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Global audience in Copenhagen, Denmark, will learn of Gene Editing Institute research targeting the NRF2 gene in cancer cells Kelly Banas, Ph.D., principal investigator at ChristianaCare’s Gene Editing Institute, will present her latest research discovery related to targeting the NRF2 gene in cancer cells at the first CRISPR Medicine Conference held in Copenhagen, Denmark, April 22 to 25. The Gene Editing Institute’s research has focused on the NRF2 gene and the strong immune response it causes within cancer cells, allowing them to grow resistant to chemotherapy and leading cancer treatments to fail. By disrupting the NRF2 gene in cancer cells while allowing healthy cells to continue producing it, chemotherapy treatment becomes more effective. Gene Editing Institute principal investigators Kelly Banas, Ph.D., and Natalia Rivera-Torres, Ph.D., in the lab. Banas’ latest research delves into the mechanism of DNA repair following the removal of NRF2, ensuring that surrounding DNA in healthy cells is not affected and that the repair does not produce an unexpected outcome. “I’m extremely honored to be invited to this conference to highlight the work that all of our researchers at the Gene Editing Institute have put into this study,” Banas said. “The work we have done to characterize the impact of CRISPR on the NRF2 gene has changed how we approach new cancer targets. “This has influenced how we design experiments and analyze our data,” she said, “so it’s got a big impact on not just our work, but the work of anyone we collaborate with in the future. This community is full of phenomenal voices, and we’re committed to sharing our work in contexts like this to continue building a foundation of CRISPR research that will uplift treatment for some of the deadliest and most resilient cancers and diseases.” Read about Banas’ earlier research here.
NASA selects University of Delaware’s CubeSat spacecraft for upcoming mission
It’s safe to say that not many students expect to lead a NASA-supported mission during their undergraduate studies. But at least a dozen from the University of Delaware will have done that by the time they collect their diplomas in the next few years. All are part of a team creating Delaware’s first orbital spacecraft, which was selected by NASA for launch in 2026 as part of its CubeSat Launch Initiative. The NASA program, which started in 2011, aims to give students an opportunity to be part of real missions and gain extraordinary experience in what it takes to do space research. CubeSats are small, modular, inexpensive satellites that carry experiments for science investigations and/or technology demonstrations. About 160 CubeSats have been launched in the NASA program over the years, many deployed from the International Space Station (ISS). Delaware’s mission — the Delaware Atmospheric Plasma Probe Experiment (DAPPEr) — will launch its CubeSat spacecraft from the ISS and orbit independently through Earth’s upper atmosphere. The CubeSat will be about the size of a loaf of bread, according to the team’s faculty mentor, Bennett Maruca, associate professor of physics and astronomy. It will gather data about the density and temperature of electrons in Earth’s upper atmosphere, recording changes observed at different latitudes and times of day. This data will inform future research on how the sun affects conditions there. Understanding the sun’s interaction with the Earth’s atmosphere is critical to development of satellite communications networks, global positioning systems (GPS) and national security. But the real objective is educational, Maruca said. The students are the “deliverables.” They’ll emerge from this work with an insider’s view of what it’s like to develop and work on a NASA mission. To arrange an interview with Maruca, contact UD's media relations team at mediarelations@udel.edu.
New research shines a light on how expert mapmakers at Ordnance Survey see the world differently
OS Remote Sensing Services survey team updating OS MasterMap using the latest aerial imagery (Image credit: OS) Aston University psychologists worked with Ordnance Survey to assess how surveyors use 3D aerial images when making maps Humans naturally assume light comes from above, but experienced surveyors can interpret visual cues to assess topography regardless of the light direction It is the first time it has been shown that experience can radically alter natural human assumptions about lighting and could improve surveyor training. Researchers at Aston University have found differences between experienced Ordnance Survey (OS) mapmakers and novices in the way that they interpret aerial images for mapmaking, which could lead to improved training processes for new recruits. OS is well known for its travel and walking maps, but is also responsible for maintaining Great Britain’s national geographic database. Every time a building is demolished or developed, or a new road and path built, the map must be updated. Aerial photographs are taken of the area that has changed, either from a plane or using drones, and expert mapmakers, known as remote sensing surveyors, will examine the images to identify change and accurately redraw the map of the area. Image pairs are presented stereoscopically, one to each eye, allowing the remote sensing surveyors to see in 3D and correctly assess the topography, such as ditches, hills and hedges. Led by Professor Andrew Schofield, a team from Aston University’s College of Health and Life Sciences, together with Dr Isabel Sargent, previously at OS, carried out a study to understand how remote sensing surveyors interpret the shadows and highlights in images. The researchers asked six trained remote sensing surveyors and six novices to assess 10,000 stereoscopic aerial images of hedges and ditches, which had been heavily masked with image distortions. The stereoscopic images the aerial surveyors use for mapmaking are usually taken on sunny days. The human brain is naturally wired to interpret light as coming from above. However, the light does not come from above in the OS aerial images, it depends on the position of the sun. In the UK, north of the equator, light comes slightly from the south, thus appearing to come from below in images viewed by the surveyors. The researchers wanted to see how manipulating the direction of the light would affect the surveyors. Professor Schofield and the team swapped the image pairs between the eyes in half of the trials, so that hedges might look like ditches, and ditches look like hedges. The images were also flipped vertically on half the trials, changing the direction of the light source. Expert surveyors were found to rely on the stereoscopic cues – the difference in images seen by the two eyes – when performing the task. Novices were more likely to rely on lighting cues – highlights and shadows – to judge the shape and relief of an object, and assumed, as is natural, that the lighting came from above. With the manipulated images, this meant that novices frequently made mistakes. Experts were more accurate, even when the images had been turned upside down, and some had learnt to assume that the light source came from the south, or below. This is the first time anyone has shown that the natural assumption that light comes from above, which is common amongst many animal species, can be changed through long term experience. The researchers say that it could be used to develop new visual training techniques for remote sensing surveyors. For example, intensive exposure to repeated, difficult images can improve performance via a process called perceptual learning. Professor Schofield said: “This is a very exciting result. Others have shown that the light-from-above assumption can be altered by a few degrees, but no one has ever found complete reversals following long term experience. Dr Sargent said: “This result will help Ordnance Survey to understand the expertise of their staff and improve surveyor training and procedures.” Remote sensing surveyor Andy Ormerod, who worked on the study, said: “This research proves that experienced remote sensing surveyors can see the world differently. Whereas non-surveyors are used to seeing the world from one perspective, our brains have learned to view the world as seen from aerial imagery.” Journal of Vision DOI:10.1167/jov.24.4.11
Demystifying Relapse: 2-part series on substance use disorder recurrence and treatment
CARF International Senior Managing Director of Behavioral Health Michael Johnson is a contributor of this terrific two-part series on substance use relapse from the National Council for Mental Wellbeing. NATCON and partnering contributors from CARF International, National Association of Addiction Treatment Providers (NAATP), and the Recovery Research Institute are excited to release the Demystifying Relapse series, which includes two issue briefs that explore the complex dynamics of substance use disorder recurrence and the difficulty of reengaging individuals in the recovery process. “I’m grateful to the National Council for Mental Wellbeing for the opportunity to work with them on these two important documents. The U.S. is facing unprecedented challenges in treating persons with substance use disorders, with access to care continuing to be difficult for many. The field, the payers, and the public at large needs to take time to recalibrate how treatment and return to use are viewed in order to have realistic expectations for care, to destigmatize what it means for a person to return to use, and to ensure there is appropriate types of care available to those who need to re-enter the treatment systems,” said Senior Managing Director of Behavioral Health Michael Johnson. “Only when we recognize that persons who return to use need to have care that is individualized to assist them to stabilize, not start over, can we better ensure that treatment systems are more accessible based on the needs of persons served. The treatment for any chronic illness can be difficult as the path to wellness is often not linear. I hope these two papers can start a dialogue on how to reframe the systems to better meet the needs of those who continue with the recurrence of symptoms.” Michael Johnson is the CARF International Senior Managing Director of Behavioral Health. If you are looking to know more or connect with Michael, view his profile below to arrange an interview today.
Video games tackle climate change
The University of Delaware recently hosted a Climate Change Video Game Jam for students that paired the ingenuity of designing a video game with activism and the use of research to address one of the world's biggest problems. The national video game design competition was the brainchild of A.R. Siders, director of the UD's Mangone Climate Change Science and Policy Hub and core faculty in the Disaster Research Center. Participants representing five universities — UD, the University of California - Irvine, Ohio University, the University of Southern California and Irvine Valley College — competed in the event at UD's Esports Arena. Eight games were submitted and ran the gamut in their design, gameplay and visual effects. They ranged from a game focused on sustainable fishing, an ocean pollution clean-up, pirates cleaning oil spills, a mermaid helping her sea creature friends and a professor collecting magical stones to address storms and sea level rise. Four games included original artwork — both hand-drawn pixel art and 3-D models — and original sound effects and music. One had voice acting by the lead developer because the team “wanted to center her voice” in the game both figuratively and literally. The students behind the latter walked away victorious. As a self-proclaimed “climate geek” and long-time gamer, the idea for such an event was a natural way for Siders to marry two of her passions while actively engaging UD’s student body in addressing environmental issues. “The Jam is a great opportunity to bring people together from totally different perspectives who are all excited about the connections across these themes,” Siders said. “Facts and charts don’t move people. They don’t inspire action or instigate change, but video games can change how people think about climate change.” Siders also hopes that the game jam helps put UD on the map as a place that does cross-disciplinary climate work. “We have excellent expertise in game design, climatology, engineering, ocean science, and environmental humanities,” Siders said. “But our real strength is our ability to put those together creatively.” Members of the media who would like to interview Siders about the Climate Change Video Game Jam or other related topics can visit her profile and click "connect" or send an email to mediarelations@udel.edu.
Professor Roslyn Bill discusses her research into brain cell membranes with Dr Matt Derry Serious brain injuries and dementia are affected by the flow of water through a protein called aquaporin-4 in brain cell membranes Aquaporins are responsible for clearing the build-up of waste products in brain cells in a process Professor Bill likens to a ‘dishwasher for your brain’. Professor Roslyn Bill, co-founder of Aston Institute for Membrane Excellence (AIME), joins Dr Matt Derry to discuss her research into brain cell membranes in the latest Aston Originals podcast. Water moves in and out of brain cells through tiny protein channels in the cell membrane called aquaporins. One in particular, aquaporin-4, is the focus of Professor Bill’s research. In 2020, she was lead author on a paper published in prestigious journal Cell on how the channels open and close and how this can be controlled. Uncontrolled water entry into brain cells can occur after head trauma, causing swelling which leads to severe brain injuries of the type suffered by racing driver Michael Schumacher after a skiing accident. Finding drugs to control this water movement could lead to treatments to prevent brain swelling in the first place. This research into brain swelling and the contribution of aquaporins led Professor Bill to research into Alzheimer’s, a common form of dementia, which is also related to the action of aquaporins. Alzheimer’s is caused by a build-up of waste products in brain cells. In a process Professor Bill likened to a ‘dishwasher for your brain’, aquaporins are responsible for clearing this waste as we sleep. Professor Bill was selected for an Advanced Grant by the European Research Council (ERC) in 2023, which is being funded by UK Research and Innovation (UKRI). The funded project will further investigate the process, and whether it might be possible to develop a drug to boost the ‘brain dishwasher’, which could be taken to slow or even prevent cognitive decline due to ageing. Bringing together this biological research with the polymer research of AIME, chemists like Dr Derry will help in the drug development and could also lead to totally different applications. Professor Bill said in the podcast to Dr Derry: “We can take the knowledge that we have of how these proteins work in cells and try and apply them to interesting applications in biotechnology. And this is where the sort of work that you (Dr Derry) do comes in, where you can develop plastic membranes, polymer membranes, and then take learning from the biology and try and make really, really good ways of purifying water, for example.” For more information about AIME, visit the webpage. The website also includes links to the previous AIME podcast and details about open positions.
Aston University pharmaceutical spin-out company shortlisted in life sciences industry awards
MESOX is a spin-out from the pharmaceutics group at Aston Pharmacy School The company partners with pharmaceutical and biotechnology companies to bring challenging therapeutics to market It has been shortlisted in the Medilink Midlands Awards 2024. A spin-out company from Aston University’s pharmaceutics research group has been shortlisted for a life sciences industry award. The Medilink Midlands Awards aim to showcase the very best collaborations between industry, academia and the NHS across the Midlands. The company, MESOX, founded by Dr Ali Al-Khattawi, a lecturer in pharmaceutics at Aston Pharmacy School, is competing in the Start-Up category for newly established companies that show a promising future. With in-depth expertise in particle engineering for drug delivery and pharmaceutical spray drying, MESOX uses IP-protected carriers to improve the bioavailability and efficacy of pharmaceuticals, partnering with pharmaceutical and biotechnology companies to bring challenging therapeutics to market. Medilink Midlands provides specialist business support to boost the region’s economic output from the life sciences industry. Working alongside the Midlands Engine and other strategic alliances, it helps stimulate additional and value-added growth of the Midlands as a prosperous community for life sciences. The awards winners will be announced at a ceremony taking place on Thursday 9 May at the Athena in Leicester. To celebrate Medilink Midlands’ 20th year anniversary of delivering business support, one finalist will be announced as the 2024 ‘Winner of all Winners’ and presented with a £5,000 prize for innovation development. Dr Ali Al-Khattawi, founder and CEO of MESOX, said: “We are excited to be nominated as a finalist for this award, which is a testament to the innovative research at Aston University that has led to MESOX and a great way to recognise the efforts of our team. “MESOX is expediting the development of life-saving therapeutics through cutting-edge carrier technologies. Our vision is to be a leading research-based pharmaceutical company in the Midlands one day and we hope this opportunity brings us a step closer to this goal.” Luke Southan, technology transfer manager at Aston University, said: “Aston University’s School of Pharmacy has always been a hotbed of innovation and entrepreneurship. This is most often seen through our many students who end up running their own independent pharmacy stores, but it is also the school that has created the most Aston spinouts. “MESOX is the latest example of this, and it is a company that is on track to be generating significant revenue and region impact over the next five years. This award nomination evidences the potential the company has to offer.”
Aston University to help Saudi Arabia turn waste into energy
Energy will help power new cities in the desert Aston University is in talks about converting waste products into vital energy Its Energy and Bioproducts Institute is experienced in the waste-to-energy sector through global collaborations. Aston University researchers are to help turn waste into energy to power new cities in the desert. The University has started talks with experts from Saudi Arabia, including those who are building two sustainable cities in the desert, called NEOM and The Line. They are to collaborate with Aston University and its Energy and Bioproducts Research Institute (EBRI) to explore how they can convert waste products into vital energy. The scientists and engineers are to apply their expertise to help Saudi Arabia create technology to convert discarded matter into a source of energy and other innovations such as using date palm waste to transform desert sand to allow it to retain water and grow crops. Aston University also hosted a two-day conference in March to discuss how to develop and apply the technology. The event is a key element of the UK-KSA Waste2Energy project supported by the Foreign, Commonwealth and Development Office under the Gulf Strategy Fund (GSF) programme and is led by senior lecturer in mechanical, biomedical and design engineering Dr Muhammad Imran. More than 70 delegates attended the conference, including representatives from King Abdulaziz City for Science and Technology (KACST), King AbdulAziz University, The National Research and Development Center for Sustainable Agriculture and the Saudi Investment Recycling Company (SIRC). Professor Patricia Thornley, director of Energy & Bioproducts Research Institute, said: “The delegation chose to collaborate with and visit EBRI because we have common research goals, but some complementarity facilities and skills. We are looking forward to working together to develop some the shared priorities we have identified.” Tim Miller, EBRI director of engagement, added: “Aston University has extensive engagement in the waste-to-energy sector through substantial industrial and academic collaborations globally. Advancements made by institutes like EBRI in waste-to-energy technologies are continually contributing to sustainable energy development.” “The meeting provided an insightful overview of the project, emphasising the significant opportunities it offers to UK industries and academia for funding, collaboration and PhD opportunities. “Our special appreciation is extended to Naif Makki from the Ministry of Energy, Saudi Arabia and his colleagues for their valuable participation.” The event ended with a tour of the EBRI lab and biochar demonstrator plant and a visit to Kew Technology’s Sustainable Energy Centre in Wednesbury.
Major UK tile company joins up with Aston University to digitise for the future
Shropshire-based Craven Dunnill has been in business for over 150 years The company will work with the University through a Management Knowledge Transfer Partnership (mKTP) It will streamline and digitise its warehouse processes and practices as part of a long-term growth plan. The UK’s longest-operating manufacturer, supplier and importer of ceramic tiles has joined forces with Aston University in a Management Knowledge Transfer Partnership (mKTP). Shropshire-based Craven Dunnill, which has been in business for over 150 years, has a large and complex supply chain, both of finished tiles and of the raw materials for manufacturing. Its customers are consumers, merchants, property developers, bathroom and kitchen retailers, in addition to architectural and building communities. A KTP is a three-way collaboration between a business, an academic partner and a highly qualified researcher, known as a KTP associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is a sector leading KTP provider, with 80% of its completed projects being graded as very good or outstanding by Innovate UK, the national body. An mKTP focuses specifically on increasing effectiveness and improving results through better management practices. The company wants to fully streamline and digitise its processes and practices, including ordering, purchasing, stock and warehouse management, as well as delivery planning and sales tracking. It would also see the company’s different business divisions integrated. Developing an accurate real-time warehouse management system is a key part of the project as, currently, different production batches vary slightly in colour and size, making it crucial not to mix them when fulfilling orders. The company is working with Aston University’s Professor Ben Clegg and Dr Gajanan Panchal (academic lead and supervisor) from Aston Business School. Professor Clegg, a professor of operations management, has pioneered a successful methodology called Process Oriented Holonic Modelling (PrOH Modelling), a way of fully engaging employees in organisational change using systems modelling and storyboarding, that will be used to help Craven Dunnill’s employees to guide and implement new processes. Dr Panchal specialises in logistics and supply chain management, including warehouse management and optimisation. He uses a variety of approaches to comprehend and analyse problems with warehousing operations. Completing the team in the KTP associate position is Dr Olanrewaju Sanda, who has started analysing the issues in the warehouse including the data around inventory accuracy and stock selection. Working closely with management and the Aston University team, he will digitalise operational systems. Part of this will include building a digital dashboard to represent the factory and move it towards a ‘digital twin’. Simon Howells, CEO of Craven Dunnill, said: “Although the mKTP is for two years, we don’t see it as a finite project. It will improve our pace of change and our developmental dynamism. Our supply chains and processes are complex, and we know getting the best advice and expertise is going to be really crucial for the long-term growth of the company.” Professor Ben Clegg said: “We’ve been using the PrOH modelling approach in various forms for several research projects. The more people we can involve, the more successful the project tends to be. I think the company was interested in our unique combination of our knowledge of digital technologies, logistics and our expertise in organisational change.” Olanrewaju Sanda said: “The warehouse is the heartbeat of the company – everything flows in and out of there. If we can solve the high-level problems at the warehouse, it will trickle down to everything else and leave the company in the best possible position for the future.”
East or West – who holds the key to our collective future? Public lecture
Professor Jun Du is an applied economist with a keen interest in economic thinking, policy and business strategy Her lecture will examine the differences between Eastern and Western economic models It will take place at Aston Business School on Wednesday 24 April 2024. An influential professor of economics and expert in global trade will be giving an inaugural public lecture at Aston Business School on Wednesday 24 April 2024. Professor Jun Du is an applied economist with a keen interest in economic thinking, policy and business strategy. Her research looks into the drivers and obstacles to boosting productivity and economic growth from the perspectives of individuals, firms, industries, regions and nations. Her lecture, East, West, which is best? - State, Market and the Return of Industrial Policy, promises to be an engaging narrative journey through the contrasting economic development experiences of Eastern and Western countries. Leveraging her extensive research and personal insights, Professor Du will delve into the complex dynamics between state, policies and the twin engines of growth – entrepreneurship and innovation. Professor Du said: “With the backdrop of global challenges, technological upheavals and pressing environmental crises, we find ourselves pondering on the critical question ‘East, West: who holds the key to our collective future?’ “In my lecture I will not just be looking at the differences, but also the strengths and lessons each brings to the table in our quest for sustainable progress and shared prosperity. We will delve into the landscape of economic governance with the formidable powers of the state, the market and entrepreneurs in conflict and convergence, collectively shaping the industries of the future. “This lecture seeks to spark a conversation that encourages innovative approaches to economic governance, with the goal of ensuring lasting prosperity for generations to come. “This is an invitation to change the world. I hope to see you there.” This lecture is free of charge and open to all to attend either in person or online. Places must be booked in advance. You can sign up for this hybrid public lecture here.
