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Why 48 Hours Outdoors Does More Than a Week of Scrolling Breaks
When people feel burned out from their phones, the default solution is often a “digital detox”: delete the apps for a week, set a screen-time limit, maybe move social icons off the home screen. Then work, group chats and FOMO pull them right back in. Personal Development Coach Mark Diamond, an expert in the Offline.now directory who ran a tech-free summer camp for 25 years, says the real reset button isn’t a slightly less frantic version of the same life. It’s 48 hours of real-world experience outdoors. “I’ve watched kids and adults go from wired and anxious to relaxed and connected in a matter of days — not because we lectured them about screens, but because they were hiking, cooking over a fire, laughing with friends, actually living,” Diamond says. “Nature gives your nervous system something it can’t get from a feed.” The science backs up what he sees at camp. A large meta-analysis of nature exposure in adults found that as little as 10 minutes in natural settings improves markers of mental health — including mood and stress — with larger benefits for longer doses of time outside. A broad review on nature and health reports that regular contact with green and blue spaces is associated with: Better mental health and reduced stress Improved cognitive function and attention Higher levels of physical activity Better sleep quality Experimental work using brain imaging has also shown that short visits to green spaces can boost positive affect and change patterns of brain activation in ways consistent with reduced rumination and improved emotional regulation, the opposite of what many people experience after long periods of doomscrolling. Diamond’s camp experience maps directly onto these findings: after even a weekend of tech-free outdoor time, he sees kids and adults become more patient, more playful and more able to tolerate “boredom”: a key ingredient for real focus and creativity. Offline.now integrates this into its digital balance approach by treating offline, outdoor experiences as a core intervention, not a reward you earn after perfect screen behavior. Instead of asking, “How can I use my phone less?” the question becomes, “What can I do offline that naturally displaces my screen time?” “You don’t have to move to the woods,” Diamond says. “Two days of walks, parks, backyard projects, or local trails can do more for your brain than seven days of white-knuckling your way through a ‘detox’ while you stay indoors thinking about your phone.” For journalists covering digital wellness, mental health, or lifestyle resets, this story connects the dots between nature research, digital fatigue, and why a simple 48-hour outdoor reset might be more realistic and more powerful than yet another all-or-nothing break from apps. Featured Expert Mark Diamond – Personal Development Coach and longtime director of a tech-free outdoor camp. He specializes in outdoor wellness, sustainable behavior change, and helping families and individuals swap abstract “detox” goals for concrete, nature-based experiences that restore mood, focus and connection. Expert interviews can be arranged through the Offline.now media team.
Playing "Ketchup": Kraft Heinz, Food Industry Work to Meet Evolving Consumer Trends
In September, the Kraft Heinz Company revealed its intention to split into two smaller entities—one focused on in-demand products, like shelf-stable meals, spreads and sauces, and the other on slower-growth businesses, such as the Oscar Mayer, Kraft Singles and Lunchables brands. The move is among the latest in a series of breakups and spinoffs announced by major "Big Food" conglomerates, including Kellogg's, Keurig Dr Pepper Inc. and Unilever, and experts speculate more divvying and downsizing are bound to follow. Beth Vallen, PhD, a professor in the Villanova School of Business who studies consumer behavior and food marketing, contends these demergers and restructurings are the direct result of a recent yet significant shift in shoppers' spending habits. "It is certainly a possibility that we are moving away from 'Big Food,'" says Dr. Vallen. "The companies are likely to be more agile as smaller entities, and the more targeted businesses will allow them to focus on their different market segments as we face increasingly complex consumer and macro trends in the food industry." Among the more noteworthy factors the professor cites are changes in how shoppers evaluate products and how often they make purchases, particularly amid rising costs, economic pressures and increased competition in the marketplace. When it comes to groceries, a LendingTree survey from earlier this year found that nearly nine in 10 Americans are reassessing what items they cart to the checkout lane. "Inflation and uncertainty have driven consumers to look for more value when they shop," says Dr. Vallen. "This might result in behaviors like switching to lower-cost alternatives, and along these lines, consumers are seeking out retailers with high-quality store brand offerings that might replace their typical, branded items. "Consumers are also shopping less frequently. This could be due to reliance on technology, like online grocery purchases, which requires more planning, as well as a desire to make groceries stretch between purchases to save money." Another development affecting the industry is a broader drive across the population toward health-conscious options and low-calorie meals, heightened to a degree by the rise of GLP-1 drugs like Ozempic. A recent KFF Health Tracking Poll evidences that these medications, which have been shown to promote weight loss, are taken by roughly one in eight American adults; and households with users are expected to account for more than a third of food and beverage sales by 2030. According to Rebecca Shenkman, MPH, RDN, LDN, the director of the MacDonald Center for Nutrition Education and Research at Villanova's M. Louise Fitzpatrick College of Nursing, the impact of these drugs' usage on consumers' eating habits should not be underestimated. "GLP-1 receptor agonists reduce appetite and food intake through multiple mechanisms, and evidence suggests both a reduction in snacking frequency and a shift toward healthier choices among users," shares Shenkman. "They report fewer cravings for sweet, salty and fatty snacks, particularly during the first 12 to 24 weeks of treatment. In addition, consumer surveys and clinical trials indicate increased intake of fruits, vegetables and water, and decreased consumption of processed foods and sugary beverages. "With millions of users and average daily reductions of 700 to 900 calories, demand for calorie-dense snacks could decline significantly." Among the brands and businesses at greatest risk, in Dr. Vallen and Shenkman's respective estimations, are "packaged and processed foods" as well as "sugary beverages and high-fat treats." In turn, with shoppers increasingly moving away from these "unhealthy" options and expressing an openness to dispensing with long-term staples, companies in the sector will need to emphasize adaptability in the coming years, making a conscious effort to understand customers' distinct preferences and needs. "Altogether, there are numerous trends that are seemingly pulling consumers in different directions—between health, taste, value and convenience," concludes Dr. Vallen. "Looking ahead, it will be important for firms to understand how these trends impact different consumers—and in different categories. Health likely means something different to Gen X and Gen Z and may vary further based on whether we are talking about a family dinner or a late-night treat. Taking efforts to understand consumer motivations will be crucial for companies to appropriately respond to current trends."
As interest in cryptocurrencies move from the fringes to mainstream conversation and public policy debate, Derek Mohr, clinical associate professor of finance at the Simon Business School at the University of Rochester, offers a clear-eyed voice on the subject. Mohr specializes in financial innovation and digital assets, and he’s been in demand with reporters looking to understand the economics behind everything from “Bitcoin-powered” home heaters to gas stations offering discounts for crypto purchases. His message? Not everything that markets itself as a breakthrough actually adds up. For instance, some companies have pitched devices that promise to heat a home using excess energy generated from bitcoin mining. Mohr recently told CNBC the idea might sound clever, but that its practicality collapses under basic financial and engineering realities. “The bitcoin heat devices I have seen appear to be simple space heaters that use your own electricity to heat the room . . . which is not an efficient way to heat a house,” Mohr said. “Yes, bitcoin mining generates a lot of heat, but the only way to get that to your house is to use your own electricity.” Bitcoin mining, he explained, has become so specialized that home computers have virtually zero chance of earning a mining reward. Industrial mining farms operate on custom-built chips far more powerful than any consumer device. In other words, consumers who think they’re heating their homes and earning crypto are, in reality, just paying for electricity and getting no real mining benefit. A pragmatic voice in a volatile space Mohr’s research and commentary help explain not just what is happening in the crypto world, but why it matters for consumers, businesses, and regulators. Whether evaluating the economics of mining or the viability of crypto payments, he brings a steady, analytical perspective to a domain dominated by hype and fast-moving news cycles. For journalists covering cryptocurrency, fintech, and the future of financial transactions, Mohr is available for interviews on digital payments, bitcoin mining economics, crypto regulation, and emerging trends in financial technologies. Top contact him, reach out to University of Rochester media relations liaison David Andreatta at david.andreatta@rochester.edu.
Tinsel, Tears, and Turkey: How Seniors Really Feel About the Holidays
Ah, the holidays. That magical season when cinnamon fills the air, grandkids are glued to their phones, and you're wondering if it's too early to spike the eggnog. (Answer: it's 5 o'clock somewhere, and that somewhere is your kitchen.) For many older adults, the season is a cocktail of nostalgia, joy, and melancholy—served in a glass rimmed with memories of when the house was full, and the turkey wasn't store-bought. Dealing With The Ghosts of Christmas Past The holidays used to mean full houses, laughter echoing off the walls, and more food than a Costco freezer aisle. Now? Smaller gatherings, missing faces, and a nagging feeling that you're somehow in the way at your own celebration. There's a certain ache that comes with the holidays as we age. It's not just arthritis—it's memory. The people who made our holidays special might no longer be around, and while their photos still grace the mantle, their absence can hit harder than a fruitcake to the forehead. It's the quiet that gets you. The stillness of a home that used to hum with chaos. The microwave hums where the oven once sang. The Christmas card list has ghosted us—literally—replaced by e-cards that can't be hung on the fridge or hugged. And yet, despite the ache, many seniors keep the traditions alive. They polish the silver, bake the cookies, and set the table—because ritual matters. It's a way to say, I'm still here, and this still matters. Loneliness: The Fear No One Talks About Let's name the holiday elephant in the room. Yes, it turns out that one really is the loneliest number. It's that heavy feeling that sneaks in right around the time commercials start showing perfect families in matching pajamas (who, let's be honest, probably fought about those pajamas in the parking lot). The numbers tell a sobering story: A report by the National Institute on Ageing, finds that as many as 41 per cent of Canadians aged 50 years and older are at risk of social isolation and up to 58 per cent have experienced loneliness before. The holidays often bring additional pressure for many. It's important to note, you don't have to live alone to feel lonely. Seniors often fear being forgotten—left out of the group chat, the dinner invite, or even the conversation at dinner. Some feel like a burden, convinced their presence is more "obligation" than "invitation." That fear of irrelevance can creep up faster than fruitcake at a church bake sale. The internal dialogue doesn't help: "They're busy." "They have their own lives." "I don't want to be a bother." But here's the truth: you're not a bother. You're the keeper of stories, the family's living archive, and—let's face it—the only one who actually knows how to carve a turkey without creating a crime scene. The health stakes are real: According to a 2023 research report from the U.S. Surgeon General, loneliness and social isolation have a profound effect on mortality, equal to smoking 15 cigarettes per day. That’s more impact than obesity or sedentary lifestyles. It's associated with increased risk of heart disease, stroke, dementia, depression, and anxiety. This isn't just about feeling blue; it's about actual health outcomes. When Depression Wears a Santa Hat Holiday depression doesn't always look like tears and tissues. Sometimes it's withdrawing from events, skipping meals, or not bothering to decorate. It's saying "I'm fine" with a smile that doesn't reach your eyes. A prominent research study of seniors in the UK over a 12-year period published in The Lancet, confirms what many seniors experience: loneliness is a significant predictor of depression in older adults. The study found that higher loneliness scores were consistently associated with increased depression severity. The relationship works both ways—people with mental health conditions are more than twice as likely to experience loneliness. It can also show up physically—fatigue, poor sleep, or that vague feeling that something's just... off. The sparkle of the season fades under the weight of grief, change, or just the exhausting pressure to be merry when you're not feeling it. A few sad moments are natural. We all get a little misty when "White Christmas" plays for the 47th time. But if the blues linger past Boxing Day, it might be time for a gentle check-in—with a friend, a doctor, or someone who actually listens (not just nods while scrolling). Remember: asking for help isn't a weakness. It's wisdom. And honestly? It's badass. The Magic of Rituals and Traditions For seniors, traditions aren't just habits—they're anchors. The same decorations, the favorite songs, the "don't touch that, it's Grandma's angel" moment that happens every. Single. Year. Research shows that rituals and traditions provide crucial psychological benefits for older adults, including a sense of stability, purpose, and belonging. They offer structure and comfort during challenging times, helping seniors feel grounded and connected to their roots. Studies have found that maintaining traditions contributes to overall mental well-being and can even reduce symptoms of anxiety and depression. These rituals offer stability in a world that keeps changing at warp speed (seriously, when did voice-activated ornaments become a thing?). But when traditions fade—when no one asks for the shortbread recipe or the ornaments stay boxed—it can feel like being erased in real time. So here's the trick: Evolve the traditions. Pass the torch, not the guilt. Let the grandkids lead carols (even if they insist on adding Mariah Carey). Use the good china. Pull out the silverware stored in the wooden case under the china cabinet that hasn't been opened since 1987. Keep the spirit alive, even if it looks different now. How Seniors Can Create a Joyful Holiday (Yes, Really!) Reach Out First: Don't wait for others to make the first move. Call, text, or—even better—show up with cookies. People are often grateful for the invitation but also afraid to impose. Be the one who breaks the ice. Host a Mini Gathering: Even if it's just tea with a neighbor, connection is the best seasoning of all. Bonus: smaller gatherings mean less cleanup and more actual conversation. Volunteer: Nothing lifts the spirit like helping someone else. Food banks, shelters, and local schools welcome extra hands. Plus, it's a great reminder that you're still needed—and you are. Laugh on Purpose: Watch old comedies. Tell those same stories (again). Laughter really is medicine—no prescription, no co-pay required. Decorate Anyway: Even if no one's visiting, do it for you. Light up your space, and your mood might just follow. And if the neighbors think you're overdoing it? Even better. What Families Can Do (Besides Show Up Hungry) Here's your holiday homework, families: Visit More, Scroll Less. You can't hug over FaceTime. And honestly, Grandma's WiFi probably can't handle it anyway. Listen Like It's a Gift. Because it is. Let seniors share their stories without rushing them or checking your phone. They're not just repeating themselves—they're reliving joy. (And yes, you've heard it before. Listen again.) Include Them in the Chaos. Let Grandma wrap presents, Grandpa set the playlist, or Aunt Sue take charge of... okay, maybe not the gravy. But give them a role. Purpose is the best present. Check In Regularly. A quick "thinking of you" text can mean more than an expensive gift. Though, to be fair, both are nice. Respect Their Pace. Big gatherings can be overwhelming. Sometimes small and meaningful beats loud and crowded. Not everyone wants to do the Macarena at Christmas dinner. (Looking at you, Uncle Bob.) Remember: the greatest present you can give an older adult is presence—yours. The Importance of Joy (and How to Find It Again) Joy doesn't always come in grand gestures. Sometimes it's hiding in the small stuff: • The smell of pine needles • The first snowflake (before it turns into gray slush) • That old ornament you swore you'd throw out • The laughter of family—even if it's at your expense Joy isn't found lying around like loose change. It's made. Sometimes it's coaxed out with a memory, a song, or a well-timed bad joke about Aunt Sue's lumpy gravy. And if all else fails, remember this: you've survived decades of holidays. Burnt turkeys. Broken ornaments. That unfortunate incident with the glue gun in 2003. You've earned the right to laugh through the tears and dance in your slippers if you damn well feel like it. The Real Gift The holidays remind us that connection—not perfection—is the true magic. For seniors, it's about being seen, heard, and loved. For families, it's about showing up, listening, and laughing together. Because one day, those elders' stories will become yours. And you'll want someone to care enough to hear them, too. So let's make this season count. Let's call more, visit more, and laugh more. Let's honor the past while making new memories. And let's remember that the best traditions aren't the ones that stay the same—they're the ones that adapt, evolve, and keep bringing us together. Now pass the eggnog. The spiked kind. Let's All Sit Under the Mistletoe and Sing the Retired Remix of "Jingle Bells" (To the tune of "Jingle Bells") Dashing through the snow, With a walker all in tow, To the mall we go, Moving nice and slow! Family's out of sight, Texting through the night, Oh, what fun it is to Zoom My grandkids once a night—hey! Chorus: Jingle bells, jingle bells, jingle all the way, Oh, what fun it is to chat With friends who won't delay—hey! Jingle bells, jingle bells, laughter saves the day, Lonely hearts can still feel joy— If love just finds a way. Happy holidays, everyone. May your turkey be moist, your family be present, and your eggnog be strong. Want more insights like this? Subscribe to my free newsletter here, where I share practical strategies, real-world stories, and straight talk about navigating retirement with confidence—not confusion. Plus, all subscribers get exclusive early access to advance chapters from my upcoming book. For Canadians 55+: Get actionable advice on making your home equity work for you, understanding your options, and living retirement on your terms. For Mortgage Brokers and Financial Professionals: Learn how to become the trusted advisor your 55+ clients—it's your opportunity to build lasting relationships in Canada's fastest-growing demographic. Sue Don’t Retire…Re-Wire! References & Resources for You or a Loved One On Loneliness and Social Isolation: • U.S. Surgeon General. (2023). Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General's Advisory on the Healing Effects of Social Connection and Community. https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdf • Medicare FAQ. (2024). Loneliness in Seniors Statistics: Combating Social Isolation. https://www.medicarefaq.com/blog/senior-loneliness-statistics/ • Mayo Clinic. (2023). Loneliness and Social Isolation Through the Holidays. https://newsnetwork.mayoclinic.org/discussion/loneliness-and-social-isolation-through-the-holidays/ On Depression and Mental Health: • Kok, R.M., & Reynolds, C.F. (2020). The association between loneliness and depressive symptoms among adults aged 50 years and older: A 12-year population-based cohort study. The Lancet Psychiatry. https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30383-7/fulltext • Cigna. (2021). The Loneliness Epidemic Persists: A Post-Pandemic Look at the State of Loneliness Among U.S. Adults. On Traditions and Rituals: • Oregon Counseling. Why Traditions Matter to Mental Health. https://oregoncounseling.com/article/why-traditions-matter-to-mental-health/ • Care365. Maintaining Traditions with Seniors. https://www.care365.care/resources/maintaining-traditions-with-seniors Additional Support: • National Council on Aging. Four Steps to Combat Loneliness in Seniors During the Holidays. https://www.ncoa.org/article/four-steps-to-combat-loneliness-in-seniors-during-the-holiday-and-beyond/ Emergency Services If the situation is urgent or someone is in immediate danger: Call 911. Canada Suicide Prevention Service (CSPS) • Call: 1-833-456-4566 (available nationwide, 24/7) • Text: 45645 (evenings) • Chat: available at 988.ca
As holiday shopping season nears, UF experts warn retail theft is growing more sophisticated
With the busiest shopping season of the year approaching, new findings from the National Retail Federation’s Impact of Retail Theft and Violence 2025 report — developed by the University of Florida’s SaferPlaces Lab and the Loss Prevention Research Council — show retailers are facing increasingly complex and technology-driven threats. UF researchers say early preparation, better data and stronger collaboration will be essential as stores brace for heavier foot traffic and heightened safety risks. Despite public reports that retail theft is decreasing, Read Hayes, Ph.D., a UF research scientist and director of the LPRC at UF Innovate, said retailer surveys tell a different story: Incidents of shoplifting, organized retail crime, online fraud and other external theft continue to rise, even as some law enforcement statistics appear flat or declining. The gap, he said, reflects how much crime goes unreported or unrecorded. “Retailers have always had a difficult time reporting much of their crime, and if you look only at police data, like calls for service or arrests, it can look like retail crime is flat or even slightly down,” he said. “But when we survey retailers, who are the actual crime victims, they consistently report year-over-year increases in theft and violence.” Criminal groups are also becoming more sophisticated. Hayes said offenders are increasingly using technology to defeat protective systems, disrupt cameras and identify vulnerable stores. They also rely heavily on social media platforms such as TikTok and Reddit to coordinate attacks and share tactics. “It’s a little disconcerting how much criminals rely on social media now to scout stores, map out easy targets, learn from each other or just plain brag about how they did it,” he said. LPRC scientists monitor social media signals to help retailers and law enforcement understand emerging threats — not in real time, Hayes said, but to help build best practices organizations can use to defend themselves. Criminals continue to focus on high-demand items such as branded apparel and footwear, prompting retailers to rethink how those products are displayed and secured. Hayes said many companies are testing new approaches to better protect vulnerable merchandise without driving customers away. One example is automated self-service systems for locked items, where customers can retrieve a product by having a code sent to their phone without waiting for a store employee. Safety remains retailers’ top concern, Hayes said. LPRC’s latest report, developed in collaboration with the security technology company Verkada, found that frontline retail workers report feeling less safe than ever, a trend that typically intensifies during the holiday rush. Rising incidents of in-store violence, limited law enforcement support in some areas and increased guest-related confrontations are pushing retailers to reassess how they protect both employees and customers. “Nothing is more important than protecting the frontline retail associates who keep this industry running,” Hayes said. “This report helps reinforce what retailers need to do to ensure those workers feel safe.” LPRC teams are also studying ways to improve safety beyond store walls, testing parking lot technologies, including license plate readers and flashing deterrent systems designed to discourage potential offenders and reassure law-abiding shoppers. At the federal level, Hayes said he and partners across the country are urging Congress to pass a bill to address organized retail crime and establish a centralized platform for reporting retail theft threats. As the holiday season approaches, Hayes said the need for evidence-based solutions has never been clearer. “Retailers are under pressure to keep their stores safe, welcoming and competitive,” Hayes said. “The more we can understand offender behavior, customer expectations and emerging technologies, the better we can help retailers, communities and law enforcement reduce harm.” The LPRC, headquartered at UF Innovate, brings together more than 200 major retailers, technology companies and public safety agencies to conduct research that strengthens store safety, reduces loss and enhances the customer experience.
NASA Missions Discover Record-Setting Blast
Black Hole Eats Star: NASA Missions Discover Record-Setting Blast Dr. Eric Burns, associate professor of Physics & Astronomy in LSU’s College of Science, leads a consortium that studies gamma-ray bursts (GRBs), including the July event that, because of its long duration, stands in a class by itself. Because opportunities to study such events are so rare, and because they may reveal new ways to create GRBs, astronomers are particularly excited about the July burst. Burns discussed the discovery and the significance of this area of research. Can you explain your interest in gamma-ray bursts, why they matter, and how they play into these new discoveries? "I run a consortium that studies gamma-ray bursts. These are the most luminous explosions in the universe, other than the Big Bang itself. The consortium's been operating for almost 50 years. We've seen 15,000 gamma-ray bursts. We've used these sightings to understand the speed of gravity, where gold is created, and fundamental properties in the universe. In July, we detected a gamma-ray burst that was longer than we've ever seen before. They're normally like 30 seconds long. This one was 8 hours. It was so long that we didn't believe it was a gamma-ray burst for a while." What was your role in investigating this phenomenon? "The consortium I run helped find it and helped figure out where it was coming from. We put a bunch of telescopes on it to try and figure out what was happening and to understand what caused this event. Normal gamma-ray bursts come from a massive star near the end of its life. The interior of the star collapses, and it forms a black hole. That black hole eats it from the inside out, and it launches this matter that's moving at basically the speed of light, and that produces your gamma-ray burst. By chance, a colleague and I had written a paper earlier this year on what is the longest gamma-ray burst you could produce with this scenario. And the answer is 1,000 seconds. So we're pretty sure that what happened here was this: You have that massive star, but instead of its core becoming the black hole, instead you have a black hole that falls into it. Or they sort of fall into each other." How was this long gamma-ray burst discovered? And what led to your involvement in studying it? "We have what’s called gamma-ray burst monitors. They're a version of a telescope, but they're not like a long tube that you use to see visible light with your eyes. They're actually crystals that detect when they are hit by a gamma ray by fluorescing and sending out light. And so we could detect them that way. In the consortium I run, there are about a dozen of these gamma ray detectors. They're all on different satellites. Most of them are around Earth, but some of them are much further out in our solar system. We've automated most of our processes. The spacecraft itself will detect this event and report it to the community. All of that happens in like 30 seconds. In this case, our satellite had four different triggers spread over eight hours, and a member of the community pointed out that these events were coming from the same general area in the sky. So, even before the last trigger, within a couple hours, we realized, oh, there's something really long happening here that we haven't really seen before." Full story available here.
Built-In Backup System Helps Muscles Counteract Fatigue
When you're running up stairs or out on a jog, your muscles eventually start to feel heavy and weak. That's fatigue setting in, a sign that the muscles’ energy reserves are becoming depleted. But a team of researchers led by Rensselaer Polytechnic Institute (RPI) biology professor Doug Swank, Ph.D., have discovered something surprising: certain muscle fibers have a built-in backup system that fights back against fatigue, potentially helping us keep going when we'd otherwise have to stop. The secret lies in a phenomenon called "stretch activation": when a muscle is stretched just before it contracts, it can produce a short burst of extra force. Stretch activation has been studied extensively in the context of insect flight muscle and heart muscle contraction in mammals, but its effects have long been assumed to be physiologically irrelevant for the big skeletal muscles we use for day-to-day activities like walking around. The new study, published in the Journal of General Physiology, shows that assumption was wrong, at least when it comes to certain fast-twitch muscle fibers used to produce quick, powerful movements. “For decades, stretch activation in skeletal muscle was considered physiologically insignificant because it contributes a relatively small amount of force under normal conditions," Swank said. "But we realized no one had tested what happens during fatigue, when the chemical environment inside muscle fibers changes significantly." The researchers tested individual muscle fibers from mice under three conditions: normal, early fatigue (with chemical changes that mimic the state of tired muscles), and severe fatigue. They found that while the fibers' normal force production dropped dramatically as expected, in certain fibers the stretch-activated force stayed the same or even increased. In the most fatigued state, stretch activation contributed up to 30% of the total force these fast-twitch fibers were generating. “What was dismissed as too small to matter may actually be an important fatigue-fighting mechanism that's been hiding in plain sight,” Swank said. The effect was specific to fast-twitch fibers, which are used to generate rapid, powerful movements like sprinting and jumping. Slow-twitch fibers, which are used during endurance tasks like long-distance running or cycling, are more fatigue-resistant to begin with, and showed almost no stretch activation response. Understanding how muscles naturally combat fatigue could eventually inform strategies for improving strength and endurance, whether for athletes, people with muscular disorders, or patients recovering from injury. Swank and his colleagues are following up on their findings by conducting more detailed explorations of how stretch activation contributes to force generation in both low-intensity and high-intensity exercise. The research is funded by a five-year, $2.7 million National Institutes of Health grant to Professor Swank.
Gates Foundation to Fund RPI Research to Develop Low-Cost Monoclonal Antibody Treatments
Professor Todd Przybycien, Ph.D., head of RPI’s Department of Chemical and Biological Engineering, has been awarded a $3.1 million share of a Gates Foundation Global Grand Challenge grant to advance exceptionally low-cost monoclonal antibody (mAb) manufacturing. Monoclonal antibodies have proven effective at treating a wide range of conditions, including infectious diseases like COVID-19, autoimmune disorders, and certain types of cancer. But they are expensive to produce, and current market prices of $50 to $100 per gram put them effectively out-of-reach for millions of people around the world. The goal of the Gates Grand Challenge is to reduce the price of mAbs to just $10 per gram. Last month, the Gates Foundation announced $10.5 million in funding to a team led by the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) in order to achieve that goal. Professor Przybycien’s group is part of that team and will focus on improving the process of purifying monoclonal antibodies after they have been produced by engineered cells. “Optimization and intensification of the downstream purification process offer the exciting possibility of breaking through to the $10/g overall target,” Przybycien said. “We are excited to advance the precipitation-based process we have developed with our collaborator at Penn State as part of the manufacturing solution to sustainably meet the global need for monoclonal antibodies.” Przybycien is an internationally recognized researcher in biomanufacturing and applied biophysics, focusing on developing processes to manufacture recombinant proteins, mRNA, and viral vectors. He has won numerous awards including the NSF CAREER Award and the Camille Dreyfus Teacher-Scholar Award. He is also a fellow of the American Chemical Society, AIChE, and AIMBE. “This grant is a testament to the years of work Todd Przybycien and his team have done to optimize and improve biopharmaceutical manufacturing processes,” said Shekhar Garde, Ph.D., the Thomas R. Farino, Jr. ’67 and Patricia E. Farino Dean of the School of Engineering. “It will pave the way for affordable access to lifesaving medications for millions of people who desperately need them.” “We are excited by the opportunity to demonstrate that there are existing solutions developed by industry and academic partners that can significantly reduce cost of goods and accelerate timelines,” said Kelvin Lee, NIIMBL Institute Director. “We are honored to receive this grant from the Gates Foundation, which will enable this exceptional team to deliver meaningful advances to antibody production efficiency.” This Gates Grand Challenge was established in honor of Dr. Steve Hadley, who championed the reduction of mAbs costs to make them affordable in low- and middle-income countries. The team’s first target will be a monoclonal antibody to treat malaria, an infectious disease which kills more than half a million people each year, primarily in Africa.
The National Cancer Institute (NCI) has renewed the Cancer Center Support Grant (CCSG) for The Wistar Institute and ChristianaCare’s Helen F. Graham Cancer Center & Research Institute, awarding $16.3 million over the next five years. The renewal received an “exceptional” rating — the highest possible — recognizing the strength and impact of a partnership that combines world-class basic science with leading community-based cancer care. A One-of-a-Kind National Model This collaboration is the only one of its kind in the nation, joining Wistar, an NCI-Designated Basic Cancer Center, with ChristianaCare, one of the country’s premier academic community cancer centers and a National Cancer Institute Community Oncology Research Program. Together, they focus on driving advances against some of the most challenging cancers, including pancreatic, melanoma, breast, lung and ovarian cancers. The grant supports shared infrastructure, scientific resources and programs that enable researchers and clinicians to work seamlessly across both institutions. By connecting laboratory breakthroughs at Wistar with ChristianaCare’s ability to rapidly apply new approaches in a diverse patient population, the partnership accelerates the path from discovery to care. NCI highlighted the collaboration’s effectiveness, noting that “the ongoing alliance with the Helen F. Graham Cancer Center & Research Institute is where most clinical translation into active oncology trials is occurring, supported by productive collaboration between Wistar investigators and Graham Cancer Center oncologists.” Impact on Patients and Community “At ChristianaCare, we are committed to bringing innovation directly to the people we serve. Our collaboration with Wistar connects the best of basic science with the realities of patient care,” said Thomas Schwaab, M.D., Ph.D., Bank of America Endowed Medical Director of the Helen F. Graham Cancer Center & Research Institute. “The NCI’s exceptional score recognizes the promise of this work and the progress we are making together. It is a powerful affirmation that our patients are benefiting from research at the highest level.” “This renewal from the NCI is proof that we are building a model for how cancer research and community care can come together,” said Nicholas J. Petrelli, M.D., director of the Cawley Center for Translational Cancer Research at the Helen F. Graham Cancer Center & Research Institute and associate director of Translational Research at The Wistar Institute Cancer Center. “Through our partnership with Wistar, patients in Delaware and beyond are gaining access to cutting-edge research and therapies for some of the toughest cancers we face.” Dario Altieri, M.D., president and CEO of The Wistar Institute and director of its Ellen and Ronald Caplan Cancer Center, added: “An exceptional rating from the NCI is a reflection of the scientific excellence and real-world impact of this partnership. What makes this collaboration unique is its ability to take discoveries in areas such as melanoma and ovarian cancer and bring them rapidly into clinical practice through ChristianaCare.” NCI underscored the alliance’s reach, noting that “the partnership with the Graham Cancer Center brought cutting-edge cancer research to the community and advanced groundbreaking discoveries to first-in-human oncology clinical trials.” A Pipeline of Research Advancing Faster Than Ever Research achievements supported by the Wistar—ChristianaCare partnership include: Advancing multiple Wistar discoveries into investigator-initiated, first-in-human oncology clinical trials, including studies in pancreatic, melanoma, lung, breast and ovarian cancers. Launching joint research programs across several cancer types, with expanding efforts in cancer risk and population health. Increasing access to high-quality biospecimens — including tumor tissue, biopsies and blood samples — that fuel translational research. Strengthening shared scientific infrastructure supporting immunotherapy research, organoid development, xenograft models and molecular profiling. The Wistar—ChristianaCare partnership, established in 2011, has grown into a nationally recognized alliance that bridges science and medicine. With this CCSG renewal, the collaboration will expand research in pancreatic, melanoma, breast, lung and ovarian cancers and continue advancing prevention, early detection and training programs for the next generation of physician—scientists. The Helen F. Graham Cancer Center & Research Institute depends on grants and community support to keep this work moving forward. To learn more or make a gift, visit Support the Helen F. Graham Cancer Center & Research Institute.
Violence alters human genomes for generations, researchers discover
In February of 1982, the Syrian government besieged the city of Hama, killing tens of thousands of its own citizens in sectarian violence. Four decades later, rebels used the memory of the massacre to help inspire the toppling of the Assad family that had overseen the operation. But there is another lasting effect of the attack, hidden deep in the genes of Syrian families. The grandchildren of women who were pregnant during the siege — grandchildren who never experienced such violence themselves — nonetheless bear marks of it in their genomes. Passed down through their mothers, this genetic imprint offers the first human evidence of a phenomenon previously documented only in animal models. The genetic transmission of stress across multiple generations. “The idea that trauma and violence can have repercussions into future generations should help people be more empathetic, help policymakers pay more attention to the problem of violence,” said Connie Mulligan, Ph.D., a professor of Anthropology and the Genetics Institute at the University of Florida and co-senior author of the new study. “It could even help explain some of the seemingly unbreakable intergenerational cycles of abuse and poverty and trauma that we see around the world, including in the U.S.” While our genes are not changed by life experiences, they can be tuned through a system known as epigenetics. In response to stress or other events, our cells can add small chemical flags to genes that may quiet them down or alter their behavior. These changes may help us adapt to stressful environments, although the effects aren’t well understood. It is these tell-tale chemical flags that Mulligan and her team were looking for in the genes of Syrian families. While lab experiments have shown that animals can pass along epigenetic signatures of stress to future generations, proving the same in people has been nearly impossible. “Resilience and perseverance is quite possibly a uniquely human trait.” —Connie Mulligan Mulligan worked with Rana Dajani, Ph.D., a molecular biologist at Hashemite University in Jordan and co-senior author, as well as anthropologist Catherine Panter-Brick, Ph.D., of Yale University, to conduct the unique study. Dajani envisioned the research project; because of her intimate knowledge of the Syrian population and its tragic history, she designed the study to cover three generations of Syrian refugees to Jordan. Some families had lived through the Hama attack before fleeing to Jordan. Other families avoided Hama, but lived through the recent civil war against the Assad regime. The team collected samples from grandmothers and mothers who were pregnant during the two conflicts, as well as from their children. This study design meant there were grandmothers, mothers and children who had each experienced violence at different stages of development. A third group of families had immigrated to Jordan before 1980, avoiding the decades of violence in Syria. These early immigrants served as a crucial control to compare to the families who had experienced the stress of civil war. Study coauthor Dima Hamadmad, a Syrian researcher and the daughter of refugees, led the search for families that met the study criteria and collected cheek swabs from 138 people across 48 families. "The participants took part in the research out of love for their children and concern for future generations,” she said. “But more than that, they wanted their stories of trauma to be heard and acknowledged.” Back in Florida, Mulligan’s lab scanned the DNA for epigenetic modifications and looked for any relationship with the families’ experience of violence. In the grandchildren of Hama survivors, the researchers discovered 14 areas in the genome that had been modified in response to the violence their grandmothers experienced. These 14 modifications demonstrate that stress-induced epigenetic changes may indeed appear in future generations in humans, just as they can in animals. The study also uncovered 21 epigenetic sites in the genomes of people who had directly experienced violence in Syria. In a third finding, the researchers reported that people exposed to violence while in their mothers’ wombs showed evidence of accelerated epigenetic aging, a type of biological aging that may be associated with susceptibility to age-related diseases. Most of these epigenetic changes showed the same pattern after exposure to violence, suggesting a kind of common epigenetic response to stress – one that can not only affect people directly exposed to stress, but also future generations. “We think our work is relevant to many forms of violence, not just refugees. Domestic violence, sexual violence, gun violence: all the different kinds of violence we have in the U.S,” said Mulligan. “We should study the effects of violence. We should take it more seriously.” It’s not clear what, if any, effect these epigenetic changes have in the lives of people carrying them inside their genomes. But some studies have found a link between stress-induced epigenetic changes and diseases like diabetes. One famous study of Dutch survivors of famine during World War II suggested that their offspring carried epigenetic changes that increased their odds of being overweight later in life. While many of these modifications likely have no effect, It’s possible that some have functional effects that can affect our health, Mulligan said. The researchers published their findings, which were supported by the National Science Foundation, Feb. 27 in the journal Scientific Reports. While carefully searching for evidence of the lasting effects of war and trauma stamped into our genomes, Mulligan and her collaborators were also struck by the perseverance of the families they worked with. Their story was much bigger than merely surviving war, Mulligan said. “In the midst of all this violence we can still celebrate their extraordinary resilience. They have persevered,” Mulligan said. “That resilience and perseverance is quite possibly a uniquely human trait.”