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Smell training, not steroids, best treatment for Covid-19 smell loss
Steroids should not be used to treat smell loss caused by Covid-19 according to an international group of smell experts, including Prof Carl Philpott from the University of East Anglia. Smell loss is a prominent symptom of Covid-19, and the pandemic is leaving many people with long-term smell loss. But a new study published today shows that corticosteroids - a class of drug that lowers inflammation in the body – are not recommended to treat smell loss due to Covid-19. Instead, the team recommend ‘smell training’ – a process that involves sniffing at least four different odours twice a day for several months. Smell loss expert Prof Carl Philpott from UEA’s Norwich Medical School, said: “The huge rise in smell loss caused by Covid-19 has created an unprecedented worldwide demand for treatment. “Around one in five people who experience smell loss as a result of Covid-19 report that their sense of smell has not returned to normal eight weeks after falling ill. “Corticosteroids are a class of drug that lowers inflammation in the body. Doctors often prescribe them to help treat conditions such as asthma, and they have been considered as a therapeutic option for smell loss caused by Covid-19. “But they have well-known potential side effects including fluid retention, high blood pressure, and problems with mood swings and behaviour.” The team carried out a systematic evidence-based review to see whether corticosteroids could help people regain their sense of smell. Prof Philpott said: “What we found that there is very little evidence that corticosteroids will help with smell loss. And because they have well known potential adverse side effects, our advice is that they should not be prescribed as a treatment for post-viral smell loss. "There might be a case for using oral corticosteroids to eliminate the possibility of another cause for smell loss actually being a confounding factor, for example chronic sinusitis – this is obviously more of a diagnostic role than as a treatment for viral smell loss. “Luckily most people who experience smell loss as a result of Covid-19 will regain their sense of smell spontaneously. Research shows that 90 per cent of people will have fully recovered their sense of smell after six months. “But we do know that smell training could be helpful. This involves sniffing at least four different odours twice a day every day for several months. It has emerged as a cheap, simple and side-effect free treatment option for various causes of smell loss, including Covid-19. “It aims to help recovery based on neuroplasticity - the brain’s ability to reorganise itself to compensate for a change or injury,” he added. The research was led by researchers at the Cliniques universitaires Saint-Luc in Brussels (Belgium) in collaboration with the Univeristé catholique de Louvain, Brussels (Belgium), the University of East Anglia (UK), Biruni University, Istanbul (Turkey), Aarhus University (Denmark), Université du Québec à Trois-Rivières (Canada), Geneve University Hospitals (Switzerland), Harvard University (USA), Aristotle University, Thessaloniki (Greece), University of Insubriae (Italy), University of Vienna (Austria), the University of Chicago (USA) and the University of Colorado (USA). ‘Systemic corticosteroids in COVID-19 related smell dysfunction: an international view’ is published in the journal International Forum of Allergy & Rhinology.
Could Smarter Guns Be the Key To Stopping Mass Shootings and Other Violence?
“Gun violence in this country is an epidemic, and it’s an international embarrassment,” President Biden recently said. At least 45 mass shootings have occurred in America in the last month, according to reports. In the same time period, news of police officers killing unarmed Black men and boys, including 20-year-old Daunte Wright in Minneapolis and 13-year-old Adam Toledo in Chicago, sparked waves of protest around the country. These all-too-common tragedies could be significantly reduced — and even eliminated — without any of the partisan rancor and gridlock typically associated with gun-related debates, says Selmer Bringsjord, an expert in artificial intelligence and reasoning and a professor of cognitive science at Rensselaer Polytechnic Institute. “There is a solution,” Bringsjord, the director of the Rensselaer AI and Reasoning Laboratory, wrote in the Times Union. “A technological alternative to the fruitless shouting match between politicians: namely, AI — of the ethical sort. Guns that are at once intelligent and ethically correct can put an end to the mass-shooting carnage.” Rather than an endless debate over whether the public should have more guns or less, Bringsjord’s novel – and, he says, plausible – proposal is to shift to “smart and virtuous guns, and intelligent restraining devices that operate in accord with ethics, and the law.” Along with his coauthors, Bringsjord detailed his ideas in a recent paper, “AI Can Stop Mass Shootings, and More.” Anticipating some counterarguments, the authors urge readers “to at least contemplate whether we are right, and whether, if we are, such AI is worth seeking.” Bringsjord and his collaborators have created simulations showing how, in only 2.3 seconds, ethical AI technology can perceive a human’s intent and environment and then, if necessary, prevent their gun from firing. Importantly, he notes, the same technology that could prevent a criminal from opening fire in a public area could also prevent a police officer from shooting a person who posed no threat. “Ultimately research along this line should enable humans, in particular some human police, to simply be replaced by machines that, as a matter of ironclad logic, cannot do wrong,” Bringsjord said in a recent public radio segment. The AI capabilities discussed by Bringsjord are the product of prior work over seven years of funding from the Office of Naval Research devoted to developing moral competence in robots. Bringsjord has spoken about robots and logic at TEDxLimassol. He is the author of What Robots Can and Can’t Be and Superminds: People Harness Hypercomputation. He is also the co-author of Artificial Intelligence and Literary Creativity: Inside the Mind of Brutus, a Storytelling Machine. Bringsjord is available to speak about his recent proposals around AI-enabled guns, as well as other aspects of AI, human and machine reasoning, and formal logic.
UMW's psychological trauma expert Laura Wilson weighs in on survivors of recent mass shootings
Media have been covering what has been a deadly year in America, with nearly a dozen mass shootings to date. UMW's psychological trauma expert Laura Wilson has been the go-to person to help journalists understand the impact these horrific events have on survivors. Recently, Dr. Wilson was interviewed about the recovery process American Olympic hopeful Maggie Montoya is facing after witnessing first-hand the shooting in Boulder, Colorado, as she prepares to represent America this summer in Tokyo. Laura C. Wilson, associate professor of psychology at the University of Mary Washington in Fredericksburg, Va., has focused on post-trauma functioning from mass trauma. She says most people's exposure and understanding of mass shootings consists of the immediate aftermath. "They see the news coverage of the crime scene and watch the investigators' news briefing," Wilson said. "Within a few days the news trucks leave and people's attention turns to the next major news event. This is when the grief and recovery work starts for the survivors." Wilson said every person will process the events differently. Some will have intense, acute reactions that subside in a few days or weeks. Effects could be chronic for others, and some experience delayed reactions. "Each person is different, and their recovery will look different," she said. Wilson didn't speak specifically about Montoya's running community but said community overall is a powerful strength for survivors in the aftermath of a mass shooting. "It creates a sense of belonging, which can promote psychological recovery," Wilson said. "Having supportive family and friends to validate the feelings and help you process your thoughts is certainly a protective factor." April 18 - The Northwest Arkansas Democrat-Gazette If you are a reporter looking to cover the issues survivors of mass-shooting events will experience, then let us help. Dr. Laura Wilson is a clinical psychologist whose expertise focuses on post-trauma functioning, particularly in survivors of sexual violence or mass trauma (e.g., terrorism, mass shootings, combat). Her research interests extend to predictors of violence and aggression, including psychophysiological and personality factors, as well as indicators of PTSD following mass trauma, long-term functioning among first responders, outcomes among survivors of sexual violence and the influence of media on mental illness stigma. Dr. Wilson is available to speak with media, simply click on her icon to arrange an interview today.
Kelley expert available to discuss Bernard Madoff's legacy, long-term effect of his scheme
Bernard “Bernie” Madoff, convicted architect of an infamous and epic securities Ponzi scheme with thousands of investors, died behind bars on April 14 at the age of 82. Noah Stoffman, an associate professor of finance and Weimer Faculty Fellow at the Indiana Kelley School of Business, has researched the effect of such fraud beyond the direct investments that were lost by victims. His 2018 paper, “Trust Busting: The Effect of Fraud on Investor Behavior,” co-authored with professors at Cornell University and the University of Texas-Dallas, showed that the collapse of the Madoff Ponzi scheme had an effect not only on his many direct victims, but also on the general level of trust in financial services. “People who live in the same areas as victims of the fraud withdrew assets from investment advisers and increased their deposits in banks. Financial advisers in these areas were also more likely to close. Our analysis shows that advisers who provided services that can build trust—such as financial planning advice—saw lower levels of withdrawals. Our evidence suggests that this decline in trust shock was transmitted through social networks,” Stoffman said. Stoffman’s research focuses on the investment decisions of professional money managers and individual investors, and on the effect of technological innovation on asset prices. Much of his work highlights the importance of social interaction in the spread of information in financial markets. Stoffman teaches courses on analysis of financial data to undergraduates, MBAs, and doctoral students at the Kelley School. He can be reached at 812-955-1758 (m) or nstoffma@indiana.edu.
Toolkit is easily incorporated into any laboratory science course Wilmington, Del., April 1, 2021 – St. Georges Technical High School in southern New Castle County, Delaware is the first high school in the United States to use ChristianaCare Gene Editing Institute’s innovative CRISPR in a Box Educational Toolkit™ in a science class. CRISPR in a Box brings to life the much-heralded CRISPR gene editing technology – the “genetic scissors” that allow scientists to edit DNA. The toolkit is designed for educational sessions in secondary and post-secondary schools and is suitable for remote learning. “Gene editing is the future of medicine,” said Eric Kmiec, Ph.D., director of ChristianaCare’s Gene Editing Institute. “Our partnership with the Delaware Department of Education will help cultivate the next generation of genetic scientists and enhance Delaware’s position as a leader in the biosciences.” “We are thrilled that students at St. Georges Technical High School will be the first In the United States to experience a live demonstration of CRISPR gene editing using our Innovative CRISPR in a Box educational toolkit,” said Siobhan Hawthorne, Education and Community Outreach leader at ChristianaCare’s Gene Editing Institute. “This toolkit will provide STEM students with a visual understanding of how the exciting CRISPR technology can unlock medical treatments to improve lives.” Delaware Secretary of Education Susan Bunting praised her department's partnership with ChristianaCare's Gene Editing Institute to develop the “Seeds of STEM” course that teaches high school students about gene editing. “Gene editing approaches diseases in new ways and will have significant impact in the health care and agriscience fields,” Bunting said. “This is a great example of an industry and education partnership investing in youth by providing hands-on knowledge and skills around emerging technology.” “We are so fortunate that ChristianaCare’s Gene Editing Institute reached out to our program to plan a high school ‘first’ opportunity with this new CRISPR experiment,” said Danya Espadas, one of the St. Georges biotech teachers. “Giving students the chance to use a cutting-edge, 21st century tool for medicine in their own high school lab – to have that technology at their fingertips – transcends what they see in a textbook or a video. By being able to do it themselves, it makes it real for them.” Espada said the experiment focuses on editing a gene of a non-infectious E.coli bacteria to become resistant to an antibiotic, thereby allowing researchers to create a new class of antibiotics that cannot be overcome by bacteria that are gene resistant. “We’re talking about eventually saving lives, here,” she said. “What can be more important than that?” The tools in CRISPR in a Box have been designed based on the pioneering discoveries of the Gene Editing Institute that are currently being used to explore next-generation medical therapies and diagnostics for diseases, including lung cancer and sickle-cell anemia. Component items in the toolkit include the CRISPR/Cas complex, a target DNA molecule, a mammalian cell free extract and a synthetic DNA molecule. All materials in the kit are safe, synthetic materials. There are no live cultures or viruses involved. The kit is meant to provide a hands-on demonstration of CRISPR’s capabilities, and not allow for manipulations of living organisms. “The kit is easy and fun to use,” said Kristen Pisarcik, research assistant at the Gene Editing Institute who has taught students at Delaware Technical Community College which first used the toolkit. “In a short period of time students will reliably and successfully complete the laboratory activity and be able to see the results of gene editing,” she said. Since the foundations of the kit touch upon key themes in biology, it can be readily incorporated into practically any science or biology course with a laboratory component, “One of the beauties of CRISPR in a Box is that there is no need to purchase specialized equipment. If a teaching lab can support bacterial cultivation, it can perform the in vitro gene editing lab activity,” Pisarcik said. CRISPR in a Box is the evolution of a partnership between the Gene Editing Institute, Delaware Technical Community College and Rockland Immunochemicals that began in 2017 with a National Science Foundation grant to develop the first-ever gene editing curriculum for community college students. Video and photo collection of first class in U.S. to use CRISPR in a Box™ educational gene editing toolkit. About ChristianaCare’s Gene Editing Institute The Gene Editing Institute, a worldwide leader in CRISPR gene editing technology and the only institute of its kind based within a community health care system, takes a patient-first approach in all its research to improve the lives of people with life-threatening disease. Since 2015, researchers at the Gene Editing Institute have been involved in several ground-breaking firsts in the field, including the development of the first CRISPR gene editing tool to allow DNA repairs outside the human cell which will rapidly speed therapies to patients and a unique version of CRISPR called EXACT that reduces the number of off-target edits to other areas of the genome, which is vital for further research and patient applications. Its researchers are currently developing a patient trial for lung cancer using CRISPR and employing the technology to combat the COVID-19 pandemic. About the biotech program St. Georges Technical High School The Biotech career program of study at St. Georges Technical High School is the first such program offered in a Delaware high school. With two teachers and approximately 100 students in grades 10-12, the program presents advanced content in biology and chemistry with opportunities for students to learn basic laboratory techniques and procedures and to maintain and operate common instruments and equipment used in a biotechnology laboratory. St. Georges is a comprehensive career and technical high school with 1,100 students who study in one of 16 different career pathways.
How worried should you be about coronavirus variants? A virologist explains his concerns
Paulo Verardi, Associate Professor of Virology and Vaccinology at UConn, was asked to lend his expertise and opinion to The Conversation about coronavirus variants and just how concerned Americans should be about the emergence of variants and the speed at which they are spreading across the country and the globe. Spring has sprung, and there is a sense of relief in the air. After one year of lockdowns and social distancing, more than 171 million COVID-19 vaccine doses have been administered in the U.S. and about 19.4% of the population is fully vaccinated. But there is something else in the air: ominous SARS-CoV-2 variants. I am a virologist and vaccinologist, which means that I spend my days studying viruses and designing and testing vaccine strategies against viral diseases. In the case of SARS-CoV-2, this work has taken on greater urgency. We humans are in a race to become immune against this cagey virus, whose ability to mutate and adapt seems to be a step ahead of our capacity to gain herd immunity. Because of the variants that are emerging, it could be a race to the wire. April 08 - The Conversation Dr. Verardi discusses the the five SARS-CoV-2 variants we all need to be watching, the rates of transmission and the severity of symptoms, and why we all need to remain on guard and get vaccinated. It is a great article, and if you are a journalist looking to cover this topic, then let us help with your stories. Dr. Paulo Verardi is a virologist who specializes in vaccine research and development and is a member of the Center of Excellence for Vaccine Research. Dr. Verardi is available to speak with media regarding variants and COVID-19 – simply click on his icon now to arrange an interview today.
This year marks 100 years since the signing of the Anglo-Irish Treaty, which eventually would establish Ireland as a republic, and Georgia Southern University undergraduate student Caitlyn Hudson is getting a first-hand look at some historical documents that chronicle U.S. efforts to help establish Ireland’s freedom from British rule. Hudson is researching a collection of documents called the Lawless papers, which follow Virginia-native and Irish descendant Joseph Thomas Lawless’ involvement in the southern leg of an extensive U.S. tour by Éamon de Valera, a prominent political leader in Ireland’s history. “My favorite part of working on the project has to be the physical work with the documents,” Hudson said. “It is fascinating to see primary documents in hand rather than online. It provides a unique form of analysis.” The collection, which was gifted in Fall 2020 to the Center for Irish Research and Teaching (CIRT) at Georgia Southern, includes letters, advertisements and more that document an important narrative in modern Irish-American history, according to Howard Keeley, Ph.D., director of CIRT. “These documents shed significant new light on how Ireland perceived Savannah and our region at a critical time in Irish history: that nation’s War of Independence from 1919 to 1921,” Keeley said. “The collection helps us understand the network that Éamonn de Valera and other future leaders of an independent Ireland sought to build in the American South, using as one anchor the sizable and active Irish-American community in Savannah.” All of the Lawless papers were either written or received by Lawless, the son of immigrants from County Galway, Ireland. Lawless was involved in arranging southern stops on de Valera’s tour, which included a stop at the Chatham Artillery Armory in April 1920, in an effort to raise funds for the self-proclaimed Republic of Ireland. Lawless, who would go on to become a lawyer and prominent political figure in Virginia, was also very devoted to Ireland and involved in several prominent Irish-American organizations, including the Friends of Irish Freedom (FOIF), which advocated for political independence for Ireland. “De Valera’s fundraising tour of the U.S. is among the most important episodes in modern Irish-American history,” said Keeley. “The collection sheds significant light on how FOIF used the tour to advance a southern strategy. Clearly, Judge Lawless was key to those efforts.” Keeley also pointed out that in time, de Valera would become prime minister, and then president, of an independent Ireland, dominating the country’s politics for decades. The collection was gifted to CIRT by direct descendants of Lawless and is now housed in the special collections section of the Zach S. Henderson Library. “We are honored to be granted stewardship of these documents,” said Autumn Johnson, special collections librarian at Zach S. Henderson Library. “Having increased opportunities for Georgia Southern students to examine rare, one-of-a-kind collections, such as the Lawless papers, enriches the learning experience, particularly for our undergraduates.” Hudson said her work on the project has allowed her to fully understand the various aspects of potential careers she can pursue, as well as narrow down specific goals for her graduate school journey and beyond. “This type of work is generally done by graduate students, and it is amazing to know that I am able to gain experience in a field while an undergraduate,” said Hudson. “It has allowed me to learn career-relevant material earlier on and in turn has allowed me to better prepare for graduate school and my overall future goals.” Keeley added a collection like the Lawless papers allows students and faculty to conduct research on high-value primary source documents. The collection will also help further CIRT’s ongoing mission to increase research productivity, particularly with respect to the history of the Irish in Savannah and the state of Georgia. “The Irish experience in the south is open to much more study than has thus far been attempted,” Keeley said. “The generous gift of the Lawless papers to the Center for Irish Research and Teaching significantly enhances our drive to conduct meaningful research. For undergraduate students, such as Caitlyn, the opportunity to uncover knowledge by analyzing primary-source documents brings new levels of rigor and satisfaction to the college experience. And for our program, this collaboration with the Special Collections unit of University Libraries is a powerful way to honor our donors’ trust in us and, in addition, celebrate Irish heritage, especially around St. Patrick’s Day.” If you're a journalist looking to learn more about his project of the historical significance the Irish had on Georgia - then let us help. Dr. Howard Keeley is available for interviews — simply reach out to Georgia Southern Director of Communications Jennifer Wise at jwise@georgiasouthern.edu to set and time and date.
UConn Researcher Develops Successful Zika Virus Vaccine in Preclinical Studies
UConn researcher Paulo Verardi, associate professor of pathobiology and veterinary science in the College of Agriculture, Health and Natural Resources, has demonstrated the success of a vaccine against Zika virus and recently published his findings in Scientific Reports, a Nature Research publication. He has also filed provisional patents with UConn’s Technology Commercialization Services for the novel vaccine platform technology used to generate the vaccine, as well as genetic modifications made to the vaccine that significantly enhance expression of the vaccine antigen. Verardi, a Brazilian native, was in Brazil visiting family in the summer of 2015 when the Zika outbreak first began to make waves and soon reached epidemic status. Back in the United States, Verardi kept tabs on the Zika epidemic and its emerging connection to microcephaly, a serious birth defect that causes babies to be born with small heads and underdeveloped brains. In October of that year, Verardi called then-Ph.D.-student Brittany Jasperse (CAHNR ‘19) into his office and told her he wanted to apply their newly developed vaccine platform and start developing a vaccine for Zika virus. It’s an impressive achievement and there’s a full article attached for those looking to know more. Verardi emphasizes that developing vaccines for viruses, in this case Zika, help the world be better prepared for outbreaks of novel and emerging viruses by having vaccine development frameworks in place. “Emerging viruses are not going to stop popping up any time soon, so we need to be prepared,” Verardi says. “Part of being prepared is to continue the development of these platforms.” If you’re a journalist looking to know more about Zika virus and this emerging news about a vaccine – then let us help. Dr. Paulo Verardi is a virologist who specializes in vaccine research and development. He is an Associate Professor at UConn and a member of the Center of Excellence for Vaccine Research. Dr. Verardi is available to speak with media regarding this emerging development – simply click on his icon now to arrange an interview today.
As President Biden Lays Out Infrastructure Plan, Experts Available to Discuss Proposals
As President Joe Biden lays out his plan for improving the nation's infrastructure, experts from Rensselaer Polytechnic Institute are available to discuss the ways in which proposed projects could affect shipping and delivery of goods, congestion in cities, and emissions in the environment, among other topics. José Holguín-Veras, the director of the Center for Infrastructure, Transportation, and the Environment at Rensselaer, and Cara Wang, an associate professor of civil and environmental engineering at Rensselaer, are leading experts in the role of infrastructure on freight and transportation systems, and the environmental impacts of both. Their research focuses on improving transportation and freight systems in order to increase efficiency, reduce traffic congestion and, in turn, reduce vehicle emissions. Holguín-Veras and Wang can also discuss what their research has uncovered that could guide policy makers as new projects are planned.
Solar geoengineering - it’s a topic that has caused an ethical lightening storm in the science community. The concept is complex. Should the world take on the crisis of climate change by attempting to artificially attempting to cool the earth? It’s an idea that has the National Academies of Sciences, Engineering and Medicine seeking a billion dollars in the next five years to investigate the theory. It’s a topic that is somewhat controversial, and journalists are looking to leading experts from across America for expert insight, opinion and perspective. Prakash Kashwan, a political scientist at the University of Connecticut, said he felt the report could have better emphasized the seriousness of some concerns over others. Uncertainties about the impacts of solar geoengineering on global weather patterns have the potential to affect some regions of the world more severely than others, he pointed out. Some experts have raised concerns about potential effects of geoengineering on monsoon rainfall in parts of Asia and Africa, he said. More than 2 billion people around the world rely on these rainfall patterns to support their water and agricultural needs. These kinds of issues should be given special weight, Kashwan suggested. "Some uncertainties are much more highly consequential for the global society, and especially for the poor and vulnerable," he told E&E News. Kashwan also reiterated concerns about potential political effects. While the report makes clear that geoengineering is not a substitute for climate mitigation, he suggests that this doesn't necessarily prevent policymakers from using it in that way. "The problem is the extent to which researchers are really helpless in deciding how research is used in the political system," he said. "That part has yet to be fully appreciated." Kashwan suggests that more dialogue might be warranted before funding a national research program, with greater input from both the international community and political experts who can weigh in on the ways that geoengineering research might affect political decisions. March 26, Scientific American It's a captivating idea – but it could have political, social and ethical consequences. Dr. Kashwan has also been interviewed by The New York Times. If you are a journalist looking to learn more about solar geoengineering, its possibilities and the reasons some scientists are worried – then let us help with your coverage. Prakash Kashwan is an Associate Professor of Political Science at UConn and an expert in the areas of environmental and climate justice, planetary justice, global commons, climate governance, and climate geoengineering governance. Dr. Kashwan is available to speak with media regarding this topic – simply click on his icon now to arrange an interview today.