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Manuka honey could help to clear deadly drug-resistant lung infection – research

• Scientists develop a potential nebulisation treatment using manuka honey to clear a drug resistant lung infection that can be fatal in cystic fibrosis patients • Aston University researchers combined the antibiotic amikacin with manuka honey as a novel treatment for Mycobacterium abscessus • Using the manuka honey combination resulted in an eight-fold reduction in the dosage of the antibiotic A potential new treatment combining natural manuka honey with a widely used drug has been developed by scientists at Aston University to treat a potentially lethal lung infection and greatly reduce side effects of one of the current drugs used for its treatment. The findings, which are published in the journal Microbiology, show that the scientists in the Mycobacterial Research Group in the College of Health and Life Sciences at Aston University were able to combine manuka honey and the drug amikacin in a lab-based nebulisation formulation to treat the harmful bacterial lung infection Mycobacterium abscessus. Manuka honey is long known to have wide ranging medicinal properties, but more recently has been identified for its broad spectrum antimicrobial activity. Now scientists have found that manuka honey has the potential to kill a number of drug resistant bacterial infections such as Mycobacterium abscessus – which usually affects patients with cystic fibrosis (CF) or bronchiectasis. According to the Cystic Fibrosis Trust, CF is a genetic condition affecting around 10,800 people - one in every 2,500 babies born in the UK -and there are more than 100,000 people with the condition worldwide. The NHS defines bronchiectasis as a long-term condition where the airways of the lungs become widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection.. In the study, the researchers used samples of the bacteria Mycobacterium abscessus taken from 16 infected CF patients. They then tested the antibiotic amikacin, combined with manuka honey, to discover what dosage was required to kill the bacteria. As part of the study the team used a lab-based lung model and nebuliser - a device that produces a fine spray of liquid often used for inhaling a medicinal drug. By nebulising manuka honey and amikacin together, it was found they could improve bacterial clearance, even when using lower doses of amikacin, which would result in less life-changing side-effects to the patient. In the UK, of the 10,800 people living with CF, Mycobacterium abscessus infects 13% of all patients with the condition. This new approach is advantageous not only because it has the potential to kill off a highly drug resistant infection, but because of the reduced side effects, benefitting quality of life and greatly improving survival chances for infected CF patients. Mycobacterium abscessus is a bacterial pathogen from the same family that causes tuberculosis, but this bug differs by causing serious lung infections in people (particularly children) with pre-existing lung conditions, such as CF and bronchiectasis, as well as causing skin and soft tissue infections. The bacteria is also highly drug resistant. Currently, patients are given a cocktail of antibiotics, consisting of 12 months or more of antimicrobial chemotherapy and often doesn’t result in a cure. The dosage of amikacin usually used on a patient to kill the infection is 16 micrograms per millilitre. But the researchers found that the new combination using manuka honey, required a dosage of just 2 micrograms per millitre of amikacin - resulting in a one eighth reduction in the dosage of the drug. Until now Mycobacterium abscessus has been virtually impossible to eradicate in people with cystic fibrosis. It can also be deadly if the patient requires a lung transplant because they are not eligible for surgery if the infection is present. Commenting on their findings, lead author and PhD researcher Victoria Nolan said: "So far treatment of Mycobacterium abscessus pulmonary infections can be problematic due to its drug resistant nature. The variety of antibiotics required to combat infection result in severe side effects. "However, the use of this potential treatment combining amikacin and manuka honey shows great promise as an improved therapy for these terrible pulmonary infections. “There is a need for better treatment outcomes and in the future we hope that this potential treatment can be tested further.” Dr Jonathan Cox, senior lecturer in microbiology, Aston University said: “By combining a totally natural ingredient such as manuka honey with amikacin, one of the most important yet toxic drugs used for treating Mycobacterium abscessus, we have found a way to potentially kill off these bacteria with eight times less drug than before. This has the potential to significantly reduce amikacin-associated hearing loss and greatly improve the quality of life of so many patients – particularly those with cystic fibrosis. “I am delighted with the outcome of this research because it paves the way for future experiments and we hope that with funding we can move towards clinical trials that could result in a change in strategy for the treatment of this debilitating infection.” Dr Peter Cotgreave, chief executive of the Microbiology Society said: "The Microbiology Society is proud to support the scientific community as it explores innovative solutions to overcome the growing global challenge of antimicrobial resistance. This study demonstrates one of many ways in which microbiologists are pioneering new methods to tackle drug-resistant infections, by incorporating natural products, like manuka honey, into existing therapies." For more information about the School of Biosciences, please visit our website.

FBI data shows murders are up, and our experts are ready to help with your coverage

FBI data shows murder rates are up, with the latest figures showing a staggering 21,570 murders happening nationwide in 2020. Dr. Kim Davies teaches a sociology of murder course at Augusta University and was recently interviewed on the topic by a local CBS affiliate. Davies has developed the course to help educate students and get them thinking about ways they can bring awareness to the violent crime problem. Students put a tick on the sidewalk in chalk to represent every murder to offer a better understanding of the number of families affected. “If I put that number on the board, it looks like a big number," said Davies. "But nobody really knows what that is. If we tick every mark and we say, ‘Look, that’s a victim,’ it means more to the students.” Davies also reiterates that even though this current number is probably the highest it’s ever been since she's been offering this class, it's not at an all-time high. "Murder was higher in the '90s when I was in grad school, but it’s been going down, down, down. Hopefully it’s not a trend where we continue up, but we’re back up.” If you’re a journalist covering true crime or any other aspect of this topic, then let us help with your stories. Davies is a sociologically trained criminologist with academic focus is on homicide and violence. Her most recent book, The Murder Book: Understanding Homicide Today, explores topics such as the increase in mass murders, the change in Stand Your Ground laws across the country and police shootings as it relates to the Black Lives Matter movement. Davies is available to speak with media about this subject – simply click on her icon now to arrange an interview today.

Aston University welcomes new Vice-Chancellor and Chief Executive

• Professor Aleks Subic has taken up the role of Vice-Chancellor and Chief Executive, joining Aston University from RMIT in Australia • Professor Subic is a recognised global leader in technology and innovation. Aston University has welcomed Professor Aleks Subic as its new Vice-Chancellor and Chief Executive. He has joined Aston University from RMIT in Australia where he was Deputy Vice-Chancellor of the College of Science, Engineering and Health and Vice President for Digital Innovation. Prior to that, he was Deputy Vice-Chancellor (Research and Enterprise) at Swinburne University of Technology. Professor Subic is a recognised global leader in technology and innovation in higher education, leading on Industry 4.0 strategy and digital transformations across the university sector and with industry and governments both in Australia and internationally. He has received a number of prestigious awards for his work, including the Australian Business Innovation Award and the Victorian Manufacturing Hall of Fame Award. He is a passionate and lifelong advocate for multiculturalism, equality, diversity and inclusion, leading through clear actions and strategic initiatives at enterprise level. These include creating and appointing the first Dean of STEMM Diversity & Inclusion in Australia, establishing Women in STEMM Fellowships and mentoring scheme, Indigenous Research Fellowships, scholarships and internships programs, and creating an innovation precinct with start-up accelerators and industry incubators focused on founders from diverse backgrounds and access. On joining Aston University, Professor Subic said: “I am arriving at a pivotal time in the University’s history, to build on the strong foundations established by its leaders and staff, past and present, and to develop and lead our new bold strategy. Our next stage of development will be ambitious, aiming to achieve our full potential within a rapidly changing world. “I can see huge potential for creating a globally relevant university, a leader in science, technology and enterprise – by transcending academic disciplines, applying the knowledge we create and driving innovation, to improve the lives and livelihoods of those with whom we work. “Building on our collective expertise, experience and professional networks, I look forward to supporting our students, industries and communities in Birmingham and the West Midlands region, as well as our strategic partners nationally and internationally.” Professor Subic is married to Tatjana, and they have three children: Sandra, Katarina and Stefan.

Russia historian on legacy of Mikhail Gorbachev

Kathryn David, Mellon Assistant Professor of Russian and East European Studies, is available for media commentary on the legacy of Russian and Soviet leader Mikhail Gorbachev. Kathryn specializes in the history of Ukraine and Russia, with research interests including connections between religious and national belonging and the aftermath of World War II in the Soviet Union. In particular, she can speak to Gorbachev's mixed legacy in Ukraine. Her initial thoughts: "On the one hand, Gorbachev made the case for Russia and Eastern Europe to be closer to the West and built on a foundation of democratic values, goals that Ukraine is fighting for today. But on the other hand, as much as Gorbachev wanted deep reforms, he still wanted the USSR to stay together. While he was willing to let the countries of Eastern Europe go their own way, he tried desperately to keep Russia, Ukraine and other republics together, reluctant to let Moscow's empire break apart. For many in Ukraine, Gorbachev represents a figure that remains common in Russian society today: one who believes in liberal values, but still clings to the idea of empire."

What does Joe Biden's forgiveness of student loans mean for debt relief?

President Joe Biden has made progress on a campaign promise to provide relief for those burdened with student debt. This plan offers targeted debt relief as part of a comprehensive effort to address the burden of growing college costs and make the student loan system more manageable for working families. The President is announcing that the Department of Education will: Provide targeted debt relief to address the financial harms of the pandemic, fulfilling the President’s campaign commitment. The Department of Education will provide up to $20,000 in debt cancellation to Pell Grant recipients with loans held by the Department of Education, and up to $10,000 in debt cancellation to non-Pell Grant recipients. Borrowers are eligible for this relief if their individual income is less than $125,000 ($250,000 for married couples). No high-income individual or high-income household – in the top 5% of incomes – will benefit from this action. To ensure a smooth transition to repayment and prevent unnecessary defaults, the pause on federal student loan repayment will be extended one final time through December 31, 2022. Borrowers should expect to resume payment in January 2023. -- White House Fact Sheet, Aug. 25 The announcement made big waves politically and news coverage is still heavy with reactions to the plan and just who it will benefit. “For some students, they will be completely debt-free afterward," said Wendy Habegger, a lecturer of finance in the James M. Hull College of Business at Augusta University. "The majority are still not going to be debt-free but instead of you having to pay an extra year, it might cut your pay time down. What this is going to do is give you money to start doing some of the other things that you have put off. You can now focus on building up an emergency fund, building up a savings account. You can put it toward your retirement.” The announcement also includes extending the student loan pause a final time through Dec. 31, 2022. “One of the good things about this debt reduction and debt forgiveness is that the Biden administration is making some very firm attempts to go in and fix some of the payment programs that are broke. So when individuals have to start paying in January, they will be able to pay a reduced amount,” said Habegger. “What’s not going to stop is the accrual of future debt. So we really need to look at the underlying problem and the costs of higher education and see if we can bring that down.” This topic will require ongoing coverage, so if you’re a reporter looking to know more, then let us help. Wendy Habegger is a respected finance expert available to offer advice on making the right money moves during volatile times. To arrange an interview, simply click on her icon now.

New method of examining the brain’s electrical signals could hold the key to better treatment of epilepsy and schizophrenia

Researchers are exploring new ways to ‘listen’ to and record electrical signals emitted from brain cells Findings could be used to help treat conditions like epilepsy and schizophrenia Project will use newly developed nanomaterials to keep removed samples of brain healthy for longer to allow more understanding of what generates epileptic seizures. A new method of examining the brain’s electrical signals could hold the key to better treatment and understanding of conditions like epilepsy and schizophrenia. Researchers at Aston University are exploring new ways to ‘listen’ to and record electrical signals emitted from brain cells, which could be used to help treat the conditions. Dr Petro Lutsyk, lecturer in electronic engineering and systems in the College of Engineering and Physical Sciences and member of Aston Institute of Photonic Technologies (AIPT), together with Dr Stuart Greenhill, senior lecturer in neuroscience in the College of Health and Life Sciences and member of Aston Institute of Health and Neurodevelopment (IHN), have been awarded £100,000 by the Royal Society to conduct the project Nanomaterial Webs for Revolutionary Brain Recording. Currently, epilepsy patients who can’t be helped by drugs may undergo brain surgery in order to prevent seizures, removing the part of the brain that is the ‘focus’ of the seizures. Dr Greenhill said: “The research project will use newly developed nanomaterials to keep samples of brain healthy and active for far longer than current technology allows, whilst recording the activity of the tissue. “This allows more understanding of what generates epileptic seizures and opens up new avenues for drug development, meaning fewer surgeries may be needed in the future. “Eventually, the technology may lead to new and better ways of recording from patients’ brains before surgery.” The two-year project will see materials and electronic engineering applied to translational neuroscience research. The grant is from the Royal Society APEX Awards scheme (Academies Partnership in Supporting Excellence in Cross-disciplinary research award) which offers researchers with a strong track record in their area an opportunity to pursue interdisciplinary research to benefit wider society. For more information about studying at Aston University please visit our website.

Aston University and Partnership Medical shortlisted for knowledge transfer partnership award

Aston University and Partnership Medical (PML) have been shortlisted for an award at the KTP Awards 2022. The partnership has been shortlisted in the category of Best Knowledge Transfer Partnership for its work on a revolutionary automated cleaning system which uses synthetic chemistry to sterilise endoscopes, reducing risks of contamination to patients and lowering rates of mortality. A knowledge transfer partnership (KTP) is a three-way collaboration between a business, an academic partner and a highly qualified researcher , known as a KTP associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is the leading KTP provider within the Midlands. The KTP Awards recognise the people and partnerships behind the UK’s most inspiring and successful KTP projects. At present there are more than 800 inspiring collaborations happening across the country. Endoscopes are long, thin tubes with a light and camera at one end. Due to the sensitivity of the materials and electronics they cannot be sterilised, opening up high potential for cross infection. Through their automated cleaning system, Aston University and PML achieved industry-leading levels of disinfection, reducing risks of contamination to patients and lowering rates of mortality. The automated prototype and new cleaning materials developed in the KTP produced astonishing results in clinical trials, with a simple five-minute treatment offering deep cleaning levels 1,000 times better than anticipated, providing hygiene levels far superior to those currently possible using conventional manual procedures Mark Smith, executive director of business and regional engagement at Aston University, said: "It’s truly wonderful that Aston University has been formally recognised as a sector leader for knowledge transfer programmes, reflecting the scale and quality of our work with business. Making the shortlist is a recognition of our continued growth and sustained achievements in the knowledge exchange area. “The Aston University and Partnership Medical project has resulted in a far more effective medical cleaning system that ensures that endoscopes are truly sterile, which will ultimately save lives. This is just one example of the University’s real-world support for businesses and their customers. “It is an honour to be considered for best KTP at such a prestigious event, especially when knowledge exchange activity is at a high, with over 800 collaborations happening across the UK.” Partnership Medical Ltd (PML), based in Stoke-on-Trent, are specialists in supplying cleaning equipment and consumables for flexible endoscopes with over 20 years of distributor experience. The company aims to become a leading manufacturer/provider for endoscopic departments in clinics and hospitals worldwide. The Aston University team who worked on the KTP included Dr Andy Sutherland, reader in organic chemistry and member of the Aston Institute of Materials Research, Dr Tony Worthington, associate professor in clinical microbiology and infectious diseases and member of the Biosciences Research Group together with KTP associate, Dr Thien Duong, an expert in synthetic chemistry. The awards ceremony will take place on Wednesday 12 October in Liverpool and will be streamed online for those unable to attend in person.

Aston University history department gears up for live talk to mark 75 years since Indian partition

75 Years On: The Partition of India in a Global Perspective will take place at Café Artum at Hockley Social Club in Birmingham The partition saw the British Indian Empire split into two independent dominions, India and Pakistan The event on 25 August is the second in the series of Society matters LIVE. Aston University’s history department is set to host a live talk to mark 75 years since Indian partition. 75 Years On: The Partition of India in a Global Perspective will take place at Café Artum in Hockley Social Club on Thursday 25 August from 1700 to 1900 hrs. The event on 25 August is the second in the series of Society matters LIVE. The British decision in June 1947 to grant independence to its colony by creating two separate states caused the displacement of over ten million people as well as hundreds of thousands of casualties. In this talk, the second of Aston University’s ‘Society matters LIVE’ series, Dr Volker Prott will invite attendees to take a step back and explore the partition of India from a global historical perspective. Why did partition seem inevitable to so many people 75 years ago, even if they saw trouble ahead? Where does the idea of partition even come from? Why did so many partitions occur in the twentieth century and in the context of decolonisation? Dr Volker Prott, senior lecturer in history at Aston University, said: “The partition of India has become a synonym of tragedy and unimaginable human suffering. “Partition is also now seen by many as a massive diplomatic failure, giving rise to the Indo-Pakistani conflict, one of the most bitter and long-lasting territorial disputes since the end of the Second World War. “We will consider other partition examples, such as Ireland, Palestine, India, and also Germany, Korea, and Vietnam in order to tease out the concept of it and understand what it means in different contexts. “And of course, we will pay attention to the partition, discussing its many facets, and taking the time to explore ways to overcome its divisive legacy.” You can sign up to the free event here. You can listen to the latest podcast episode of ‘Society matters’ with Dr Volker Prott, who speaks about the legacy of India and Pakistan’s independence with journalist Steve Dyson, here. You can find out more about how Aston University’s history department is marking 75 years since Indian partition here. For more information about studying history at Aston University visit our website.

Driving the Ambitious $30M Plan for an Autonomous Vehicle Test Track and Research Center

Innovation and the automobile industry are on the move at UConn -- after four years of planning, coordinating, and developing, a major project is moving closer to reality in Connecticut: UConn’s Board of Trustees recently approved an option agreement to sell 105 acres in the southwest portion of the school’s Mansfield Depot Campus to a private company — Promesa Capital LLC — headed by Cortese, who would lead a group of investors in developing the site as the region’s first-ever connected and autonomous vehicle test track and research facility. Such a facility, Jackson and Cortese said, would be a boon for the university and region, helping make UConn a leader in autonomous vehicle research, technology and safety. “My goal is to raise the stature of UConn to a school where world-class research takes place on this technology, and students come to UConn specifically to work with leading faculty on projects that will change the way we travel,” Jackson said. “UConn will be transformational in terms of research and will provide a world-class facility to open opportunities we’ve never had before for the future of transportation.”  August 15 - Hartford Business Journal The endeavor has the potential for lasting positive impact in areas including innovation, research, investment, and the economy, and Eric Jackson -- director of the Connecticut Transportation Safety Research Center at UConn -- is at the forefront of this exciting development.  If you are a journalist looking to know more, let us help. Simply click on Jackson’s icon to arrange an interview today.

Aston University and ADInstruments join forces to bring game-changing animal telemetry system to market

Aston University and ADInstruments Ltd (ADI) enter 24-month knowledge transfer partnership to develop ground-breaking animal telemetry system World-leading expertise in neuroscience to help bring game-changing system to market Outcomes of KTP will feed directly into the product hardware and software development, ensuring technological advantage for ADI. Aston University has teamed up with research software experts ADInstruments Ltd (ADI) through a knowledge transfer partnership to develop a revolutionary dual-function wireless telemetry system for neuroscience research that is set to transform how implanted biosensors are used for data generation in animals. Telemetry is the automatic recording and transmission of data from remote or inaccessible sources to an IT system in a different location for monitoring and analysis. ADI has an established reputation for developing, supplying and supporting its customers in specific areas of life science research, particularly in cardiovascular science. The company has recently acquired Kaha Sciences, which has developed ground-breaking telemetry technology that can be used to measure neuroscience-relevant signals in free-moving animals for research. The company is looking to use the KTP to harness the world-leading expertise of Aston University to build their reputation in neuroscience. Mark de Reus, head of support at ADInstruments, said: “The evidence-base of research papers, training and support materials from Aston University will be invaluable in improving the product design, identifying development opportunities and embedding a culture of neuroscience within the company.” A knowledge transfer partnership (KTP) is a three-way collaboration between a business, an academic partner and a highly qualified graduate, known as a KTP associate. The UK-wide programme helps businesses to improve their competitiveness and productivity through the better use of knowledge, technology and skills. Aston University is the leading KTP provider within the Midlands. The Aston University team features Professor Gavin Woodhall and Dr Stuart Greenhill from its Pharmacy School’s Pharmacology and Translational Neuroscience Research Group. Professor Woodhall is co-director of the Institute of Health and Neurodevelopment (IHN) and a neuroscientist who studies epilepsy and schizophrenia in rodent models of disease. Dr Stuart Greenhill is a member of IHN and senior lecturer in neuroscience, with a longstanding track record in developing and deploying novel and difficult mechanisms of recording from brain tissue both in vivo and in vitro. Dr Stuart Greenhill said: “It is a privilege to be involved in the development of this important technology, which will be invaluable to thousands of research groups across the globe, and we are delighted to be able to help the product team realise the potential of this device.”