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Researchers awarded £2 million to develop drugs to prevent epileptic seizures in children
• Three-year research project to develop new drug treatments for childhood epilepsy • Scientists will test new treatment on pieces of living brain tissue • The research is a collaboration between Aston University, Bristol University and Jazz Pharmaceuticals. Scientists at Aston University have started work on a project that will look for new drug treatments to prevent the onset of childhood epilepsy. The three-year Medical Research Council (MRC) funded project is a collaboration led by researchers in the College of Health and Life Sciences at Aston University, partnered with Bristol University and Jazz Pharmaceuticals. They have been awarded £2 million to explore how epilepsy becomes established in the brain and how this process might be prevented. The researchers will test new drugs in the human brain, using samples of living tissue taken from children with difficult to treat epilepsies who have had to have brain surgery. Epilepsy is a brain disease which is characterised by seizures. As Professor Gavin Woodhall, lead researcher and co-director of Aston Institute of Health and Neurodevelopment, explains: “Seizures are periods of time when networks of brain cells are too active and are uncontrollably excited and spiking. If uncontrolled excitation spreads to brain regions that control movement, then too many brain cells are ‘talking at the same time’ and we can see seizures as changes in movement such as jerks and twitches.” Upon receiving the grant, Professor Woodhall said: “We will be able to study epilepsy in such detail that we hope to be able to treat the problems that underly epilepsy and not just the seizures themselves. And this could help pave the way to prevent epilepsy from developing in children at all. “Essentially we want to find a treatment that stops the brain from being able to establish epilepsy after the first seizure - via a new drug treatment. We will be testing a known drug and a new drug to see if the drug can do this.” As part of the research for this project the scientists will look at how different amounts of epileptic activity in the brain can alter the brain’s excitability. The researchers predict that if there are a lot of seizures, the synapses in the brain will decrease their activity and brain cells will become more likely to spike. Professor Woodhall added: “This is why we will test antiepileptic drugs, and new drugs designed to interfere with homeostatic scaling - which is a form of plasticity, in which the brain responds to chronically elevated activity in a neural circuit with negative feedback, allowing individual neurons to reduce their overall action potential firing rate. “By interfering with homeostatic scaling we will be able to see if they can prevent seizures from developing or reducing their intensity.” The research will allow Professor Woodhall and his team to be able to record the life history of the disease. This is something which has not been done before in this level of detail and it is predicted it will help to shed light on how epilepsy initially develops in the brain. Following on from the three-year project the team will move into drug development and then clinical trial. For more information about research being undertaken at AIHN please go to our website. If you are interested in the courses we have available in this area please go to our course pages.
COP27 should be turning point to switch from heating homes with fossil fuels Professor Patricia Thornley, was a presenter at COP26 in Glasgow She believes one year on there’s not enough progress to cut emissions from homes. One of the UK’s leading bioenergy experts has said COP27 should be a turning point to help UK consumers switch from heating their homes with fossil fuels. Professor Patricia Thornley, director of Aston University’s Energy and Bioproducts Institute (EBRI), was a presenter at COP26 in Glasgow last year. She leads the UK’s national bioenergy research programme, SUPERGEN Bioenergy hub. Her research focuses on assessing the sustainability of bioenergy and low carbon fuels. Professor Thornley believes that one year on, not enough has been done to encourage the public to cut down on the emissions their homes produce. The UK has the oldest housing stock among developed countries, with 8.5 million homes being at least 60 years old. That is despite COP26’s reaffirmation of the Paris Agreement goal of moving away from fossil fuels, and the call for stronger national action plans to reduce carbon dioxide emissions. She has welcomed initiatives to help some UK industries move towards net zero, but believes householders are not getting the same support, for example with help to insulate their homes more effectively. She said: “Responses to the energy crisis in which we find ourselves have been mixed. “Government initiatives such as funding feasibility studies for hydrogen from bioenergy (turning biomass into hydrogen whilst separating and capturing the carbon portion of the biomass) and other technologies are promising.” Professor Thornley adds: “The recent price hikes in petrol and natural gas highlight the extent to which the UK relies on fossil fuels. “Unlike some areas of industry, domestic consumers have been treated differently, and recent help with energy costs is arguably subsidising us to keep emitting carbon dioxide. “A more forward-thinking approach would have been to invest in tackling the root cause of the problem by addressing home insulation.” Professor Thornley is a fellow of the Royal Academy of Engineering, and recently gave evidence to the Environmental Audit Committee about the use of sustainable timber in the UK as an alternative fossil fuel.
New research highlights the economic importance of live music to Birmingham and the West Midlands
It found local authorities need to more explicitly recognise the economic, social and cultural value of live music and live music venues The report calls for dialogue between music stakeholders and government The research is published by Aston University and supported by the AHRC-funded Creative Industries Policy and Evidence Centre. New research by the Birmingham Live Music Project (BLMP) highlights the huge economic value of Birmingham’s live music scene, the vital contribution small independent venues make, the ongoing impact of the pandemic and what is needed to support the recovery of the sector in the city. The research is published by Aston University, with colleagues from Newcastle University and Birmingham City University, and supported by the Arts and Humanities Research Council (AHRC)-funded Creative Industries Policy and Evidence Centre. In 2019, the UK’s live music sector was valued at over £1.3 billion. After almost a decade of strong growth the sector helped push the UK music’s overall GVA from £3.5 billion in 2012 to £5.8 billion in 2019, the outbreak of the global pandemic brought it to a near standstill. This paper explores, through a local lens and a focus on Birmingham, the challenges stakeholders across the live music sector have faced in recent years. The research finds that small live music venues are the lifeblood of this financial, cultural and community asset for the city. In 2019 Birmingham helped bring 877,000 music tourists to the West Midlands, with a total cultural spend in the region of £252,000,000 (UK Music). But during summer 2020, the research published today found, Birmingham’s live music capacity of approx. 98,000 dropped by around 75%. This impacted ticket prices, the availability of events across the city, and the economic viability of shows – while some venues could stay open, they couldn’t make a profit. The report makes clear independent venues need protection and support particularly in the wake of the pandemic. It calls for dialogue between music stakeholders and government in advance of the 2025 review of the EU-UK Trade and Co-Operation Agreement to identify the best means of reducing friction and support for the efforts to improve the Agreement, for example work on border force training, expanding the number of checkpoints where carnets and Music Instrument Certificates can be checked, reducing bureaucracy for live event transport and haulage, examination of further measures to develop the ’dual registration’ system for specialist hauliers to ease pressure on touring. Dr Patrycja Rozbicka, a senior lecturer in politics and international relations at Aston University and one of the report authors, said: “Local authorities need to more explicitly recognise the economic, social and cultural value of live music and live music venues, including grassroots venues, to their region(s). “Environmental, health, culture and city regeneration strategies have to take account of the existing and huge potential contribution of live music to the city and region. “What is needed is a cross-policy approach, implementation of a Night-time Industry Impact Assessment and dialogue between local authorities and the music sector, where the recently launched West Midlands Music Board could play a role. “We would like to see the creation of information hubs to support local venues and audiences with initiatives such those undertaken by the Liverpool City Region including a Music Fund which supports activities of the Liverpool City Region Music Board as well as helping with funding applications and advice. You can read the full report here.
• University expert helps clothes designer measure and tackle their carbon emissions • Upcycler, ‘Missfit Creations’, has saved CO2 equivalent of three tonnes • Call to COP27 to issue a protocol to measure all garments’ environmental impact. 8 November 2022 | Birmingham UK As policymakers at COP27 are to discuss the effects of the fashion industry on the environment, an Aston University scientist has been helping a clothes designer measure and tackle their carbon emissions. Debbie Murphy runs Missfit Creations which provides an alternative to fast fashion. She saves clothes from clogging up landfill by restoring and reworking second-hand and vintage clothing, from de-mob suits and 1970s psychedelia, to the present day. Dr Maria Pimenta da Costa Ocampo, a researcher from the Energy & Bioproducts Research Institute (EBRI) at Aston University, has been identifying the impact the business is having on reducing carbon emissions. By analysing the recirculation of second-hand clothes alone, she found Debbie’s current fashion collection has the potential to save the CO2 equivalent of three tonnes – equal in size to at least three semi-detached houses. The support provided to Tamworth-based Missfit Creations was through EBRI's European Regional Development Fund (ERDF) programme that helps West Midlands companies develop low carbon goods and services. Debbie said: “It was eye-opening to work with Aston University. “I collect and restore a huge amount of old, unwanted clothes that would otherwise have ended up in landfill, so I decided to find out what impact my business has on the environment. “I knew my business would help tackle the effects of fast fashion, but I didn’t realise I’ve been able to prevent the production of so much CO2. “Raising awareness of second-hand clothes over fast fashion, and the increased awareness of clothing care efficiency will help reduce the carbon footprint of the textile industry.” The Aston University report also suggests ways the business can further decrease emissions. As a result, it will be introducing a ‘take-back’ scheme, offering vouchers or exchanges in return for previous purchases. Debbie will also be changing production methods by ensuring all packaging is biodegradable, ironing fabrics less and switching to a more sustainable energy provider. The COP27 fashion charter event (11 November 2022) will explore whether the sector’s planned transformation to net zero is underway, practical solutions that are being applied and what is needed to achieve the goal. However, Dr Pimenta-Ocampo said: “Every single action taken towards the production and recirculation of clothing has an environmental impact. “For example, we calculated that by recirculating vintage clothing, Missfit Creations was reducing CO2 equivalent by almost two tonnes just by diverting clothes from landfill. “And by outsourcing their vintage clothes for cleaning services that don’t use tumble driers, not taking into account transport emissions, Missfit Creations is reducing CO2 equivalent by another one tonne. “There is a great need for the textile industry to monitor and provide accurate data and to become more transparent, specially when global supply chains are involved. “However, the creation of a protocol and standardisation of the Life Cycle Assessment, which measures a product’s environmental impact from raw material to final disposal, is also required. Without it, it will be impossible to produce results that can be representative.”
Aston University and Birmingham Women’s and Children’s NHS Foundation Trust (BWCH) have pledged to work together to address health provision in the city by signing a Memorandum of Understanding to co-develop paediatric health initiatives and the health services workforce of the future to deliver them. The strategic partnership between the University and BWCH aims to develop the health services workforce of the future together (particularly focusing on course development and delivery, including placements). It will also invest in shared posts that support closer links between academic, education and healthcare provision and support honorary appointments and initiate collaborative projects including joint research, to develop world-leading research and provision in the field of paediatric health and wellbeing. The partnership will make the most efficient use of resources and reduce duplication by providing a range of shared services, as well as continuously developing new ways to work together, with a view to supporting innovation in the field of healthcare. These activities will build on the existing joined up work taking place between Aston University and Birmingham Women’s and Children’s NHS Foundation Trust, such as shared use of the MRI scanning services in the Aston Institute for Health and Neurodevelopment and joint research projects examining topics including epilepsy in children, eating behaviours and neurodevelopment. Both organisations are also members of Birmingham Health Partners, the city’s clinical-academic research alliance, which includes maternal health as one as its key strategic focus areas. Professor Anthony Hilton, pro-vice-chancellor and executive dean of the College of Health and Life Sciences at Aston University, said: “The signing of this Memorandum of Understanding formalises the existing relationship between our two organisations and represents a strong joint commitment to improving healthcare provision in our city. “Working collaboratively enables us to bring together world-leading research with outstanding clinical provision, for the benefit of our students, patients accessing BWCH services and our city and region. I look forward to developing the many ways in which our organisations can work together to improve healthcare provision in Birmingham.” Matthew Boazman, deputy chief executive officer of Birmingham Women’s and Children’s Hospital NHS Foundation Trust, said: “The partnership between BWCH and Aston University represents a wonderful opportunity for us to ensure that Birmingham has access to world-class healthcare provision and that those entering the workforce are as ready as they can be.”
New approach to help ease poor countries’ debt burden Many face having national credit rating downgraded Aston University expert coins the term the ‘credit rating impasse’ in new book. An Aston University financial regulation expert has suggested a new approach to help ease poor countries’ debt burden. Currently many poorer countries face having their credit rating downgraded if they ask private investors for loans. Dr Daniel Cash, senior lecturer in law and founder of the Credit Rating Research Initiative, has suggested that a temporary change to the way ratings are decided could help these countries avoid a damaging credit rating, which would prevent them borrowing money in the future. His theory is explored in his new book Sovereign Debt Sustainability: Multilateral Debt Treatment and the Credit Rating Impasse. The study details the history of multilateral debt treatment in Africa, whilst also looking at the impact of the pandemic. When vulnerable countries try to negotiate new lending terms with their lenders their credit rating is immediately downgraded, in some cases they could be labelled as in default - failing to repay a loan. Dr Cash calls this situation the ‘credit rating impasse’. To avoid this happening, he argues that other factors should be temporarily taken into account, making it easier for them to borrow money in the future to spend on improvements such as healthcare or infrastructure. The UN has identified 54 developing economies with severe debt problems. While accounting for little more than 3% of the global economy, they represent 18% of the world’s population, and more than 50% of people living in extreme poverty. The book sets out a new framework which could be used to overlie the existing credit rating system. The book suggests considering factors such as ESG (Environmental, Social and Governance) – which indicates a country’s impact on society, the environment, and how transparent and accountable it is. Taking ESG and sustainability factors into account indicates if a nation has the potential to grow while benefiting the environment and communities. Dr Cash said: “The credit rating impasse is a systemic problem, and a cure is needed to prevent the bankruptcy of countries around the world. “Lower-income states are being forced to prioritise debt payments over public spending on healthcare or access to food. “Instead, they should be offered help to enable borrowing to make vital improvements.” The book is free to read via Open Access Book and was funded by the Open Society Foundations (OSF).
High quality biodiesel produced from microalgae ‘fed’ on leftover coffee grounds Breakthrough in the microalgal cultivation system Could decrease reliance on palm oil to produce biofuel. Two Aston University researchers have produced high-quality biodiesel after ‘feeding’ and growing microalgae on leftover coffee grounds. Dr Vesna Najdanovic, senior lecturer in chemical engineering and Dr Jiawei Wang were part of a team that grew algae which was then processed into fuel. In just the UK, approximately 98 million cups of coffee are drunk each day, contributing to a massive amount of spent coffee grounds which are processed as general waste, often ending up in landfill or incineration. However the researchers found that spent coffee grounds provide both nutrients to feed, and a structure on which the microalgae (Chlorella vulgaris sp.) can grow. As a result, they were able to extract enhanced biodiesel that produces minimal emissions and good engine performance, and meets US and European specifications. The study, Enhancing growth environment for attached microalgae to populate onto spent coffee grounds in producing biodiesel, appears in the November 2022 issue of Renewable and Sustainable Energy Reviews. Up till now, algae has been grown on materials such as polyurethane foam and nylon that don’t provide any nutrients. However, the researchers found that microalgal cells can grow on the leftover coffee without needing other external nutrients. They also found that exposing the algae to light for 20 hours a day, and dark for just four hours days created the best quality biodiesel. Dr Najdanovic said: “This is a breakthrough in the microalgal cultivation system. “Biodiesel from microalgae attached to spent coffee grounds could be an ideal choice for new feedstock commercialisation, avoiding competition with food crops. “Furthermore, using this new feedstock could decrease the cutting down of palm trees to extract oil to produce biofuel. “In southeast Asia this has led to continuous deforestation and increased greenhouse gas emissions.” The research was developed in collaboration with colleagues from Malaysia, Thailand, Egypt, South Africa and India. Their work was supported by the 2020-21 Global Challenges Research Fund (GCRF) block grant funded by the UK Research and Innovation (Aston University).
Evidence that behaviour follow a two-step process when we’re in a crowd We are likely to imitate the crowd first and think independently second Findings will increase understanding of how humans make decisions based on others’ actions. An Aston University computer scientist has used artificial intelligence (AI) to show that we are not as individual as we may like to think. In the late 1960s, famous psychologist Stanley Milgram demonstrated that if a person sees a crowd looking in one direction, they’re likely to follow their gaze. Now, Dr Ulysses Bernardet in the Computer Science Research Group at Aston University , collaborating with experts from Belgium and Germany, has found evidence that our actions follow a two-step process when we’re in a crowd. Their results, Evidence for a two-step model of social group influence, published in iScience show that we go through a two-stage process, where we’re more likely to imitate a crowd first and think independently second. The researchers believe their findings will increase the understanding of how humans make decisions based on what others are doing. To test this idea the academics created an immersive virtual reality (VR) experiment set in a simulated city street. Each of the 160 participants was observed individually as they watched a movie within the virtual reality environment that had been created for the experiment. As they watched the movie, 10 computer-generated ‘spectators’ within the VR simulated street were operated by AI to attempt to influence the direction of the gaze of the individual participants. During the experiment, three different sounds such as an explosion were played coming from either the left or right of the virtual street. At the same time, a number of the ‘spectators’ looked in a specific direction, not always in the direction of the virtual blast or the other two sounds. The academics calculated a direct, and an indirect, measure of gaze-following. The direct measure was the proportion of trials in which participants followed the gaze of the crowd. The indirect measure took into account the reaction speed of participants dependent on whether they were instructed to look in the same or opposite direction as the audience. The experiment’s results support the understanding that the influence of a crowd is best explained by a two-step model. Dr Bernardet, said: “Humans demonstrate an initial tendence to follow others – a reflexive, imitative process. But this is followed by a more deliberate, strategic processes when a person will decide whether to copy others around them, or not. “One way in which groups affect individuals is by steering their gaze. “This influence is not only felt in the form of social norms but also impacts immediate actions and lies at the heart of group behaviours such as rioting and mass panic. “Our model is not only consistent with evidence gained using brain imaging, but also with recent evidence that gaze following is the manifestation of a complex interplay between basic attentional and advanced social processes.” The researchers believe their experiments will pave the way for increased use of VR and AI in behavioural sciences.
Are butter boards bad for you? An expert view on the latest food trend
In an unexpected twist, butter seems to be back on the menu. After years of being a maligned ingredient that many people shied away from, butter has now become the latest food trend on social media, thanks to the recent popularity of “butter boards”. These are sort of the meat-free equivalent of a charcuterie board. Butter is whipped then spread onto a chopping board, sprinkled with a variety of toppings – from sweet to savoury – and served with an accompaniment of choice (such as bread or a toasted baguette). But although they may be delicious, butter is still full of saturated fat – which many of us know can be harmful to our health. Here’s what you may want to consider before whipping up a butter board of your own. Is butter really that bad? Butter is made from cream, the fat-rich part of milk. While it’s usually made from cow’s milk, it can also be made from other milks such as goat milk. The reason that butter has been seen as a no-go for so many years is because it’s one of the ultimate sources of saturated fat. Butter contains around 80% fat, of which about two-thirds is saturated fat. It contains little else nutrient-wise. Saturated fats should be avoided in large amounts as they’re linked with many health problems, including heart disease and shorter life expectancy. Clinical trials have also shown that saturated fats can have an negative effects on blood cholesterol levels. When it comes to butter on its own, it appears that eating it has a relatively small or neutral effect on the risk of heart disease. But research that compared butter to olive oil (another source of saturated fat) found that butter can increase levels of LDL cholesterol, which is sometimes called “bad” cholesterol as it’s linked to greater risk of heart disease. But the majority of the butter many of us consume in our diets comes from other foods such as biscuits, cakes and pastries. Alongside butter, these foods tend also to contain high amounts of sugar, while being low in other nutrients. High intakes of these types of foods is also linked with greater risk of heart disease. Overall, sharing a butter board with friends every now and then is unlikely to cause much harm to your health. But doing it often, or eating very large quantities, could raise cholesterol levels and increase your risk of cardiovascular disease somewhat. It’s also worth bearing in mind what toppings you serve your butter board with. Certain foods (such as processed or cured meats) also contain saturated fats, and should only be enjoyed occasionally. Butter alternatives Since butter is very calorific and fat-rich, some people may want to look at using butter alternatives for the base of their butter board. The first substitute many people might look to is margarine. Margarine is chemically very similar to butter. Depending on the product though, it only contains around 40%-70% fat, making it a lighter alternative with a possibly similar taste. In the past, the processes needed to make margarine solid resulted in the production of trans fats, which have been linked to increased risk of heart disease. But these processes have since been improved so margarine no longer contain trans fat. So it may be a good option for people wary of the amount of fat they consume. Another alternative people may look at using is ghee, also sometimes known as clarified butter. A staple of Indian cooking, this is still made from milk, but the fat is much more concentrated as most of the water has been simmered away. This means it won’t have the same creamy texture as butter. Grass-fed ghee is as rich in saturated fats as butter. It also contains naturally produced trans fats. However, these trans fats are different to the industrially produced types which are bad for our health. But since ghee contains more calories than butter, it may not be the best choice for a butter board, especially if you’re looking for the best flavour. Cultured butter may also be a choice for your butter board. This is made from cream which has been fermented like yoghurt. However, no research to date has looked at whether the probiotics in cultured butter provide the same health benefits as those in yoghurt and other fermented foods. Nutrition-wise, it contains the same amount of fat and calories as regular butter. All in all, butter is not bad. But since it’s very high in calories and cholesterol, you may want to try not to have too much. Sharing a butter board with some friends or loved ones every now and again is unlikely to have any long-term negative impact on your health.
Research suggests nutrition education should be on the curriculum of all medical students as well as other healthcare professionals Association for Nutrition develops new curriculum ready for medical students Aston University is one of the pioneers in delivering and embedding nutrition education as part of its medical school undergraduate programme. All healthcare professionals should study a curriculum of nutrition education during their studies in order to help better support public health – new paper suggests. Nutritional researchers from Aston University, with colleagues from other universities and leading nutritional groups, worked with the Association of Nutrition (AfN) to help develop a curriculum that can be rolled out amongst all undergraduate medical school students with potential for modules to be taught to other healthcare professional courses. The paper jointly published in the British Journal for Nutrition and BMJ Nutrition, Prevention and Health examined the development of a new curriculum aimed at undergraduate medical students and made recommendations on its roll out nationally, with a view to it subsequently being implemented into other healthcare courses. The AfN Undergraduate Curriculum in Nutrition for medical doctors has been designed to be presented to medical students as an integral part of their general undergraduate training, making it clear how nutrition interrelates with the study of other systems and contributes to an inclusive understanding of health and disease. Dr Duane Mellor, clinical dietitian and senior lecturer at Aston Medical School at Aston University and co-author on the paper, said: “At present, lifestyle related health problems from living with obesity, through to high blood pressure, type 2 diabetes, heart disease and several cancers can all be linked to diet across our communities. Whereas in hospitals around a third of patients coming in can be undernourished. “Nutrition and food play a key role to both keeping us healthy and helping to manage disease, which is why it is imperative we educate our future doctors and other health professionals about the role of nutrition in patient care.” The paper sets out not only the need for nutrition education and the gaps, but how it can be included as part of what is already a very busy and content heavy curriculum. It builds on areas of the curriculum where nutrition could even be used to help teach concepts such as epidemiology. It highlights how historically medical education along with the education of many health professionals not specialising in nutrition often have only a few hours of teaching on the subject. Dr Glenys Jones, deputy chief executive at the Association for Nutrition, who led the curriculum development project and is co-author on the recent paper, said: “Nutrition is a key and modifiable determinant of health and wellbeing, therefore it is essential our future medical and healthcare professionals are equipped to be able to identify when nutrition could be involved in a patient’s condition in order for this to form part of their care. “The curriculum is not designed to turn our doctors into nutritionists or dietitians, but to give them the knowledge and skills to be able to think about whether nutrition could be playing a role and having the confidence and knowledge of who, when and how to refer on to suitable nutrition professionals when this is needed.” Aston University is a pioneer in the key area of nutrition education of the future healthcare workforce. As one of few UK universities with a dietitian or nutritionist as part of the teaching team within its medical school, these skills are now being developed to benefit the training of other health professionals. Dr Mellor added: “As one of a few dietitians and nutritionists embedded into the teaching team at Aston Medical School, we have been able to integrate nutrition across our curriculum. “It is great to be able to highlight how nutrition links to the basic science areas such as biochemistry through to how you can encourage a patient to think about changing their diet in clinical skills". Aston University has also started to explore with the Association for Nutrition the potential need for nutrition education in other professions. From this an outline of a core curriculum for nutrition for a range of health professionals is in development. Dr Mellor also plans to work with colleagues to further develop nutrition teaching at Aston University, thus helping students across subjects such as optometry and pharmacy to gain a better understanding of nutrition and how it impacts on their areas of expertise. For more information about Aston Medical School please visit our website.