI-designated basic research institution with a community cancer center that is also an NCI Community Oncology Research Program (NCORP). “Our partnership with Wistar has attracted national recognition as a model of collaboration that leverages cutting-edge research to benefit cancer prevention and therapy statewide,” says Nicholas J. Petrelli, M.D., Bank of America endowed medical director of ChristianaCare’s Helen F. Graham Cancer Center and Research Institute. “With Wistar, our productive collaborations over the last decade continue to drive discovery research toward clinical trials to benefit patients here at the Graham Cancer Center and in communities everywhere.” “The Graham Center has been an ideal partner in our mission,” said Dario C. Altieri, M.D., Wistar president and CEO and director of the Ellen and Ronald Caplan Cancer Center. “Our scientists at Wistar have access to clinically-annotated primary patient specimens of the highest quality. As the majority of patients at the Graham Cancer Center are treatment naïve, this collaboration affords an opportunity to conduct unique, high impact mechanistic and correlative studies that will ultimately advance important scientific discoveries that hopefully will lead to better cancer therapies.”
As the war rages in Ukraine, what's next? Augusta University expert answers key questions
For a month now, the world has watched the invasion of Ukraine by Russian forces. The war has dominated news coverage since before the invasion, with journalists asking why Russia would invade a sovereign country and whether this could expand to an all-out war in Europe for the first time since World War II? There are still many questions to be asked, which is why we’ve enlisted Dr. Craig Albert, from Augusta University. Albert has been speaking extensively with the media answering key questions about the invasion. Q: How has Russia ramped up their war efforts and are the latest attacks a signal that they are going "all in" in taking over Ukraine? “Right now, Russia is still not fighting the war they are prepared for. In other words, they have a massive war-machine but are still only using small parts of it in this war. There are several reasons for this: they may not want to expose their hands to great powers; they may want to bring Ukraine back to the fold, so annihilating them, vis-à-vis, Grozny, might not be the best play. As it is, Russia is still poised to take Kyiv within a few months unless Ukraine has alliance boots on the ground, which is not likely since it will raise the specter of WWIII." Q: What do you expect we will see next? "I think we will most likely see the rise in dirty war tactics and techniques, with more mercenaries, more artillery bombardment, and more foreign fighters joining on both sides, especially former NATO special operations forces moving into the Ukraine International Legion, and well-paid Syrians on the side of Russia. With this increase in contract soldiers, we can expect more human rights atrocities and atrocities committed against soldiers as well as a relaxation of Geneva rules for armed conflict amongst combatants." Q. Do you expect to see Russia direct more cyber warfare the U.S. way? "I expect a steady, prolonged consistent cyber-conflict campaign waged by Russia against Ukraine and its allies, including the US. I don’t expect an escalation on this front at least at it applies to NATO forces. Russia is saving its most savvy cyberweapons for a possible larger-scaled conflict against a major power." If you’re a journalist looking to know more about what lies ahead as the war between Ukraine and Russia continues and how it may impact the United States, then let us help with your questions and coverage. Dr. Craig Albert is director of the Master of Arts in Intelligence and Security Studies at Augusta University. He is a leading expert on war, terrorism, and American politics. This is an important national and international issue. Albert is available to speak with media – simply click on his name to arrange an interview today.
Journalism, Libel, and Political Messaging in America - UConn's Expert Weighs in
Former Alaska governor and vice presidential candidate Sarah Palin didn't cause the deadly 2011 shooting in Tuscon, Arizona, that injured Congresswoman Gabrielle Giffords, says former journalist and UConn expert Amanda Crawford in a new essay for Nieman Reports. Palin is asking for a new trial after a jury in February rejected her libel lawsuit against the New York Times. Palin sued the newspaper after it published a 2017 editorial that erroneously claimed she was responsible for the shooting. The Times quickly issued a correction. But Crawford says that, in her opinion, Palin has contributed to increased vitriol in American politics today, and that libel laws protecting freedom of the press need to be guarded: Palin, the 2008 Republican vice presidential nominee known for her gun-toting right-wing invective, is now asking for a new trial in the case that hinges on an error in a 2017 Times editorial, “America’s Lethal Politics.” The piece, which bemoaned the viciousness of political discourse and pondered links to acts of violence, was published after a man who had supported Sen. Bernie Sanders opened fire at congressional Republicans’ baseball practice, injuring House Majority Whip Steve Scalise. The Times editorial noted that Palin’s political action committee published a campaign map in 2010 that used a graphic resembling the crosshairs of a rifle’s scope to mark targeted districts. It incorrectly drew a link between the map and the shooting of Rep. Gabrielle Giffords, the Democratic incumbent in one of those districts, while she was at a constituent event in a grocery store parking lot in Tucson less than a year later. I was a political reporter in Arizona at the time, and I remember how Giffords herself had warned that the map could incite violence. “We’re on Sarah Palin’s targeted list,” she said in a 2010 interview, according to The Washington Post, “but the thing is that the way that she has it depicted has the crosshairs of a gun sight over our district, and when people do that, they’ve got to realize there are consequences to that action.” In the wake of the mass shooting in Tucson, some officials and members of the media suggested that political rhetoric, including Palin’s, may be to blame. In fact, no link between the campaign map and the shooting was ever established. As the judge said, the shooter’s own mental illness was to blame. That is where the Times blundered. An editor inserted language that said, “the link to political incitement was clear.” (The Times promptly issued a correction.) This was an egregious mistake and the product of sloppy journalism, but both the judge and the jury agreed that it was not done with actual malice or reckless disregard for the truth. That’s the standard that a public figure like Palin must meet because of the precedent set in the Sullivan case and subsequent decisions. Even if Palin is granted a new trial and loses again, she is likely to appeal. Her lawsuit is part of a concerted effort by critics of the “lamestream media,” including former President Donald Trump, to change the libel standard to make it easier for political figures to sue journalists and win judgments for unintentional mistakes. They want to inhibit free debate and make it harder for journalists to hold them accountable. -- Nieman Reports, March 14, 2022 If you are a reporter who is interested in covering this topic, or who would like to discuss the intersection between politics and media, let us help. Amanda Crawford is a veteran political reporter, literary journalist, and expert in journalism ethics, misinformation, conspiracy theories, and the First Amendment. Click on her icon now to arrange an interview today.
Aston University partners with HSBC UK to support black and ethnic minority student entrepreneurs
HSBC UK launched new student incubator programme in March 2022 Aston University is one of five universities in the country collaborating with HSBC on the pilot programme The programme will support BAME students to bring their business ideas to life. Aston University is partnering with HSBC UK on a new pilot student incubator programme to support black and ethnic minority students to start new businesses. It is one of five universities in the country working in collaboration with HSBC UK to pilot a competitive enterprise programme that will target aspiring entrepreneurs from under-represented and low-income backgrounds to bring their business ideas to reality. The programme will support students of black and minority ethnic backgrounds from Aston University, University of Bedfordshire, De Montfort University, University of East London and Kingston University to bring their commercial aspirations to life. The programme is now live, with successful candidates from each university embarking in March on a 12-week bespoke course run by Start Up Discovery School. The programme will culminate with a finals day to be held in HSBC UK’s Birmingham head office in June. The successful candidates will receive one to one HSBC UK mentoring from commercial banking relationship directors, alongside guidance from the Start Up Discovery School, access to HSBC UK customer webinars and some modest financial support to enable them to bring their commercial ambitions to fruition. It is hoped that the pilot will provide a model for other banks and financial institutions to emulate in collaboration with universities as a way to nurture talent, encourage innovation, and offer support to aspiring entrepreneurs from underrepresented and low-income backgrounds across the UK. Kemi Badenoch MP, Minister of State for Equalities, said: "We’re pleased to see HSBC act on the Commission’s recommendation by launching their Student Incubator Programme to collaborate with a number of universities across the UK. “The programme is designed to support aspiring entrepreneurs from disadvantaged backgrounds to bring their commercial ideas to life and help entrants to attain the business skills they need to aid their long-term success. “We want programmes like this to encourage more people from ethnic minority backgrounds to flourish and to build the next generation of entrepreneurs.” Peter McIntyre, head of small business banking, HSBC UK said: “We are delighted to support new aspiring entrepreneurs and look forward to seeing their creative ideas at the pitch day at our HSBC UK head office in Birmingham. “We are committed to ensuring that access to finance is fair and open to all entrepreneurs and are delighted to be able to further enable these students to start their businesses and to nurture their entrepreneurial talent.” Paula Whitehouse, associate dean for enterprise in the College of Business and Social Sciences at Aston University, said: “Aston Business School is delighted to join HSBC in the development of this major initiative to support the entrepreneurial aspirations of black and ethnic minority students. “The HSBC Student Incubator Programme will provide all-important national networking and expert support to help our leading student entrepreneurs with their new ventures. “We were delighted to be invited by HSBC to help shape this exciting initiative which will support Aston University’s mission to promote inclusive growth in our region and give our innovative students a unique opportunity.” Gosbert Chagula, co-founder of Start Up Discovery School, said: “The early support that entrepreneurs receive, particularly in the early stages, really does have a disproportionate impact on their long-term success prospects. “This impact is even more pronounced when concerning ethnic minority students who typically may not benefit from deep social and professional networks or early funding from family and friends. “This programme is designed to both nurture and grow participants whilst ensuring they are connected to wide ecosystem of support from both across HSBC and beyond.”
Podcast: Women in business - why it’s a strength, not a weakness
Self-confidence is the key when it comes to overcoming barriers in the male-dominated boardroom Unlock the value of mentoring and the ‘coaching culture’ to get the best out of yourself and your business Successful female business leader launched company while doing an MBA at Aston University and caring for her baby. Budding female entrepreneurs should ignore the “voice on the shoulder” undermining their confidence and fulfil their dream of starting their own business. That is the advice given by a professor at Aston University and a successful female business leader in a podcast created to mark International Women’s Day on 8 March. Helen Higson, professor of higher education learning and management at Aston Business School, spoke about the challenges facing women in the latest episode of the ‘Aston means business' podcast series, presented by journalist Steve Dyson. Daniella Genas, who launched her consultancy company She’s The Boss International while studying for her MBA at Aston Business School, was also interviewed on the podcast. Professor Higson, who was awarded an OBE in 2011 for services to higher education, said she had three main tips for women seeking to start their own businesses. She said: “Be yourself, be authentic, don’t try to mimic anyone else, and don’t let that voice on the shoulder chipping away at your confidence win out. “Where this lack of confidence comes from, I do not know, but self-doubt can really get in the way, so have a conversation with your lack of self-confidence by saying ‘shut up you, I will show you’.” The second piece of advice was to “challenge yourself kindly, be very kind to yourself, and don’t beat yourself up”, while the third was to grasp the “power of mentoring and coaching”, with Professor Higson herself having trained as an executive coach during lockdown. She added: “Coaching culture is fashionable now but it’s actually only trying to help people to take responsibility for maximising their own performance.” Daniella Genas, who also completed the Goldman Sachs 10,000 Small Businesses programme at Aston Business School, has similar advice for women looking to emulate her success. She explained that the first issue was for women to “see your difference as a strength, not as a weakness”. She said: “If more women embraced their femininity, their knowledge and competence, and stop allowing the fact that they are women to make them second guess themselves, we’d be able to get so much further.” Ms Genas said women entrepreneurs should also focus on key systems when building businesses so they are not heavily reliant on the owner. She said: “If you do need to step away to have a child, you are [then] not put in a position where you have to sell your business”. That is particularly relevant to Ms Genas as she was forced to sell her first business, Aspire For You, which she set up in 2006, after becoming pregnant with her first child. However, that decision led her to study rather than go on maternity leave, starting with the Goldman Sachs 10,000 Small Businesses programme and then the MBA at Aston Business School, while caring for her baby. Goldman Sachs 10,000 Small Businesses programme, she recalled, “really changed my mindset”. She said: “I found there were businesses double, triple, quadruple the size that I had that were facing the exact same challenges and problems.” Daniella, who obtained a distinction with her MBA, said completing the programmes gave her the confidence to say ‘I am as good as anybody else and probably better in many areas’. She added: “The idea that I may be seen as less than because I am a woman kind of left my brain.” Her company, which helps female-run businesses grow but in a sustainable way, recently became She’s The Boss International after taking on clients in the US and St Maarten. It is a far cry, she says, from being told by teachers at her comprehensive school that she should set her sights a bit lower, even asking her ‘have you considered being a cleaner?’. Professor Higson said Daniella’s story demonstrated the value of education and energy. “You shouldn’t see anything as a barrier,” she said. “I am quite small, 5ft 2in, and one woman leader said to me: ‘You’re going to find it very difficult to be a female leader because you are so small.’ I replied ‘I may be small but I make up for it with my energy.’ It’s about your impact rather than what you look like.” Episode 7 in series 4 of ‘Aston Means Business’ podcast can be found HERE.
Podcast: Russia expert discusses fears of Putin's 'madness' over Ukraine
Speculation that isolation caused by Covid-19 pandemic could have affected his state of mind Closest advisers said to fear for their lives if they speak out against him Potential scenarios considered include a ‘heart attack-style’ assassination of dictator by senior military and secret services. Two years spent isolating during the coronavirus pandemic have led to a debate that Russian President Vladimir Putin has gone ‘bonkers’, resulting in the invasion of Ukraine. There is now even speculation that only a “heart attack-style” assassination of the dictator by his senior military and secret services could prevent Putin from seeking to expand his borders even further. These themes were discussed by Dr Elisabeth Schimpfössl, a senior lecturer in sociology and policy at Aston University, and author of the award-winning book Rich Russians: From Oligarchs to Bourgeoisie. Dr Schimpfössl, speaking about the ongoing Russian invasion of Ukraine as part of the 'Society matters' podcast series, presented by journalist Steve Dyson, explained there were two reasons why Putin had decided to invade its neighbour. She considered two potential reasons behind the invasion: “The first is he has always had ambitions to incorporate eastern Ukraine and, particularly, keep NATO at bay and not have it anywhere so close to Russia’s own borders. The second thought is whether Putin might have simply lost it, in a clinical sense.” Dr Schimpfössl said Putin had been “extremely isolated” during the pandemic, with very few people allowed to see him in his “bunker”. She added: “It might well be, as bizarre as it sounds and unimaginable as it might be, that he is losing it and courting advice from people who have such fear of him that they would say what he wanted to hear.” While such madness is currently pure speculation, Dr Schimpfössl explained how people close to him would potentially “fear for their lives” if they contradicted him or alerted him to what a “crazy idea” war was. She said Russian Foreign Minister Sergey Lavrov, whose daughter lives in New York, had wanted to retire “years ago” but Putin would not let him. And she mentioned claims that the former head of Russia’s foreign secret service died from an apparent heart attack after he “pretty much messed up” the poisoning of double agent Sergei Skripal in Salisbury in 2018. She said: “It’s pretty obvious that similar fears were deep in the bones of all the closest entourage of Putin. They all know pretty well how the system works.” Dr Schimpfössl described reports on how opposition activists and investigative journalists “suddenly, suspiciously, jump off their balcony to their death. And they threaten people that if they don’t jump then their family will suffer”. She suggested that Russia’s billionaire oligarchs could have taken measures if they had seen what was coming. However, the European Union had now added oligarchs onto the sanctions list for the first time after being deeming them “Putin’s cronies” instead of business leaders. Dr Schimpfössl said: “Until Friday, Putin’s plan was to succeed within maybe a week and sanctions would have become effective in weeks, or months from now. Now things have changed and the EU sanctions have gone a big step further on.” She said it will be a “catastrophe” for Russia’s oligarchs now they are subject to sanctions. The only thing that could “save their skin”, she added, is if they create an image of being “anti-war, anti-Putin”. But would this help stop Putin? “Not if he’s completely gone bonkers, then nothing will stop him,” Dr Schimpfössl again speculated. “It makes him extremely dangerous in terms of his announcement of using nuclear weapons. It would be the maddest possible thing to do, but there is no guarantee anymore.” The only thing that could stop him, she hypothesised, was if Putin suffered the similar fate of a “sudden heart attack” following a “silent coup” by Russia’s top military and secret services, although it is pure conjecture that any such actions are being planned. Opinion polls in Russia suggest that only 40 per cent of the population support the action against Ukraine, compared to 80 per cent over the annexation of Crimea in 2014. Dr Schimpfössl said she hoped negotiations between Russia and Ukraine would lead to an agreement, but added: “We know from history when an aggressor sees itself being on the losing end, or things not go according to plan, they often lash out at the very last moment. Any escalation of the conflict could easily and very quickly get very cruel and barbaric.” Episode 1 in series 3 of the ‘Society matters’ podcast and all previous episodes can be found HERE.
