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Discovery may lead to more precise treatments for advanced colorectal cancer Researchers at ChristianaCare’s Cawley Center for Translational Cancer Research at the Helen F. Graham Cancer Center & Research Institute have demonstrated for the first time that microRNA (miRNA) expression leads to a diversity of cancer stem cells within a colorectal cancer tumor. This diversity of cancer cells may explain why advanced colorectal cancer is difficult to treat. Study results have been in the Journal of Stem Cell Research and Therapy. The findings broaden the understanding of how miRNA expression adds to cancer stem cell diversity and may lead to more precise anti-cancer treatments for patients with advanced colorectal cancer. The research builds on prior discoveries by scientists at the Graham Cancer Center about how cancer stem cell activity contributes to the development and spread of colorectal cancer. “Our research shows — at least in the laboratory — that there are different subpopulations of cancer stem cells in a tumor, and they may be driving the growth of the cancer,” said Principal Investigator Bruce Boman, M.D., Ph.D., MSPH, FACP, medical director of Cancer Genetics and Stem Cell Biology at the Graham Cancer Center. “In one subpopulation of cancer stem cells, its miRNA will shut down the stem cell genes that are expressed in another subpopulation, and vice versa, within the same tumor.” From left: ChristianaCare researchers Lynn Opdenaker, Ph.D., Brian Osmond, Bruce Boman, M.D., Ph.D., Chi Zhang, Victoria Hunsu, Caroline Facey, Ph.D. Not pictured Victoria Stark, MS. The study focused on the composition of cancer stem cells within a colorectal cancer cell line (HT29) in the laboratory setting. Researchers evaluated the different cancer stem cell subpopulations that were identified by examining patterns of miRNA expression in each subpopulation and looking for differences. The researchers found that each of the four diverse subpopulations that were studied (ALDH, LRIG1, CD166 and LGR5) had a different miRNA expression or gene signature. The researchers found that miRNA expression could inhibit the expression of messenger RNA (mRNA), which carries instructions from the DNA to encode specific proteins within cells. Therefore, miRNA, by controlling gene expression, dictate which proteins are contained in the stem cells. The researchers discovered the miRNA that are upregulated in certain cancer stem cell subpopulations are downregulated in other cancer stem cell subpopulations. In this way, differential miRNA expression leads to cancer stem cell heterogeneity within colorectal tumor tissue. “It’s an early research finding and needs to be followed up with other experiments, but it has clear relevance to the clinic,” Boman said. “The question is: Can you target the miRNA to make cancer more sensitive to certain treatments? Because we know what the current anti-cancer treatments are targeting, we may be able to modulate or manipulate the cancer, so it becomes more sensitive to the treatment.” Identification of a network of genes regulated by microRNAs in a cancer stem cell subpopulation. For more than a decade, ChristianaCare’s researchers have contributed to the understanding of the role that cancer stem cells and miRNA expression play in the development and spread of colorectal cancer. This latest finding builds on earlier discoveries that examined a link between two cellular signaling pathways: retinoic acid (RA) signaling and wingless-related integration site (WNT) signaling, which are dysregulated by different gene mutations in colorectal tumors. The RA signaling pathway induces growth arrest and differentiation of cancer stem cells. Notably, retinoic acid is effective against other types of cancer such as leukemia. The role of the WNT signaling pathway has an opposite effect on tumor growth. The WNT signaling pathway is activated by a mutation in the APC (adenomatous polyposis coli) gene in about 90% of cases of colorectal cancer. In APC mutant tissue, dysregulated miRNA expression may underlie an imbalance between the RA and WNT signaling, which then leads to intratumoral cancer stem cell heterogeneity. Still, this mechanism that may enable the cancer to proliferate could also provide clues on how to more effectively treat cancer. “If you’ve got an imbalance between these two signaling pathways, then you’ve likely got a growth driver,” Boman said. “The question is: Can you suppress the WNT signaling and enhance the retinoic acid signaling?” It may be possible to increase the sensitivity of colorectal cancer to retinoic acid-type drugs, and therapeutically shift the balance between different cancer stem cell subpopulations, thereby suppressing cancer growth. More research is needed to determine how targeted cancer therapies containing retinoic acid-type drugs may be made more effective against advanced cancer. This research will be presented at the annual meeting of the American Association for Cancer Research in Orlando, Florida, April 14-19. This research project was supported by a grant from the Lisa Dean Moseley Foundation.

• Professor Patricia Thornley welcomes latest UK energy security plans • But calls for more exploration of bioenergy with carbon capture and storage • She believes plans shouldn’t concentrate solely on energy such as wind and solar power. A leading biomass scientist at Aston University has welcomed the government’s announcement to ensure UK energy is more secure. However, Professor Patricia Thornley, director of Aston University’s Energy and Bioproducts Research Institute (EBRI), believes the government shouldn’t just concentrate on energy such as wind and solar power. She is calling for the government to explore the use of power bioenergy with carbon capture and storage (or power BECCS). On 30 March the Department for Energy Security and Net Zero published the Powering Up Britain: Net Zero Growth Plan, and the Powering Up Britain: Energy Security Plan to set out steps to make the UK more energy independent, secure and resilient. Professor Thornley believes that the UK’s carbon reduction targets could be tackled by delivering negative emission BECCS projects. The process uses sustainable biomass and waste materials to generate electricity in combination with carbon capture and permanent storage. Through this physical removal of greenhouse gases from the atmosphere, power BECCS is able to deliver negative emissions. Professor Thornley said: “It is wonderful to see the government moving forward with its carbon reduction plans, whilst recognising the scale of the challenge faced. “Bioenergy is delivering carbon reductions around the UK today - 62% of our renewable energy and around 13% of our electricity comes from biomass - and developing sustainable biomass conversion with carbon capture and storage (CCS) would be a natural progression for the UK. “So it is good to see commitment to CCS, but to fully leverage the UK’s negative emission potential we need BECCS technology to be rapidly deployed.” EBRI and the Supergen Bioenergy hub, which is led by Aston University, are working on applied research to progress this ambition. Professor Thornley added: “Our research at Aston University has demonstrated the potential for sustainable BECCS facilities to deliver a substantial proportion of UK required negative emissions but that the exact amount of negative emissions achieved can vary hugely with plant design and operational choices. So we hope to use our knowledge and research outputs to support UK deployment of sustainable bioenergy moving forward.“ As well as her research at Aston University, Professor Thornley has been contributing her expertise to a government working group exploring the sustainable use of biomass for two years. ENDS

Aston University establishes new independent investment company
Aston University is part of a group of eight universities which has established a new investment company Midlands Mindforge will accelerate the commercialisation of university research It aims to raise up to £250 million from investors. Aston University is one of eight research intensive universities in the Midlands to establish a new investment company to accelerate the commercialisation of university spinouts and early-stage IP rich businesses in the region. Midlands Mindforge Limited has been co-founded by Aston University, University of Birmingham, Cranfield University, Keele University, University of Leicester, Loughborough University, University of Nottingham and University of Warwick, collectively Midlands Innovation. This ambitious, patent capital investment company plans to raise up to £250 million from strategic corporate partners, institutional investors and qualifying individuals. It aims to transform ground-breaking science and technology into successful businesses with real-world impact. Midlands Mindforge will help to address the significant funding deficit for early-stage technology businesses in the region. Through the combination of additional capital and company-building skills, Midlands Mindforge will lay the foundations of a more vibrant ecosystem for emerging science-backed companies in areas such as Clean Technology, AI and Computational Science, Life Sciences and Health Tech. Professor Aleks Subic, Vice-Chancellor of Aston University, said: "Aston University has a strong track record in bringing together industry and academia to solve real world problems and drive innovation through applied and translational research. Â Investment raised through Midlands Mindforge will enable a step change that will ensure we get the very best outcomes for our research. "The impact of increased investment in research translation will be felt widely, with Midlands Mindforge supporting the growth of high value added businesses and jobs in the region and creating the right conditions to build future global companies. This is a hugely exciting time for Aston University and the wider Midlands Innovation group of universities, and I look forward to seeing the benefits that this strategic development will bring." Collectively, the eight founding universities have the most postgraduate students, the highest levels of annual income, more research disclosures and patents generated per unit of research spend in the last three years, in comparison to any other UK university grouping. Minister of State for Science, Research & Innovation George Freeman MP said: "Commercialising UK science & technology for global industrial adoption has never been more urgent for both the UK economy and the global resource challenges facing us. The Midlands Innovation universities are driving a new era of innovation from robotics and advanced manufacturing to life science and autonomous vehicles and much more. "As we in Government increase UK public R&D to a record £20 billion a year, the key is private finance backing spinouts and scale-ups. The Midlands is rapidly becoming a world class UK cluster of excellence and Midlands Mindforge will play a key role in bringing global investors to help back world class companies." Chairman of the Midlands Engine Partnership, Sir John Peace, said: "The Midlands has always been associated with exceptional invention and creativity, but has long experienced significant underinvestment and consequently productivity levels have lagged behind the rest of the UK. "This bold and ambitious initiative led by the Midlands Innovation universities has the potential to help close the investment gap, supporting our region to reach its true potential for sustainable economic growth. Midlands Mindforge will help to further fast-track commercialisation of research ideas, creating a more resilient economy and playing an important role in levelling up the Midlands." Andy Street, Mayor of the West Midlands, said: "A key part of my mayoral mission is to drive our regional recovery forward and help generate the high-quality jobs of the future in order to improve quality of life for local people. This exciting new investment vehicle will very much support that mission planting the seeds for long-term sustainable economic growth here in the West Midlands. "Many brilliant ideas and top businesses have spun out from Midlands universities and this new venture will help us to advance that agenda and retain more of our innovative success stories within our region. "Together we can better nurture the enterprising talent on our doorstep and this new endeavour creates a wonderful opportunity to do just that." For more information about Midlands Mindforge visit www.midlandsmindforge.com

Ask an Expert: Is the "AI Moratorium" too far reaching?
Recent responses to chatGPT have featured eminent technologists calling for a six-month moratorium on the development of “AI systems more powerful than GPT-4.” Dr. Jeremy Kedziora, PieperPower Endowed Chair in Artificial Intelligence at Milwaukee School of Engineering, supports a middle ground approach between unregulated development and a pause. He says, "I do not agree with a moratorium, but I would call for government action to develop regulatory guidelines for AI use, particularly for endowing AIs with actions." Dr. Kedziora is available as a subject matter expert on the recent "AI moratorium" that was issued by tech leaders. According to Dr. Kedziora: There are good reasons to call for additional oversight of AI creation: Large deep or reinforcement learning systems encode complicated relationships that are difficult for users to predict and understand. Integrating them into daily use by billions of people implies some sort of complex adaptive system in which it is even more difficult for planners to anticipate, predict, and plan. This is likely fertile ground for unintended – and bad – outcomes. Rather than outright replacement, a very real possibility is that AI-enabled workers will have sufficiently high productivity that we’ll need less workers to accomplish tasks. The implication is that there won’t be enough jobs for those who want them. This means that governments will need to seriously consider proposals for UBI and work to limit economic displacement, work which will require time and political bargaining. I do not think it is controversial that we would not want a research group at MIT or CalTech, or anywhere developing an unregulated nuclear weapon. Given the difficulty in predicting its impact, AI may well be in the same category of powerful, suggesting that its creation should be subject to the democratic process. At the same time, there are some important things to keep in mind regarding chatGPT-like AI systems that suggest there are inherent limits to their impact: Though chatGPT may appear–at times–to pass the famous Turing test, this does not imply these systems ’think,’ or are ’self-aware,’ or are ’alive.’ The Turing test aims to avoid answering these questions altogether by simply asking if a machine can be distinguished from a human by another human. At the end of the day, chatGPT is nothing more than a bunch of weights! Contemporary AIs–chatGPT included–have very limited levers to pull. They simply can’t take many actions. Indeed, chatGPT’s only action is to create text in response to a prompt. It cannot do anything independently. Its effects, for now, are limited to passing through the hands of humans and to the social changes it could thereby create. The call for a moratorium emphasizes ‘control’ over AI. It is worth asking just what this control means. Take chatGPT as an example–can its makers control responses to prompts? Probably only in a limited fashion at best, with less and less ability as more people use it. There simply aren’t resources to police its responses. Can chatGPT’s makers ‘flip the off switch?’ Absolutely – restricting access to the API would effectively turn chatGPT off. In that sense, it is certainly under the same kind of control humans subjected to government are. Keep in mind that there are coordination problems – just because there is an AI moratorium in the US does not mean that other countries–particularly US adversaries– will stop development. And as others have said: “as long as AI systems have objectives set by humans, most ethics concerns related to artificial intelligence come from the ethics of the countries wielding them.” There are definitional problems with this sort of moratorium – who would be subject to it? Industry actors? Academics? The criterion those who call for the moratorium use is “AI systems more powerful than GPT-4.” What does “powerful” mean? Enforcement requires drawing boundaries around which AI development is subject to a moratorium – without those boundaries how would such a policy be enforced? It might already be too late – some already claim that they’ve recreated chatGPT. There are two major groups to think about when looking for develop regulatory solutions for AI: academia and industry. There may already be good vehicles for regulating academic research, for example oversight of grant funding. Oversight of AI development in industry is an area that requires attention and application of expertise. If you're a journalist covering Artificial Intelligence, then let us help. Dr. Kedziora is a respected expert in Data Science, Machine Learning, Statistical Modeling, Bayesian Inference, Game Theory and things AI. He's available to speak with the media - simply click on the icon now to arrange an interview today.

Aston University and asbestos consultancy to use AI to improve social housing maintenance
• Aston University and Thames Laboratories enter 30-month Knowledge Transfer Partnership • Will use machine-learning and AI to create a maintenance prioritisation system • Collaboration will reduce costs, emissions, enhance productivity and improve residents' satisfaction. Aston University is teaming up with asbestos consultancy, Thames Laboratories (TL) to improve efficiency of social housing repairs. There are over 1,600 registered social housing providers in England, managing in excess of 4.4 million homes. Each of these properties requires statutory inspections to check gas, asbestos and water hygiene, in addition to general upkeep. However, there is not currently a scheduling system available that offers integration between key maintenance and safety contractors, resulting in additional site visits and increased travel costs and re-work. Aston University computer scientists will use machine-learning and AI to create a maintenance prioritisation system that will centralise job requests and automatically allocate them to the relevant contractors. The collaboration is through a Knowledge Transfer Partnership (KTP) - a collaboration between a business, an academic partner and a highly-qualified researcher, known as a KTP associate. This partnership builds on the outcomes of TL’s first collaboration with Aston University, by expanding the system developed for the company’s in-house use - which directs its field staff to jobs. The project team will improve the system developed during the current KTP to enable it to interact with client and contractor systems, by combining an input data processing unit, enhanced optimisation algorithms, customer enhancements and third-party add-ons into a single dynamic system. The Aston University team will be led by Aniko Ekart, professor of artificial intelligence. She said: “It is a privilege to be involved in the creation of this system, which will select the best contractor for each job based on their skill set, availability and location and be reactive to changing priorities of jobs." TL, based in Fenstanton, just outside Cambridge, provides asbestos consultancy, project management and training to businesses, local authorities, social housing and education facilities, using a fleet of mobile engineers across the UK. John Richards, managing director at Thames Laboratories, said: “This partnership will allow us to adopt the latest research and expertise from a world-leading academic institute to develop an original solution to improving the efficiency of social housing repairs, maintenance and improvements to better meet the needs of social housing residents.” Professor Ekart will be joined by Dr Alina Patelli as academic supervisor. Dr Patelli brings experience of software development in the commercial sector as well as expertise in applying optimisation techniques with focus on urban systems. She said: “This is a great opportunity to enhance state-of-the-art optimisation and machine learning in order to fit the needs of the commercial sector and deliver meaningful impact to Thames Laboratories.”

• Leading scientist wins €2.2 million ERC Advanced Grant • The five-year project will explore early dementia interventions through understanding how an aquaporin water channel regulates glymphatic clearance • ERC Advanced Grant funding is amongst the most prestigious and competitive of the EU funding schemes. A world leading scientist in the College of Health and Life Sciences at Aston University has been awarded a €2.2 million ERC Advanced Grant to understand how the movement of a protein known as aquaporin-4 in the brain can help slow cognitive decline. The FORTIFY project, which will run for five years, is led by Professor Roslyn Bill in the School of Biosciences. She will apply her discovery of the movement of aquaporin-4 to understand how the cleaning mechanism in the brain works during sleep. The research will focus on how aquaporin-4 controls the glymphatic system, which is the mechanism that allows us to clear waste products from our brains while we sleep. Her hypothesis is that the movement of aquaporin-4 in the brain changes the effectiveness of this cleansing mechanism - which lessens as people age. A greater understanding of this process could lead to an early intervention treatment that could slow the onset of dementia, such as Alzheimer’s and Parkinson’s Diseases. ERC Advanced Grant funding is amongst the most prestigious and competitive of the EU funding schemes, providing researchers with the opportunity to pursue ambitious, curiosity-driven projects that could lead to major scientific breakthroughs. Professor Bill said: “Every three seconds someone in the world develops dementia and there is no cure. I want to stop that from happening. By understanding the molecular mechanisms of brain waste clearance, we have an opportunity to develop medicines that can slow the onset of dementia, very much in the same way that statins are prescribed to control heart disease”. Roslyn Bill discovered that the water channel protein aquaporin-4 increases the permeability of brain cells to water after a brain or spinal cord injury. Around 60 million people a year suffer such injuries following falls or accidents. For example, after a skiing accident in the French Alps in 2013, Michael Schumacher suffered a severe head injury. He was placed in a medically induced coma and underwent several surgeries to treat his injuries. Until now doctors have only been able to manage the symptoms of brain injury (swelling on the brain) through interventions that may require surgery. Professor Bill and her team are due to start clinical trials in summer 2023, to test a method to stop the swelling from happening in its tracks, building on her discoveries. Roslyn’s new ERC-funded project, FORTIFY, will focus on how aquaporin-4 controls fluid flow in the healthy, uninjured brain. In this round of Advanced Grants, the European Research Council (ERC) is awarding €544 million to 218 outstanding research leaders across Europe, as part of the Horizon Europe programme. The grants will support cutting edge research in a wide range of fields, from medicine and physics to social sciences and humanities. The grant is awarded to established, leading researchers with a proven track-record of significant research achievements over the past decade. The funding will enable the researchers to explore their most innovative and ambitious ideas. Mariya Gabriel, European Commissioner for Innovation, Research, Culture, Education and Youth, said: “ERC grants are a top recognition and a significant commitment from our best researchers. The €544 million funding puts our 218 research leaders, together with their teams of postdoctoral fellows, PhD students and research staff, in pole position to push back the boundaries of our knowledge, break new ground and build foundations for future growth and prosperity in Europe” Maria Leptin, ERC President, added: "These new ERC Advanced Grantees are a testament to the outstanding quality of research carried out across Europe. I am especially pleased to see such a high number of female researchers in this competition and that they are increasingly successful in securing funding. “We look forward to seeing the results of the new projects in the years to come, with many likely to lead to breakthroughs and new advances.”

Expert comment available Powering up Britain new policy paper
Powering up Britain policy paper The government has this morning announced policy plans to improve the UK’s energy security, economic opportunities of the transition, and achieve its net zero commitments. Professor Patricia Thornley director of Aston University’s Energy and Bioproducts Research Institute (EBRI) is available to explain what this is and how it could affect our lives. Professor Thornley is an expert in the use of power bioenergy with carbon capture and storage (power BECCS). For further details contact Nicola Jones, Press and Communications Manager, on (+44) 7825 342091 or email: n.jones6@aston.ac.uk

MEDIA RELEASE: CAA Worst Roads Campaign marks 20 Years of Driving Change in Ontario
The annual CAA Worst Roads advocacy campaign is marking its 20th year of influencing change. For the past two decades, the campaign has given decision-makers a snapshot of the roads that the public perceives as not meeting their expectations. “Our research tells us that 85 per cent of Ontarians are concerned about the state of our roads,” says Teresa Di Felice, assistant vice president of government and community relations, CAA SCO. “Due to inflation, consumers are being more mindful of their purchases, and people are opting to hold on to their cars for longer instead of buying a new one. Funding for roadway improvements and proper infrastructure needs to be consistent to ensure that quality and safety are maintained.” CAA’s research also indicates that over half of CAA members (59 per cent) say Ontario’s roads have worsened. Drivers often alter their driving behaviour to accommodate road issues. Many of them – two-thirds (66 per cent) of Ontarians – are slowing down for bad spots on the road or swerving to avoid potholes. We also know that many people are frustrated with Ontario's roads (78 per cent) and often express their dissatisfaction to their loved ones or colleagues instead of government officials. The CAA Worst Roads campaign allows all road users in Ontario to vote for roads that they think need urgent repair. Since 2003, 114 roads in Ontario have appeared on the provincial Top 10 list, of which governments have prioritized some of the roads for repair. In 2022, Barton Street East in Hamilton, Ontario, secured the top spot on the provincial Worst Roads list. Shortly after the 2022 Worst Road reveal, the City of Hamilton announced a multi-year, multi-phase reconstruction of the beleaguered Hamilton route scheduled to begin late last year. Other roads, such as Plank Road in Sarnia, Victoria Road in Prince Edward County, Lauzon Parkway in Windsor, and Bell Farm Road in Barrie, have also undergone significant repairs after appearing on the provincial Top 10 Worst Roads list. “The campaign has demonstrated that decision-makers are paying attention to the results, which has prompted municipal officials to move up infrastructure projects in their communities,” says Di Felice. The CAA Worst Roads campaign calls on all Ontarians to vote for their Worst Road today and join the community of drivers, cyclists, and pedestrians committed to improving Ontario’s roads. Ontarians can vote for their worst road at caaworstroads.com. Watch Teresa Di Felice, Assistant Vice President, Government and Community Relations for CAA SCO answers questions regarding the annual CAA Worst Roads Campaign: https://vimeo.com/user140657252/caawrl2023

Professor James Wolffsohn and Dr Sònia Travé Huarte in collaboration with NuVision won the Medilink Business Award 2023 for a Partnership between Academia and Business The optometry researchers were recognised with an award for their partnership with a company that develops treatments for ocular diseases The collaboration has directly benefitted patients and enhanced global research knowledge. Researchers in the School of Optometry and Vision Sciences at Aston University have been recognised with an award for their partnership work with NuVision, a company that develops treatments for ocular diseases Professor James Wolffsohn and Dr Sònia Travé Huarte recieved the Medilink Business Award 2023 for a Partnership between Academia and Business at a prestigious ceremony held on 16 March in the Great Hall at the University of Birmingham. Professor Wolffsohn, who is also the head of the School of Optometry at Aston University, said: “We are delighted to have won this Medilink award in partnership with NuVision. This collaboration has directly benefitted our patients with this common chronic, debilitating disease, has enhanced global research knowledge in dry eye management and enhanced the local economy. The team at NuVision are exceptional and it is a pleasure to continue to innovate with them.” NuVision has an expert team of scientific, clinical and industry professionals dedicated to building innovative ocular biotherapies. It was founded in 2015 based on 15 years of translational research at the University of Nottingham. The company develops ocular biotherapies through research and innovation. The Medilink Midlands Business Awards 2023 are sponsored by the University of Birmingham and the Precision Health Technologies Accelerator Ltd. The awards event saw 13 life science companies based in the East and West Midlands receive awards from Start-Up to Outstanding Achievement. A further six companies received Highly Commended certificates. For more information about the School of Optometry and the Vision Sciences Research Group please visit our website.

Cyber threats have become one of the leading issues for corporations, governments, and public institutions across America. With ransomware attacks, hackers, and other nefarious threats, the issue is becoming a daily occurrence and leading news story. Rensselaer Polytechnic Institute’s James Hendler, director of the Future of Computing Institute, Tetherless World Professor of Computer, Web, and Cognitive Sciences, and director of the RPI-IBM Artificial Intelligence Research Collaboration, weighs in on what we should all know about cybersecurity. Overview Think about cybersecurity the way you think about home security – the more valuables you have, the more security you need. A normal user needs the equivalent of a lock on the door, which most of our computers provide out of the box. However, a user with a fair amount of personal information, who keeps financial records or runs a small business, probably wants a firewall or other additional protection. We used to tell people to protect their computers with firewalls, malware detectors, and the like, but now it is much more important to protect your web access, be wary of external sites, and keep your passwords secure and not easily guessed. Use of a password manager program can be really helpful for people who use a lot of different accounts. Threats The biggest threat facing individuals is identity theft caused by someone getting into an account that you don’t control. Most malware or password stealing comes via a phishing attack (a fake email that convinces you to click a bad link), so if you see an offer that looks too good to be true, don’t believe it. Never give out a password or personal information without confirming that it is legitimate. We also recommend not using major accounts (like Google, Facebook, etc.) to log in to new apps where you aren’t completely sure of the reliability – you’re safer if you use a separate password. It’s also worth noting that these kinds of attacks are now happening on cell phones – if you get a text saying your Amazon, Netflix, or other services have been shut off, be very careful. These companies almost never send out such messages, and if they do, they come via email, not text. For businesses, ransomware is becoming an increasing challenge. Frequent backups and dual authentication are absolute musts for small businesses. Large businesses, and especially those with cyber-physical connections such as a manufacturing device, must have someone on the team who understands internet technology. Outside audits done annually, at least, are also highly recommended. The biggest danger in cybersecurity is that people, especially in businesses, think that the software industry will fix things and that they don’t have to worry. That’s like expecting auto manufacturers to stop car theft, or the government to prevent all crime – these organizations certainly need to help, but they cannot be perfect. So while there definitely needs to be a role for manufacturers and government, people need to understand that the threats are now coming from social interactions such as phishing, or serious criminal enterprises such as ransomware attackers, and not just maladjusted teenagers. They must be ready to pay for some security if they have things on their network that need protection. The Cloud Cloud-based services are a major boon to cybersecurity for individuals and small businesses if, and only if, people protect their access. If a breach is reported to you by a company, don’t ignore it, change your password, and, whenever possible, use dual authentication. The cloud companies can afford to spend more on security than you can and thus your information stored in these services tends to be quite secure. However, people need to be careful in using the cloud. Just as you may trust a bank with your money, you want to be sure not to be robbed on your way there. Future Computing Systems and Cybersecurity New technologies, such as artificial intelligence (AI), are arising all the time in today’s fast-moving cyber world. As these technologies arise, they can create new opportunities for cybersecurity, but can also create new challenges. Cybercrime will never disappear, and each new capability comes with a price. Increased education and awareness of emerging computing technologies (blockchain, quantum, etc.) are important not just for the expert, but also for the general public. It is important to stay informed and pay attention to what is being reported. Just as buying a new appliance can be a great advantage at home (I love my new air-fryer), you also have to be sure to be using it appropriately (used wrong, it can cause fires). Looking to learn more or connect with an expert for your questions and coverage? James Hendler is the director of the Rensselaer Future of Computing Institute, Tetherless World Professor of Computer, Web, and Cognitive Sciences, and director of the RPI-IBM Artificial Intelligence Research Collaboration. Hendler has authored over 400 books, technical papers, and articles in the areas of Semantic Web, artificial intelligence, cybersecurity, and high-performance processing. Hendler is available to speak with media - simply click on his icon now to arrange an interview today.





